LOCUS       NM_016531               5594 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens KLF transcription factor 3 (KLF3), mRNA.
ACCESSION   NM_016531
VERSION     NM_016531.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5594)
  AUTHORS   Wan,B., Zhang,W., Deng,X., Lu,Y., Zhang,Z. and Yang,Y.
  TITLE     Molecular Expression and Prognostic Implications of Kruppel-Like
            Factor 3 (KLF3) in Clear Cell Renal Cell Carcinoma
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (2), 45-59 (2024)
   PUBMED   38073441
  REMARK    GeneRIF: Molecular Expression and Prognostic Implications of
            Kruppel-Like Factor 3 (KLF3) in Clear Cell Renal Cell Carcinoma.
REFERENCE   2  (bases 1 to 5594)
  AUTHORS   Liu,X. and Zhang,L.
  TITLE     microRNA-92b-3p augments colon cancer development through
            inhibiting KLF3
  JOURNAL   J Biochem Mol Toxicol 37 (12), e23488 (2023)
   PUBMED   37597242
  REMARK    GeneRIF: microRNA-92b-3p augments colon cancer development through
            inhibiting KLF3.
REFERENCE   3  (bases 1 to 5594)
  AUTHORS   Yu,W., Shen,J., Wang,X., Qin,H. and Xing,C.
  TITLE     Decreased KLF3 Expression via miR-660-5p Targeting Suppresses
            Gastric Cancer Cell Progression
  JOURNAL   Ann Clin Lab Sci 53 (5), 771-783 (2023)
   PUBMED   37945021
  REMARK    GeneRIF: Decreased KLF3 Expression via miR-660-5p Targeting
            Suppresses Gastric Cancer Cell Progression.
REFERENCE   4  (bases 1 to 5594)
  AUTHORS   Zhu,J., Teng,H., Zhu,X., Yuan,J., Zhang,Q. and Zou,Y.
  TITLE     Pan-cancer analysis of Kruppel-like factor 3 and its carcinogenesis
            in pancreatic cancer
  JOURNAL   Front Immunol 14, 1167018 (2023)
   PUBMED   37600783
  REMARK    GeneRIF: Pan-cancer analysis of Kruppel-like factor 3 and its
            carcinogenesis in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5594)
  AUTHORS   Li,Y., Wang,Y., Zou,Q., Li,S. and Zhang,F.
  TITLE     KLF3 Transcription Activates WNT1 and Promotes the Growth and
            Metastasis of Gastric Cancer via Activation of the WNT/beta-Catenin
            Signaling Pathway
  JOURNAL   Lab Invest 103 (6), 100078 (2023)
   PUBMED   36827869
  REMARK    GeneRIF: KLF3 Transcription Activates WNT1 and Promotes the Growth
            and Metastasis of Gastric Cancer via Activation of the
            WNT/beta-Catenin Signaling Pathway.
REFERENCE   6  (bases 1 to 5594)
  AUTHORS   Perdomo,J., Verger,A., Turner,J. and Crossley,M.
  TITLE     Role for SUMO modification in facilitating transcriptional
            repression by BKLF
  JOURNAL   Mol Cell Biol 25 (4), 1549-1559 (2005)
   PUBMED   15684403
  REMARK    GeneRIF: The recruitment of CtBP and sumoylation are required for
            full repression by BKLF.
REFERENCE   7  (bases 1 to 5594)
  AUTHORS   Wang,M.J., Qu,X.H., Wang,L.S., Zhai,Y., Wu,S.L. and He,F.C.
  TITLE     [cDNA cloning, subcellular localization and tissue expression of a
            new human Kruppel-like transcription factor: human basic
            Kruppel-like factor (hBKLF)]
  JOURNAL   Yi Chuan Xue Bao 30 (1), 1-9 (2003)
   PUBMED   12812068
REFERENCE   8  (bases 1 to 5594)
  AUTHORS   Turner,J. and Crossley,M.
  TITLE     Basic Kruppel-like factor functions within a network of interacting
            haematopoietic transcription factors
  JOURNAL   Int J Biochem Cell Biol 31 (10), 1169-1174 (1999)
   PUBMED   10582345
  REMARK    Review article
REFERENCE   9  (bases 1 to 5594)
  AUTHORS   Turner,J. and Crossley,M.
  TITLE     Cloning and characterization of mCtBP2, a co-repressor that
            associates with basic Kruppel-like factor and other mammalian
            transcriptional regulators
  JOURNAL   EMBO J 17 (17), 5129-5140 (1998)
   PUBMED   9724649
REFERENCE   10 (bases 1 to 5594)
  AUTHORS   Salesiotis,A.N., Wang,C.K., Wang,C.D., Burger,A., Li,H. and Seth,A.
