LOCUS       NM_031918               2901 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens KLF transcription factor 16 (KLF16), mRNA.
ACCESSION   NM_031918
VERSION     NM_031918.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2901)
  AUTHORS   Yang,Z., Wang,Y.X., Wen,J.K., Gao,H.T., Han,Z.W., Qi,J.C., Gu,J.F.,
            Zhao,C.M., Zhang,H., Shi,B., Wang,D.D., Wang,X.L. and Qu,C.B.
  TITLE     SF3B4 promotes Twist1 expression and clear cell renal cell
            carcinoma progression by facilitating the export of KLF 16 mRNA
            from the nucleus to the cytoplasm
  JOURNAL   Cell Death Dis 14 (1), 26 (2023)
   PUBMED   36639679
  REMARK    GeneRIF: SF3B4 promotes Twist1 expression and clear cell renal cell
            carcinoma progression by facilitating the export of KLF 16 mRNA
            from the nucleus to the cytoplasm.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2901)
  AUTHORS   Li,L., Zhang,X., Li,Y., Xiao,B., Pei,S., Jiang,H. and Zhang,X.
  TITLE     Transcription factor KLF16 activates MAGT1 to regulate the
            tumorigenesis and progression of breast cancer
  JOURNAL   Int J Mol Med 50 (3) (2022)
   PUBMED   35796007
  REMARK    GeneRIF: Transcription factor KLF16 activates MAGT1 to regulate the
            tumorigenesis and progression of breast cancer.
REFERENCE   3  (bases 1 to 2901)
  AUTHORS   Yang,F., Chen,Y., Luo,L., Nong,S. and Li,T.
  TITLE     circFOXO3 Induced by KLF16 Modulates Clear Cell Renal Cell
            Carcinoma Growth and Natural Killer Cell Cytotoxic Activity through
            Sponging miR-29a-3p and miR-122-5p
  JOURNAL   Dis Markers 2022, 6062236 (2022)
   PUBMED   36072902
  REMARK    GeneRIF: circFOXO3 Induced by KLF16 Modulates Clear Cell Renal Cell
            Carcinoma Growth and Natural Killer Cell Cytotoxic Activity through
            Sponging miR-29a-3p and miR-122-5p.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2901)
  AUTHORS   Ma,X.D., Xu,S.D., Hao,S.H., Han,K., Chen,J.W., Ling,H., Chen,R.X.,
            Jin,X.H., Cao,J.H., Lin,J.L., Ou,Q.J., Fang,Y.J., Pan,Z.Z., Xie,D.
            and Wang,F.W.
  TITLE     KLF16 enhances stress tolerance of colorectal carcinomas by
            modulating nucleolar homeostasis and translational reprogramming
  JOURNAL   Mol Ther 30 (8), 2828-2843 (2022)
   PUBMED   35524408
  REMARK    GeneRIF: KLF16 enhances stress tolerance of colorectal carcinomas
            by modulating nucleolar homeostasis and translational
            reprogramming.
REFERENCE   5  (bases 1 to 2901)
  AUTHORS   Yang,L., Shi,Y.L., Ma,Y., Ren,W.W., Pang,G.M. and Liu,J.
  TITLE     Silencing KLF16 inhibits oral squamous cell carcinoma cell
            proliferation by arresting the cell cycle and inducing apoptosis
  JOURNAL   APMIS 130 (1), 43-52 (2022)
   PUBMED   34779529
  REMARK    GeneRIF: Silencing KLF16 inhibits oral squamous cell carcinoma cell
            proliferation by arresting the cell cycle and inducing apoptosis.
REFERENCE   6  (bases 1 to 2901)
  AUTHORS   Parker-Katiraee,L., Carson,A.R., Yamada,T., Arnaud,P., Feil,R.,
            Abu-Amero,S.N., Moore,G.E., Kaneda,M., Perry,G.H., Stone,A.C.,
            Lee,C., Meguro-Horike,M., Sasaki,H., Kobayashi,K., Nakabayashi,K.
            and Scherer,S.W.
  TITLE     Identification of the imprinted KLF14 transcription factor
            undergoing human-specific accelerated evolution
  JOURNAL   PLoS Genet 3 (5), e65 (2007)
   PUBMED   17480121
REFERENCE   7  (bases 1 to 2901)
  AUTHORS   Kanazawa,A., Kawamura,Y., Sekine,A., Iida,A., Tsunoda,T.,
            Kashiwagi,A., Tanaka,Y., Babazono,T., Matsuda,M., Kawai,K.,
            Iiizumi,T., Fujioka,T., Imanishi,M., Kaku,K., Iwamoto,Y.,
            Kawamori,R., Kikkawa,R., Nakamura,Y. and Maeda,S.
