LOCUS       NM_001400136           11074 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens KLF transcription factor 12 (KLF12), transcript
            variant 1, mRNA.
ACCESSION   NM_001400136 XM_005266251
VERSION     NM_001400136.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11074)
  AUTHORS   Pan,X., Zhang,W., Wang,L., Guo,H., Zheng,M., Wu,H., Weng,Q., He,Q.,
            Ding,L. and Yang,B.
  TITLE     KLF12 transcriptionally regulates PD-L1 expression in non-small
            cell lung cancer
  JOURNAL   Mol Oncol 17 (12), 2659-2674 (2023)
   PUBMED   37606530
  REMARK    GeneRIF: KLF12 transcriptionally regulates PD-L1 expression in
            non-small cell lung cancer.
REFERENCE   2  (bases 1 to 11074)
  AUTHORS   Wu,C.C., Hou,B.C., Yang,Y.H., Li,X.F., Ma,H.C. and Li,B.X.
  TITLE     Circ_0084188 promotes colorectal cancer progression by sponging
            miR-654-3p and regulating kruppel-like factor 12
  JOURNAL   Kaohsiung J Med Sci 39 (11), 1062-1076 (2023)
   PUBMED   37698263
  REMARK    GeneRIF: Circ_0084188 promotes colorectal cancer progression by
            sponging miR-654-3p and regulating kruppel-like factor 12.
REFERENCE   3  (bases 1 to 11074)
  AUTHORS   Zhang,C.X., Lin,Y.L., Lu,F.F., Yu,L.N., Liu,Y., Zhou,J.D., Kong,N.,
            Li,D., Yan,G.J., Sun,H.X. and Cao,G.Y.
  TITLE     Kruppel-like factor 12 regulates aging ovarian granulosa cell
            apoptosis by repressing SPHK1 transcription and
            sphingosine-1-phosphate (S1P) production
  JOURNAL   J Biol Chem 299 (9), 105126 (2023)
   PUBMED   37543362
  REMARK    GeneRIF: Kruppel-like factor 12 regulates aging ovarian granulosa
            cell apoptosis by repressing SPHK1 transcription and
            sphingosine-1-phosphate (S1P) production.
REFERENCE   4  (bases 1 to 11074)
  AUTHORS   Yang,X., Tao,Y., Jin,O., Lai,J. and Yang,X.
  TITLE     MiR-17-5p promoter methylation regulated by DNA methyltransferase 3
            beta (DNMT3B) expedites endometriosis via the Kruppel-like factor
            12 (KLF12)/Wnt/beta-catenin axis
  JOURNAL   J Reprod Immunol 158, 103974 (2023)
   PUBMED   37290172
  REMARK    GeneRIF: MiR-17-5p promoter methylation regulated by DNA
            methyltransferase 3 beta (DNMT3B) expedites endometriosis via the
            Kruppel-like factor 12 (KLF12)/Wnt/beta-catenin axis.
REFERENCE   5  (bases 1 to 11074)
  AUTHORS   Li,Y., Li,S., Shi,X., Xin,Z., Yang,Y., Zhao,B., Li,Y., Lv,L.,
            Ren,P. and Wu,H.
  TITLE     KLF12 promotes the proliferation of breast cancer cells by reducing
            the transcription of p21 in a p53-dependent and p53-independent
            manner
  JOURNAL   Cell Death Dis 14 (5), 313 (2023)
   PUBMED   37156774
  REMARK    GeneRIF: KLF12 promotes the proliferation of breast cancer cells by
            reducing the transcription of p21 in a p53-dependent and
            p53-independent manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11074)
  AUTHORS   Rozenblum,E., Vahteristo,P., Sandberg,T., Bergthorsson,J.T.,
            Syrjakoski,K., Weaver,D., Haraldsson,K., Johannsdottir,H.K.,
            Vehmanen,P., Nigam,S., Golberger,N., Robbins,C., Pak,E., Dutra,A.,
            Gillander,E., Stephan,D.A., Bailey-Wilson,J., Juo,S.H., Kainu,T.,
            Arason,A., Barkardottir,R.B., Nevanlinna,H., Borg,A. and
            Kallioniemi,O.P.
