LOCUS       NM_015995               6845 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens KLF transcription factor 13 (KLF13), transcript
            variant 1, mRNA.
ACCESSION   NM_015995
VERSION     NM_015995.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6845)
  AUTHORS   Yang,S., Xiong,L., Yang,G., Xiang,J., Li,L., Kang,L. and Liang,Z.
  TITLE     KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle
            atrophy
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (5), 1869-1882 (2024)
   PUBMED   38973459
  REMARK    GeneRIF: KLF13 restrains Dll4-muscular Notch2 axis to improve the
            muscle atrophy.
REFERENCE   2  (bases 1 to 6845)
  AUTHORS   Liu,Y., Song,Y., He,Y., Kong,Z., Li,H., Zhu,Y. and Liu,S.
  TITLE     Kruppel-like factor 13 acts as a tumor suppressor in thyroid
            carcinoma by downregulating IFIT1
  JOURNAL   Biol Direct 18 (1), 65 (2023)
   PUBMED   37817224
  REMARK    GeneRIF: Kruppel-like factor 13 acts as a tumor suppressor in
            thyroid carcinoma by downregulating IFIT1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6845)
  AUTHORS   Liang,X., Feng,Z., Yan,R., Liu,F., Yin,L., Shen,H., Lu,H. and
            Zhang,L.
  TITLE     Kruppel-like Factors 3 Regulates Migration and Invasion of Gastric
            Cancer Cells Through NF-kappaB Pathway
  JOURNAL   Altern Ther Health Med 29 (2), 64-69 (2023)
   PUBMED   36580668
  REMARK    GeneRIF: Kruppel-like Factors 3 Regulates Migration and Invasion of
            Gastric Cancer Cells Through NF-kappaB Pathway.
REFERENCE   4  (bases 1 to 6845)
  AUTHORS   Tu,J., Zheng,N., Mao,C., Liu,S., Zhang,H. and Sun,L.
  TITLE     UC-BSCs Exosomes Regulate Th17/Treg Balance in Patients with
            Systemic Lupus Erythematosus via miR-19b/KLF13
  JOURNAL   Cells 11 (24), 4123 (2022)
   PUBMED   36552891
  REMARK    GeneRIF: UC-BSCs Exosomes Regulate Th17/Treg Balance in Patients
            with Systemic Lupus Erythematosus via miR-19b/KLF13.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6845)
  AUTHORS   Guo,Y.H., Wang,J., Guo,X.J., Gao,R.F., Yang,C.X., Li,L., Sun,Y.M.,
            Qiu,X.B., Xu,Y.J. and Yang,Y.Q.
  TITLE     KLF13 Loss-of-Function Mutations Underlying Familial Dilated
            Cardiomyopathy
  JOURNAL   J Am Heart Assoc 11 (22), e027578 (2022)
   PUBMED   36346048
  REMARK    GeneRIF: KLF13 Loss-of-Function Mutations Underlying Familial
            Dilated Cardiomyopathy.
REFERENCE   6  (bases 1 to 6845)
  AUTHORS   Scohy,S., Gabant,P., Van Reeth,T., Hertveldt,V., Dreze,P.L., Van
            Vooren,P., Riviere,M., Szpirer,J. and Szpirer,C.
  TITLE     Identification of KLF13 and KLF14 (SP6), novel members of the
            SP/XKLF transcription factor family
  JOURNAL   Genomics 70 (1), 93-101 (2000)
   PUBMED   11087666
REFERENCE   7  (bases 1 to 6845)
  AUTHORS   Asano,H., Li,X.S. and Stamatoyannopoulos,G.
  TITLE     FKLF-2: a novel Kruppel-like transcriptional factor that activates
            globin and other erythroid lineage genes
  JOURNAL   Blood 95 (11), 3578-3584 (2000)
   PUBMED   10828046
REFERENCE   8  (bases 1 to 6845)
  AUTHORS   Cook,T., Gebelein,B. and Urrutia,R.
  TITLE     Sp1 and its likes: biochemical and functional predictions for a
            growing family of zinc finger transcription factors
  JOURNAL   Ann N Y Acad Sci 880, 94-102 (1999)
   PUBMED   10415854
  REMARK    Review article
REFERENCE   9  (bases 1 to 6845)
  AUTHORS   Song,A., Chen,Y.F., Thamatrakoln,K., Storm,T.A. and Krensky,A.M.