  TITLE     Single nucleotide polymorphisms in the gene encoding Kruppel-like
            factor 7 are associated with type 2 diabetes
  JOURNAL   Diabetologia 48 (7), 1315-1322 (2005)
   PUBMED   15937668
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2901)
  AUTHORS   Kaczynski,J.A., Conley,A.A., Fernandez Zapico,M., Delgado,S.M.,
            Zhang,J.S. and Urrutia,R.
  TITLE     Functional analysis of basic transcription element (BTE)-binding
            protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a
            subfamily of transcriptional repressors for the BTE site of the
            cytochrome P4501A1 gene promoter
  JOURNAL   Biochem J 366 (Pt 3), 873-882 (2002)
   PUBMED   12036432
  REMARK    GeneRIF: protein analysis of BTEB3 and BTEB4 and their binding to
            CYP1A1
REFERENCE   9  (bases 1 to 2901)
  AUTHORS   Zhang,J.S., Moncrieffe,M.C., Kaczynski,J., Ellenrieder,V.,
            Prendergast,F.G. and Urrutia,R.
  TITLE     A conserved alpha-helical motif mediates the interaction of
            Sp1-like transcriptional repressors with the corepressor mSin3A
  JOURNAL   Mol Cell Biol 21 (15), 5041-5049 (2001)
   PUBMED   11438660
REFERENCE   10 (bases 1 to 2901)
  AUTHORS   Hwang,C.K., D'Souza,U.M., Eisch,A.J., Yajima,S., Lammers,C.H.,
            Yang,Y., Lee,S.H., Kim,Y.M., Nestler,E.J. and Mouradian,M.M.
  TITLE     Dopamine receptor regulating factor, DRRF: a zinc finger
            transcription factor
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7558-7563 (2001)
   PUBMED   11390978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012615.4, BE243730.1, AF327440.1 and BQ447922.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031918.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.312212.1, CV809534.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250916.6/ ENSP00000250916.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC012615.4         56013-56026         c
            15-82               BE243730.1         1-68
            83-1019             AF327440.1         1-937
            1020-2362           AC012615.4         45385-46727         c
            2363-2901           BQ447922.1         18-556              c
FEATURES             Location/Qualifiers
     source          1..2901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2901
                     /gene="KLF16"
                     /gene_synonym="BTEB4; DRRF; NSLP2"
                     /note="KLF transcription factor 16"
                     /db_xref="GeneID:83855"
                     /db_xref="HGNC:HGNC:16857"
                     /db_xref="MIM:606139"
     exon            1..539
                     /gene="KLF16"
                     /gene_synonym="BTEB4; DRRF; NSLP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..841
                     /gene="KLF16"
                     /gene_synonym="BTEB4; DRRF; NSLP2"
                     /note="basic transcription element binding protein 4;
                     BTE-binding protein 4; dopamine receptor regulating
                     factor; transcription factor BTEB4; transcription factor
                     NSLP2; novel Sp1-like zinc finger transcription factor 2;
                     unknown transcript; Kruppel like factor 16"
                     /codon_start=1
                     /product="Krueppel-like factor 16"
                     /protein_id="NP_114124.1"
                     /db_xref="CCDS:CCDS12075.1"
                     /db_xref="GeneID:83855"
                     /db_xref="HGNC:HGNC:16857"
                     /db_xref="MIM:606139"
                     /translation="MSAAVACVDYFAADVLMAISSGAVVHRGRPGPEGAGPAAGLDVR
                     AARREAASPGTPGPPPPPPAASGPGPGAAAAPHLLAASILADLRGGPGAAPGGASPAS
                     SSSAASSPSSGRAPGAAPSAAAKSHRCPFPDCAKAYYKSSHLKSHLRTHTGERPFACD
                     WQGCDKKFARSDELARHHRTHTGEKRFSCPLCSKRFTRSDHLAKHARRHPGFHPDLLR
                     RPGARSTSPSDSLPCSLAGSPAPSPAPSPAPAGL"
     exon            540..2901
                     /gene="KLF16"
