LOCUS       NM_016270               2820 bp    mRNA    linear   PRI 17-FEB-2025
DEFINITION  Homo sapiens KLF transcription factor 2 (KLF2), mRNA.
ACCESSION   NM_016270
VERSION     NM_016270.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2820)
  AUTHORS   Singh,M.K., Rallabandi,H.R., Zhou,X.J., Qi,Y.Y., Zhao,Z.Z., Gan,T.,
            Zhang,H., Looger,L.L. and Nath,S.K.
  TITLE     KLF2 enhancer variant rs4808485 increases lupus risk by modulating
            inflammasome machinery and cellular homoeostasis
  JOURNAL   Ann Rheum Dis 83 (7), 879-888 (2024)
   PUBMED   38373841
  REMARK    GeneRIF: KLF2 enhancer variant rs4808485 increases lupus risk by
            modulating inflammasome machinery and cellular homoeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2820)
  AUTHORS   Kang,K., Xiang,J., Zhang,X., Xie,Y., Zhou,M., Zeng,L., Zhuang,J.,
            Kuang,J., Lin,Y., Hu,B., Xiong,Q., Yin,Q., Su,Q., Liao,X., Wang,J.,
            Niu,Y., Liu,C., Tian,J. and Gou,D.
  TITLE     N6-methyladenosine modification of KLF2 may contribute to
            endothelial-to-mesenchymal transition in pulmonary hypertension
  JOURNAL   Cell Mol Biol Lett 29 (1), 69 (2024)
   PUBMED   38741032
  REMARK    GeneRIF: N6-methyladenosine modification of KLF2 may contribute to
            endothelial-to-mesenchymal transition in pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2820)
  AUTHORS   Tamargo,I.A., Baek,K.I., Xu,C., Kang,D.W., Kim,Y., Andueza,A.,
            Williams,D., Demos,C., Villa-Roel,N., Kumar,S., Park,C., Choi,R.,
            Johnson,J., Chang,S., Kim,P., Tan,S., Jeong,K., Tsuji,S. and Jo,H.
  TITLE     HEG1 Protects Against Atherosclerosis by Regulating Stable
            Flow-Induced KLF2/4 Expression in Endothelial Cells
  JOURNAL   Circulation 149 (15), 1183-1201 (2024)
   PUBMED   38099436
  REMARK    GeneRIF: HEG1 Protects Against Atherosclerosis by Regulating Stable
            Flow-Induced KLF2/4 Expression in Endothelial Cells.
REFERENCE   4  (bases 1 to 2820)
  AUTHORS   Cheng,X., Shen,C. and Liao,Z.
  TITLE     KLF2 transcription suppresses endometrial cancer cell
            proliferation, invasion, and migration through the inhibition of
            NPM1
  JOURNAL   J Obstet Gynaecol 43 (2), 2238827 (2023)
   PUBMED   37610103
  REMARK    GeneRIF: KLF2 transcription suppresses endometrial cancer cell
            proliferation, invasion, and migration through the inhibition of
            NPM1.
REFERENCE   5  (bases 1 to 2820)
  AUTHORS   Prateeksha,P., Naidu,P., Das,M., Barthels,D. and Das,H.
  TITLE     KLF2 Regulates Neural Differentiation of Dental Pulp-derived Stem
            Cells by Modulating Autophagy and Mitophagy
  JOURNAL   Stem Cell Rev Rep 19 (8), 2886-2900 (2023)
   PUBMED   37642902
  REMARK    GeneRIF: KLF2 Regulates Neural Differentiation of Dental
            Pulp-derived Stem Cells by Modulating Autophagy and Mitophagy.
REFERENCE   6  (bases 1 to 2820)
  AUTHORS   Denkinger,D.J., Cushman-Vokoun,A.M. and Kawahara,R.S.
  TITLE     Regulation of the vav proto-oncogene by LKLF
  JOURNAL   Gene 281 (1-2), 133-142 (2001)
   PUBMED   11750135
REFERENCE   7  (bases 1 to 2820)
  AUTHORS   Conkright,M.D., Wani,M.A. and Lingrel,J.B.
  TITLE     Lung Kruppel-like factor contains an autoinhibitory domain that
            regulates its transcriptional activation by binding WWP1, an E3
            ubiquitin ligase
  JOURNAL   J Biol Chem 276 (31), 29299-29306 (2001)
   PUBMED   11375995
REFERENCE   8  (bases 1 to 2820)
  AUTHORS   Wani,M.A., Conkright,M.D., Jeffries,S., Hughes,M.J. and
            Lingrel,J.B.
  TITLE     cDNA isolation, genomic structure, regulation, and chromosomal
            localization of human lung Kruppel-like factor
  JOURNAL   Genomics 60 (1), 78-86 (1999)
   PUBMED   10458913
REFERENCE   9  (bases 1 to 2820)
  AUTHORS   Kozyrev,S.V., Hansen,L.L., Poltaraus,A.B., Domninsky,D.A. and
            Kisselev,L.L.
