LOCUS       NM_005655               2915 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens KLF transcription factor 10 (KLF10), transcript
            variant 1, mRNA.
ACCESSION   NM_005655
VERSION     NM_005655.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2915)
  AUTHORS   Pan,X., Hu,S., Xu,Y., Gopoju,R., Zhu,Y., Cassim Bawa,F.N., Wang,H.,
            Wang,J., Batayneh,Z., Clark,A., Zeng,Y., Lin,L., Wang,X., Yin,L.
            and Zhang,Y.
  TITLE     Kruppel-like factor 10 protects against metabolic
            dysfunction-associated steatohepatitis by regulating
            HNF4alpha-mediated metabolic pathways
  JOURNAL   Metabolism 155, 155909 (2024)
   PUBMED   38582490
  REMARK    GeneRIF: Kruppel-like factor 10 protects against metabolic
            dysfunction-associated steatohepatitis by regulating
            HNF4alpha-mediated metabolic pathways.
REFERENCE   2  (bases 1 to 2915)
  AUTHORS   Yang,X.X. and Wang,C.
  TITLE     CircITGA7 regulates malignant phenotypes in bladder cancer cells
            via targeting miR-330-3p/KLF10 axis
  JOURNAL   Kaohsiung J Med Sci 40 (4), 324-334 (2024)
   PUBMED   38523597
  REMARK    GeneRIF: CircITGA7 regulates malignant phenotypes in bladder cancer
            cells via targeting miR-330-3p/KLF10 axis.
REFERENCE   3  (bases 1 to 2915)
  AUTHORS   Yaseen,U., Hwang,S., Park,S., Kim,S.B., Lee,H.J. and Cha,J.Y.
  TITLE     New Insights into the Role of KLF10 in Tissue Fibrosis
  JOURNAL   Int J Mol Sci 25 (2), 1276 (2024)
   PUBMED   38279278
  REMARK    GeneRIF: New Insights into the Role of KLF10 in Tissue Fibrosis.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2915)
  AUTHORS   Camacho-Vanegas,O., Till,J., Miranda-Lorenzo,I., Ozturk,B.,
            Camacho,S.C. and Martignetti,J.A.
  TITLE     Shaking the family tree: identification of novel and biologically
            active alternatively spliced isoforms across the KLF family of
            transcription factors
  JOURNAL   FASEB J 27 (2), 432-436 (2013)
   PUBMED   23134681
REFERENCE   5  (bases 1 to 2915)
  AUTHORS   Fautsch,M.P., Vrabel,A., Subramaniam,M., Hefferen,T.E.,
            Spelsberg,T.C. and Wieben,E.D.
  TITLE     TGFbeta-inducible early gene (TIEG) also codes for early growth
            response alpha (EGRalpha): evidence of multiple transcripts from
            alternate promoters
  JOURNAL   Genomics 51 (3), 408-416 (1998)
   PUBMED   9721211
REFERENCE   6  (bases 1 to 2915)
  AUTHORS   Subramaniam,M., Hefferan,T.E., Tau,K., Peus,D., Pittelkow,M.,
            Jalal,S., Riggs,B.L., Roche,P. and Spelsberg,T.C.
  TITLE     Tissue, cell type, and breast cancer stage-specific expression of a
            TGF-beta inducible early transcription factor gene
  JOURNAL   J Cell Biochem 68 (2), 226-236 (1998)
   PUBMED   9443078
REFERENCE   7  (bases 1 to 2915)
  AUTHORS   Tachibana,I., Imoto,M., Adjei,P.N., Gores,G.J., Subramaniam,M.,
            Spelsberg,T.C. and Urrutia,R.
  TITLE     Overexpression of the TGFbeta-regulated zinc finger encoding gene,
            TIEG, induces apoptosis in pancreatic epithelial cells
  JOURNAL   J Clin Invest 99 (10), 2365-2374 (1997)
   PUBMED   9153278
REFERENCE   8  (bases 1 to 2915)
  AUTHORS   Subramaniam,M., Harris,S.A., Oursler,M.J., Rasmussen,K., Riggs,B.L.
            and Spelsberg,T.C.
  TITLE     Identification of a novel TGF-beta-regulated gene encoding a
            putative zinc finger protein in human osteoblasts
  JOURNAL   Nucleic Acids Res 23 (23), 4907-4912 (1995)
   PUBMED   8532536
REFERENCE   9  (bases 1 to 2915)
  AUTHORS   Blok,L.J., Grossmann,M.E., Perry,J.E. and Tindall,D.J.
  TITLE     Characterization of an early growth response gene, which encodes a
            zinc finger transcription factor, potentially involved in cell
            cycle regulation
  JOURNAL   Mol Endocrinol 9 (11), 1610-1620 (1995)
   PUBMED   8584037
REFERENCE   10 (bases 1 to 2915)
  AUTHORS   Cirino,A.L. and Ho,C.
