LOCUS       NM_006563               1613 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens KLF transcription factor 1 (KLF1), mRNA.
ACCESSION   NM_006563
VERSION     NM_006563.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1613)
  AUTHORS   Song,L., Xu,Q., Chen,R., Sun,W. and Zhan,J.
  TITLE     KLF1 Activates RAC3 to Mediate Fatty Acid Synthesis and Enhance
            Cisplatin Resistance in Bladder Cancer Cells
  JOURNAL   Am J Mens Health 18 (5), 15579883241273305 (2024)
   PUBMED   39376007
  REMARK    GeneRIF: KLF1 Activates RAC3 to Mediate Fatty Acid Synthesis and
            Enhance Cisplatin Resistance in Bladder Cancer Cells.
REFERENCE   2  (bases 1 to 1613)
  AUTHORS   Ye,L., Wang,C., Li,A., Li,M., Pi,Y., Yang,J., Zhu,Z. and Lu,D.
  TITLE     Targeted next-generation sequencing and long-read HiFi sequencing
            provide novel insights into clinically significant KLF1 variants
  JOURNAL   BMC Genomics 25 (1), 230 (2024)
   PUBMED   38429690
  REMARK    GeneRIF: Targeted next-generation sequencing and long-read HiFi
            sequencing provide novel insights into clinically significant KLF1
            variants.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1613)
  AUTHORS   Manco,L., Bento,C., Relvas,L., Maia,T. and Ribeiro,L.
  TITLE     Association study of common KLF1 variants with Hb F and Hb A2
            levels in beta-thalassaemia carriers of Portuguese ancestry
  JOURNAL   J Genet 103 (2024)
   PUBMED   39445566
  REMARK    GeneRIF: Association study of common KLF1 variants with Hb F and Hb
            A2 levels in beta-thalassaemia carriers of Portuguese ancestry.
REFERENCE   4  (bases 1 to 1613)
  AUTHORS   Bieker,J.J. and Philipsen,S.
  TITLE     Erythroid Kruppel-Like Factor (KLF1): A Surprisingly Versatile
            Regulator of Erythroid Differentiation
  JOURNAL   Adv Exp Med Biol 1459, 217-242 (2024)
   PUBMED   39017846
  REMARK    GeneRIF: Erythroid Kruppel-Like Factor (KLF1): A Surprisingly
            Versatile Regulator of Erythroid Differentiation.
            Review article
REFERENCE   5  (bases 1 to 1613)
  AUTHORS   Lu,Y., Ma,W.B., Ren,G.M., Liu,X., Li,Y.T., Wang,T., Zhan,Y.Q.,
            Xiang,S.S., Yu,M., Li,C.Y., Yang,X.M. and Yin,R.H.
  TITLE     VPS37C facilitates erythroid differentiation by promoting EKLF
            stability
  JOURNAL   Biochem Biophys Res Commun 671, 229-235 (2023)
   PUBMED   37307706
  REMARK    GeneRIF: VPS37C facilitates erythroid differentiation by promoting
            EKLF stability.
REFERENCE   6  (bases 1 to 1613)
  AUTHORS   Armstrong,J.A., Bieker,J.J. and Emerson,B.M.
  TITLE     A SWI/SNF-related chromatin remodeling complex, E-RC1, is required
            for tissue-specific transcriptional regulation by EKLF in vitro
  JOURNAL   Cell 95 (1), 93-104 (1998)
   PUBMED   9778250
REFERENCE   7  (bases 1 to 1613)
  AUTHORS   Ouyang,L., Chen,X. and Bieker,J.J.
  TITLE     Regulation of erythroid Kruppel-like factor (EKLF) transcriptional
            activity by phosphorylation of a protein kinase casein kinase II
            site within its interaction domain
  JOURNAL   J Biol Chem 273 (36), 23019-23025 (1998)
   PUBMED   9722526
REFERENCE   8  (bases 1 to 1613)
  AUTHORS   van Ree,J.H., Roskrow,M.A., Becher,A.M., McNall,R., Valentine,V.A.,
            Jane,S.M. and Cunningham,J.M.
  TITLE     The human erythroid-specific transcription factor EKLF localizes to
            chromosome 19p13.12-p13.13
  JOURNAL   Genomics 39 (3), 393-395 (1997)
   PUBMED   9119377
REFERENCE   9  (bases 1 to 1613)
  AUTHORS   Bieker,J.J.
  TITLE     Isolation, genomic structure, and expression of human erythroid
            Kruppel-like factor (EKLF)
  JOURNAL   DNA Cell Biol 15 (5), 347-352 (1996)
   PUBMED   8924208
REFERENCE   10 (bases 1 to 1613)
  AUTHORS   Nuez,B., Michalovich,D., Bygrave,A., Ploemacher,R. and Grosveld,F.
  TITLE     Defective haematopoiesis in fetal liver resulting from inactivation
            of the EKLF gene
  JOURNAL   Nature 375 (6529), 316-318 (1995)
   PUBMED   7753194
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AD000092.1 and BC040000.1.
            
            On Aug 31, 2019 this sequence version replaced NM_006563.4.
            
            Summary: This gene encodes a hematopoietic-specific transcription
            factor that induces high-level expression of adult beta-globin and
            other erythroid genes. The zinc-finger protein binds to the DNA
            sequence CCACACCCT found in the beta hemoglobin promoter.