  TITLE     RFLAT-1: a new zinc finger transcription factor that activates
            RANTES gene expression in T lymphocytes
  JOURNAL   Immunity 10 (1), 93-103 (1999)
   PUBMED   10023774
REFERENCE   10 (bases 1 to 6845)
  AUTHORS   van Bon,B.W.M., Mefford,H.C., de Vries,B.B.A. and Schaaf,C.P.
  TITLE     15q13.3 Recurrent Deletion
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21290787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012236.12, AF132599.1, AL390127.1, BX474032.1 and BC064552.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015995.3.
            
            Summary: KLF13 belongs to a family of transcription factors that
            contain 3 classical zinc finger DNA-binding domains consisting of a
            zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines
            (C2H2 motif). These transcription factors bind to GC-rich sequences
            and related GT and CACCC boxes (Scohy et al., 2000 [PubMed
            11087666]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF132599.1, SRR1163655.58527.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307145.4/ ENSP00000302456.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC012236.12        129095-129114
            21-1361             AF132599.1         15-1355
            1362-1405           AL390127.1         65-108
            1406-2185           AL390127.1         111-890
            2186-2664           BX474032.1         110-588
            2665-4226           AL390127.1         1370-2931
            4227-6845           BC064552.1         1-2619
FEATURES             Location/Qualifiers
     source          1..6845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.3"
     gene            1..6845
                     /gene="KLF13"
                     /gene_synonym="BTEB3; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /note="KLF transcription factor 13"
                     /db_xref="GeneID:51621"
                     /db_xref="HGNC:HGNC:13672"
                     /db_xref="MIM:605328"
     exon            1..955
                     /gene="KLF13"
                     /gene_synonym="BTEB3; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..1245
                     /gene="KLF13"
                     /gene_synonym="BTEB3; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /note="isoform 1 is encoded by transcript variant 1; basic
                     transcription element binding protein 3; RANTES factor of
                     late activated T lymphocytes-1; Kruppel like factor 13;
                     transcription factor NSLP1; BTE-binding protein 3;
                     transcription factor BTEB3; novel Sp1-like zinc finger
                     transcription factor 1"
                     /codon_start=1
                     /product="Krueppel-like factor 13 isoform 1"
                     /protein_id="NP_057079.2"
                     /db_xref="CCDS:CCDS10025.1"
                     /db_xref="GeneID:51621"
                     /db_xref="HGNC:HGNC:13672"
                     /db_xref="MIM:605328"
                     /translation="MAAAAYVDHFAAECLVSMSSRAVVHGPREGPESRPEGAAVAATP
