LOCUS       NM_138693               3511 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens KLF transcription factor 14 (KLF14), mRNA.
ACCESSION   NM_138693
VERSION     NM_138693.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3511)
  AUTHORS   Ye,H., Ding,X., Lv,X., Du,Y., Guo,R., Qiu,J., Li,R. and Cao,L.
  TITLE     KLF14 directly downregulates the expression of GPX4 to exert
            antitumor effects by promoting ferroptosis in cervical cancer
  JOURNAL   J Transl Med 22 (1), 923 (2024)
   PUBMED   39390559
  REMARK    GeneRIF: KLF14 directly downregulates the expression of GPX4 to
            exert antitumor effects by promoting ferroptosis in cervical
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3511)
  AUTHORS   Elfaki,I., Mir,R., Tayeb,F., Alalawy,A.I., Barnawi,J., Dabla,P.K.
            and Moawadh,M.S.
  TITLE     Potential Association of The Pathogenic Kruppel-like Factor 14
            (KLF14) and Adiponectin (ADIPOQ) SNVs with Susceptibility to T2DM
  JOURNAL   Endocr Metab Immune Disord Drug Targets 24 (9), 1090-1100 (2024)
   PUBMED   38031795
  REMARK    GeneRIF: Potential Association of The Pathogenic Kruppel-like
            Factor 14 (KLF14) and Adiponectin (ADIPOQ) SNVs with Susceptibility
            to T2DM.
REFERENCE   3  (bases 1 to 3511)
  AUTHORS   Du,Y., Ye,H., Lin,M. and Cao,L.
  TITLE     KLF14 activates the JNK-signaling pathway to induce S-phase arrest
            in cervical cancer cells
  JOURNAL   Front Immunol 14, 1267950 (2023)
   PUBMED   38143751
  REMARK    GeneRIF: KLF14 activates the JNK-signaling pathway to induce
            S-phase arrest in cervical cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3511)
  AUTHORS   Alanazi,A.S., Rasheed,S., Rehman,K., Mallhi,T.H., Akash,M.S.H.,
            Alotaibi,N.H., Alzarea,A.I., Tanveer,N. and Khan,Y.H.
  TITLE     Biochemical association of regulatory variant of KLF14 genotype in
            the pathogenesis of cardiodiabetic patients
  JOURNAL   Front Endocrinol (Lausanne) 14, 1176166 (2023)
   PUBMED   37351102
  REMARK    GeneRIF: Biochemical association of regulatory variant of KLF14
            genotype in the pathogenesis of cardiodiabetic patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3511)
  AUTHORS   Chen,X.Z., He,W.X., Luo,R.G., Xia,G.J., Zhong,J.X., Chen,Q.J.,
            Huang,Y.Y. and Guan,Y.X.
  TITLE     KLF14/miR-1283/TFAP2C axis inhibits HER2-positive breast cancer
            progression via declining tumor cell proliferation
  JOURNAL   Mol Carcinog 62 (4), 532-545 (2023)
   PUBMED   36752341
  REMARK    GeneRIF: KLF14/miR-1283/TFAP2C axis inhibits HER2-positive breast
            cancer progression via declining tumor cell proliferation.
REFERENCE   6  (bases 1 to 3511)
  AUTHORS   Fernandez-Zapico,M.E., Lomberk,G.A., Tsuji,S., DeMars,C.J.,
            Bardsley,M.R., Lin,Y.H., Almada,L.L., Han,J.J., Mukhopadhyay,D.,
            Ordog,T., Buttar,N.S. and Urrutia,R.
  TITLE     A functional family-wide screening of SP/KLF proteins identifies a
            subset of suppressors of KRAS-mediated cell growth
  JOURNAL   Biochem J 435 (2), 529-537 (2011)
   PUBMED   21171965
REFERENCE   7  (bases 1 to 3511)
  AUTHORS   Chasman,D.I., Pare,G., Mora,S., Hopewell,J.C., Peloso,G.,
            Clarke,R., Cupples,L.A., Hamsten,A., Kathiresan,S., Malarstig,A.,
            Ordovas,J.M., Ripatti,S., Parker,A.N., Miletich,J.P. and
            Ridker,P.M.