            Heterozygous loss-of-function mutations in this gene result in the
            dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040000.1, U65404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264834.6/ ENSP00000264834.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AD000092.1         33717-33736         c
            21-1613             BC040000.1         1-1593
FEATURES             Location/Qualifiers
     source          1..1613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..1613
                     /gene="KLF1"
                     /gene_synonym="CDAN4A; CDAN4B; EKLF; EKLF/KLF1"
                     /note="KLF transcription factor 1"
                     /db_xref="GeneID:10661"
                     /db_xref="HGNC:HGNC:6345"
                     /db_xref="MIM:600599"
     exon            1..148
                     /gene="KLF1"
                     /gene_synonym="CDAN4A; CDAN4B; EKLF; EKLF/KLF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1150
                     /gene="KLF1"
                     /gene_synonym="CDAN4A; CDAN4B; EKLF; EKLF/KLF1"
                     /note="erythroid Kruppel-like factor; erythroid-specific
                     transcription factor EKLF; erythroid krueppel-like
                     transcription factor; Kruppel like factor 1"
                     /codon_start=1
                     /product="Krueppel-like factor 1"
                     /protein_id="NP_006554.1"
                     /db_xref="CCDS:CCDS12285.1"
                     /db_xref="GeneID:10661"
                     /db_xref="HGNC:HGNC:6345"
                     /db_xref="MIM:600599"
                     /translation="MATAETALPSISTLTALGPFPDTQDDFLKWWRSEEAQDMGPGPP
                     DPTEPPLHVKSEDQPGEEEDDERGADATWDLDLLLTNFSGPEPGGAPQTCALAPSEAS
                     GAQYPPPPETLGAYAGGPGLVAGLLGSEDHSGWVRPALRARAPDAFVGPALAPAPAPE
                     PKALALQPVYPGPGAGSSGGYFPRTGLSVPAASGAPYGLLSGYPAMYPAPQYQGHFQL
                     FRGLQGPAPGPATSPSFLSCLGPGTVGTGLGGTAEDPGVIAETAPSKRGRRSWARKRQ
                     AAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYACTWEGCGWRFARSDELTRHYRKHT
                     GQRPFRCQLCPRAFSRSDHLALHMKRHL"
     exon            149..974
                     /gene="KLF1"
                     /gene_synonym="CDAN4A; CDAN4B; EKLF; EKLF/KLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1613
                     /gene="KLF1"
                     /gene_synonym="CDAN4A; CDAN4B; EKLF; EKLF/KLF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1589..1594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLF1"
                     /gene_synonym="CDAN4A; CDAN4B; EKLF; EKLF/KLF1"
                     /note="hexamer: TATAAA"
     polyA_site      1613
                     /gene="KLF1"
                     /gene_synonym="CDAN4A; CDAN4B; EKLF; EKLF/KLF1"
                     /note="major polyA site"
ORIGIN      
        1 agagttcacg aggcagccga ggaagaggag gcttgaggcc cagggtgggc accagccagc
       61 catggccaca gccgagaccg ccttgccctc catcagcaca ctgaccgccc tgggcccctt
      121 cccggacaca caggatgact tcctcaagtg gtggcgctcc gaagaggcgc aggacatggg
      181 cccgggtcct cctgacccca cggagccgcc cctccacgtg aagtctgagg accagcccgg
      241 ggaggaagag gacgatgaga ggggcgcgga cgccacctgg gacctggatc tcctcctcac
      301 caacttctcg ggcccggagc ccggtggcgc gccccagacc tgcgctctgg cgcccagcga
      361 ggcctccggg gcgcaatatc cgccgccgcc cgagactctg ggcgcatatg ctggcggccc
      421 ggggctggtg gctgggcttt tgggttcgga ggatcactcg ggttgggtgc gccctgccct
      481 gcgagcccgg gctcccgacg ccttcgtggg cccagccctg gctccagccc cggcccccga
      541 gcccaaggcg ctggcgctgc aaccggtgta cccggggccc ggcgccggct cctcgggtgg
      601 ctacttcccg cggaccgggc tttcagtgcc tgcggcgtcg ggcgccccct acgggctact
      661 gtccgggtac cccgcgatgt acccggcgcc tcagtaccaa gggcacttcc agctcttccg
      721 cgggctccag ggacccgcgc ccggtcccgc cacgtccccc tccttcctga gttgtttggg
      781 acccgggacg gtgggcactg gactcggggg gactgcagag gatccaggtg tgatagccga
      841 gaccgcgcca tccaagcgag gccgacgttc gtgggcgcgc aagaggcagg cagcgcacac
      901 gtgcgcgcac ccgggttgcg gcaagagcta caccaagagc tcccacctga aggcgcatct
      961 gcgcacgcac acaggggaga agccatacgc ctgcacgtgg gaaggctgcg gctggagatt
     1021 cgcgcgctcg gacgagctga cccgccacta ccggaaacac acggggcagc gccccttccg
     1081 ctgccagctc tgcccacgtg ctttttcgcg ctctgaccac ctggccttgc acatgaagcg
     1141 ccacctttga gccctgccct ggcacttgga ctctcctagt gactggggat gggacaagaa
     1201 gcctgtttgg tggtctcttc acacggacgc gcgtgacaca atgctgggtg gttttcccac
     1261 gaatggaccc tctcctggac tcgcgttccc aaagatccac ccaaatatca aacacggacc
     1321 catagacagc cctgggggag cctcttacgg aaaatccgac aagccttcag ccacagggag
     1381 ccacacagag atgtccaaac tgtcgtgcaa acccagtgag acagaccgcc aaataaacgg
     1441 actcagtgga cactcagacc agctcccaga tggccctgga cagcaggaga gggtgtggga
     1501 tgaggcttcc cagagaccct gggtctagaa agcggctcct gaaggtccct tattgtggct
     1561 gatattaact gtcaatggtt atgggtccta taaaaatgcc cctcccagat aaa
//
