LOCUS       NM_175737               6002 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens klotho beta (KLB), mRNA.
ACCESSION   NM_175737
VERSION     NM_175737.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6002)
  AUTHORS   Zhou,D., Shi,Y., Zhang,D., Zuo,J., Zeng,C., Mamtawla,G., Huang,L.,
            Gao,X., Zhang,L. and Wang,X.
  TITLE     Liver-secreted FGF21 induces sarcopenia by inhibiting satellite
            cell myogenesis via klotho beta in decompensated cirrhosis
  JOURNAL   Redox Biol 76, 103333 (2024)
   PUBMED   39226764
  REMARK    GeneRIF: Liver-secreted FGF21 induces sarcopenia by inhibiting
            satellite cell myogenesis via klotho beta in decompensated
            cirrhosis.
REFERENCE   2  (bases 1 to 6002)
  AUTHORS   Wang,X., Liu,H., Wu,G., Lu,Y. and Cui,Y.
  TITLE     Development and validation of a predictive model based on
            beta-Klotho for head and neck squamous cell carcinoma
  JOURNAL   Sci Rep 14 (1), 17081 (2024)
   PUBMED   39048709
  REMARK    GeneRIF: Development and validation of a predictive model based on
            beta-Klotho for head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6002)
  AUTHORS   Tzur,Y., Winek,K., Madrer,N., Dubnov,S., Bennett,E.R.,
            Greenberg,D.S., Hanin,G., Gammal,A., Tam,J., Arkin,I.T., Paldor,I.
            and Soreq,H.
  TITLE     Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis
            via beta-Klotho and perilipin 2
  JOURNAL   Mol Metab 79, 101856 (2024)
   PUBMED   38141848
  REMARK    GeneRIF: Lysine tRNA fragments and miR-194-5p co-regulate hepatic
            steatosis via beta-Klotho and perilipin 2.
REFERENCE   4  (bases 1 to 6002)
  AUTHORS   Xu,T., Zhu,Q., Huang,Q., Gu,Q., Zhu,Y., Tang,M., Tian,S., Wang,L.,
            Yan,F., Ge,J., Sha,W. and Lin,X.
  TITLE     FGF21 prevents neuronal cell ferroptosis after spinal cord injury
            by activating the FGFR1/beta-Klotho pathway
  JOURNAL   Brain Res Bull 202, 110753 (2023)
   PUBMED   37660729
  REMARK    GeneRIF: FGF21 prevents neuronal cell ferroptosis after spinal cord
            injury by activating the FGFR1/beta-Klotho pathway.
REFERENCE   5  (bases 1 to 6002)
  AUTHORS   Wu,T., Zhang,Y., Han,Q., Lu,X., Cheng,Y., Chen,J., Sha,J. and
            Xia,W.
  TITLE     Klotho-beta attenuates Rab8a-mediated exosome regulation and
            promotes prostate cancer progression
  JOURNAL   Oncogene 42 (38), 2801-2815 (2023)
   PUBMED   37582861
  REMARK    GeneRIF: Klotho-beta attenuates Rab8a-mediated exosome regulation
            and promotes prostate cancer progression.
REFERENCE   6  (bases 1 to 6002)
  AUTHORS   Wu,X., Lemon,B., Li,X., Gupte,J., Weiszmann,J., Stevens,J.,
            Hawkins,N., Shen,W., Lindberg,R., Chen,J.L., Tian,H. and Li,Y.
  TITLE     C-terminal tail of FGF19 determines its specificity toward Klotho
            co-receptors
  JOURNAL   J Biol Chem 283 (48), 33304-33309 (2008)
   PUBMED   18829467
  REMARK    GeneRIF: Both FGF23 and FGF21 require intact alpha or betaKlotho
            for signaling, respectively, whereas FGF19 can signal through a
            Klotho chimera consisting of the N terminus of alphaKlotho and the
            C terminus of betaKlotho.
REFERENCE   7  (bases 1 to 6002)
  AUTHORS   Lu,L., Katsaros,D., Wiley,A., de la Longrais,I.A., Puopolo,M. and
            Yu,H.
  TITLE     Klotho expression in epithelial ovarian cancer and its association
            with insulin-like growth factors and disease progression
  JOURNAL   Cancer Invest 26 (2), 185-192 (2008)
   PUBMED   18259951
  REMARK    GeneRIF: High expression of Klotho is associated with ovarian
            disease progression
REFERENCE   8  (bases 1 to 6002)
  AUTHORS   Wu,X., Ge,H., Gupte,J., Weiszmann,J., Shimamoto,G., Stevens,J.,
            Hawkins,N., Lemon,B., Shen,W., Xu,J., Veniant,M.M., Li,Y.S.,
            Lindberg,R., Chen,J.L., Tian,H. and Li,Y.