  TITLE     Identification of novel genes from stomach cancer cell lines by
            differential display
  JOURNAL   Cancer Lett 91 (1), 47-54 (1995)
   PUBMED   7750094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB246277.1, AF285837.1, AC021860.6 and BU689914.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016531.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.185490.1,
                                           SRR1803612.216210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261438.10/ ENSP00000261438.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               DB246277.1         34-177
            145-1379            AF285837.1         2-1236
            1380-5461           AC021860.6         105187-109268
            5462-5585           BU689914.1         18-141              c
            5586-5594           AC021860.6         109393-109401
FEATURES             Location/Qualifiers
     source          1..5594
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..5594
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /note="KLF transcription factor 3"
                     /db_xref="GeneID:51274"
                     /db_xref="HGNC:HGNC:16516"
                     /db_xref="MIM:609392"
     exon            1..263
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            264..359
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1340
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /note="basic kruppel like factor; basic Kruppel-like
                     factor; TEF-2; Kruppel like factor 3; Kruppel-like factor
                     3 (basic); basic krueppel-like factor; CACCC-box-binding
                     protein BKLF; transcript ch138"
                     /codon_start=1
                     /product="Krueppel-like factor 3"
                     /protein_id="NP_057615.3"
                     /db_xref="CCDS:CCDS3444.1"
                     /db_xref="GeneID:51274"
                     /db_xref="HGNC:HGNC:16516"
                     /db_xref="MIM:609392"
                     /translation="MLMFDPVPVKQEAMDPVSVSYPSNYMESMKPNKYGVIYSTPLPE
                     KFFQTPEGLSHGIQMEPVDLTVNKRSSPPSAGNSPSSLKFPSSHRRASPGLSMPSSSP
                     PIKKYSPPSPGVQPFGVPLSMPPVMAAALSRHGIRSPGILPVIQPVVVQPVPFMYTSH
                     LQQPLMVSLSEEMENSSSSMQVPVIESYEKPISQKKIKIEPGIEPQRTDYYPEEMSPP
                     LMNSVSPPQALLQENHPSVIVQPGKRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSH
                     LKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDH
                     LALHRKRHMLV"
     exon            360..846
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            847..997
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1158
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..5594
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1692..1697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /note="hexamer: AGTAAA"
     polyA_site      1712
                     /gene="KLF3"
                     /gene_synonym="BKLF"
     regulatory      5097..5102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /note="hexamer: AATAAA"
     regulatory      5114..5119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /note="hexamer: ATTAAA"
     polyA_site      5119
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /note="major polyA site"
     polyA_site      5135
                     /gene="KLF3"
                     /gene_synonym="BKLF"
     regulatory      5565..5570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /note="hexamer: ATTAAA"
     regulatory      5570..5575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF3"
                     /gene_synonym="BKLF"