  TITLE     A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer
            development: identification and characterization of candidate genes
  JOURNAL   Hum Genet 110 (2), 111-121 (2002)
   PUBMED   11935316
REFERENCE   7  (bases 1 to 11074)
  AUTHORS   Schuierer,M., Hilger-Eversheim,K., Dobner,T., Bosserhoff,A.K.,
            Moser,M., Turner,J., Crossley,M. and Buettner,R.
  TITLE     Induction of AP-2alpha expression by adenoviral infection involves
            inactivation of the AP-2rep transcriptional corepressor CtBP1
  JOURNAL   J Biol Chem 276 (30), 27944-27949 (2001)
   PUBMED   11373277
REFERENCE   8  (bases 1 to 11074)
  AUTHORS   Zhu,C.H., Huang,Y., Broman,M.T. and Domann,F.E.
  TITLE     Expression of AP-2 alpha in SV40 immortalized human lung
            fibroblasts is associated with a distinct pattern of cytosine
            methylation in the AP-2 alpha promoter
  JOURNAL   Biochim Biophys Acta 1519 (1-2), 85-91 (2001)
   PUBMED   11406275
REFERENCE   9  (bases 1 to 11074)
  AUTHORS   Roth,C., Schuierer,M., Gunther,K. and Buettner,R.
  TITLE     Genomic structure and DNA binding properties of the human zinc
            finger transcriptional repressor AP-2rep (KLF12)
  JOURNAL   Genomics 63 (3), 384-390 (2000)
   PUBMED   10704285
REFERENCE   10 (bases 1 to 11074)
  AUTHORS   Imhof,A., Schuierer,M., Werner,O., Moser,M., Roth,C., Bauer,R. and
            Buettner,R.
  TITLE     Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and
            AP-2rep, a novel wt-1/egr-related zinc finger repressor
  JOURNAL   Mol Cell Biol 19 (1), 194-204 (1999)
   PUBMED   9858544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356319.18, AL139036.12, AL159972.8, AL138713.12 and AL160032.14.
            
            On Jan 20, 2022 this sequence version replaced XM_005266251.4.
            
            Summary: Activator protein-2 alpha (AP-2 alpha) is a
            developmentally-regulated transcription factor and important
            regulator of gene expression during vertebrate development and
            carcinogenesis. The protein encoded by this gene is a member of the
            Kruppel-like zinc finger protein family and can repress expression
            of the AP-2 alpha gene by binding to a specific site in the AP-2
            alpha gene promoter. Repression by the encoded protein requires
            binding with a corepressor, CtBP1. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1295733.1,
                                           SRR14038197.680953.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000703967.1/ ENSP00000515592.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               AL356319.18        40461-40893         c
            434-497             AL139036.12        11189-11252         c
            498-587             AL159972.8         109592-109681       c
            588-1134            AL159972.8         11438-11984         c
            1135-1270           AL138713.12        104572-104707       c
            1271-1333           AL138713.12        56358-56420         c
            1334-1491           AL138713.12        6788-6945           c
            1492-11074          AL160032.14        158733-168315       c
FEATURES             Location/Qualifiers