  TITLE     Structure of the human CpG-island-containing lung Kruppel-like
            factor (LKLF) gene and its location in chromosome 19p13.11-13 locus
  JOURNAL   FEBS Lett 448 (1), 149-152 (1999)
   PUBMED   10217429
REFERENCE   10 (bases 1 to 2820)
  AUTHORS   Anderson,K.P., Kern,C.B., Crable,S.C. and Lingrel,J.B.
  TITLE     Isolation of a gene encoding a functional zinc finger protein
            homologous to erythroid Kruppel-like factor: identification of a
            new multigene family
  JOURNAL   Mol Cell Biol 15 (11), 5957-5965 (1995)
   PUBMED   7565748
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020917.4.
            
            On Aug 31, 2019 this sequence version replaced NM_016270.3.
            
            Summary: This gene encodes a protein that belongs to the Kruppel
            family of transcription factors. The encoded zinc finger protein is
            expressed early in mammalian development and is found in many
            different cell types. The protein acts to bind the CACCC box found
            in the promoter of target genes to activate their transcription. It
            plays a role in many processes during development and disease
            including adipogenesis, embryonic erythropoiesis, epithelial
            integrity, inflammation and t-cell viability. [provided by RefSeq,
            Mar 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225820.1, BC071983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248071.6/ ENSP00000248071.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC020917.4         11673-11845
            174-990             AC020917.4         12063-12879
            991-2820            AC020917.4         13703-15532
FEATURES             Location/Qualifiers
     source          1..2820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2820
                     /gene="KLF2"
                     /gene_synonym="LKLF"
                     /note="KLF transcription factor 2"
                     /db_xref="GeneID:10365"
                     /db_xref="HGNC:HGNC:6347"
                     /db_xref="MIM:602016"
     exon            1..173
                     /gene="KLF2"
                     /gene_synonym="LKLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1166
                     /gene="KLF2"
                     /gene_synonym="LKLF"
                     /note="lung Kruppel-like zinc finger transcription factor;
                     Kruppel-like factor LKLF; lung krueppel-like factor;
                     Kruppel-like factor 2 (lung); lung Kruppel-like factor;
                     Kruppel like factor 2"
                     /codon_start=1
                     /product="Krueppel-like factor 2"
                     /protein_id="NP_057354.1"
                     /db_xref="CCDS:CCDS12343.1"
                     /db_xref="GeneID:10365"
                     /db_xref="HGNC:HGNC:6347"
                     /db_xref="MIM:602016"
                     /translation="MALSEPILPSFSTFASPCRERGLQERWPRAEPESGGTDDDLNSV
                     LDFILSMGLDGLGAEAAPEPPPPPPPPAFYYPEPGAPPPYSAPAGGLVSELLRPELDA
                     PLGPALHGRFLLAPPGRLVKAEPPEADGGGGYGCAPGLTRGPRGLKREGAPGPAASCM
                     RGPGGRPPPPPDTPPLSPDGPARLPAPGPRASFPPPFGGPGFGAPGPGLHYAPPAPPA
                     FGLFDDAAAAAAALGLAPPAARGLLTPPASPLELLEAKPKRGRRSWPRKRTATHTCSY
                     AGCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQC
                     HLCDRAFSRSDHLALHMKRHM"
     exon            174..990
                     /gene="KLF2"
                     /gene_synonym="LKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            991..2820
                     /gene="KLF2"
                     /gene_synonym="LKLF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1983..1988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF2"
                     /gene_synonym="LKLF"
                     /note="hexamer: AATAAA"
     polyA_site      2009
                     /gene="KLF2"
                     /gene_synonym="LKLF"
