LOCUS       NM_001394837            2550 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens kinesin light chain 1 (KLC1), transcript variant 9,
            mRNA.
ACCESSION   NM_001394837
VERSION     NM_001394837.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2550)
  AUTHORS   Kikuchi,M., Viet,J., Nagata,K., Sato,M., David,G., Audic,Y.,
            Silverman,M.A., Yamamoto,M., Akatsu,H., Hashizume,Y., Takeda,S.,
            Akamine,S., Miyamoto,T., Uozumi,R., Gotoh,S., Mori,K., Ikeda,M.,
            Paillard,L. and Morihara,T.
  TITLE     Gene-gene functional relationships in Alzheimer's disease: CELF1
            regulates KLC1 alternative splicing
  JOURNAL   Biochem Biophys Res Commun 721, 150025 (2024)
   PUBMED   38768546
  REMARK    GeneRIF: Gene-gene functional relationships in Alzheimer's disease:
            CELF1 regulates KLC1 alternative splicing.
REFERENCE   2  (bases 1 to 2550)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 2550)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 2550)
  AUTHORS   Christensen,J.R., Kendrick,A.A., Truong,J.B., Aguilar-Maldonado,A.,
            Adani,V., Dzieciatkowska,M. and Reck-Peterson,S.L.
  TITLE     Cytoplasmic dynein-1 cargo diversity is mediated by the
            combinatorial assembly of FTS-Hook-FHIP complexes
  JOURNAL   Elife 10, e74538 (2021)
   PUBMED   34882091
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2550)
  AUTHORS   Chen,X.Q., Das,U., Park,G. and Mobley,W.C.
  TITLE     Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer
            disease and Alzheimer disease in Down syndrome: evidence suggesting
            defects in anterograde transport
  JOURNAL   Alzheimers Res Ther 13 (1), 59 (2021)
   PUBMED   33691783
  REMARK    GeneRIF: Normal levels of KIF5 but reduced KLC1 levels in both
            Alzheimer disease and Alzheimer disease in Down syndrome: evidence
            suggesting defects in anterograde transport.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2550)
  AUTHORS   Gyoeva,F.K., Bybikova,E.M. and Minin,A.A.
  TITLE     An isoform of kinesin light chain specific for the Golgi complex
  JOURNAL   J Cell Sci 113 (Pt 11), 2047-2054 (2000)
   PUBMED   10806115
REFERENCE   7  (bases 1 to 2550)
  AUTHORS   Khodjakov,A., Lizunova,E.M., Minin,A.A., Koonce,M.P. and
            Gyoeva,F.K.
  TITLE     A specific light chain of kinesin associates with mitochondria in
            cultured cells
  JOURNAL   Mol Biol Cell 9 (2), 333-343 (1998)
   PUBMED   9450959
REFERENCE   8  (bases 1 to 2550)
  AUTHORS   Chernajovsky,Y., Brown,A. and Clark,J.
  TITLE     Human kinesin light (beta) chain gene: DNA sequence and functional
            characterization of its promoter and first exon
  JOURNAL   DNA Cell Biol 15 (11), 965-974 (1996)
   PUBMED   8945637
REFERENCE   9  (bases 1 to 2550)
  AUTHORS   Goedert,M., Marsh,S. and Carter,N.
  TITLE     Localization of the human kinesin light chain gene (KNS2) to
            chromosome 14q32.3 by fluorescence in situ hybridization
  JOURNAL   Genomics 32 (1), 173-175 (1996)
   PUBMED   8786116
REFERENCE   10 (bases 1 to 2550)
  AUTHORS   Cabeza-Arvelaiz,Y., Shih,L.C., Hardman,N., Asselbergs,F., Bilbe,G.,
            Schmitz,A., White,B., Siciliano,M.J. and Lachman,L.B.