     source          1..11074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q22.1"
     gene            1..11074
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /note="KLF transcription factor 12"
                     /db_xref="GeneID:11278"
                     /db_xref="HGNC:HGNC:6346"
                     /db_xref="MIM:607531"
     exon            1..433
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /inference="alignment:Splign:2.1.0"
     exon            434..497
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /inference="alignment:Splign:2.1.0"
     CDS             465..1673
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /note="isoform 1 is encoded by transcript variant 1; KLF12
                     zinc finger transcriptional repressor; AP-2 repressor;
                     AP-2rep transcription factor; krueppel-like factor 12;
                     Kruppel like factor 12; transcriptional repressor AP-2rep"
                     /codon_start=1
                     /product="Krueppel-like factor 12 isoform 1"
                     /protein_id="NP_001387065.1"
                     /db_xref="CCDS:CCDS9449.1"
                     /db_xref="GeneID:11278"
                     /db_xref="HGNC:HGNC:6346"
                     /db_xref="MIM:607531"
                     /translation="MNIHMKRKTIKNINTFENRMLMLDGMPAVRVKTELLESEQGSPN
                     VHNYPDMEAVPLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVS
                     MTASASSPSSTSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQF
                     LHIIHPVPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDG
                     RGHGKAQMDPRGLSPRQSKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVS
                     RVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHL
                     KAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHL
                     ALHRRRHMLV"
     exon            498..587
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /inference="alignment:Splign:2.1.0"
     exon            588..1134
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1270
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1333
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1491
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..11074
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11049..11054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /note="hexamer: AATAAA"
     polyA_site      11074
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /note="major polyA site"
ORIGIN      
        1 acactcagag cccgcctcct aatcctcggg cggagcggct cgggggcccc attttatggc
       61 aataaagcga cttagcgcct gctgagcgag cccctccccg ccgccgcccc cgccctcggc
      121 cccaccccgg ggctcgccgg cagcggcggg gctttgtttc tggggaggag gacccggagc
      181 tcttttgttt gggggtttct tgttttcggc cccccccctc acagcacccc accccacccc
      241 accccaagcg cctctccggt ttcctgagct gcgggctgcg agggaggaga agcggcgtcc
      301 tgcaaccccc tcggctgggc cccggggtaa ttcgatgcgg gcctggcgag gctccccaca
      361 ctagaccggg gctcgcaact cggcagcctc cacccaccgg cccaccctac atttagcgca
      421 tcatgtgatc cgggatcaat gtgactctaa gaacaaatgg atgaatgaat atccatatga
      481 agagaaaaac aataaagaat atcaacacct ttgagaacag aatgttaatg cttgatggga
      541 tgccggcagt cagagtcaaa acagagcttt tggaatctga acaagggtct ccaaacgtcc