  TITLE     Co-receptor requirements for fibroblast growth factor-19 signaling
  JOURNAL   J Biol Chem 282 (40), 29069-29072 (2007)
   PUBMED   17711860
  REMARK    GeneRIF: a functional FGF19 receptor may consist of FGF receptor
            (FGFR) and heparan sulfate complexed with either alphaKlotho or
            betaKlotho
REFERENCE   9  (bases 1 to 6002)
  AUTHORS   Lin,B.C., Wang,M., Blackmore,C. and Desnoyers,L.R.
  TITLE     Liver-specific activities of FGF19 require Klotho beta
  JOURNAL   J Biol Chem 282 (37), 27277-27284 (2007)
   PUBMED   17627937
  REMARK    GeneRIF: Liver-specific activities of FGF19 require Klotho beta.
REFERENCE   10 (bases 1 to 6002)
  AUTHORS   Negri,A.L.
  TITLE     The klotho gene: a gene predominantly expressed in the kidney is a
            fundamental regulator of aging and calcium/phosphorus metabolism
  JOURNAL   J Nephrol 18 (6), 654-658 (2005)
   PUBMED   16358222
  REMARK    GeneRIF: The down-regulation of the renal klotho gene could
            increase renal damage induced by angiotensin II, while klotho gene
            induction could have therapeutic possibilities in treating
            angiotensin II-induced kidney damage.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB079373.1, AK302436.1, BJ993426.1 and AC021148.8.
            
            On Nov 22, 2018 this sequence version replaced NM_175737.3.
            
            Sequence Note: The 3' UTR of the RefSeq transcript was derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record was based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104871.1, AB079373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257408.5/ ENSP00000257408.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3202              AB079373.1         78-3279
            3203-3911           AK302436.1         924-1632
            3912-4030           BJ993426.1         414-532
            4031-6002           AC021148.8         15379-17350
FEATURES             Location/Qualifiers
     source          1..6002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..6002
                     /gene="KLB"
                     /gene_synonym="BKL"
                     /note="klotho beta"
                     /db_xref="GeneID:152831"
                     /db_xref="HGNC:HGNC:15527"
                     /db_xref="MIM:611135"
     exon            1..845
                     /gene="KLB"
                     /gene_synonym="BKL"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..3155
                     /gene="KLB"
                     /gene_synonym="BKL"
                     /note="klotho beta like; betaKlotho; klotho beta-like
                     protein; b-Klotho"
                     /codon_start=1
                     /product="beta-klotho"
                     /protein_id="NP_783864.1"
                     /db_xref="CCDS:CCDS3451.1"
                     /db_xref="GeneID:152831"
                     /db_xref="HGNC:HGNC:15527"
                     /db_xref="MIM:611135"
                     /translation="MKPGCAAGSPGNEWIFFSTDEITTRYRNTMSNGGLQRSVILSAL
                     ILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYDTFPKNFFWGIGTGALQVEGSWKK
                     DGKGPSIWDHFIHTHLKNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFP
                     DGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIF
                     NDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKA
                     HSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENTMDIFKCQQSMVSVLGWFANPI
                     HGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNV
                     SLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDTTAIYMMKNFLSQVLQAIRLD
                     EIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF
                     SLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSDPHLYVWNATGNRLLHRVEG
                     VRLKTRPAQCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYR
                     CVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELG
                     DLVKLWITINEPNRLSDIYNRSGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSL
                     SLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGL
                     SSSALPRLTEAERRLLKGTVDFCALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRL
                     SSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEV
                     LKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENS
