LOCUS       NM_003597               4035 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens KLF transcription factor 11 (KLF11), transcript
            variant 1, mRNA.
ACCESSION   NM_003597 XM_938887
VERSION     NM_003597.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4035)
  AUTHORS   Tsumura,K., Fujimoto,M., Tian,Y., Kawahara,T., Fujimoto,H.,
            Maeshima,A.M., Nakagawa,T., Kume,H., Yoshida,T., Kanai,Y. and
            Arai,E.
  TITLE     Aberrant cell adhesiveness due to DNA hypermethylation of KLF11 in
            papillary urothelial carcinomas
  JOURNAL   Exp Mol Pathol 137, 104908 (2024)
   PUBMED   38824688
  REMARK    GeneRIF: Aberrant cell adhesiveness due to DNA hypermethylation of
            KLF11 in papillary urothelial carcinomas.
REFERENCE   2  (bases 1 to 4035)
  AUTHORS   Wang,Y., Ye,X., Chen,X., Zang,H., Shen,Q. and Chen,L.
  TITLE     Maturity-onset diabetes of the young type 7 (MODY7) and mutation in
            the Kruppel-like transcription factor 11 (KLF11) gene
  JOURNAL   QJM 117 (3), 219-222 (2024)
   PUBMED   37952239
  REMARK    GeneRIF: Maturity-onset diabetes of the young type 7 (MODY7) and
            mutation in the Kruppel-like transcription factor 11 (KLF11) gene.
REFERENCE   3  (bases 1 to 4035)
  AUTHORS   Mancera-Rincon,P., Luna-Espana,M.C., Rincon,O., Guzman,I. and
            Alvarez,M.
  TITLE     Maturity-onset Diabetes of the Young Type 7 (MODY7) and the
            Kruppellike Factor 11 Mutation (KLF11). A Review
  JOURNAL   Curr Diabetes Rev 20 (1), e210323214817 (2024)
   PUBMED   36944622
  REMARK    GeneRIF: Maturity-onset Diabetes of the Young Type 7 (MODY7) and
            the Kruppellike Factor 11 Mutation (KLF11). A Review.
            Review article
REFERENCE   4  (bases 1 to 4035)
  AUTHORS   Zhao,G., Liang,J., Shan,G., Gu,J., Xu,F., Lu,C., Ma,T., Bi,G.,
            Zhan,C. and Ge,D.
  TITLE     KLF11 regulates lung adenocarcinoma ferroptosis and
            chemosensitivity by suppressing GPX4
  JOURNAL   Commun Biol 6 (1), 570 (2023)
   PUBMED   37248295
  REMARK    GeneRIF: KLF11 regulates lung adenocarcinoma ferroptosis and
            chemosensitivity by suppressing GPX4.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4035)
  AUTHORS   Guan,G., Qin,T., Zhao,L.L. and Jin,P.
  TITLE     Genetic and Functional Analyses of the Novel KLF11 Pro193Thr
            Variant in a Three-Generation Family with MODY7
  JOURNAL   Horm Metab Res 55 (2), 136-141 (2023)
   PUBMED   36241199
  REMARK    GeneRIF: Genetic and Functional Analyses of the Novel KLF11
            Pro193Thr Variant in a Three-Generation Family with MODY7.
REFERENCE   6  (bases 1 to 4035)
  AUTHORS   Zhang,J.S., Moncrieffe,M.C., Kaczynski,J., Ellenrieder,V.,
            Prendergast,F.G. and Urrutia,R.
  TITLE     A conserved alpha-helical motif mediates the interaction of
            Sp1-like transcriptional repressors with the corepressor mSin3A
  JOURNAL   Mol Cell Biol 21 (15), 5041-5049 (2001)
   PUBMED   11438660
REFERENCE   7  (bases 1 to 4035)
  AUTHORS   Scohy,S., Gabant,P., Van Reeth,T., Hertveldt,V., Dreze,P.L., Van
            Vooren,P., Riviere,M., Szpirer,J. and Szpirer,C.
  TITLE     Identification of KLF13 and KLF14 (SP6), novel members of the
            SP/XKLF transcription factor family
  JOURNAL   Genomics 70 (1), 93-101 (2000)
   PUBMED   11087666
REFERENCE   8  (bases 1 to 4035)
  AUTHORS   Asano,H., Li,X.S. and Stamatoyannopoulos,G.