                     /note="hexamer: AGTAAA"
     polyA_site      5585
                     /gene="KLF3"
                     /gene_synonym="BKLF"
     polyA_site      5594
                     /gene="KLF3"
                     /gene_synonym="BKLF"
ORIGIN      
        1 agagcgagcg gcgccggcgt catgtgactg cccggagttg gtgccaggag ccagagggga
       61 gccaggagcg gagccgcgcg gagccggggc ccgagccgga gcgcagcgag agcgcccgcc
      121 gcacgcgcgc ccgtccccgt cccctgcggc cgccaacgcc gcccggactg gagccctgac
      181 attgctgcgc tcggggggct ccaggcagcc cgtatcgggg cctttatttc tcgtcggcgg
      241 cgccctgcac cgcgcctcgc aaagccaaac accagagcac cctagaaggt ttaactaaaa
      301 gaatgctcat gtttgaccca gttcctgtca agcaagaggc catggaccct gtctcagtgt
      361 catacccatc taattacatg gaatccatga agcctaacaa gtatggggtc atctactcca
      421 caccattgcc tgagaagttc tttcagaccc cagaaggtct gtcgcacgga atacagatgg
      481 agccagtgga cctcacggtg aacaagcgga gttcaccccc ttcggctggg aattcgccct
      541 cctctctgaa gttcccgtcc tcacaccgga gagcctcgcc tgggttgagc atgccttctt
      601 ccagcccacc gataaaaaaa tactcacccc cttctccagg cgtgcagccc ttcggcgtgc
      661 cgctgtccat gccaccagtg atggcagctg ccctctcgcg gcatggaata cggagcccgg
      721 ggatcctgcc cgtcatccag ccggtggtgg tgcagcccgt cccctttatg tacacaagtc
      781 acctccagca gcctctcatg gtctccttat cggaggagat ggaaaattcc agtagtagca
      841 tgcaagtacc tgtaattgaa tcatatgaga agcctatatc acagaaaaaa attaaaatag
      901 aacctgggat cgaaccacag aggacagatt attatcctga agaaatgtca ccccccttaa
      961 tgaactcagt gtcccccccg caagcattgt tgcaagagaa tcacccttcg gtcatcgtgc
     1021 agcctgggaa gagaccttta cctgtggaat ccccggatac tcaaaggaag cggaggatac
     1081 acagatgtga ttatgatgga tgcaacaaag tgtacactaa aagctcccac ttgaaagcac
     1141 acagaagaac acacacagga gaaaaaccct acaaatgtac atgggaaggg tgcacatgga
     1201 agtttgctcg gtctgatgaa ctaacaagac atttccgaaa acatactgga atcaaacctt
     1261 tccagtgccc ggactgtgac cgcagcttct cccgttctga ccatcttgcc ctccatagga
     1321 aacgccacat gctagtctga ttgcctctgt gtcctgcctc agcgtgactc cccactcacc
     1381 tggctctctc tctgtcctgc ctcccattat ctaacacatt ttttacatgt acattttaat
     1441 ttgattcagc tggtctgaat ctctgaattt atatcatcca aaacttccat atggtcagta
     1501 gtagatgttc tctaatcctc cctctcctta ccacgggtca gacctaaaga atgtgaacac
     1561 tttttttttt ttttctgggg atgctaagca aacccttctt acagatacgt ttaatgtaat
     1621 aagaacaagg gaacatgtaa actaacataa ccaattgtca gttctccatg tattcctcaa
     1681 aagaatgtca gagtaaatgt attagaaata cagtatccag actgctagtc cttgccagag
     1741 acattcttac ctctgccctg tgataatatt ttatgcttga cagtgaaaac aagtgtggcc
     1801 ccttgcaccg gttagctaga agtacagcca gatttcaagc tagtgcagtc acctcttccg
     1861 tcattcttca caaatcttgt caacctggat cttagacttc atctgaatcg agttctttgc
     1921 cctcctttgt gcctgcagct catatggagg tctttgccac caatgggaga tgagcccaaa
     1981 ctttcgatct aggtgggtga tgtgtagcag ttcaagggaa gggtgctgtg ttttcatagc
     2041 atggagtcgg aggagagggc catttagcag ggggagcaga agaggcaatt cctcctgggc
     2101 taggggttgt cagtgaggtt tcaacatttt gttagctgtg tgcagcattc ccagagcttc
     2161 agtctctgtg catactcagc tttgtagaac catgctgcaa agccatatac cgatggggtt
     2221 atccatgcaa ctatctccat tcctacaatg tccttaatat gagatcatca aacattgata
     2281 gtagggactc catggaatat ttgcccagta atggtaagaa atctttcggg taagagtatg
     2341 gatggttctt cttttaccca atctgcttat agcttttttt gtaaacaggg aaatgttgag
     2401 tggtacttgt attcccttat caaattaatc acatagcttt tatacagaaa ctcttcctgt
     2461 gtgagctgtt aaggtgccaa attggctgtc atttgtattc atgacacata ccataaagca
     2521 tctgctaatg ctttaatgga ttgattcaat taagacctga gtgacactat ttgtaaatat
     2581 aactagttgt gaagcacaca tacctttatt ttgggaattt atgagaaaat atagaaaacc
     2641 acagatcagg gattcatata tgtagctcaa aaattcccaa aagtttactg ttagagttgg
