LOCUS       NM_177417               1782 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens kinesin light chain 3 (KLC3), mRNA.
ACCESSION   NM_177417 XM_005258538
VERSION     NM_177417.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1782)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1782)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 1782)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 1782)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1782)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1782)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   7  (bases 1 to 1782)
  AUTHORS   Bhullar,B., Zhang,Y., Junco,A., Oko,R. and van der Hoorn,F.A.
  TITLE     Association of kinesin light chain with outer dense fibers in a
            microtubule-independent fashion
  JOURNAL   J Biol Chem 278 (18), 16159-16168 (2003)
   PUBMED   12594206
  REMARK    GeneRIF: Rat KLC3 associates with the outer dense fibers of
            maturing sperm tails.
REFERENCE   8  (bases 1 to 1782)
  AUTHORS   Junco,A., Bhullar,B., Tarnasky,H.A. and van der Hoorn,F.A.
  TITLE     Kinesin light-chain KLC3 expression in testis is restricted to
            spermatids
  JOURNAL   Biol Reprod 64 (5), 1320-1330 (2001)
   PUBMED   11319135
  REMARK    GeneRIF: Rat KLC3 interacts with KHC and microtubules in vitro.
            Expressed in spleen, intestine, brain, ovary, testis.  Testis
            expression restricted to post-meiotic spermatids.
REFERENCE   9  (bases 1 to 1782)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   10 (bases 1 to 1782)
  AUTHORS   Lamerdin,J.E., Stilwagen,S.A., Ramirez,M.H., Stubbs,L. and
            Carrano,A.V.
  TITLE     Sequence analysis of the ERCC2 gene regions in human, mouse, and
            hamster reveals three linked genes
  JOURNAL   Genomics 34 (3), 399-409 (1996)
   PUBMED   8786141
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF569806.1, BC062998.1 and
            AK092481.1.
            
            On Nov 23, 2018 this sequence version replaced NM_177417.2.
            
            Summary: This gene encodes a member of the kinesin light chain gene
            family. Kinesins are molecular motors involved in the transport of
            cargo along microtubules, and are composed of two kinesin heavy
            chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are
            thought to typically be involved in binding cargo and regulating
            kinesin activity. In the rat, a protein similar to this gene
            product is expressed in post-meiotic spermatids, where it
            associates with structural components of sperm tails and
            mitochondria. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062998.1, SRR14038192.371829.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391946.7/ ENSP00000375810.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BF569806.1         12-14
            4-1776              BC062998.1         1-1773
            1777-1782           AK092481.1         1814-1819
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..1782
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /note="kinesin light chain 3"
                     /db_xref="GeneID:147700"
                     /db_xref="HGNC:HGNC:20717"
                     /db_xref="MIM:601334"
     exon            1..97
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     exon            98..363
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1620
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /note="kinesin light chain 2"
                     /codon_start=1
                     /product="kinesin light chain 3"
                     /protein_id="NP_803136.2"
                     /db_xref="CCDS:CCDS12660.2"
                     /db_xref="GeneID:147700"
                     /db_xref="HGNC:HGNC:20717"
                     /db_xref="MIM:601334"
                     /translation="MSVQVAAPGSAGLGPERLSPEELVRQTRQVVQGLEALRAEHHGL