                     /note="major polyA site"
     polyA_site      2030
                     /gene="KLF2"
                     /gene_synonym="LKLF"
     regulatory      2797..2802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF2"
                     /gene_synonym="LKLF"
                     /note="hexamer: AGTAAA"
     polyA_site      2820
                     /gene="KLF2"
                     /gene_synonym="LKLF"
ORIGIN      
        1 acagagccgt ccccgcccgc ccgcgccccg accagcccgg cctcgggcag ccactcaccg
       61 gtgtccccgt ccgcgtcctt tctccccggg tcccggccat ggcgctgagt gaacccatcc
      121 tgccgtcctt ctccactttc gccagcccgt gccgcgagcg cggcctgcag gagcgctggc
      181 cgcgcgccga acccgagtcc ggcggcaccg acgacgacct caacagcgtg ctggacttca
      241 tcctgtccat ggggctggat ggcctgggcg ccgaggccgc cccggagccg ccgccgccgc
      301 ccccgccgcc tgcgttctat taccccgaac ccggcgcgcc cccgccctac agcgcccccg
      361 cgggtggcct ggtgtctgag ctgctgcgac ccgagctgga tgcgccgctg gggcccgcac
      421 tgcacggccg ctttctgctg gcgccgcccg gccgcctggt caaggccgag ccccctgaag
      481 cggacggcgg cggcggctac ggctgcgccc ccgggctgac ccgtggaccg cgcggcctca
      541 agcgcgaggg cgccccgggc ccggcggctt cgtgcatgcg aggtcccggg ggccgccccc
      601 cgccgccgcc cgacacaccg ccgctcagcc ccgacggccc cgcgcgcctg cccgcgcccg
      661 gtccgcgcgc ctccttcccg ccgcctttcg gtggccctgg tttcggcgcg cccgggcccg
      721 gcctgcatta cgcgccgcct gcgcccccag ccttcggtct cttcgacgac gcggccgccg
      781 ccgcggcagc cctgggcctg gcgccccccg ccgcccgcgg tctcctcacg ccgcctgcgt
      841 ccccgctgga gctgctggag gccaagccaa agcgcggccg ccgctcttgg ccccgcaaac
      901 gcaccgccac tcacacctgc agctacgcgg gctgcggcaa gacctacacc aagagttcgc
      961 atctgaaggc gcatctgcgc acgcacacag gtgagaagcc ctaccactgc aactgggacg
     1021 gctgcggctg gaagtttgcg cgctcagacg agctcacgcg ccactaccga aagcacacgg
     1081 gccaccggcc attccagtgc catctgtgcg atcgtgcctt ctcgcgctcc gatcacctgg
     1141 cgctgcacat gaaacggcac atgtagccgg gacgcccccg cccacctgcg cgcggccgtg
     1201 gcgggtccca cgcgccgggc gcggccccct cccaaactgt gactggtatt tattggaccc
     1261 agagaaccgg gccgggcaca gcgtggctac agagggtctc cctcgatgac gacgacgacg
     1321 acgccaccac cccagccccc gtctgtgact gaaggcccgg tgggaaaaga ccacgatcct
     1381 ccttgacgag ttttgttttt caaaatggtg caataattta agtggcatct tctctcccac
     1441 cgggtctaca ctagaggatc gaggcttgtg atgccttgtg agaaataagg gccttaattt
     1501 gtactgtctg cggcattttt tataatattg tatatagtga ctgacaaata ttgtattact
     1561 gtacatagag agacaggtgg gcatttttgg gctacctggt tcgtttttat aagattttgc
     1621 tgggttggtt ttttttttaa ttaaaaagtt ttgcatcttt taaaaaaaat cacagcactg
     1681 gtctggttgc ttggaactgg ggccttgggg cacttgggag gaggggggag cggagagttt
     1741 gatggagggc agccccacta aagcatcgtg tgcagtgggt cctgcgtctg ccagcaccgg
     1801 gactgccagc tgctgtgcct gcctgccagg aacctgtggg tttttctgta aatttagaca
     1861 ctgcatttta ggactgaggg agggttattt taaggttgtt ctttgagcca taaattgcct
     1921 ctttgcccca cagctgggga aagtgctggt cccactgacg tggcctcctc tacgttgaaa
     1981 aaaataaaac tacttacctc ttcctggaag cctctgaggt tttagccaaa tttctggagt
     2041 gccagctcta tatttttatt tttattttta aagggggtta acctgctgag tttctggcat
     2101 gttctgccct ttactcgtct cgacatttag caagtctttt cttaaggggt gagttcccca
     2161 ttctgctagc ggaaaacagt gaaacctgca ttcgagggcc atgcatgaag ctcttttcca
     2221 gatgaggaaa cggaggcccg gagaggtagc ggcagggtgg tggagttggg ttgttagcct
     2281 gctctgtctg cctccaaggg tccctgaacc ccactggaag ggagtggtag ctttctacaa
     2341 tgacccacct gttgtgtgca ttggaaggct aggagagcct cctcccctgt aggtctcctg
     2401 gtgcaaaaaa ttcactgcct caatggtagg aggtgaccag tctggaaacc cacctggaga
     2461 gcagaggaga cccctaaatc ccaccacccc aagtgtctca ggcaaggagg tatctctccc
     2521 cccagatttc acctgccacc cctcaccttc cccattctca ggggccccgg gtaaccatga
     2581 ccaccaacca ttgcacaagt ttccagaaag tgaaaatagc tcgtaagcag cgcctgcttt
     2641 aaaacactct caccccgttg cgacagaggc tgggatttcc tccctccctg catccttcct
     2701 cctccccaac tacggcagcc ctggaaacag ctgagaggtg tttggtaatc cacgaaaagc
     2761 agaaatacga tttgacaatc tgattcattt tccgagagta aatagcctgg cctcacttcc
//
