LOCUS       NM_173484               3160 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens KLF transcription factor 17 (KLF17), mRNA.
ACCESSION   NM_173484
VERSION     NM_173484.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3160)
  AUTHORS   Wang,S.H., Hao,J., Zhang,C., Duan,F.F., Chiu,Y.T., Shi,M.,
            Huang,X., Yang,J., Cao,H. and Wang,Y.
  TITLE     KLF17 promotes human naive pluripotency through repressing MAPK3
            and ZIC2
  JOURNAL   Sci China Life Sci 65 (10), 1985-1997 (2022)
   PUBMED   35391627
  REMARK    GeneRIF: KLF17 promotes human naive pluripotency through repressing
            MAPK3 and ZIC2.
REFERENCE   2  (bases 1 to 3160)
  AUTHORS   Lea,R.A., McCarthy,A., Boeing,S., Fallesen,T., Elder,K., Snell,P.,
            Christie,L., Adkins,S., Shaikly,V., Taranissi,M. and Niakan,K.K.
  TITLE     KLF17 promotes human naive pluripotency but is not required for its
            establishment
  JOURNAL   Development 148 (22) (2021)
   PUBMED   34661235
  REMARK    GeneRIF: KLF17 promotes human naive pluripotency but is not
            required for its establishment.
REFERENCE   3  (bases 1 to 3160)
  AUTHORS   Li,S., Li,Y., Tan,B. and An,Z.
  TITLE     Effect of KLF17 overexpression on epithelial-mesenchymal transition
            of gastric cancer cells
  JOURNAL   J Int Med Res 49 (11), 3000605211051581 (2021)
   PUBMED   34738482
  REMARK    GeneRIF: Effect of KLF17 overexpression on epithelial-mesenchymal
            transition of gastric cancer cells.
REFERENCE   4  (bases 1 to 3160)
  AUTHORS   Feng,J., Li,K., Liu,G., Feng,Y., Shi,H. and Zhang,X.
  TITLE     Precision hyperthermia-induced miRNA-409-3p upregulation inhibits
            migration, invasion, and EMT of gastric cancer cells by targeting
            KLF17
  JOURNAL   Biochem Biophys Res Commun 549, 113-119 (2021)
   PUBMED   33667708
  REMARK    GeneRIF: Precision hyperthermia-induced miRNA-409-3p upregulation
            inhibits migration, invasion, and EMT of gastric cancer cells by
            targeting KLF17.
REFERENCE   5  (bases 1 to 3160)
  AUTHORS   An,Z.J., Li,Y., Tan,B.B., Zhao,Q., Fan,L.Q., Zhang,Z.D., Zhao,X.F.
            and Li,S.Y.
  TITLE     Up-regulation of KLF17 expression increases the sensitivity of
            gastric cancer to 5-fluorouracil
  JOURNAL   Int J Immunopathol Pharmacol 35, 20587384211010925 (2021)
   PUBMED   33960231
  REMARK    GeneRIF: Up-regulation of KLF17 expression increases the
            sensitivity of gastric cancer to 5-fluorouracil.
REFERENCE   6  (bases 1 to 3160)
  AUTHORS   Cai,X.D., Zhou,Y.B., Huang,L.X., Zeng,Q.L., Zhang,L.J., Wang,Q.Q.,
            Li,S.L., Feng,J.Q. and Han,A.J.
  TITLE     Reduced expression of Kruppel-like factor 17 is related to tumor
            growth and poor prognosis in lung adenocarcinoma
  JOURNAL   Biochem Biophys Res Commun 418 (1), 67-73 (2012)
   PUBMED   22240024
  REMARK    GeneRIF: it is possible that KLF17 inhibits tumor growth in lung
            adenocarcinoma.
REFERENCE   7  (bases 1 to 3160)
  AUTHORS   Gumireddy,K., Li,A., Gimotty,P.A., Klein-Szanto,A.J., Showe,L.C.,
            Katsaros,D., Coukos,G., Zhang,L. and Huang,Q.
  TITLE     KLF17 is a negative regulator of epithelial-mesenchymal transition
            and metastasis in breast cancer
  JOURNAL   Nat Cell Biol 11 (11), 1297-1304 (2009)
   PUBMED   19801974
  REMARK    GeneRIF: demonstrate that KLF17 expression is significantly
            downregulated in primary human breast cancer samples and that the
            combined expression pattern of KLF17 and Id1 can serve as a
            potential biomarker for lymph node metastasis in breast cancer
REFERENCE   8  (bases 1 to 3160)
  AUTHORS   Iwanicki,M.P. and Brugge,J.S.
  TITLE     Transcriptional regulation of metastatic [Id]entity by KLF17
  JOURNAL   Genome Biol 10 (11), 244 (2009)
   PUBMED   19951400
  REMARK    GeneRIF: KLF17 has a role in transcriptional regulation of
            metastasis by Id1 [review]
            Review article
REFERENCE   9  (bases 1 to 3160)
  AUTHORS   van Vliet,J., Crofts,L.A., Quinlan,K.G., Czolij,R., Perkins,A.C.
            and Crossley,M.