                     /gene_synonym="BTEB4; DRRF; NSLP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2879..2884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF16"
                     /gene_synonym="BTEB4; DRRF; NSLP2"
                     /note="hexamer: AACAAG"
     polyA_site      2901
                     /gene="KLF16"
                     /gene_synonym="BTEB4; DRRF; NSLP2"
                     /note="major polyA site"
ORIGIN      
        1 actcgagcag ccgccgccgg ccggacggac gccgctcccg ccgcctccgc tccgcccgcc
       61 gcgccgcgcg cccttgctcg gcatgtcggc ggccgtggcg tgcgtggatt acttcgccgc
      121 cgacgtgctc atggccatct cttcgggcgc cgtggtgcac cgcgggcggc ccggccccga
      181 gggcgcgggc cccgccgccg gcctggatgt gcgcgcggcg cgccgcgagg ccgcctcacc
      241 cgggaccccg gggccacccc cgccgccccc cgccgcttct ggcccgggcc ccggcgccgc
      301 cgcggcgccc cacctgctgg ccgccagcat cctggccgac ctgcgcggcg gacccggagc
      361 cgccccgggg ggcgcctcgc ccgcctcctc ctcctcagcc gcctcgtccc cgtcctcggg
      421 ccgcgccccc ggcgccgcgc cctccgccgc cgccaagagc caccgctgtc ccttcccgga
      481 ctgcgccaaa gcctactaca agtcctcgca cctaaagtcg cacctgcgga cgcacacagg
      541 ggaacgccct tttgcttgtg actggcaggg ctgcgacaag aagttcgccc gctccgacga
      601 gctggcccgc caccaccgga cgcacacggg cgagaagcgc ttctcctgcc ctctgtgctc
      661 caagcgcttc acccgcagtg accacctggc caagcacgcc cgccgccacc ccggcttcca
      721 cccggacctg ctccggcgcc ctggtgcccg cagtacctcc cccagcgact cgctgccctg
      781 cagcctggcc gggagccctg cgcccagccc cgcgcccagc ccagcccccg caggcctgta
      841 gggccctcgt gcagcccacc ctgaccgcca ggatgcttct gccatccagg ggtgtagtga
      901 ggacccacgg ggagcctggg ccccttccag ccgtgggcaa accctgaaga cacccctgcc
      961 cccctccaga gagtgaggag ggggcctgag actggacctg ggtctgcctg acctcagagg
     1021 tggctctcag gatgggtgac gggggcttgt gtctgtaaat agccatgata ctaactttct
     1081 tcccatctgt gcaacggggc ccccccaggg cagctaggag gtcctcccct ctcctctcca
     1141 ccaccccctg ctgcccccct cccggggtgg ggtttggggg ggtggagtgg acttctggga
     1201 gccggcccgg ggaaagcacc ccctgcccca tccctgcaga ttgggatgaa gtgttcagac
     1261 agccatagag gagtcggggg ttgacacggc ccctgcctct ccccacccca cccccacccc
     1321 accgaaagcc atgggagtag ttcagggaaa tgggggtgca gcccagccac cccccattcg
     1381 ggtactcaat ctcaggtgtc cacaagttct gcccacggta ggggctgcct ggccccccag
     1441 acctcggggg tagagccagg agtggggcag cgttaggatg cccggagggg ctccaggtgt
     1501 tgcttctgag acctgggatg gggagggagg ggacctctgg gttcttccaa agaacatttg
     1561 actcagtggg gtcgggaggg aatcctggct tatttatttt cctctgtcct cgggtgtggg
     1621 ggccctagct cgccctctct gggtgggtgg gtgagagagg ctgcagggga ggctggcacc
     1681 gggcttgggc ctccagtccc tgccttgctg actttggccg ttgcggtatc acgtgacaat
     1741 caactctccc ttaacgacga ctgcggctgt tgggctgcgc tgccctccct ggcctgcagg
     1801 tggggccgtg gagcccatgc ccgccggggt tgcaggctct tccgggcctg ggctgcagcc
     1861 tggcccggcc ctgcttccct ggcctcccct ccttctcctg ggtgcttgga agaggtgggt
     1921 cctggcccgt ggttgaggtc ttgcctcgtg gactggaagc agagggctgg ctgtgcagcc
     1981 tcctggggta gctcgttttt tttgcaccgg gtagaatatt ttttcaggca cggattcctt
     2041 tttttctggg cccccatggg tggtccggca tcctcagggg gtgtgagtgt gtgtgggggg
     2101 tctctgagct gaacttgggt ggggtgggga cttgttcctc gggggccacc tttgtgtcct
     2161 tgtcagcggt cgtcctgctg tggcctgggt tgcatttcct cttggggggg gtattgagga
     2221 cccccagcct ggaatgagaa gggtccccgg ttccatgtca gacccagaaa ggtggatccc
     2281 cccactgttg gctgcaggag gtttttggta cccccttttg ttccagaacc gtcctgcctc
     2341 tcgcttgggg acaggggggc tttggatggc actggtgtgc acctggaccc agccccggcc
     2401 tggcaggatc cagggatggg tgcctgggat cctgggggga gggaggcagg ggacgccctt
     2461 ctggagctgg gctcggaggg tcctgcccca tccagccctc ggctctctgt gttctctgtc
     2521 cctagcctca aaccctcttc tggcagcgct agtgagatgc cttagtctgt gggggtgggt
     2581 gggggactgg ggccccgttt tcctttgtga gtcttggttg gccccagccc tggcaggggc
     2641 ctgtctggag caggggtagg tagggctgtg ggttccagaa ctctataact gggcccctct
     2701 ccagtgtcca ggggcttgga gagacctgcg cccacccctc cactctccca ggagtcgctg
     2761 atcactggga cctggttcca gccgtttgca ggggaggcgg ctccgagagg cgtgtgcttt
     2821 ccgtgggtgg cgcccctccc ccgccctgcc tggcctcatc cttgtattta attaattaaa
     2881 caagcccctt tttaaaccct a
//