  TITLE     Forty-three loci associated with plasma lipoprotein size,
            concentration, and cholesterol content in genome-wide analysis
  JOURNAL   PLoS Genet 5 (11), e1000730 (2009)
   PUBMED   19936222
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 3511)
  AUTHORS   Truty,M.J., Lomberk,G., Fernandez-Zapico,M.E. and Urrutia,R.
  TITLE     Silencing of the transforming growth factor-beta (TGFbeta) receptor
            II by Kruppel-like factor 14 underscores the importance of a
            negative feedback mechanism in TGFbeta signaling
  JOURNAL   J Biol Chem 284 (10), 6291-6300 (2009)
   PUBMED   19088080
  REMARK    GeneRIF: the TGFbeta pathway activation leads to recruitment of a
            KLF14-mSin3A-HDAC2 repressor complex to the TGFbetaRII promoter, as
            well as the remodeling of chromatin to increase histone marks that
            associate with transcriptional silencing.
REFERENCE   9  (bases 1 to 3511)
  AUTHORS   Parker-Katiraee,L., Carson,A.R., Yamada,T., Arnaud,P., Feil,R.,
            Abu-Amero,S.N., Moore,G.E., Kaneda,M., Perry,G.H., Stone,A.C.,
            Lee,C., Meguro-Horike,M., Sasaki,H., Kobayashi,K., Nakabayashi,K.
            and Scherer,S.W.
  TITLE     Identification of the imprinted KLF14 transcription factor
            undergoing human-specific accelerated evolution
  JOURNAL   PLoS Genet 3 (5), e65 (2007)
   PUBMED   17480121
  REMARK    GeneRIF: KLF14 gene is imprinted, with preferential expression from
            the maternal allele.
REFERENCE   10 (bases 1 to 3511)
  AUTHORS   Suske,G., Bruford,E. and Philipsen,S.
  TITLE     Mammalian SP/KLF transcription factors: bring in the family
  JOURNAL   Genomics 85 (5), 551-556 (2005)
   PUBMED   15820306
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC234644.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 18, 2020 this sequence version replaced NM_138693.3.
            
            Summary: This intronless gene encodes a member of the Kruppel-like
            family of transcription factors. The encoded protein functions as a
            transcriptional co-repressor, and is induced by transforming growth
            factor-beta (TGF-beta) to repress TGF-beta receptor II gene
            expression. This gene exhibits imprinted expression from the
            maternal allele in embryonic and extra-embryonic tissues. [provided
            by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF490374.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 17480121
            MANE Ensembl match     :: ENST00000583337.4/ ENSP00000463287.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3511              AC234644.1         12752-16262
FEATURES             Location/Qualifiers
     source          1..3511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.2"
     gene            1..3511
                     /gene="KLF14"
                     /gene_synonym="BTEB5"
                     /note="KLF transcription factor 14"
                     /db_xref="GeneID:136259"
                     /db_xref="HGNC:HGNC:23025"
                     /db_xref="MIM:609393"