  TITLE     Human KLF17 is a new member of the Sp/KLF family of transcription
            factors
  JOURNAL   Genomics 87 (4), 474-482 (2006)
   PUBMED   16460907
  REMARK    GeneRIF: KLF17 is a new member of the Sp/KLF family of
            transcription factors.
REFERENCE   10 (bases 1 to 3160)
  AUTHORS   Yan,W., Burns,K.H., Ma,L. and Matzuk,M.M.
  TITLE     Identification of Zfp393, a germ cell-specific gene encoding a
            novel zinc finger protein
  JOURNAL   Mech Dev 118 (1-2), 233-239 (2002)
   PUBMED   12351194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356653.13, BC049844.1 and DB046781.1.
            
            On May 22, 2019 this sequence version replaced NM_173484.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049844.1, AK097479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000372299.4/
                                                ENSP00000361373.3
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL356653.13        2384-2412
            30-256              BC049844.1         1-227
            257-622             DB046781.1         200-565
            623-3160            BC049844.1         594-3131
FEATURES             Location/Qualifiers
     source          1..3160
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..3160
                     /gene="KLF17"
                     /gene_synonym="Zfp393; ZLF393; ZNF393"
                     /note="KLF transcription factor 17"
                     /db_xref="GeneID:128209"
                     /db_xref="HGNC:HGNC:18830"
                     /db_xref="MIM:609602"
     exon            1..168
                     /gene="KLF17"
                     /gene_synonym="Zfp393; ZLF393; ZNF393"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1257
                     /gene="KLF17"
                     /gene_synonym="Zfp393; ZLF393; ZNF393"
                     /note="zinc finger protein 393; novel zinc-finger protein;
                     Kruppel like factor 17"
                     /codon_start=1
                     /product="Krueppel-like factor 17"
                     /protein_id="NP_775755.3"
                     /db_xref="CCDS:CCDS508.1"
                     /db_xref="GeneID:128209"
                     /db_xref="HGNC:HGNC:18830"
                     /db_xref="MIM:609602"
                     /translation="MYGRPQAEMEQEAGELSRWQAAHQAAQDNENSAPILNMSSSSGS
                     SGVHTSWNQGLPSIQHFPHSAEMLGSPLVSVEAPGQNVNEGGPQFSMPLPERGMSYCP
                     QATLTPSRMIYCQRMSPPQQEMTIFSGPQLMPVGEPNIPRVARPFGGNLRMPPNGLPV
                     SASTGIPIMSHTGNPPVPYPGLSTVPSDETLLGPTVPSTEAQAVLPSMAQMLPPQDAH
                     DLGMPPAESQSLLVLGSQDSLVSQPDSQEGPFLPEQPGPAPQTVEKNSRPQEGTGRRG
                     SSEARPYCCNYENCGKAYTKRSHLVSHQRKHTGERPYSCNWESCSWSFFRSDELRRHM
                     RVHTRYRPYKCDQCSREFMRSDHLKQHQKTHRPGPSDPQANNNNGEQDSPPAAGP"
     exon            169..1012
                     /gene="KLF17"
                     /gene_synonym="Zfp393; ZLF393; ZNF393"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1257
                     /gene="KLF17"
                     /gene_synonym="Zfp393; ZLF393; ZNF393"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..3160
                     /gene="KLF17"
                     /gene_synonym="Zfp393; ZLF393; ZNF393"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1867..1872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF17"
                     /gene_synonym="Zfp393; ZLF393; ZNF393"
                     /note="hexamer: ATTAAA"
     polyA_site      1887
                     /gene="KLF17"
                     /gene_synonym="Zfp393; ZLF393; ZNF393"
                     /note="major polyA site"
ORIGIN      
        1 gtggcgatgt accgataccc gcctgcgacg ccgtggtggc tggttccctg tctcttcagt
       61 agagagtcta gaccccaccc agtcttcatg tacggccgac cgcaggctga gatggaacag