  TITLE     Cloning and genetic characterization of the human kinesin
            light-chain (KLC) gene
  JOURNAL   DNA Cell Biol 12 (10), 881-892 (1993)
   PUBMED   8274221
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139300.6 and AL049840.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Conventional kinesin is a tetrameric molecule composed of
            two heavy chains and two light chains, and transports various
            cargos along microtubules toward their plus ends. The heavy chains
            provide the motor activity, while the light chains bind to various
            cargos. This gene encodes a member of the kinesin light chain
            family. It associates with kinesin heavy chain through an
            N-terminal domain, and six tetratricopeptide repeat (TPR) motifs
            are thought to be involved in binding of cargos such as vesicles,
            mitochondria, and the Golgi complex. Thus, kinesin light chains
            function as adapter molecules and not motors per se. Although
            previously named 'kinesin 2', this gene is not a member of the
            kinesin-2 / kinesin heavy chain subfamily of kinesin motor
            proteins. Extensive alternative splicing produces isoforms with
            different C-termini that are proposed to bind to different cargos;
            however, the full-length nature and/or biological validity of most
            of these variants have not been determined. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000681.1, SRR18074969.2304479.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334553.11/ ENSP00000334523.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AL139300.6         51840-52123         c
            285-546             AL139300.6         26509-26770         c
            547-777             AL139300.6         23558-23788         c
            778-856             AL139300.6         19140-19218         c
            857-1082            AL139300.6         18407-18632         c
            1083-1170           AL139300.6         11736-11823         c
            1171-1272           AL139300.6         11051-11152         c
            1273-1446           AL139300.6         8147-8320           c
            1447-1546           AL139300.6         7903-8002           c
            1547-1596           AL139300.6         5733-5782           c
            1597-1664           AL139300.6         5578-5645           c
            1665-1773           AL139300.6         3811-3919           c
            1774-1935           AL139300.6         1789-1950           c
            1936-2066           AL049840.8         159594-159724       c
            2067-2133           AL049840.8         154380-154446       c
            2134-2206           AL049840.8         146078-146150       c
            2207-2550           AL049840.8         145261-145604       c
FEATURES             Location/Qualifiers
     source          1..2550
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..2550
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /note="kinesin light chain 1"
                     /db_xref="GeneID:3831"
                     /db_xref="HGNC:HGNC:6387"
                     /db_xref="MIM:600025"
     exon            1..284
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            285..546
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..2205
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /EC_number="2.7.1.21"
                     /note="isoform 9 is encoded by transcript variant 9;
                     kinesin 2 60/70kDa; medulloblastoma antigen MU-MB-2.50"
                     /codon_start=1
                     /product="kinesin light chain 1 isoform 9"
                     /protein_id="NP_001381766.1"
                     /db_xref="CCDS:CCDS91953.1"
                     /db_xref="GeneID:3831"
                     /db_xref="HGNC:HGNC:6387"
                     /db_xref="MIM:600025"
                     /translation="MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNS
                     ILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESE
                     KQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDD
                     ISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHN
                     LVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAN
                     LLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKD
                     HPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYL
                     KQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYG
                     GWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAE
                     VLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGDGTGSLKRSGSFSKLR
                     ASIRRSSEKLVRKLKGGSSRESEPKNPGMKRASSLNVLNVGGKAAEDRFQGVSGRASF
                     CGKRQQQQWPGRRHR"
     exon            547..777
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            778..856
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1082
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1170
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1272
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1446
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1546
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1596
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1664
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1773
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1935
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2066
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2133
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2206
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2550
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /note="hexamer: ATTAAA"
     polyA_site      2550
                     /gene="KLC1"
                     /gene_synonym="KLC; KNS2; KNS2A"
                     /note="major polyA site"
ORIGIN      
        1 attttcggcg gcgggagcgg cgcaggcggc cgagcgggac tggctgggtc ggctgggctg
       61 ctggtgcgag gagccgcggg gctgtgctcg gcggccaagg ggacagcgcg tgggtggccg
      121 aggatgctgc ggggcggtag ctccggcgcc cctagctggt gactgctgcg ccgtgcctca
      181 cacagccgag gcgggctcgg cgcacagtcg ctgctccgcg cgcgcgcccg gcggcgctcc
      241 aggtgctgac agcgcgagag agcgcggccc tcaggagcaa ggcgaatgta tgacaacatg
      301 tccacaatgg tgtacataaa ggaagacaag ttggagaagc ttacacagga tgaaattatt
      361 tctaagacaa agcaagtaat tcaggggctg gaagctttga agaatgagca caattccatt
      421 ttacaaagtt tgctggagac actgaagtgt ttgaagaaag atgatgaaag taatttggtg
      481 gaggagaaat caaacatgat ccggaagtca ctggagatgt tggagctcgg cctgagtgag
      541 gcacaggtta tgatggcttt gtcaaatcac ctgaatgctg tggagtccga gaagcagaaa
      601 ctgcgtgcgc aggttcgtcg tctgtgccag gagaatcagt ggctacggga tgaactggcc
      661 aacacgcagc agaaactgca gaagagtgag cagtctgtgg ctcaactgga ggaggagaag
      721 aagcatctgg agtttatgaa tcagctaaaa aaatatgatg acgacatttc cccatccgag
      781 gacaaagaca ctgattctac caaagagcct ctggatgacc ttttccccaa tgatgaagac
      841 gacccagggc aaggaatcca gcagcagcac agcagtgcag ccgcggctgc ccagcagggc
      901 ggctacgaga tccccgcgcg gctgcggacg ctccacaacc tggtgatcca gtacgcctcg
      961 caggggcgct acgaggtagc tgtgcccctc tgcaagcagg ccctggagga cctggagaag
     1021 acttcaggac acgaccaccc ggacgtggcc accatgctca acatcctggc cttggtgtac
     1081 agggatcaga ataaatacaa agatgcagct aacctactga atgatgcctt ggctattcgt
     1141 gagaaaactt tgggcaaaga tcatcctgcg gtggcggcga ctttgaataa ccttgcagtc
     1201 ctttatggta aaagagggaa gtacaaagaa gcagagccgt tgtgtaaaag agctctggaa
     1261 atccgagaaa aggttttggg gaaggatcac cccgatgttg ccaagcagtt aaataacttg
     1321 gccttactgt gccagaacca gggcaagtat gaagaagtag aatattatta tcaaagagcc
     1381 ctcgagatct accagacaaa actgggacct gatgacccca acgtggctaa gacgaaaaat
     1441 aacctggcat cctgctattt gaaacaagga aagttcaagc aagcagaaac actgtacaaa
     1501 gagattctca ctcgtgcaca tgaaagggag tttggttctg tagatgatga aaataaaccc
     1561 atctggatgc atgctgaaga aagagaagaa tgcaaaggaa agcaaaagga tgggacatct
     1621 tttggagagt atggcggctg gtacaaagcc tgcaaagttg atagtccaac tgttacaacc
     1681 actctaaaaa accttggggc actttacaga cgtcaaggca aatttgaagc tgcagaaacg
     1741 ttagaagaag ctgctatgag gtctcgtaaa cagggtcttg acaatgttca caaacagagg
     1801 gtggcagaag tgctcaatga ccctgagaac atggagaagc gcaggagccg tgagagcctc
     1861 aacgtggacg tggtcaagta cgagagtggc cctgacggag gggaggaagt gagtatgagc
     1921 gtagagtgga acggggatgg cactggatct ttaaaacgca gtggttcctt tagcaaactc
     1981 cgggcttcca ttagacgcag cagtgagaag ctggttagga agctgaaggg aggaagttca
     2041 cgagagagtg agccaaagaa ccccggcatg aagcgtgcca gctctctgaa tgtccttaac
     2101 gtgggtggca aggctgctga agatcgcttt caaggcgtct ctggccgagc ctctttttgt
     2161 ggaaaacgac agcagcagca gtggcctgga agacgccacc gctaactgac cccgacctgg
     2221 ccccgctcca ggatgggact gccgagtgtg gcccggagct ggcccgggac agccagggcg
     2281 gcagggaggg cccctggccg ggagccgcag cgctcactca tttctcctgc gtctgtgtgc
     2341 ataggacatg atactaataa ccacacggct ggcgtgacct tggggctggg gctgggccta
     2401 agctggtgcc ctggtgcggc gtggtctctc ccaggagacc tggggcatga gctgggccca
     2461 cggctccctt cccatgtgta acttcctcac gttgtgtgcg ataacgtatt ttattgtaca
     2521 tttttttaaa ttaaaagttt atatgcctta
//