                     AGHLAEALAGQGPAAGLEMLEEKQQVVSHSLEAIELGLGEAQVLLALSAHVGALEAEK
                     QRLRSQARRLAQENVWLREELEETQRRLRASEESVAQLEEEKRHLEFLGQLRQYDPPA
                     ESQQSESPPRRDSLASLFPSEEEERKGPEAAGAAAAQQGGYEIPARLRTLHNLVIQYA
                     GQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEATDLLHDAL
                     QIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHPDVAK
                     QLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQ
                     QAEELYKEILHKEDLPAPLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGSEKLVSRL
                     RGEAAAGAAGMKRAMSLNTLNVDAPRAPGTQFPSWHLDKAPRTLSASTQDLSPH"
     exon            364..594
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     exon            595..664
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     exon            665..884
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     exon            885..972
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1074
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1248
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1339
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1377
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1484
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1548
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1782
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1757..1762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /note="hexamer: ATTAAA"
     polyA_site      1782
                     /gene="KLC3"
                     /gene_synonym="KLC2; KLC2L; KLCt; KNS2B"
                     /note="major polyA site"
ORIGIN      
        1 agacgcccgg cgcagcggga gcggcggggc gtgcctggcc tgcgggacgc gactgatcgc
       61 agtggggcga agcggggccg gagccgcccg cggtcaggag cagcaatgtc tgtgcaggta
      121 gcggctcctg gaagtgcagg gctgggccca gagcgcctga gccctgagga gctggtgcgg
      181 cagacgcggc aagtggtcca ggggctggag gcgctgcggg cagagcacca tggcctggct
      241 gggcacctgg cggaggccct ggcgggacag ggcccggcag ccggcttgga gatgctggag
      301 gaaaagcagc aggtggtgag ccactcgctg gaggccatcg agctggggct gggcgaggcc
      361 caggtgctgc tggccctgtc ggcacatgtg ggtgcactgg aggcagagaa gcagcggctg
      421 cgctcgcagg cccggcggct ggcccaggag aacgtgtggc tgcgggagga actggaggag
      481 acgcagcggc ggcttcgggc cagcgaggag tccgtggccc agctggagga ggagaagcgc
      541 cacctggagt tcctggggca gctgcgacag tacgacccac cggcggagag ccagcagtct
      601 gagtccccgc ctcgccgaga cagcctggcc tccctgttcc ccagcgagga ggaggagagg
      661 aaaggtcctg aggccgcagg agcagcagct gctcagcagg gtggctatga gatccctgcc
      721 cgccttcgga ccctgcataa cctcgtgatc cagtacgcgg ggcagggccg ctatgaggtg
      781 gcggtgcctc tgtgccgcca ggccttggag gacctggagc gcagctcggg ccactgccac
      841 cctgacgtgg ccaccatgct caacatcctg gcgctggtgt accgggacca gaacaagtac
      901 aaagaagcca cagaccttct ccatgatgcc ctgcagatcc gggagcagac gctgggccct
      961 gagcaccccg cggtggccgc cacgctcaac aacttggctg tcctctatgg gaagcgtggg
     1021 cgttaccggg aggcagagcc cctgtgccag cgcgctttgg agatccgaga gaaggtcctg
     1081 ggtgctgacc acccagatgt ggccaagcag ctcaacaacc tggccctgct gtgccagaac
     1141 cagggcaagt ttgaggacgt ggagcggcac tatgcccggg ccctgagcat ctatgaggca
     1201 ctgggcgggc cccatgaccc caacgtggcc aagaccaaga acaacctggc ctcagcctac
     1261 ctgaaacaga acaagtatca acaagcggaa gagctgtaca aagaaatcct ccacaaggag
     1321 gacctacccg cccctctcgg tgcccccaac acaggcacag ctggtgacgc agaacaggcc
     1381 cttcgccgca gcagctcact ctccaagatc cgtgagtcta tcaggcgagg aagtgagaag
     1441 ctggtctccc ggctccgagg cgaggcggcg gcaggagcag ccggaatgaa gagagccatg
     1501 tcactcaaca cactgaacgt ggatgctcca agggctcctg ggactcagtt tcccagctgg
     1561 cacctggaca aggcccctcg gaccctcagc gccagcaccc aggacctgag cccccactaa
     1621 cgtccagtga actgcgctgg ccgcagcttc ttgggaacag tgcaggaggg atgggctggt
     1681 ggggtgagag ggggtctatc atctcctggc ccccccttgc ctctgggtac ctggtggata
     1741 gctgccttct cctgcgatta aaggctgtgg acgtgacagt ga
//