      121 gaggctgggg agctgagccg gtggcaggcg gcgcaccagg ctgcccagga taacgagaac
      181 tcagcgccca tcttgaacat gtcttcatct tctggaagct ctggagtgca cacctcttgg
      241 aaccaaggcc taccaagcat tcagcacttt cctcacagcg cagagatgct ggggtcccct
      301 ttggtgtctg ttgaggcgcc ggggcagaat gtgaatgaag gggggccaca gttcagtatg
      361 ccactgcctg agcgtggtat gagctactgc ccccaagcga ctctcactcc ttcccggatg
      421 atttactgtc agagaatgtc tccccctcag caagagatga cgattttcag tgggccccaa
      481 ctaatgcccg taggagagcc caatattcca agggtagcca ggcccttcgg tgggaatcta
      541 aggatgcccc ccaatgggct gccagtctcg gcttccactg gaatcccaat aatgtcccac
      601 actgggaacc ctccagtgcc ttaccctggc ctctcgacag taccttctga cgaaacattg
      661 ttgggcccga ctgtgccttc cactgaggcc caggcagtgc tcccctccat ggctcagatg
      721 ttgcccccgc aagatgccca tgaccttggg atgcccccag ctgagtccca gtcattgctg
      781 gttttaggat ctcaggactc tcttgtcagt cagccagact ctcaagaagg cccatttcta
      841 ccagagcagc ccggacctgc tccacagaca gtagagaaga actccaggcc tcaggaaggg
      901 actggtagaa ggggctcctc agaggcaagg ccttactgct gcaactacga gaactgcgga
      961 aaagcttata ccaaacgctc ccacctcgtg agccaccagc gcaagcacac aggtgagagg
     1021 ccatattctt gcaactggga aagttgttca tggtctttct tccgttctga tgagcttaga
     1081 cgacatatgc gggtacacac cagatatcga ccatataaat gtgatcagtg cagccgggag
     1141 ttcatgaggt ctgaccatct caagcaacac cagaagactc atcggccggg accctcagac
     1201 ccacaggcca acaacaacaa tggagagcag gacagtcctc ctgctgctgg tccttaggtg
     1261 aatgaagaag gaagaggatt ccaggctgag agcactggac gtggcaactg ttcagaggag
     1321 aggcagtctt caagttctac attcattcag aaaaatgttt tttgagccta caatactgag
     1381 cgcaacaagg ctgtggagac ccatggtgag gagcatggag ttaactaaag gatgtgtcag
     1441 ggaagaaaga cttctcaagg aggtgcctcc atcagaccca aaggactcat gggggctagc
     1501 tgcacctcac atttcttgga catataccgt tggacatgtc tatcttctgg aaactatggc
     1561 atggacagta aggattcaga agtgcatgaa ggcaccctgc ctctgcagag cagaaagatc
     1621 atagacaaca tttatgaatg tgcccagtgc tgccaagaag agaagccggt cctctgcagg
     1681 ctcaagccta tctgggcctc tggggaagcc ccacagcctt ggctgtgcct gcccctgccc
     1741 tctcacccct accctgacct tgtcctactt cactgccttt gtctgtgtta ctagtggccc
     1801 cagtatacct gggatggaca tccaggtgcc cttcatccaa gctcctatgt gaggggaatg
     1861 gacattatta aaagaacagg ggcagaagtg gctcatttat gacccattca ctagccccag
     1921 ggattgaagt cttgggtact caaagtgtct ttctaccagg gcaccagatc ccttccatgg
     1981 agcaggtcat ctcgggttca ctgggccagg gatggtctct gttccccagc ccacctggct
     2041 cacacacagc ctcatgggta gggtcagcaa accagatggc ttgttgttgg aatgtaggat
     2101 gagaggcctg cttggtgacc tagcattttc accaagaagt ggacgtggag aggaccagag
     2161 tgatcaaggg tgtatgatgt gcactacaat ggtgggcaaa acaggctcct gctcttgtgg
     2221 aggtcacaat ctagcggaga aaggatgtta ctagaagtac acaaattggg cccggcgcga
     2281 tggctcacgc ctgtaatccc agcacttttg gaggccgagg caggcggatc atttgaggtt
     2341 agagattcga gaccagccgg gccaacatgg tgaaacccca tctctacaaa aaatacaaaa
     2401 attagcctgg catatggcgg gtaccgtaat cctagctact cgggagactg acgggagaat
     2461 cgcttgaacc caggaggcgg aggttgcagt gagctcagat ctcaccattg cactccagcc
     2521 tgggcgactg agcgagactc tatctcaaaa caatcaaaac aaaaaagacc tgtggactct
     2581 agtagatttt gaatcctgcc tctgccattt cctggctatg aggtgtcttg agaaatttac
     2641 ttgtcactct tgcttctgat agtaaagggg atggtgcgat agattcaaga tggagagata
     2701 aggttaagtg ttttctttgg ctgcaacatg gagattagat tagagcaagg atgtaaggga
     2761 gaggaaggga catagcagta tttcaggtga gagtcaaggt ggctttggct agggtgtgag
     2821 agtggaggta gggagaagta ggaaagtgat agttaactgg atttgttagg tgagggtgag
     2881 gccaagggtg acttccaggt tcctgacttg tgttataagt aacacagaag aagaatggat
     2941 gaacttgatt cgttttccat tgattgtgat atctatcata cctgcaaaaa atattttgta
     3001 tatatccaat ttaataataa atgcactcat gttaggaagg tcaaaaaaaa ggaaaaaaga
     3061 aaaataataa aaaataataa aaatccttag gataacttga ggccaggagt ttgagaccag
     3121 tgtgaccttg tctctgtaaa aaataaaatt aaaagaaaaa
//
