LOCUS       NM_014079               2540 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens KLF transcription factor 15 (KLF15), mRNA.
ACCESSION   NM_014079
VERSION     NM_014079.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2540)
  AUTHORS   Zheng,H., Ye,W., Huang,K., Chen,Q., Yang,J. and Luo,L.
  TITLE     KLF15 alleviates oxidative stress and apoptosis of H/R-induced
            trophoblast cells to improve invasion and migration capacity via
            the activation of IGF1R
  JOURNAL   Tissue Cell 90, 102485 (2024)
   PUBMED   39067323
  REMARK    GeneRIF: KLF15 alleviates oxidative stress and apoptosis of
            H/R-induced trophoblast cells to improve invasion and migration
            capacity via the activation of IGF1R.
REFERENCE   2  (bases 1 to 2540)
  AUTHORS   Ni,D., Qi,Z., Wang,Y., Man,Y., Pang,J., Tang,W., Chen,J., Li,J. and
            Li,G.
  TITLE     KLF15-activated MARCH2 boosts cell proliferation and
            epithelial-mesenchymal transition and presents diagnostic
            significance for hepatocellular carcinoma
  JOURNAL   Exp Cell Res 440 (1), 114117 (2024)
   PUBMED   38848952
  REMARK    GeneRIF: KLF15-activated MARCH2 boosts cell proliferation and
            epithelial-mesenchymal transition and presents diagnostic
            significance for hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 2540)
  AUTHORS   Fang,G., Tian,Y., Huang,S., Zhang,X., Liu,Y., Li,Y., Du,J. and
            Gao,S.
  TITLE     KLF15 maintains contractile phenotype of vascular smooth muscle
            cells and prevents thoracic aortic dissection by interacting with
            MRTFB
  JOURNAL   J Biol Chem 300 (5), 107260 (2024)
   PUBMED   38582447
  REMARK    GeneRIF: KLF15 maintains contractile phenotype of vascular smooth
            muscle cells and prevents thoracic aortic dissection by interacting
            with MRTFB.
REFERENCE   4  (bases 1 to 2540)
  AUTHORS   Huang,Y., Wang,Z., Li,B., Ke,L., Xiong,Y. and Zhang,Y.
  TITLE     Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in
            endometriosis
  JOURNAL   J Endocrinol 261 (2), e230319 (2024)
   PUBMED   38513352
  REMARK    GeneRIF: Loss of KLF15 impairs endometrial receptivity by
            inhibiting EMT in endometriosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2540)
  AUTHORS   Yang,X., Dong,S., Fan,Y., Xia,Y., Yang,F., Chen,Z., Chen,D.,
            Zhang,M., Liang,D. and Zeng,C.
  TITLE     Kruppel-like Factor 15 Suppresses Ferroptosis by Activating an
            NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney
            Injury
  JOURNAL   Int J Mol Sci 24 (19), 14530 (2023)
   PUBMED   37833977
  REMARK    GeneRIF: Kruppel-like Factor 15 Suppresses Ferroptosis by
            Activating an NRF2/GPX4 Signal to Protect against Folic
            Acid-Induced Acute Kidney Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2540)
  AUTHORS   Fisch,S., Gray,S., Heymans,S., Haldar,S.M., Wang,B., Pfister,O.,
            Cui,L., Kumar,A., Lin,Z., Sen-Banerjee,S., Das,H., Petersen,C.A.,
            Mende,U., Burleigh,B.A., Zhu,Y., Pinto,Y.M., Liao,R. and Jain,M.K.
  TITLE     Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy
  JOURNAL   Proc Natl Acad Sci U S A 104 (17), 7074-7079 (2007)
   PUBMED   17438289
  REMARK    GeneRIF: These studies identify KLF15 as part of a heretofore
            unrecognized pathway regulating the cardiac response to hemodynamic
            stress
            Erratum:[Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13851.
            Pinto, Yigal [corrected to Pinto, Yigal M]]
REFERENCE   7  (bases 1 to 2540)
  AUTHORS   Kanazawa,A., Kawamura,Y., Sekine,A., Iida,A., Tsunoda,T.,
            Kashiwagi,A., Tanaka,Y., Babazono,T., Matsuda,M., Kawai,K.,
            Iiizumi,T., Fujioka,T., Imanishi,M., Kaku,K., Iwamoto,Y.,
            Kawamori,R., Kikkawa,R., Nakamura,Y. and Maeda,S.
  TITLE     Single nucleotide polymorphisms in the gene encoding Kruppel-like
            factor 7 are associated with type 2 diabetes
  JOURNAL   Diabetologia 48 (7), 1315-1322 (2005)
   PUBMED   15937668
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2540)
  AUTHORS   Otteson,D.C., Lai,H., Liu,Y. and Zack,D.J.