                     TLPRVEERRDGKDSASLFVVARILADLNQQAPAPAPAERREGAAARKARTPCRLPPPA
                     PEPTSPGAEGAAAAPPSPAWSEPEPEAGLEPEREPGPAGSGEPGLRQRVRRGRSRADL
                     ESPQRKHKCHYAGCEKVYGKSSHLKAHLRTHTGERPFACSWQDCNKKFARSDELARHY
                     RTHTGEKKFSCPICEKRFMRSDHLTKHARRHANFHPGMLQRRGGGSRTGSLSDYSRSD
                     ASSPTISPASSP"
     exon            956..6845
                     /gene="KLF13"
                     /gene_synonym="BTEB3; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6820..6825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF13"
                     /gene_synonym="BTEB3; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /note="hexamer: AATAAA"
     polyA_site      6845
                     /gene="KLF13"
                     /gene_synonym="BTEB3; FKLF2; NSLP1; RFLAT-1; RFLAT1"
                     /note="major polyA site"
ORIGIN      
        1 acacggagcc gcggcgcgca cggcagctgt cccgcctgcc acaatgcgcg gcgaagctgc
       61 ggccgcgact tggcgaggtg gtccctaacg ttgccgctcg gcatccttag aaccggccgc
      121 ccctgacgcc gcgcggggac cccagtcgcc cgcgcgcccc atgcgctcac tcttcggtgc
      181 ccggccgggc cggcgcctcg cagacgcgga gccgcgcggg tgacggcaca ggcggctgcg
      241 cgcccagccc agcccagccc agcccgagga gagggcgcgc cgcgcccccg ccccccgccc
      301 gctctcccga ggccgtgggt gcggatgcgc ggctgacgac tcgcagcaag agcaccgccg
      361 ccggccccag cccgcagcat ggcagccgcc gcctatgtgg accacttcgc cgccgagtgc
      421 ctcgtgtcca tgtcgagccg cgcggtcgtg cacgggccgc gggaggggcc ggagtcccgg
      481 cccgagggcg cggccgtggc cgccaccccc acgctgcccc gcgtcgagga gcgccgcgac
      541 ggtaaggaca gcgcctcgct cttcgtggtg gcgcggatcc tagcggacct caaccagcaa
      601 gcgccggcgc ccgccccggc ggagcgcagg gagggcgccg cggcccggaa ggcgaggacc
      661 ccctgccgcc tgccgccgcc cgcccccgag cccacctccc ccggcgccga aggcgcggcg
      721 gccgcgcccc ccagcccggc gtggagcgag ccggagcccg aggcggggct ggagcccgag
      781 cgggagccgg ggcccgcggg gagcggcgag cccggcctca gacaaagggt ccggcggggc
      841 cgaagtcgcg ccgacctcga gtccccgcag aggaagcaca agtgccacta cgcgggctgc
      901 gagaaagttt acgggaaatc ttcgcacctc aaggcgcacc tgagaactca cacaggtgag
      961 aggcccttcg cctgcagctg gcaggactgc aacaagaagt tcgcgcgctc cgacgagctg
     1021 gcgcggcact accgcacaca cacgggcgag aagaagttca gctgccccat ctgcgagaag
     1081 cgcttcatgc gcagcgacca cctgaccaag cacgcgcgcc gccacgccaa cttccacccg
     1141 ggaatgctgc agcggcgcgg cgggggctcg cggaccggct ccctcagcga ctacagccgc
     1201 tccgacgcca gcagccccac catcagcccg gccagctcgc cctgagcccg ccacagccat
     1261 gagcagccgc tcccaccccc tcgtgagtcc ctggcctttc cttttgtaat aagaaagaag
     1321 agagagaact tgatgcaaag tccacgaaaa aacaattttt ttcacctcag gtgtcaaagt
     1381 aaatttgtta aaaaaacaaa aaaaacacaa aaatttcaaa aaacaccacc caccaaattg
     1441 cacaatagat acacccacaa agttgagatt cagcgttgtt gaaccccctt tctcagggat
     1501 ggacacgttt cacgaggtca gtgaggacac cccttcctgc cgccttactc tgtacataga
     1561 tttgcactct ggagttttct gttaggttcg ggaacacgct ggggacagag caggccagcc
     1621 agtctggtgg agctcagcgt ctggctggct ggccagcctg tgggtctgtt gggagcagat
     1681 gtgctcactg acgtttgtgc ctccagggca gattcctaag cagctggcct gacctcttcc
     1741 tgcccagccc ccaacccagt ctctggcctc tgcccaacga gcctggctgg gcttgcaacg