     exon            1..3511
                     /gene="KLF14"
                     /gene_synonym="BTEB5"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1146
                     /gene="KLF14"
                     /gene_synonym="BTEB5"
                     /note="BTE-binding protein 5; basic transcription
                     element-binding protein 5; transcription factor BTEB5;
                     Kruppel like factor 14"
                     /codon_start=1
                     /product="Krueppel-like factor 14"
                     /protein_id="NP_619638.2"
                     /db_xref="CCDS:CCDS5825.1"
                     /db_xref="GeneID:136259"
                     /db_xref="HGNC:HGNC:23025"
                     /db_xref="MIM:609393"
                     /translation="MSAAVACLDYFAAECLVSMSAGAVVHRRPPDPEGAGGAAGSEVG
                     AAPPESALPGPGPPGPASVPQLPQVPAPSPGAGGAAPHLLAASVWADLRGSSGEGSWE
                     NSGEAPRASSGFSDPIPCSVQTPCSELAPASGAAAVCAPESSSDAPAVPSAPAAPGAP
                     AASGGFSGGALGAGPAPAADQAPRRRSVTPAAKRHQCPFPGCTKAYYKSSHLKSHQRT
                     HTGERPFSCDWLDCDKKFTRSDELARHYRTHTGEKRFSCPLCPKQFSRSDHLTKHARR
                     HPTYHPDMIEYRGRRRTPRIDPPLTSEVESSASGSGPGPAPSFTTCL"
     polyA_site      1638
                     /gene="KLF14"
                     /gene_synonym="BTEB5"
                     /note="major polyA site"
     polyA_site      1654
                     /gene="KLF14"
                     /gene_synonym="BTEB5"
     regulatory      3480..3485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF14"
                     /gene_synonym="BTEB5"
                     /note="hexamer: GATAAA"
     polyA_site      3511
                     /gene="KLF14"
                     /gene_synonym="BTEB5"
ORIGIN      
        1 gggcggcggc ggcagcggcg gctgcggcgg cggcggcggc agcaggcggc aggcggcgag
       61 cacccggcct cctgcttctc gctccgaggc tgcgggacgg acgctcccgg gaactccgtc
      121 gcccgcggcc ggccgcgttc ggacggcgct cgccggcggc cgggcggtcc cagcatgtcg
      181 gccgccgtgg cgtgcctgga ctacttcgcc gccgagtgcc tggtgtccat gtccgcgggc
      241 gccgtggttc accgccgccc gccggacccc gagggcgcgg gtggagccgc tggctcggag
      301 gtgggtgcgg cgccgccgga gtccgctctg ccgggtccgg ggccaccggg gcccgcgtcg
      361 gtcccccagc tcccgcaggt ccccgccccc agccccggcg cgggcggcgc cgcgccccac
      421 ctgctggctg caagcgtctg ggcggacttg cgcggcagct ctggcgaggg ctcctgggag
      481 aactcggggg aagctccacg cgcctcgtcc ggcttctccg acccgatccc gtgctccgtc
      541 cagaccccgt gctccgagct ggctcccgcc tccggcgccg cggcggtctg cgctcccgag
      601 agctcctccg atgcgcccgc cgtcccaagc gcgcctgctg ccccgggcgc accagcagcc
      661 tctggtgggt tctctggagg ggccctaggg gcaggccccg cccccgccgc ggatcaggcg
      721 ccccggagga ggtctgtcac acctgctgcc aagcgccacc aatgcccctt cccgggctgc
      781 accaaagcct attacaagtc gtcgcacctc aagtcccacc agcgcaccca cacgggtgag
      841 cgccctttct cctgcgactg gctcgactgc gacaagaagt ttacgcgttc cgacgagctg
      901 gcccgccact acaggacgca cacgggcgag aagcgcttct cctgccccct ctgccccaag
      961 cagttctccc ggagcgacca cctgaccaag catgctcgcc gccacccaac ctatcatcca
     1021 gatatgatcg agtaccgggg acgtcgtcga actccccgca tcgacccgcc actcaccagc