  TITLE     Zinc-finger domains of the transcriptional repressor KLF15 bind
            multiple sites in rhodopsin and IRBP promoters including the CRS-1
            and G-rich repressor elements
  JOURNAL   BMC Mol Biol 6, 15 (2005)
   PUBMED   15963234
  REMARK    GeneRIF: KLF15 binds to multiple 9 bp consensus sites in the
            Rhodospin and IRBP promoters including the CRS-1 and G-rich
            repressor elements. An in vivo role for KLF15 in repressing
            photoreceptor-specific gene expression in the inner retina is
            hypothesized.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2540)
  AUTHORS   Uchida,S., Sasaki,S. and Marumo,F.
  TITLE     Isolation of a novel zinc finger repressor that regulates the
            kidney-specific CLC-K1 promoter
  JOURNAL   Kidney Int 60 (2), 416-421 (2001)
   PUBMED   11473619
REFERENCE   10 (bases 1 to 2540)
  AUTHORS   Uchida,S., Tanaka,Y., Ito,H., Saitoh-Ohara,F., Inazawa,J.,
            Yokoyama,K.K., Sasaki,S. and Marumo,F.
  TITLE     Transcriptional regulation of the CLC-K1 promoter by myc-associated
            zinc finger protein and kidney-enriched Kruppel-like factor, a
            novel zinc finger repressor
  JOURNAL   Mol Cell Biol 20 (19), 7319-7331 (2000)
   PUBMED   10982849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC063919.15 and BC036733.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014079.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036733.1, SRR14038197.699968.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296233.4/ ENSP00000296233.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC063919.15        73473-73487
            16-1994             BC036733.1         13-1991
            1995-2024           AC063919.15        87701-87730
            2025-2540           BC036733.1         2014-2529
FEATURES             Location/Qualifiers
     source          1..2540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..2540
                     /gene="KLF15"
                     /gene_synonym="KKLF"
                     /note="KLF transcription factor 15"
                     /db_xref="GeneID:28999"
                     /db_xref="HGNC:HGNC:14536"
                     /db_xref="MIM:606465"
     exon            1..172
                     /gene="KLF15"
                     /gene_synonym="KKLF"
                     /inference="alignment:Splign:2.1.0"
     exon            173..1279
                     /gene="KLF15"
                     /gene_synonym="KKLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1448
                     /gene="KLF15"
                     /gene_synonym="KKLF"
                     /note="kidney-enriched Kruppel-like factor;
                     kidney-enriched krueppel-like factor; Kruppel like factor
                     15"
                     /codon_start=1
                     /product="Krueppel-like factor 15"
                     /protein_id="NP_054798.1"
                     /db_xref="CCDS:CCDS3036.1"
                     /db_xref="GeneID:28999"
                     /db_xref="HGNC:HGNC:14536"
                     /db_xref="MIM:606465"
                     /translation="MVDHLLPVDENFSSPKCPVGYLGDRLVGRRAYHMLPSPVSEDDS
                     DASSPCSCSSPDSQALCSCYGGGLGTESQDSILDFLLSQATLGSGGGSGSSIGASSGP
                     VAWGPWRRAAAPVKGEHFCLPEFPLGDPDDVPRPFQPTLEEIEEFLEENMEPGVKEVP
                     EGNSKDLDACSQLSAGPHKSHLHPGSSGRERCSPPPGGASAGGAQGPGGGPTPDGPIP
                     VLLQIQPVPVKQESGTGPASPGQAPENVKVAQLLVNIQGQTFALVPQVVPSSNLNLPS
                     KFVRIAPVPIAAKPVGSGPLGPGPAGLLMGQKFPKNPAAELIKMHKCTFPGCSKMYTK
                     SSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFAR
                     SDHLSKHIKVHRFPRSSRSVRSVN"