      601 acaactatcc cgatatggaa gccgttcccc tgttgctaaa taatgtgaaa ggggagcccc
      661 cggaggactc gttatctgta gatcacttcc aaacacaaac tgagccagtg gacttgtcaa
      721 taaacaaagc caggacgtcc cctactgccg tttcatcctc cccagtttcc atgacagcat
      781 ctgcctcctc accttcttca acttcaacct cttcatcgtc ttctagtcgt ctagcctcat
      841 ccccaactgt tatcacatca gtatcttcag cgtcatcttc gtcaacagta ttaactccag
      901 ggccccttgt ggcctctgca tctggtgttg gaggccagca gtttttgcac attatccatc
      961 ccgtaccgcc ttcaagtccc atgaatttac agtctaacaa actgagtcat gttcaccgca
     1021 tccccgtggt ggtacagtcg gtgcctgttg tctacacagc tgtaaggtca cctggaaatg
     1081 tgaacaacac tattgtcgtg ccgcttttgg aggatgggag aggccatggc aaagcacaaa
     1141 tggacccccg aggcctatct cccagacaaa gtaaaagtga cagtgatgat gatgacctgc
     1201 caaatgtgac cttagatagc gttaatgaaa ctggatctac ggccctttcc atagccagag
     1261 cagtacaaga ggtacatccg tccccagtat caagggtccg gggcaatcga atgaataatc
     1321 aaaagtttcc ttgttcaatt tcaccattta gtattgagag cacaagacgc cagagacggt
     1381 ctgaatcccc agactccaga aaacggcgta tccacagatg tgattttgag ggatgcaaca
     1441 aagtgtacac aaaaagttct cacctgaagg ctcaccggag gacacataca ggagagaaac
     1501 cttacaagtg tacctgggaa ggctgcacct ggaagttcgc tcgttcagat gaactgacga
     1561 ggcattaccg caaacatacg ggagtgaagc cattcaagtg cgcggactgt gatcgcagct
     1621 tttcccggtc agatcatttg gccctgcacc gccggaggca tatgttggtg tgaggaatgc
     1681 tacctgtcca gctgagcgta agagctggat ctcttagcgg cacccaattc agcagggctg
     1741 aatccccttc acagtgttaa cacaaaaggg catcaccatc ccacgatgtc tgaaaccaga
     1801 gcaggaaaaa gaaggcacac ttcttttggt ctgaaggtaa cccccatcat gactagacga
     1861 gaaccgtctt tacccgggcc tgggagctca gtgacataaa tgctgaagag acaggcattg
     1921 ttttccgtgc tgtgtcctct gccatttaaa gatgtttgta gcttgtacat tttctgagct
     1981 gtcagacatt ttgttattga taccttaaag gtcacctacc acaaattgat ggctagagca
     2041 agacctttta aatttggatg aatctcccat catcccatcc cttaacccct ttttacagaa
     2101 attttagtta caatctgagt aagctagaac acacatccaa tctgttacca gcaagcagca
     2161 tgaaagtaga aacgaagaag cagatggaga ggtcccatta cctgcaaaga aagggcactc
     2221 aggcagccct ttgcaatcgc gatggcagcc actagatatc actctcaact tgtcattctg
     2281 ccatgccctg aagaaaacca acattgaatc tttcatttgt ttgtcgttga ttgtttttgt
     2341 tttgtttcga ttctgttttg ttcatctgtt cgagcagagg ggcagttgaa gtctcgtcct
     2401 ggtctctgcc ctggcatgga ctggcacaga ggtgttctgt agttgaatag gaagagcctg
     2461 tctaaaaaac tactgcccca cttcaaattg cagtgttctg tcacctaggc atcatctctt
     2521 cctgccccta gtatttgatt acaaggaacc aggggaaaaa aactttctta gacacactgg
     2581 caccaaggta agaggtgggg ctgcccaggc aaagtcagtg aacatgaaaa ctcagacaaa
     2641 gcagagatgg aaataatgcg cctcttgagg agaaaagcaa taatgaataa aaggactttc
     2701 ctacaataac ttcactgagg actcacgtta ccaattttca tacttactaa agggattgta
     2761 aaaaacaccc cagcatttta ggtgtcttgg ttccatttac agcactgagg taatctttct
     2821 gctgtttgtt gtcctgcttg gttgagtacc acaattaaag attatgctcc ccttttcttg
     2881 tttgaaaaca gttatttggt gactagaaag gcaagggagg catagccggg aattaactct
     2941 tcggttaatg ggtcagttct ccttggaact gaatcagtgg aaagagaatg cttcccatag
     3001 aaagcccgac atggtgctag tttcctctct tggagagcca aggataagtg actctccaat
     3061 aggttcttct ataccgattt cattttctaa actgtatcag gacccaggtg tcctgcattg
     3121 gcatctgcag ggatattgaa cccactcatc ctgtgcagag gatgagagga aggtgttagt
     3181 tccatcagcc ccataaaatt atgaaccttt ttgcaactag gaacatatac agtaaacaag