  TITLE     FKLF, a novel Kruppel-like factor that activates human embryonic
            and fetal beta-like globin genes
  JOURNAL   Mol Cell Biol 19 (5), 3571-3579 (1999)
   PUBMED   10207080
REFERENCE   9  (bases 1 to 4035)
  AUTHORS   Cook,T., Gebelein,B., Mesa,K., Mladek,A. and Urrutia,R.
  TITLE     Molecular cloning and characterization of TIEG2 reveals a new
            subfamily of transforming growth factor-beta-inducible Sp1-like
            zinc finger-encoding genes involved in the regulation of cell
            growth
  JOURNAL   J Biol Chem 273 (40), 25929-25936 (1998)
   PUBMED   9748269
REFERENCE   10 (bases 1 to 4035)
  AUTHORS   Naylor,R., Knight Johnson,A. and del Gaudio,D.
  TITLE     Maturity-Onset Diabetes of the Young Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29792621
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104794.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_003597.4.
            
            Summary: The protein encoded by this gene is a zinc finger
            transcription factor that binds to SP1-like sequences in epsilon-
            and gamma-globin gene promoters. This binding inhibits cell growth
            and causes apoptosis. Defects in this gene are a cause of
            maturity-onset diabetes of the young type 7 (MODY7). Three
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063286.1, SRR1803616.230193.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305883.6/ ENSP00000307023.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC104794.4         25500-25708
            210-479             AC104794.4         28100-28369
            480-1425            AC104794.4         29600-30545
            1426-4035           AC104794.4         34177-36786
FEATURES             Location/Qualifiers
     source          1..4035
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..4035
                     /gene="KLF11"
                     /gene_synonym="FKLF; FKLF1; MODY7; TIEG2; Tieg3"
                     /note="KLF transcription factor 11"
                     /db_xref="GeneID:8462"
                     /db_xref="HGNC:HGNC:11811"
                     /db_xref="MIM:603301"
     exon            1..209
                     /gene="KLF11"
                     /gene_synonym="FKLF; FKLF1; MODY7; TIEG2; Tieg3"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1706
                     /gene="KLF11"
                     /gene_synonym="FKLF; FKLF1; MODY7; TIEG2; Tieg3"
                     /note="isoform a is encoded by transcript variant 1;
                     krueppel-like factor 11; TIEG-2; Kruppel like factor 11;
                     TGFB-inducible early growth response protein 2;
                     transforming growth factor-beta-inducible early growth
                     response protein 2"
                     /codon_start=1
                     /product="Krueppel-like factor 11 isoform a"
                     /protein_id="NP_003588.1"
                     /db_xref="CCDS:CCDS1668.1"
                     /db_xref="GeneID:8462"
                     /db_xref="HGNC:HGNC:11811"
                     /db_xref="MIM:603301"
                     /translation="MHTPDFAGPDDARAVDIMDICESILERKRHDSERSTCSILEQTD
                     MEAVEALVCMSSWGQRSQKGDLLRIRPLTPVSDSGDVTTTVHMDAATPELPKDFHSLS