     1801 cagctgattc tgagacaggc ccctgcagag ggatgcctta aagctgtccc tggctggagg
     1861 agcactccac cttggggata gtggaggggg ccttcagccc tctgcaccct gcctgcctca
     1921 caccccgcct tcaggagccc tctcctacgg cgctagggag cactggaagc agagatgcca
     1981 gccctggctg agcgtagcac tgcaccgtcc gacctccgag gcaggggccg gggtcacacc
     2041 tgccaggact ccgcttctcc gtgtcccagc agaaggcatg caggaccctg tcactactat
     2101 acctgggcct ctgatgggga attctggtct tctaaaaaga tgttagaaat tcctggtggc
     2161 acatccagtt ccgagtttgc ccgcacgggc acttttgttg gaaacagtgg gcaggtcatg
     2221 gggcctcctc atcagagggt ctgtgtgagc ggctgtgcat gtggcagcgc accatgcttc
     2281 acagagacca ttctgtagca agagaccgga acattgtgac ttggaccttt tcaggagtgg
     2341 cgcggatgtt acaggaaatg ctgtcggaga gcgcgcattc tatttcctcc gcagggaatg
     2401 ccagatagaa agttgcgggc aacacttttc tcagacccac catgtcccca actcagactt
     2461 agcaaacctc cagcctctcc gtttcccctg gactcctcct cccttttcct cctgcttctc
     2521 cttgtcctgc ctggaggctc caggccacac ccagctggtg gggctgctcc agtgccccat
     2581 caccggcctt ctcctggcag gagaggagga gcagagagct gggtcctggg ctgggattcg
     2641 agccctgggc gggggtcagt caagccgtgg tccagcaaac tcctctgcag atggctggag
     2701 tgttgaccca ggcttgtggc ccaggtatca ccttcccttc ctcctgagag ttgaggcctg
     2761 taaatacaag ggcccaggac agagtgtgtg cgtgcgtgtg ggtgtgtgcg cgcgtgagca
     2821 cacacgcgtg tgttgggggg ggtgggggga ttggggtgga ctcagggtat cttgccagag
     2881 atacctgttt tgatgagtac ctattttgat gcaaaggaac ggccctggga cctcagaggg
     2941 ccacagatgg gcttcctggg cctagcgtgc cttggttgtg gccatcctgc ttctactcag
     3001 ccctgccatg ctatggggtg cagcacaaac ccaggaccca ggcctagcca ctgcccacag
     3061 ctgatggtca ctgttttggc tggctccaga gtggacaggt acgctctgtc cacagcagct
     3121 gctcaggcac agtatgccgt caggtgcccg cttcttacca ctgtgtgtca gctgggattg
     3181 gccgacagcg tggtggtgac ttctaggtag accgatggac cctaaattgg gcagtggcat
     3241 tgtttctgct gtggtgggaa ctggcaggga gagggtcacc tccactctgg ttggatgcgg
     3301 agctggtccc tctggctgcc atgctgtgtt ggggctctct gacctccctg cttgcattgg
     3361 gtctgggaga gagagtggaa tatttggtag ggaccttgac agaagagagc cctgggtgct
     3421 tgtggtgcaa agatcttcat gcccagttcc aaagtgaggt ccctcccaaa gttgttttcg
     3481 tgtgaggcag agaaagccac actctgaata cattttatgt ctcaggaatt cacattccag
     3541 gttcaggaat tttattccaa agtcctttgg tgcactcacc gtccaccgtt ccccaaggca
     3601 gggagaggga gtggcccgtc cctgggaggc tggcaaagtg ctctccaggg aggggtcaga
     3661 cgtccttgtg atctgcccag ggtgtcacgg aaggagattt tctagctcca catctgtctg
     3721 cacataggaa ggaaaagata ggactctaaa cctagtcatc ttggaataaa aagaagagct
     3781 ggtttgtttt agagcagggc ggggggtggg ggagggaagc gggtgttggc tgtttccaaa
     3841 gagagcactt aatttaattt ttcctttaaa tgacccaggg ctgttccgtc tgatagatgg
     3901 aagggtaaca ttgccttaaa acagaaatat gcaggcgttg gctatttttg gcataagagc
     3961 gtgtcttcat tcccaaagtg gttctcgttt aatggcaggg tgcggtcctt aggccccggc
     4021 ctggactggg aaatgggggt agggcaccag gagagaaatc ctcctgggta ctcctggcca
     4081 gaccctcctg aatcatctgc ggcttaaact catctcgctt gaagggcagg gagaaaccca
     4141 tgaatctcag gcacggttca caggggtcct caagggcagg tttccatttc atcatgaagt
     4201 gagggactcc tgtggaagag ggtggtgggc cttggaacgc tgcctccact gaggcgggca
     4261 cacaaggcgg accctcctga aacagcctcc attttcttca aacatgcaga atgttttccc