     3241 caatacatca ccaacgagca ttctttcaga aaaattacca tatttttgtc cccaccacaa
     3301 gctgggtttt tttccagctt tctgtggctg aggggctggt gagatttttt gttgttattg
     3361 ttgttgttgc tagaattttt tatagcttag atataaaagg tctccaacaa agacctttgc
     3421 aatatatttt aattacaaac acttgatttt gggaattgca catattaacc tcacaatatt
     3481 actagctcat ttttaaatgt ctggacattc tgaaataatt tccggttaca gaattaccct
     3541 ttttaggatc atcttctaat tcagataatc ttattctgat gaagcgagaa ctatgaacgt
     3601 tgaaacaagg acaatttgtg ttggatggta ttcaaaagga attttttaaa acattaagca
     3661 acagtgtaat gattttcagg tcaaattatg gcttcacaaa tatgtgctct atattgtctg
     3721 ccaggtctca aaaattcatc aagcaatttc cctccaacaa gggctgcagt tctagtgata
     3781 aatagcatct ttagctgcac agtctactac tcatcaacca gtgggttttt tttagcacct
     3841 ggaaagtttt tttgtactat atgcaactcc tacttcacat tgcctgtgac cattcagaat
     3901 agaaaaaggt ctgttgatgc atgccagtgc tggttactag tcagtgacag agaacacaga
     3961 gagggacaaa cacagccatg aaccccctgg cactagtacc agcacctagt tggcaagtag
     4021 tgggtgcatc tctcaagtga agtgtagatt tgtatttagt cctgcttgct ctcataaaaa
     4081 gagccagttc ttttctctgc tgaaagatgt cttgagagta ttacaggtag acttggtttt
     4141 tagaattcat aaaactgaca ggcaggggaa tcttcctgag tgacagcttg gtttaaattt
     4201 agcacagaac tagatgagtt gcacttttct aataacatag gatggatttg gggaagggaa
     4261 cattttccct catcctctga aagtggaaac cagactgaga tggtaagtta actgataaaa
     4321 cctgtcagca ttccatcatt ttcccctttt gacgtatcag tacttctaag aagggatcta
     4381 agcacaatta agtgaattga gtccctggtc tagcctcagg aactgaaact tctttggggc
     4441 ttgtcttgag acgtggcaaa ttctccttgg tgagttttct aaaagtattt ccccatggaa
     4501 aggagaaagt ggtttgggac agaaagaaat ggaatgtctt cagtcatgga agagcctcca
     4561 tttcatctca tgtccatttc tagcctcttt caaaaagcac agtgcatcat gagcaacaga
     4621 aaagcagtag aatcctaaag gacataacag ttgttccgta actagaagca ttctttgatt
     4681 ttaaatttga agctgttcag tttgcagctg gggatatgtg catggttggg aacttataca
     4741 catagagcca ttaactactt aagcagctgc agtagacctg attttctgtt tgcagtatag
     4801 agattgattt caagggagtt acattatttg aaaagttatg actttcagcc tttgaggttt
     4861 taagaatccc ttttcatggt ctgatcttaa gttgtttgaa aaaagattca cgcttctgca
     4921 tccacctctg ccctcattct gtcaattgtg tgtggactct gagaagcctg cttgataact
     4981 tgtcttaagt tctattaagg cagttagact gagatttcta atgacttcac cataaagatt
     5041 atacttctgc ctggcgtcgt ttctataaaa cactatagga catttgtttt caaaagcagt
     5101 tgagtaacag caacataaac cacatttttt aaaaaaatga gcacttttca ttcacttgaa
     5161 agcttaagtg ggaaaaagga agatgattgt caggggaaaa acttacaaaa tgctacagtg
     5221 tttacaaatg ccagttccag gtgattagaa aggccgtttt cattatggtt cagatttgga
     5281 atagcttatg caaagattgt gttcattttt atacaattct ttttaacttt aaattgccat
     5341 ctgtgtttta aacataattc tgcactttgg aatcagttca ttagaatgat aacatttata
     5401 tggataaaga tgcagtattc cttattctgt acttgattta ttatacttac caaagctgca
     5461 actgaataaa tctggtgagg tgaggccttc aaaatgtatt aatacgcctt tgttatgttg
     5521 ttatgactgc ttagaaatgt agccatgatg ttgttctaaa gatgtcttaa catttatagt
     5581 gaggattgac agaaattaag cagtgttaag aataccagca tccatgttac agtctgcgta
     5641 taagggactg aatgtgaggt aactcttatg aatcataata ggcccagaaa gccttaatat
     5701 tcatagttca taatccagtc tcagattttg ctcttcaatg ttgcctgtaa acttagcagg
     5761 taaatgtatt ctagtataaa acatcattga ccaaatctct tcctttagtt tttctgaggt