  TITLE     Hypertrophic Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301725
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA720479.1, BC095399.1,
            AP002851.2 and BQ575313.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005655.3.
            
            Summary: This gene encodes a member of a family of proteins that
            feature C2H2-type zinc finger domains. The encoded protein is a
            transcriptional repressor that acts as an effector of transforming
            growth factor beta signaling. Activity of this protein may inhibit
            the growth of cancers, particularly pancreatic cancer. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jun 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095399.1, SRR1660803.19444.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2154529
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285407.11/ ENSP00000285407.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA720479.1         178-179
            3-2213              BC095399.1         1-2211
            2214-2214           AP002851.2         126626-126626       c
            2215-2914           BC095399.1         2213-2912
            2915-2915           BQ575313.1         24-24               c
FEATURES             Location/Qualifiers
     source          1..2915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..2915
                     /gene="KLF10"
                     /gene_synonym="EGR-alpha; EGRA; TIEG; TIEG1"
                     /note="KLF transcription factor 10"
                     /db_xref="GeneID:7071"
                     /db_xref="HGNC:HGNC:11810"
                     /db_xref="MIM:601878"
     exon            1..160
                     /gene="KLF10"
                     /gene_synonym="EGR-alpha; EGRA; TIEG; TIEG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1567
                     /gene="KLF10"
                     /gene_synonym="EGR-alpha; EGRA; TIEG; TIEG1"
                     /note="isoform a is encoded by transcript variant 1;
                     krueppel-like factor 10; TGFB-inducible early growth
                     response protein 1; transforming growth
                     factor-beta-inducible early growth response protein 1;
                     zinc finger transcription factor TIEG; early growth
                     response-alpha; Kruppel like factor 10"
                     /codon_start=1
                     /product="Krueppel-like factor 10 isoform a"
                     /protein_id="NP_005646.1"
                     /db_xref="CCDS:CCDS6294.1"
                     /db_xref="GeneID:7071"
                     /db_xref="HGNC:HGNC:11810"
                     /db_xref="MIM:601878"
                     /translation="MLNFGASLQQTAEERMEMISERPKESMYSWNKTAEKSDFEAVEA
                     LMSMSCSWKSDFKKYVENRPVTPVSDLSEEENLLPGTPDFHTIPAFCLTPPYSPSDFE
                     PSQVSNLMAPAPSTVHFKSLSDTAKPHIAAPFKEEEKSPVSAPKLPKAQATSVIRHTA
                     DAQLCNHQTCPMKAASILNYQNNSFRRRTHLNVEAARKNIPCAAVSPNRSKCERNTVA
                     DVDEKASAALYDFSVPSSETVICRSQPAPVSPQQKSVLVSPPAVSAGGVPPMPVICQM
                     VPLPANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGAVMFVVPQPVVQSSKPPVV
                     SPNGTRLSPIAPAPGFSPSAAKVTPQIDSSRIRSHICSHPGCGKTYFKSSHLKAHTRT
                     HTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARR
                     HLSAKKLPNWQMEVSKLNDIALPPTPAPTQ"
     exon            161..394
                     /gene="KLF10"
                     /gene_synonym="EGR-alpha; EGRA; TIEG; TIEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..1307
                     /gene="KLF10"
                     /gene_synonym="EGR-alpha; EGRA; TIEG; TIEG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..2915
                     /gene="KLF10"
                     /gene_synonym="EGR-alpha; EGRA; TIEG; TIEG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2895..2900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF10"
