LOCUS       NM_001318734            2953 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens kinesin light chain 2 (KLC2), transcript variant 5,
            mRNA.
ACCESSION   NM_001318734 XM_005274182
VERSION     NM_001318734.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2953)
  AUTHORS   Qiao,S., Jiang,Y., Li,N. and Zhu,X.
  TITLE     The kinesin light chain-2, a target of mRNA stabilizing protein
            HuR, inhibits p53 protein phosphorylation to promote
            radioresistance in NSCLC
  JOURNAL   Thorac Cancer 14 (16), 1440-1450 (2023)
   PUBMED   37055376
  REMARK    GeneRIF: The kinesin light chain-2, a target of mRNA stabilizing
            protein HuR, inhibits p53 protein phosphorylation to promote
            radioresistance in NSCLC.
REFERENCE   2  (bases 1 to 2953)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 2953)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   4  (bases 1 to 2953)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2953)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2953)
  AUTHORS   Ligon,L.A., Tokito,M., Finklestein,J.M., Grossman,F.E. and
            Holzbaur,E.L.
  TITLE     A direct interaction between cytoplasmic dynein and kinesin I may
            coordinate motor activity
  JOURNAL   J Biol Chem 279 (18), 19201-19208 (2004)
   PUBMED   14985359
REFERENCE   7  (bases 1 to 2953)
  AUTHORS   Bowman,A.B., Kamal,A., Ritchings,B.W., Philp,A.V., McGrail,M.,
            Gindhart,J.G. and Goldstein,L.S.
  TITLE     Kinesin-dependent axonal transport is mediated by the sunday driver
            (SYD) protein
  JOURNAL   Cell 103 (4), 583-594 (2000)
   PUBMED   11106729
REFERENCE   8  (bases 1 to 2953)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 2953)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   10 (bases 1 to 2953)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA589927.1, BC034373.1,
            AL136864.1 and AP001107.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001318734.1.
            
            Summary: The protein encoded by this gene is a light chain of
            kinesin, a molecular motor responsible for moving vesicles and
            organelles along microtubules. Defects in this gene are a cause of
            spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome.
            [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (5) represents an alternate 5' UTR
            and encodes the longer protein isoform (1). The same protein is
            encoded by transcript variants 1, 3, 4, and 5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1173921.1, BC034373.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394067.7/ ENSP00000377631.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                DA589927.1         1-75
            76-2877             BC034373.1         1-2802
            2878-2908           AL136864.1         2841-2871
            2909-2909           AP001107.5         8072-8072
            2910-2953           AL136864.1         2872-2915
FEATURES             Location/Qualifiers
     source          1..2953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..2953
                     /gene="KLC2"
                     /note="kinesin light chain 2"
                     /db_xref="GeneID:64837"
                     /db_xref="HGNC:HGNC:20716"
                     /db_xref="MIM:611729"
     exon            1..169
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            170..408
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2049
                     /gene="KLC2"
                     /note="isoform 1 is encoded by transcript variant 5; KLC
                     2"
                     /codon_start=1
                     /product="kinesin light chain 2 isoform 1"
                     /protein_id="NP_001305663.1"
                     /db_xref="CCDS:CCDS8130.1"
                     /db_xref="GeneID:64837"
                     /db_xref="HGNC:HGNC:20716"
                     /db_xref="MIM:611729"
                     /translation="MAMMVFPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVA
                     PEAGEAEPGSQERCILLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRL
                     VQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEDASPNEEKGDVP
                     KDTLDDLFPNEDEQSPAPSPGGGDVSGQHGGYEIPARLRTLHNLVIQYASQGRYEVAV
                     PLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGK
                     DHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLC
                     QNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEI
                     LTRAHEKEFGSVNGDNKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNT
                     TLRSLGALYRRQGKLEAAHTLEDCASRNRKQGLDPASQTKVVELLKDGSGRRGDRRSS
                     RDMAGGAGPRSESDLEDVGPTAEWNGDGSGSLRRSGSFGKLRDALRRSSEMLVKKLQG