     5821 agtgcatccc attaaaaaag tctcttcaat tagatttggc tttagtttag aaaggggttt
     5881 ggtaagtcat gtcttccata tgacatttct actcatcccc acactgcctt ccacttaacc
     5941 tgtacagaca gccccaacac atgcacatgt gtgtacacaa ctgtatatgc agcagccagt
     6001 gggctaacaa atatcagcaa agaacttttt taaaaagaat ttgtaataat ccgtgctgtc
     6061 tagaaatgtg agttacttac cttattagga aaccggctta taatactata tatgactctg
     6121 cctgcatttt atagttaaga aatgtacata aaaattgcta tattttcaca gtttcattat
     6181 aatgtctgtt tagtaaccca tgtccactga tactttaaat atgctaatta ctgagcaatt
     6241 gcaatagaaa tccagatttt cataagaaaa tgaaatagaa ggatactgca tctttaaaaa
     6301 atagagtgaa gatattttac tgtattcgta acatatgtga tagtggaaaa agtattttca
     6361 aactcacaaa ttttacagag gttgtaaata gtttgatgaa gtatgttggg aaagagagct
     6421 tctagttttc atcacaataa aaagaaaaaa cttgttcaga tatgccttgt atatcttaca
     6481 cacaatgagt gaaattgcca tgggaactct gtccaacttt gtcagagcat gctcttcgtg
     6541 ttctgttcaa aatagagtgg ccacttgtca tggtttagcc aggatggttt aaaatataat
     6601 gaagtcattt taagttgcag acaactgatt ccaaactagt aatgtctttt cctgaaaagg
     6661 gcaaaacagc tgcacaggat tttgcttgta ctaaagagga gcatcttaca attgttctct
     6721 tttctcagtt atctccctcc tcaacagagt gtgaacaacc atacaggtgt ttattcttgt
     6781 tttattccag ggagactgct tttaggtata actacatgtt gacaagatta agtgctgtgg
     6841 atatggccac gtgttaaagg aatctatact cgcaatagga ataagctaat gcccattttc
     6901 agaaataaat taaatgctga aagtgcctgt cagtaaacct tatgaccaat gagatattcc
     6961 tatactttta cacagcaata attcttaata agactgggtt ttttcctgca catgtgaaca
     7021 cacacacaca tacacacaga gagagtaaat acatacacat agtaaatcaa atctgttcac
     7081 atgcccacaa aaaacgcttt tatagctttc aaatatacct aatcttgttt acattaacat
     7141 ttcttaattt gatctttcta acttgcagaa cgttaagaac acaaatctga acattaagtt
     7201 tatcttcagt gaacactatt gcatatggta attataattt ccagataaaa agttgactgt
     7261 catttgcccc aaacttatga aacagtatgt atgattcaaa aagttttgct cagttaaaaa
     7321 caccaattta tttggcgcaa aagactgaag gatatttgtt tgcttgttca ttttatccac
     7381 tcatatcaaa cgcacaaatt catctttaca tttcttcatt cccctttccc ctaatatttc
     7441 ctattatcat cttaagaatc attttggaat gaatattgac agaatcattt ctccccaaaa
     7501 agtctgttga agtaccactg acacttagta agcctagcct ttaaccatct ttgcagttag
     7561 tcctaaaaat taccagatgc acattcagaa gctcacaggt tttttcctgt aattactgta
     7621 ctgctaaaag tggagtcatg gatagaaata tacaatgaga ctatatgaat agacatgaac
     7681 cctggaaatt ctccaaccct gccatctcag agcacaaatt cacccaaaca agctactgag
     7741 gctatcagta aaattatact catggagagt cacacatcgg gtaagggcaa ttttaaaagt
     7801 aggactgtga ttaaacattc aggctttaga cttccatgat ggactcagac cacaggcctc
     7861 aaaaaaacat ccactgtttt ctcctcccaa tgttagaaag aagaaaaggg agacggaaat
     7921 gtaccaggat aagggggtaa aataaccaat taagtgtcaa aggaaagctg ctgggttcct
     7981 taatctcact gaagtcaagt cttctgactg ggcttcttac catgtgttgt ctgaaaaaac
     8041 taaagtacct tgaaaggtta cacattcagc aaaccatgaa gataatagct attctttatt
     8101 aaacactgtg tgccaagcaa tagactaggc aatttttaga tacgttacct gcaacctgta
     8161 caacatttct acactttatg gatgggaaac ggagacatgg gaagtgtggc tgagttgttc
     8221 atggatgtag aaatagtaaa cggcagagta ggaaagtgaa accgcctatc tctgacctgg
     8281 aggtctgcct gtatctttcc cactccacca cactgcacgt gggtgtcccg aaaccacctt
     8341 cccagattcc tgactctcag taattttatt atggacaaca tgcatgagta gtcatcatat
     8401 ttttcaagtg aaatatcggg acatgatata acacatgact taacaatggt actgaatatt