     2701 caatttccta tcactatttc agtgtcagaa caaactgaaa ataatggctc gtgtttatgt
     2761 tgaagataaa tagcaccatt attgggggaa gttattcaaa agcaggcttt tgagcaccat
     2821 agtctaaatg ccaataaaaa taattcatac atagaaatgt cattggtcct gaatttgaag
     2881 aaagtgagca acagtagtta aatgtgggtg catataacca aattcccctt catcaagaat
     2941 ggaggagaag agagaagaat gaaatcctga agattcatcc cagccgcaac tcaggatcca
     3001 acacaacttt aactgggagg aatacattgt ttgatcattt ttaaaacatc tgtgaatgag
     3061 tgattccgga ggcctgtgaa ttgtgtgggg agcttgcttt gatggcactg tgttaataaa
     3121 agttgtaggg actgtgcacc taagaggcta agaggtccca ctcatccgcc ctgtgaacca
     3181 gctgtaaaga aatgtagtta agaaatgcaa agaaatgtgt tatcttggca cttgggtttg
     3241 attttccttt ttttaaagca ctgcaaaact tctttaggat actaaaacat cctaattggg
     3301 ctgttttttt gttttgtttt gtttttcagc taaaggcaaa gataattttt ttttcagctg
     3361 aagtttttct tttttgcaac tatgacatga attgagtgat aaaatggctc tttgaaaagt
     3421 agatattgtc tgtattgtaa atgcttagtc atattcatgg caaagtgttc atttcttgag
     3481 atggttcttt cacaacacac aagaatcaag atggaacgca aggaaaatct ttttgttttg
     3541 accgaggtaa ccagtttatg tgtgttccaa tccatagaga agtgggggaa agggcgagaa
     3601 aggatcagat tgatctggga tcagctttga gcctgagttc agtgaatagc ctcatgggca
     3661 tctcatggaa ttgatgcatt tgctgtggca tatttaaatt ttgttcaaaa gatttgaagc
     3721 aagaccttgc aaagactctt aacattactg ttcagcttgc ttagattgtg ttaacagttc
     3781 atttaacaaa gatccgtttt aactctgaac aaaagcaacc cagagcggcc attctctatt
     3841 cccatgctgg tcaatacgct ttcattacca attggccctt accaaacttt tcttatatat
     3901 atatttgtat tttactatga tagttgagaa atttagcctc ttagtcattt ttagctgtta
     3961 ttgtggaaga cctcaaatac aagattagat gcccttgaac atgttttaat gatgtgtgtc
     4021 atgttactat caatggtgat ttcaatcgca atattttaaa ttgatgagaa tgatttgtaa
     4081 acatgaagtt actattacgt aaattctgtt tgttatagag tttcttcagt tgttacccaa
     4141 gtgtcatcct agagaagtca gaagaatcag aatccatcgt attttagagt tatgtgaatc
     4201 tacatcataa atgggcatta acattctaaa ttgcttggtt tggagaatgt gttagcagca
     4261 tagctatatt caactaggga gatgctaaat acacagaagt ttcaagagcc ttggaacaga
     4321 attacagggg aactatatat gtatatgtat attttattaa acacccatct gcactatcag
     4381 tattgcacta atgtggaatt tgaaagacta ttttgctgat actgtatata tgcgcatcat
     4441 tcctgattag attgttgtaa agacaatctg aaagatctaa ggttttaaaa taatttggtt
     4501 tgaaaatata cagttgtctt gaaggaattg ctgtcataca tgaagttgct ccgagctgtc
     4561 tttattctct tcttggtcaa ggttaacaat tgctaaatga tcgcaaattc acctaaacaa
     4621 tacatttaca aagccatctt tacatgcatt aaacgagggc tacaacaata ttgttttaca
     4681 aatactagca cttttttttc tgttatgtac ttagtgttag agggtcaaaa taatctttct
     4741 gcttagcatc tcttaaacca tacctgcaaa tatagcagga ttattacatt tacagtactt
     4801 taatacttgt ataaactatg cagaaatttt taataaagtg taatatattt tataagctaa
     4861 taagactgaa tgggtaaagg tttttagcat gcattagtat acttgcagat actgaaacat
     4921 tttggtaatc tttcttacta aagatgtgaa tgtttaatgt accttctctg tttctactct
     4981 gtagtccaat gggaattcag taatgacatt ttgtcatgtc aaactgtgaa cataaatttg
     5041 tactgtacag tcctcatata ctatatacag tatgcaatat atattatata cttgttaata
     5101 aaaccatcag aatattaaat gtgatcatgt gattacttca tatgcagtga tcactagagc
     5161 aaaacttaca gagcaatgta agaacccttg cttagaacat tacttactct gatgggcagt
     5221 tattgttgat ggagggacag aaaaatagat ctaactggaa gatgaactac cggaattaac
     5281 tcagccctca agctatgtcc ctggttttct gaaaacagcc aacaggaagt ctcctaggct
     5341 gaaatcataa aactgcagac aatccagcaa aaatctacaa actcacctag ttcattcttg
     5401 aaatacttct tgtatttgtt atttatgaac ccctgcctgc ttccaaaaag aacttgcagc
     5461 attttgtatt aaaagacgca tgtgtataat actttaaact tttagagtaa aatatcaaga
     5521 ctctcatgtt ggggagtggg gaacgaggaa cagaacaata acgcattaaa gtaaataact
     5581 ctggataaaa gtaa
//