                     /gene_synonym="EGR-alpha; EGRA; TIEG; TIEG1"
                     /note="hexamer: AATAAA"
     polyA_site      2915
                     /gene="KLF10"
                     /gene_synonym="EGR-alpha; EGRA; TIEG; TIEG1"
                     /note="major polyA site"
ORIGIN      
        1 gcagacggcg ctgagcgcgg cggcggcggg agcggcgtcg agtgtctccg tgcgcccgtc
       61 tgtggccaag cagccagcag cctagcagcc agtcagcttg ccgccggcgg ccaagcagcc
      121 aaccatgctc aacttcggtg cctctctcca gcagactgcg gaggaaagaa tggaaatgat
      181 ttctgaaagg ccaaaagaga gtatgtattc ctggaacaaa actgcagaga aaagtgattt
      241 tgaagctgta gaagcactta tgtcaatgag ctgcagttgg aagtctgatt ttaagaaata
      301 cgttgaaaac agacctgtta caccagtatc tgatttgtca gaggaagaga atctgcttcc
      361 gggaacacct gattttcata caatcccagc attttgtttg actccacctt acagtccttc
      421 tgactttgaa ccctctcaag tgtcaaatct gatggcacca gcgccatcta ctgtacactt
      481 caagtcactc tcagatactg ccaaacctca cattgccgca cctttcaaag aggaagaaaa
      541 gagcccagta tctgccccca aactccccaa agctcaggca acaagtgtga ttcgtcatac
      601 agctgatgcc cagctatgta accaccagac ctgcccaatg aaagcagcca gcatcctcaa
      661 ctatcagaac aattctttta gaagaagaac ccacctaaat gttgaggctg caagaaagaa
      721 cataccatgt gccgctgtgt caccaaacag atccaaatgt gagagaaaca cagtggcaga
      781 tgttgatgag aaagcaagtg ctgcacttta tgacttttct gtgccttcct cagagacggt
      841 catctgcagg tctcagccag cccctgtgtc cccacaacag aagtcagtgt tggtctctcc
      901 acctgcagta tctgcagggg gagtgccacc tatgccggtc atctgccaga tggttcccct
      961 tcctgccaac aaccctgttg tgacaacagt cgttcccagc actcctccca gccagccacc
     1021 agccgtttgc ccccctgttg tgttcatggg cacacaagtc cccaaaggcg ctgtcatgtt
     1081 tgtggtaccc cagcccgttg tgcagagttc aaagcctccg gtggtgagcc cgaatggcac
     1141 cagactctct cccattgccc ctgctcctgg gttttcccct tcagcagcaa aagtcactcc
     1201 tcagattgat tcatcaagga taaggagtca catctgtagc cacccaggat gtggcaagac
     1261 atactttaaa agttcccatc tgaaggccca cacgaggacg cacacaggag aaaagccttt
     1321 cagctgtagc tggaaaggtt gtgaaaggag gtttgcccgt tctgatgaac tgtccagaca
     1381 caggcgaacc cacacgggtg agaagaaatt tgcgtgcccc atgtgtgacc ggcggttcat
     1441 gaggagtgac catttgacca agcatgcccg gcgccatcta tcagccaaga agctaccaaa
     1501 ctggcagatg gaagtgagca agctaaatga cattgctcta cctccaaccc ctgctcccac
     1561 acagtgacag accggaaagt gaagagtcag aactaacttt ggtctcagcg ggagccagtg
     1621 gtgatgtaaa aatgcttcca ctgcaagtct gtggccccac aacgtgggct taaagcagaa
     1681 gccccacagc ctggcacgaa ggccccgcct gggttaggtg actaaaaggg cttcggccac
     1741 aggcaggtca cagaaaggca ggtttcattt cttatcacat aagagagatg agaaagcttt
     1801 tattcctttg aatatttttt gaaggtttca gatgaggtca acacaggtag cacagatttt
     1861 gaatctgtgt gcatatttgt tactttactt ttgctgttta tacttgagac caacttttca
     1921 atgtgattct tctaaagcac tggtttcaag aatatggagg ctggaaggaa ataaacatta
     1981 cggtacagac atggagatgt aaaatgagtt tgtattatta caaatattgt catctttttc
     2041 tagagttatc ttctttatta ttcctagtct ttccagtcaa catcgtggat gtagtgatta
     2101 aatatatcta gaactatcat ttttacacta ttgtgaatat ttggaattga acgactgtat
     2161 attgctaaga gggcccaaag aattggaatc ctccttaatt taattgcttt gaagcatagc
     2221 tacaatttgt ttttgcattt ttgttttgaa agtttaacaa atgactgtat ctaggcattt
     2281 cattatgctt tgaactttag tttgcctgca gtttcttgtg tagatttgaa aattgtatac
     2341 caatgtgttt tctgtagact ctaagataca ctgcactttg tttagaaaaa aaactgaaga
     2401 tgaaatatat attgtaaaga agggatatta agaatcttag ataacttctt gaaaaagatg
     2461 gcttatgtca tcagtaaagt acctttatgt tatgaggata taatgtgtgc tttattgaat
     2521 tagaaaatta gtgaccatta ttcacaggtg gacaaatgtt gatgttgtcc tgttaattta
     2581 taggcgtttt ttggggatgt ggaggtagtt gggtagaaaa attattagaa cattcacttt
     2641 tgttaacagt atttctcttt tattctgtta tatagtggat gatatacaca gtggcaaaac
     2701 aaaagtacat tgcttaaaat atatagtgaa aaatgtcact atatcttccc atttaacatt
     2761 gtttttgtat attgggtgta gatttctgac atcaaaactt ggacccttgg aaaacaaaag
     2821 ttttaattaa aaaaaatcct tgtgacttac aatttgcaca atatttcttt tgttgtactt
     2881 tatatcttgt ttacaataaa gaattccctt tggta
//