     exon            1280..2540
                     /gene="KLF15"
                     /gene_synonym="KKLF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2518..2523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF15"
                     /gene_synonym="KKLF"
                     /note="hexamer: AATAAA"
     polyA_site      2540
                     /gene="KLF15"
                     /gene_synonym="KKLF"
                     /note="major polyA site"
ORIGIN      
        1 agtgctccgc cgcagcgacc cgcgggccgg cgggcgatcg agccagcgca ggacccgcgg
       61 ctcggccccc ggccgccgcc ggaccgagag tctagccgcc gcccccagcc cagcccgccc
      121 ggccgcagga ccgccggggc ctggccgccg gtccggcgtg cgccaagttc agccgccacc
      181 ggcacggcca ggccagcatg gtggaccact tacttccagt ggacgagaac ttctcgtcgc
      241 caaaatgccc agttgggtat ctgggtgata ggctggttgg ccggcgggca tatcacatgc
      301 tgccctcacc cgtctctgaa gatgacagcg atgcctccag cccctgctcc tgttccagtc
      361 ccgactctca agccctctgc tcctgctatg gtggaggcct gggcaccgag agccaggaca
      421 gcatcttgga cttcctattg tcccaggcca cgctgggcag tggcgggggc agcggcagta
      481 gcattggggc cagcagtggc cccgtggcct gggggccctg gcgaagggca gcggcccctg
      541 tgaaggggga gcatttctgc ttgcccgagt ttcctttggg tgatcctgat gacgtcccac
      601 ggcccttcca gcctaccctg gaggagattg aagagtttct ggaggagaac atggagcctg
      661 gagtcaagga ggtccctgag ggcaacagca aggacttgga tgcctgcagc cagctctcag
      721 ctgggccaca caagagccac ctccatcctg ggtccagcgg gagagagcgc tgttcccctc
      781 caccaggtgg tgccagtgca ggaggtgccc agggcccagg tgggggcccc acgcctgatg
      841 gccccatccc agtgttgctg cagatccagc ccgtgcctgt gaagcaggaa tcgggcacag
      901 ggcctgcctc ccctgggcaa gccccagaga atgtcaaggt tgcccagctc ctggtcaaca
      961 tccaggggca gaccttcgca ctcgtgcccc aggtggtacc ctcctccaac ttgaacctgc
     1021 cctccaagtt tgtgcgcatt gcccctgtgc ccattgccgc caagcctgtt ggatcgggac
     1081 ccctggggcc tggccctgcc ggtctcctca tgggccagaa gttccccaag aacccagccg
     1141 cagaactcat caaaatgcac aaatgtactt tccctggctg cagcaagatg tacaccaaaa
     1201 gcagccacct caaggcccac ctgcgccggc acacgggtga gaagcccttc gcctgcacct
     1261 ggccaggctg cggctggagg ttctcgcgct ctgacgagct gtcgcggcac aggcgctcgc
     1321 actcaggtgt gaagccgtac cagtgtcctg tgtgcgagaa gaagttcgcg cggagcgacc
     1381 acctctccaa gcacatcaag gtgcaccgct tcccgcggag cagccgctcc gtgcgctccg
     1441 tgaactgaaa gcgccctgaa ccccagcctg tccgtcaccc cggatcccca ccccatcccc
     1501 atttttttaa gcaataattt atttgcctcc tccagaggga catggcaatg ttaccagccc
     1561 accttctgaa gcctgggagg tgtgaaccca gggcccgcca accgctgcct ttctcgggag
     1621 tacttagagc ctcgaacccg cgtccctggg ggctgggccc caggcgcacg gggctggagg
     1681 caggccttcg tgccttcgtg ccttcgtgcc ttcccgcggt ggccaggcct ctgctgcagc
     1741 cgctggttgc aggcagagtt ttggggacct ggcccttctc ccactgggct cccccatcct
     1801 gggccaaggc cagaacttta gtgctagggg aagatgaaat gtgcagtttt gaaatgttgg
     1861 gtttccagag agagtcatgc tggaggagaa ggaagtaggc cagaagtcca gggctgcact
     1921 gtggtgtgag ggtggctttg tctaagatgc ctgctcagca tgatcaccag agggtgtggg
     1981 caggtccctg gagccggggg gggggggggg gggggggggg ggcaggaccg ggccgctggg
     2041 ccctcatgtg ggagagaggt gaaaagcgtc ccccactagg gggctggcag tgcatgtgct
     2101 tgagttaaat gtgcagggca gacagagcca gaagggcctg tacccagggg ctcgtcccct
     2161 cctccggttt cccagacaaa tccagacacc agcctttagg gtggccttgg gaggagaggg
     2221 ccaggctgtc ctgggtgtga gagaactaga tagagcctcc caaccctgat ttagaaatgc
     2281 attccttatt ttgtctagaa attaataaat gaactagctt gttttgacag gtttatttca
     2341 catcctatga atgtatgtaa ataaactgta cataggtcca tccacataaa atatctttta
     2401 ataacatatc aacatttgtg taaatttgaa atttaaaaaa atctatgaag ctggtgtaca
     2461 tatgttacaa ttacgtatat tttctttggt ccttcataaa aatatattta ctttgccaat
     2521 aaaaagaaaa agaactcaca
//