                     GTPQEPPNPRMKRASSLNFLNKSVEEPTQPGGTGLSDSRTLSSSSMDLSRRSSLVG"
     exon            409..639
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..709
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            710..932
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1020
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1122
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1296
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1396
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1446
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1514
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1623
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1782
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1907
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1965
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2953
                     /gene="KLC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2932..2937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLC2"
                     /note="hexamer: AATAAA"
     polyA_site      2953
                     /gene="KLC2"
                     /note="major polyA site"
ORIGIN      
        1 gtgtttcgcc ccctccgacg ccaccgaggt agcggcttca cctttaaggc ggcgcggggg
       61 ctgctgggaa ggccggcggg atggaggcgg cgggaccggc tcgcgggtgc gggtccgggt
      121 gaagcgggag gcagccagag tcggagccgg gcccgagcac caggcgcaga cgccacagcc
      181 atggccatga tggtgtttcc gcgggaggag aagctgagcc aggatgagat cgtgctgggc
      241 accaaggctg tcatccaggg actggagact ctgcgtgggg agcatcgtgc cctgctggct
      301 cctctggttg cacctgaggc cggcgaagcc gagcctggct cgcaggagcg ctgcatcctc
      361 ctgcgtcgct ccctggaagc cattgagctt gggctggggg aggcccaggt gatcttggca
      421 ttgtcgagcc acctgggggc tgtagaatca gagaagcaga agctgcgggc gcaggtgcgg
      481 cgtctggtgc aggagaacca gtggctgcgt gaggagctgg cggggacaca gcagaagctg
      541 cagcgcagtg agcaggccgt ggcccagctc gaggaggaga agcagcactt gctgttcatg
      601 agccagatcc gcaagttgga tgaagacgcc tcccctaacg aggagaaggg ggacgtcccc
      661 aaagacacac tggatgacct gttccccaat gaggatgagc agagcccagc ccctagccca
      721 ggaggagggg atgtgtctgg tcagcatggg ggctacgaga tcccggcccg gctccgcacc
      781 ctgcacaacc tggtgatcca atacgcctca cagggccgct acgaggtagc tgtgccactc
      841 tgcaagcagg cactcgaaga cctggagaag acgtcaggcc acgaccaccc tgacgttgcc
      901 accatgctga acatcctggc actggtctat cgggatcaga acaagtacaa ggaggctgcc
      961 cacctgctca atgatgctct ggccatccgg gagaaaacac tgggcaagga ccacccagcc
     1021 gtggctgcga cactaaacaa cctggcagtc ctgtatggca agaggggcaa gtacaaggag
     1081 gctgagccat tgtgcaagcg ggcactggag atccgggaga aggtcctggg caagtttcac
     1141 ccagatgtgg ccaagcagct cagcaacctg gccctgctgt gccagaacca gggcaaagct
     1201 gaggaggtgg aatattacta tcggcgggca ctggagatct atgctacacg cctcgggccc
     1261 gatgacccca atgtggccaa gaccaagaac aacctggctt cctgctacct gaagcagggc
     1321 aagtaccagg atgcggagac cttgtacaag gagatcctca cccgcgctca tgagaaagag
     1381 tttggctctg tcaatgggga caacaagccc atctggatgc acgcagagga gcgggaggaa
     1441 agcaaggata agcgccggga cagcgccccc tatggggaat acggcagctg gtacaaggcc
     1501 tgtaaagtag acagccccac agtcaacacc accctgcgca gcttgggggc cctataccgg
     1561 cgccagggca agctggaagc cgcgcacaca ctagaggact gtgccagccg taaccgcaag
     1621 cagggtttgg accccgcaag ccagaccaag gtggtagaac tgctgaaaga tggcagtggc
     1681 aggcggggag accgccgcag cagccgagac atggctgggg gtgccgggcc tcggtctgag
     1741 tctgacctcg aggacgtggg acctacagct gagtggaatg gggatggcag tggctccttg
     1801 aggcgcagcg gttcctttgg gaaactccgg gatgccctga ggcgcagcag tgagatgctg
     1861 gtaaagaagc tgcagggggg caccccccag gagcccccta accccaggat gaagcgggcc
     1921 agttccctca acttcctcaa caagagcgtg gaagagccga cccagcctgg aggcacaggt
     1981 ctctctgaca gccgcactct cagctccagc tccatggacc tctcccgacg aagctccctg
     2041 gtgggctaat gctgaagggg cagccagtca ccagagcgcc cacctggcac acccccctca
     2101 ccccagccct gcgcatgggc ctgctgcttg tcccgcctgt ctctcccaca gcccctgtct
     2161 tttctgttca atctcagggt aaccttctcc cttgtcatct cagcctgagc cctggaggct
     2221 gggcctgccc actccagctc catcccttat ttattccttc cagcagggcc ctcttcccta
     2281 ggttcgggcc agcaggaggt gccggctgga gtctccacca tagactcagt ggcctggcct
     2341 ccccagaccc cagagccaag aacactaagc actcgccggc ccttcggcac cctcgccctc
     2401 cctcccgact caacccggcc gttgcttctg tatatagaga aataagttat tggccgcgcg
     2461 cctcccttca gtccacggta ctacccgggc ctcccctcgt ccctcttcta gtggtaccgc
     2521 ccaggcctta atcaccccca ttccgtgcgg tggtatctcc caggctctac attctcggga
     2581 gcggcgcctc ccaagggggt cctgggacct tctcgcgctc ctcctggcct ctgagggatg
     2641 cgtcctaccc gcgccatcgc cccgtggccc aggacgggga cctcccctta gtccgtcctc
     2701 ccaccgccgg gccctgcccc gcatcccggc cttatgcact gcccctccca cccggccccg
     2761 cccaggcacg gccgaccccg ccccgggcac cgcccaccga gccatcctgc ctcgcctccc
     2821 cccacgcctg cagcttctcg cgaggggcgg cgacggtccc ctggtggcag gaggggctcc
     2881 ccctgttgcg ggtgaggcgg ctgctctcat attttcagat gttgctgtag aaataaagac
     2941 ggtttaaatc tga
//