     8461 tgaaatcagg cctttcccgg aaaatcatgc atgaaggatc attataaaca aacaatagca
     8521 accagttgtc tccccgaact tgtcactttt ctcataaatg tctggcctgg agctccaaaa
     8581 tcatccaaat acttagtagc attttagcct gagtacactt tctcagttcc tcaactcttt
     8641 gtataccttt ccaccaatat agacattcta gaatctgctt cagatgcatt tgaaattttc
     8701 acccccatgg aactagtgat taatatcaga gcccactctt gcagttggta atggggtggc
     8761 aatcaaacgt tcagatgatg ataaaggaga gataatggat aattcttttt cagagttctc
     8821 acttaacagc tctgttgtgg aatgttttaa atagtcttat aaataatttg tttatagtat
     8881 tgttgttagt ttaattgaat tttatgtaag aagctgtcca acatcagaga aatgaaattc
     8941 ctcccacttt ctgtgtagaa caaggtctct gacagtattg attcatggaa gtactaatgg
     9001 acttagaaaa cattaagaga atgtcatttc tcatagtgtt tctgtttctg aaaatgaatc
     9061 tcctgaatta ttatctttct ccctgttact tggctgggga aagagataga agctgtataa
     9121 acaaattctc ttccatgctc aaagcaagtg ttccatgtgc acaacctgct gcagactggg
     9181 gcccttctca gttaattggg tttcacaagc aataatttct ccacaacaaa aaccacaact
     9241 tgaagtgagt tgaaaagaga tcaatagtgg aaacagtcgc ctcagtactt tttctttctg
     9301 gatttcatct ctagaaattt gaagtgtttg agacagagtc caccctttgt gcaaggcgag
     9361 aaccaatgaa tggactcctt gtgtgaatta ttgcatcttc ttccaaagca ggttcatcaa
     9421 gactttcaca gagattcatt tttgttgaga agtaagggtt aataggagga tagaatttgg
     9481 atccaaatct agtgataaaa gtgtccaagc aatcaaaaag taagatattt tagggacata
     9541 ccaacatctt ccctttctgc taatttcatg ctccaaagat atggcaaaaa aaaaaatcat
     9601 aaaaagtgct tttgccctac ttgtgttcta gttttcccat ggcagaattt tgtaattaca
     9661 tccagaatat agtgtatatt ttgttcctca aactttatta cattggatgg atattgttga
     9721 actggggcac tggtgcctat attcaaggct ctttcctatc aacgtgtctg tccacgattt
     9781 gttgtgttta aagcttcatt ttgaaaaatc actgtccccc tgtggggtag tgactgtatt
     9841 gttttgttca tgtctatgtg ggacacattg catcacatgg caaaccaact ctctgtggat
     9901 gtgagataag tacttataaa accagcttga aaacatcgtc ttatgtatta tgtcatcctg
     9961 catcataatg caattatgtg tatcataaca tgctcattta aaaaaagaga aaccagcaaa
    10021 ttcatgtttg tccatagaag aatgtactca gaactttgtg ttgtgaaacg atgagaacag
    10081 accaccttta agatacccac ctgccactta aaatgactta gttataatta gtagtagtct
    10141 agacgttgtt cttggtgtgt gggggtcaat tctaacgtca tgttcttttg aataaatctc
    10201 tcagtcatat ttgaaaaaaa aatacatggg aataaagaaa aatatcatct ttggccaaat
    10261 caagcaggca tcttttttct tttccttgac gtttagctca ttatacgtgg tgattggatc
    10321 acgagatctg tccgtgtgaa aatacagaaa catcctttag tttacaaaac agttattcta
    10381 ggcttgaagc ctctgaacag caaattgaat agatgggctg catctgattt gctttatgga
    10441 tgtaatttta caaaacactc ttgggtctct gaccccaggg agttaagagt gcccagagga
    10501 ggtcctacac attaaaggat aaagcccccc agtgatgctg gcaagcaaat gtgttgagtt
    10561 cttaaatctt catttggttt tctgttcagg attttaattg caaatgaatt tatttctcca
    10621 gtttatctaa agacctaatt tcccaatagt ttcctctgca tttatatact ctgtagtgtt
    10681 taggcaaccc tgttataagt ttattaatat tatgtaagtg ttgttcttgt atttatgtat
    10741 agtgtatgta ttgtaaatat actcagagct tttttccttt tactgtaaaa tggtgatttt
    10801 tttgccctat gataatgtaa agggagaccc tcctaatgag attctctcag aggatgatta
    10861 ttccagtcta ttctcagaga tttaaatgaa caagtgttat tgtttttaat ggtgtctcag
    10921 acatattctg ttggtgcatt gcttttctgt attcaacttt cctatgaatt gagctgtgaa
    10981 ctgaaataga gtttaaacct ttaactgtat gcatttgtat aattatctga atgaaggcat
    11041 gaaggttaaa taaagcattt tgtatggaac aaaa
//