                     TLCITPPQSPDLVEPSTRTPVSPQVTDSKACTATDVLQSSAVVARALSGGAERGLLGL
                     EPVPSSPCRAKGTSVIRHTGESPAACFPTIQTPDCRLSDSREGEEQLLGHFETLQDTH
                     LTDSLLSTNLVSCQPCLHKSGGLLLTDKGQQAGWPGAVQTCSPKNYENDLPRKTTPLI
                     SVSVPAPPVLCQMIPVTGQSSMLPAFLKPPPQLSVGTVRPILAQAAPAPQPVFVGPAV
                     PQGAVMLVLPQGALPPPAPCAANVMAAGNTKLLPLAPAPVFITSSQNCVPQVDFSRRR
                     NYVCSFPGCRKTYFKSSHLKAHLRTHTGEKPFNCSWDGCDKKFARSDELSRHRRTHTG
                     EKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVGKLNRIASAESPGSPLVSM
                     PASA"
     exon            210..479
                     /gene="KLF11"
                     /gene_synonym="FKLF; FKLF1; MODY7; TIEG2; Tieg3"
                     /inference="alignment:Splign:2.1.0"
     exon            480..1425
                     /gene="KLF11"
                     /gene_synonym="FKLF; FKLF1; MODY7; TIEG2; Tieg3"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..4035
                     /gene="KLF11"
                     /gene_synonym="FKLF; FKLF1; MODY7; TIEG2; Tieg3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4014..4019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF11"
                     /gene_synonym="FKLF; FKLF1; MODY7; TIEG2; Tieg3"
                     /note="hexamer: TATAAA"
     polyA_site      4035
                     /gene="KLF11"
                     /gene_synonym="FKLF; FKLF1; MODY7; TIEG2; Tieg3"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgaggg ccgcgccggg gcagagccgc gcgggcgggc gaggcgcgtg ccggccgcag
       61 gagctccggg ttgccgccgc cgccgccgcc cgcagcccac gtgcggccgc tgctgcgccc
      121 gagctcacgc cccgcggccg ctttgttgct cccggccggc ctgcacgatg cacacgccgg
      181 acttcgcagg cccagacgac gcgcgcgcag ttgacatcat ggacatatgt gagtccatcc
      241 tggagaggaa gcggcatgac agcgaaaggt ctacttgcag catcttggag cagacagaca
      301 tggaagctgt cgaggctctt gtttgtatga gctcctgggg tcaaagatcc cagaaaggtg
      361 acctgttgcg gataagaccc ctcacgcctg tctctgactc tggggatgtc accaccactg
      421 tgcatatgga tgcagccaca cctgaactac caaaagactt ccattcttta tcgactctgt
      481 gcataactcc tcctcagagc cctgatctcg tggagccatc gacaaggaca cctgtttctc
      541 cccaagtaac agattccaaa gcatgtacag ccacggatgt tctccagtcc tctgccgtag
      601 tggccagagc tctgagcggg ggcgcggaga ggggcttgct gggtttggag ccagtgccca
      661 gctctccctg cagggccaag gggactagcg tgatccgaca cactggggag agccctgctg
      721 cctgctttcc caccatccag actccagatt gccggctttc tgacagcaga gaaggagaag
      781 agcagcttct gggacacttt gaaactttgc aggacacaca cctcacggac agtttactca
      841 gcactaactt ggtgtcctgt cagccctgct tgcacaagtc tggtggcctg ctgctcactg
      901 acaaaggcca gcaggcaggg tggcctggtg cagttcagac ttgctcacca aagaattatg
      961 aaaatgacct gcccaggaaa accacccctc tgatttctgt ctctgtccct gctccccctg
     1021 tcctttgcca gatgatccct gtgactggac aaagtagcat gttaccagct tttttgaagc
     1081 cccctcccca gttgtctgtg gggactgtga gacccatcct agctcaggct gctccagcgc
     1141 ctcaacctgt gttcgtggga cctgctgtgc ctcagggagc tgtgatgttg gtcctgcccc
     1201 agggagccct ccctccgcct gccccctgtg cagccaatgt catggctgcc gggaatacca
     1261 agttgttgcc ccttgcccct gctccagtgt tcatcacctc tagccaaaac tgtgtccctc
     1321 aggtagactt ttcccgaagg aggaactatg tatgcagctt cccaggttgc cggaagacct
     1381 acttcaaaag ttcccacctt aaggcccatc ttcgcactca cacaggggag aagcctttca