     1081 gaggtggaaa gctccgcctc cggctccggt cccggcccgg cgcccagctt caccacctgc
     1141 ctgtaggaca gtcattgctg tcagtcttac cctcaaggat gatcccccag gccgttgtcc
     1201 ctgctttctc tctgcccatc cttctttccc agagtcatta caccaaggca cagactggtt
     1261 cctctgctct gagggtgggt ccaggcagac atgtggactc tggggaggta ctgggggccg
     1321 gaaaatagcg ggaattcttg caacgtgtat atcatcctaa aagtgggggt tgcctcaaga
     1381 cagcccccag gaactgataa gaagggatga actcccgtac tctccagagt actgaagatt
     1441 ctcccctccc tggaaccagg gatgtgaaac tggaattctc agatgcctga ggagctccca
     1501 gtctcaaagg actctggtgt ctcacccatc caccagggcg gaccttggag agggtgtcag
     1561 gggtggcagt cttggaaatg tccaggactg ggatggtgag aggcctttgg aaacagaaat
     1621 gatttctatt tctgtaaaca gcaatgttta ctaatttatt tttagcatct tttaaatagg
     1681 gatcccaggt tgatgggagg cttatgccct ccaatccccc aattgcccca gctacctctg
     1741 ctaggagagg ccacataagc tccatgtaga tgtgtggctg ggagatactt cttgatgtct
     1801 ggggtgtgag tctgtttgca ggtcctgttg catgatttgg aaccctgcgc ttgcgtcgta
     1861 gcccttctcc ccatttggat tcctacttga ggatggtaac ttcctggctc actctcacgc
     1921 tgagattggt taaacaattt gaaaactacc gtaaaggcac cagcaagaaa agggtggtcc
     1981 agactagttc ccccttcact cagagagaaa actcaagcga ccttaagttt gggcggggcc
     2041 cgaaacaaga ccgctcataa ccattgataa ctttcaggga aatagaggcg tgtggacaca
     2101 gctgccccac cttatgtaat ctcaggagtg gtagattctg ttaatttcct aatggctaac
     2161 tagggggtta tttccctcag agtctgcaga ttttcgtttc tgaaacaggt gagttggtgg
     2221 gtgggagagg gaagggtaac agactggttt cttccaagga gctggctgcc ttggatttga
     2281 ggaaggagta gcaaggtgat agctattatg aaataggagg aactttctcc tctgaccata
     2341 tagtccctcc aagttatatc ctcagggccc ctttcccgat aagaaggaat cagacatcaa
     2401 cagtatttgt tttttctata tgtgtctctg ctgctgtgga tgaaatcact gaccactctg
     2461 cttgtgtatg tatgaatgtg tatatatgtg accctttctt tagagatgag gctgaaaggc
     2521 atttcctgcc ctgggagatc ccctctggcc ccctcctgaa tattttgcaa tagtccatca
     2581 ctgacacttg gggaagatgc tgtaatctca taggacccta acgggcatct ggttaaacaa
     2641 attgctttcc cctattttgc agatgaggat actgaagact agataagctc aaagtcatat
     2701 gctaggttgc tgggaagagc catgactaga acttaggtgt ctggcctgct aagtgactct
     2761 ttccctcaca cttgattacc cccatctctt cctcctctct gggatcttag tccctccctc
     2821 gctccctatt ctgtattgct tctgtgtacc ttcacatgtt gattgaaccc tttgcctatt
     2881 gtgtttgacc caaaagccct tttcttaact ggttacgttc cctcccttca caccatgtgg
     2941 acataaagtg agaatgactt tttggcatcc taggagagac tttctctttg gacctgctag
     3001 gttaattttc agtgtgaatt cccttctttt tctggtcctg ggcattccag catcctcaag
     3061 agagtgaatg atacaaacat gacattggga ctgtactaag tgctcctaca ctaagtgagg
     3121 gaggggtcct tagaaaggac caaaagagta tggcctatga ccctgaagag gttcagtatt
     3181 tcctaatgaa ggctaagcag ggaaggtggg gctgttgagt tacatgtggg aggagaaggc
     3241 cccccactgt gaaagtgatt tttggtagtg gaaggagtct tctctttgct ctgtttgtct
     3301 cttcagctag ggctggatag ctagggcatt gggggtccta ttgaagacta ctgtttcctc
     3361 tttgtccttt tcagttgaag atctgccatt gggtaagtgg accaaggaag ccaacaggaa
     3421 tttccactaa ccattctgaa attggtttca agaaagcttg gcttttccaa tcacctgttg
     3481 ataaataact tttgattctc aagctcccaa a
//