     4321 agactgcgtc tatttcaggg tcttccattt ttgtggttta tggccatgct tgccagtttt
     4381 ggtggggttg aggaacccat aggactcata gaaataatag tgaaaactca aacccttatt
     4441 ttgggacttc agttctcgtg gtccataggg gcagagatgt caaagtgaag gttgcctgag
     4501 tgaagggaga gttcccctat aaaaggccta aaattgatct ggggctcagc catcaagggg
     4561 ctggtgttgc tcctgtccca gacaaggaag cccctcttta catcagccat attaggggaa
     4621 cggttgtcag ctccccaaat gcctactgga tcctacagcc atacaggaaa acagacggac
     4681 acagcccttt ccttaaagag ccctggggtc ctgtcctgca ggatgctgca taggaatggg
     4741 cagagatgtc ctggatggga acatggtcct ggaggtgccc tacctgcatc ctgctgcacc
     4801 cccacccacg acactcgagt gcaagatcgc ctcactccta accctgactt tattcccagg
     4861 ccccacaccg aggcaggtgc aggattcgcc atggtgcagc ctccgggtac aaacatctga
     4921 ggcactggcg atcccagtcc ttgcagcacc ctgaacacag ctcagaccag tgaggggtga
     4981 ttcagaggtg gggatgggca gagagggctg gccactctgc ctcaggactt gacctcaagt
     5041 gttctgtctc cccacccggt gtgtccagaa gaccagcctc tttcttgcca gaagcaggtg
     5101 ctaagatgga ctgcacaggg tcccggcact ccctcgggac ccattcagga tctcagctgg
     5161 gcaggggtgc cacccaacag gaagatgtga tctgagcaat agtgtggcct tgtttctccg
     5221 cttctggttg tggctgtgtg tacagggcta cctattttga cttctgacag gtgtcactga
     5281 ttttctttcc cccatttaaa aaaggtcatt tagtcaaaga cacagtgcta gaggtttaaa
     5341 gggtgtaatg tgttggtcac atcacaacca gtaagaaacg cttggtaggt tatccacatc
     5401 ttttgctgac tgtttccata tacaattctg gtcaccatat tttccaaagc taaaatctga
     5461 ggcgtgggct gatggttttt gaaatcagga ttaccccagg aagaaccagg tcctattact
     5521 aattttcctg attctgaggc tctgaaggct tgtctgagac acattccgga gacctttgta
     5581 ccagaacttg gatgcatagt ccaccttact actgatacac gcctgagcac cctttagggc
     5641 gaggcgccgc ctcctgcctg ctgtcctgtc cctcagcatc agaagagttg aattcagcag
     5701 gagacgggag cccggtgtcc atgagggaag aggggtcgcg cttggtttct actgaccccc
     5761 atgaagattt cagacttgca gtgcggccac ctggccctgc cctgcctctc tctttctcat
     5821 acagctttaa aactttacta cttttattta aaaatgaact ggatgggaga gaagtagcgt
     5881 cccctaccct acaagtcaca cattccgggg aggggggtgg ggggtggagg caggaagtca
     5941 tgggggtggg ggtgggagca cgggaacagc tttcttaagg cctcagggtc ctgttttccc
     6001 tggcctcttc tagagggccc gtggacaggt cgcagtgcgt gcttatttgg aaaccaggtg
     6061 tgtgagccga atgcctgcca ggccatgcac tcagcagagg agcccttgta cctggctgcc
     6121 ctgagaggag caagaggcca cctcccatgt ggctctagac accacgtggg ctcattagcc
     6181 ccagcgtctg tgccggctcc aggtgcctgc ctctgggtgt gtgagtggga gactttgctc
     6241 cctggcctca tcctagagag gcccctggtg cctagtgctg aggcctctgg ggctggaaag
     6301 cctcagcaga aaggaggcac tactgagcaa ctatgcattg tcattgtcgg gtttggggct
     6361 ttcggtggtt ccttggtgac tgggaattgc ttgtgtgcat gtgttgggtg catgcttccg
     6421 ggtctcagct gccccaggcc cgcacaggca accccttccc atccaaagcc attggtggag
     6481 cttctctgga atcatttgcc aaaagcccaa ggcagaatcc aagggtccaa gaccatttcc
     6541 atggagctca tgtttttctt ttctgtagga actttttttt aaccagcacc caccataatt
     6601 ccgaaggcca cgtttcatct ttcctggatc actacagtga agtattacag ttgtacagtt
     6661 cccagtctgg ccttggcttg ctcggataaa actttgtatg tattttgtat ggcatagatt
     6721 ctatattgta atgatgtcct atgcaaaaag aaaaattaac gaaattgtaa attttattgt
     6781 tttaacgtgt atgcatgttt agtgacgttt acattttgaa ataaaattta tgattcatta
     6841 tttta
//