     1441 actgcagctg ggatggctgt gataaaaagt ttgctcgttc ggatgagctg tcacgccacc
     1501 gcagaactca cacaggggag aagaagtttg tgtgcccggt gtgtgaccga cgtttcatgc
     1561 gcagtgacca cctgacgaag catgcccggc gccacatgac gaccaagaag atcccaggct
     1621 ggcaggcaga ggttggcaag ctgaacagaa tcgcctctgc agagagcccg gggagcccac
     1681 tggtgagcat gccagcctct gcctgaaagg tccattagga catcactcat gggattttta
     1741 aaaagcctct ttccaggaat ggaactgatg gattcctctc ccactgcctc acccaaaaaa
     1801 aacggtcttg gcggcctagg ggaagatcgg ggagctggtt ttgatgaaag tatgttaact
     1861 tttcttttcc acttgggacc ctgttcagta tcttttgtag tttcagaagt ttttttgttt
     1921 tggttttttt tttaaagaaa tggtagaaaa tttgataatc tgaatcacca gcattcaaac
     1981 aaatatttcg gcaataaagt ttacaaaatc tggattttta caaccttttc tattgatgtt
     2041 ttgtagaaat aagacagggt actaattttt atactggttt ttagaaaaat atttatattg
     2101 ttggtgctca aatcaccaat ttctagctag atcattttgc agccttcttt tcagtgttta
     2161 ataacaaagt ttttcctaat ggcccttctt ttagtaaact ggacatgtta ttccactaca
     2221 aaaaccacaa gttatctggc cttttagatc tttttggaat cggacctggt tgagtaagga
     2281 cctcttaaaa gggaaaaata aattttgccg tcagcttctt cataacgttt tcaaggaaat
     2341 tctaggcaat cattcctgtc accaaagaac taaaattttg gttgactgga actagtgagc
     2401 tgtgtccatg gtgtgtcatg aaggatgtac cccagagagt aacatgagcc actgggcaga
     2461 tcccagggac cagtacttgc tgcaggatct agtctgtaat agtcttggcc atggctctgc
     2521 tgaaagcaag ccattcagtt tcttgtttgt acctaaaaca ccaaaaaaga aacactcaaa
     2581 tccagctgct ttgtcaattg tcagttctga ctccttttgc tgtggcctta tccgtactat
     2641 attgtgggta gagtaacttc tcagaaaaaa aggaaatgtc tgtattggtt ggatgaaact
     2701 ccaccagagc acagcttagc tggggcgaga tgcatgtgaa ggcaggcagt gccaagattc
     2761 cgcttccttt gtttgccaaa tactagaaac acaaggaaat gcaagttacg ctaaatggca
     2821 gtaatactac ccaactgcct ttctgttcat tttgtttgaa ggaaattgtt ttgaccaaac
     2881 agaaaattac ttggaatggt gtgttttaca gtctacctag aaaatagatg gacaatattt
     2941 ttcaactgta tgagcacgta gataaccgag agaatgtggc cacctgtgtt caagaagcca
     3001 ctgatactgg tttttgttaa acattggaag ttcaggcaat ggaataaatg taggaacata
     3061 cagaatgttg cactaatttg gtagcctggg aatttttttt attgtgcagt atgtatttaa
     3121 attttgtcta tgttaattac cagcatttac ctttatttaa atgatggtaa ggtggaatat
     3181 tgaataaaat taggttttgt gttttgttct ttgtagtctg ataaaatctc cacctggtca
     3241 ttcattgtgt gtgacttgat acctgttaac ttgcccctta gtatcagctg ttacttgaca
     3301 caaatgtgtg tgttattcag aggttttcag tctggacact ccataggtga gtgtcgtgtc
     3361 ttcgtgagac agcacagttg tctcatgttg tgcatagttc atgtttcctc accacccagt
     3421 cctttctcct gctcatcaaa atcagcatac acatttttga ctgtacacac tataaatggc
     3481 atcaaatttg gatatttttc ttaattatga catgcaaagt aatgtgagtc ctgccagtat
     3541 tctggtggat aaggtctttt gagtatttgg ttgcttgtca caacattctc caagcagtga
     3601 tatttctaaa gaggagatac atgttgaaaa cggttttaat ttacacttcc atttcctgat
     3661 tacatttgga aatactttgt gtaaaccatc ccccttccac ctccatttgt ctgttgaaag
     3721 attttaagtt ggaaacagtt cctgtctgaa aactcttctg agaaccacaa accttgtgta
     3781 tggattcggc atggagccct cagctggcgg ctctgggtgc tgacggccgc tggagaggtg
     3841 ggctcccctc gtgcacttta ttgcctgggc agttttgctt gatcttttgt gactttgagc
     3901 cttttaagta gtttgaatga taagacttaa aatgtttcat aattatgttt tatgtaacag
     3961 actttgacat tatttaaacg agcatgtgta atgtaacttt tctctttgaa tcatataaaa
     4021 cttgatttta cattg
//