                     SSRCSQTQENTECTVCLFLVQKKPLIFLGCCFFSTLVLLLSIAIFQRQKRRKFWKAKN
                     LQHIPLKKGKRVVS"
     exon            846..1356
                     /gene="KLB"
                     /gene_synonym="BKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1625
                     /gene="KLB"
                     /gene_synonym="BKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..2769
                     /gene="KLB"
                     /gene_synonym="BKL"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..6002
                     /gene="KLB"
                     /gene_synonym="BKL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3481..3486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLB"
                     /gene_synonym="BKL"
                     /note="hexamer: AATAAA"
     polyA_site      3505
                     /gene="KLB"
                     /gene_synonym="BKL"
                     /note="major polyA site"
     regulatory      5965..5970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KLB"
                     /gene_synonym="BKL"
                     /note="hexamer: AATAAA"
     polyA_site      6002
                     /gene="KLB"
                     /gene_synonym="BKL"
                     /note="major polyA site"
ORIGIN      
        1 agtccagcag ttggtggcaa atgaagccag gctgtgcggc aggatctcca gggaatgaat
       61 ggattttctt cagcactgat gaaataacca cacgctatag gaatacaatg tccaacgggg
      121 gattgcaaag atctgtcatc ctgtcagcac ttattctgct acgagctgtt actggattct
      181 ctggagatgg aagagctata tggtctaaaa atcctaattt tactccggta aatgaaagtc
      241 agctgtttct ctatgacact ttccctaaaa actttttctg gggtattggg actggagcat
      301 tgcaagtgga agggagttgg aagaaggatg gaaaaggacc ttctatatgg gatcatttca
      361 tccacacaca ccttaaaaat gtcagcagca cgaatggttc cagtgacagt tatatttttc
      421 tggaaaaaga cttatcagcc ctggatttta taggagtttc tttttatcaa ttttcaattt
      481 cctggccaag gcttttcccc gatggaatag taacagttgc caacgcaaaa ggtctgcagt
      541 actacagtac tcttctggac gctctagtgc ttagaaacat tgaacctata gttactttat
      601 accactggga tttgcctttg gcactacaag aaaaatatgg ggggtggaaa aatgatacca
      661 taatagatat cttcaatgac tatgccacat actgtttcca gatgtttggg gaccgtgtca
      721 aatattggat tacaattcac aacccatatc tagtggcttg gcatgggtat gggacaggta
      781 tgcatgcccc tggagagaag ggaaatttag cagctgtcta cactgtggga cacaacttga
      841 tcaaggctca ctcgaaagtt tggcataact acaacacaca tttccgccca catcagaagg
      901 gttggttatc gatcacgttg ggatctcatt ggatcgagcc aaaccggtcg gaaaacacga
      961 tggatatatt caaatgtcaa caatccatgg tttctgtgct tggatggttt gccaacccta
     1021 tccatgggga tggcgactat ccagagggga tgagaaagaa gttgttctcc gttctaccca
     1081 ttttctctga agcagagaag catgagatga gaggcacagc tgatttcttt gccttttctt
     1141 ttggacccaa caacttcaag cccctaaaca ccatggctaa aatgggacaa aatgtttcac
     1201 ttaatttaag agaagcgctg aactggatta aactggaata caacaaccct cgaatcttga
     1261 ttgctgagaa tggctggttc acagacagtc gtgtgaaaac agaagacacc acggccatct
     1321 acatgatgaa gaatttcctc agccaggtgc ttcaagcaat aaggttagat gaaatacgag
     1381 tgtttggtta tactgcctgg tctctcctgg atggctttga atggcaggat gcttacacca
     1441 tccgccgagg attattttat gtggatttta acagtaaaca gaaagagcgg aaacctaagt
     1501 cttcagcaca ctactacaaa cagatcatac gagaaaatgg tttttcttta aaagagtcca
     1561 cgccagatgt gcagggccag tttccctgtg acttctcctg gggtgtcact gaatctgttc
     1621 ttaagcccga gtctgtggct tcgtccccac agttcagcga tcctcatctg tacgtgtgga
     1681 acgccactgg caacagactg ttgcaccgag tggaaggggt gaggctgaaa acacgacccg
     1741 ctcaatgcac agattttgta aacatcaaaa aacaacttga gatgttggca agaatgaaag
     1801 tcacccacta ccggtttgct ctggattggg cctcggtcct tcccactggc aacctgtccg
     1861 cggtgaaccg acaggccctg aggtactaca ggtgcgtggt cagtgagggg ctgaagcttg
     1921 gcatctccgc gatggtcacc ctgtattatc cgacccacgc ccacctaggc ctccccgagc
     1981 ctctgttgca tgccgacggg tggctgaacc catcgacggc cgaggccttc caggcctacg
     2041 ctgggctgtg cttccaggag ctgggggacc tggtgaagct ctggatcacc atcaacgagc
     2101 ctaaccggct aagtgacatc tacaaccgct ctggcaacga cacctacggg gcggcgcaca
     2161 acctgctggt ggcccacgcc ctggcctggc gcctctacga ccggcagttc aggccctcac
     2221 agcgcggggc cgtgtcgctg tcgctgcacg cggactgggc ggaacccgcc aacccctatg
     2281 ctgactcgca ctggagggcg gccgagcgct tcctgcagtt cgagatcgcc tggttcgccg
     2341 agccgctctt caagaccggg gactaccccg cggccatgag ggaatacatt gcctccaagc
     2401 accgacgggg gctttccagc tcggccctgc cgcgcctcac cgaggccgaa aggaggctgc
     2461 tcaagggcac ggtcgacttc tgcgcgctca accacttcac cactaggttc gtgatgcacg
     2521 agcagctggc cggcagccgc tacgactcgg acagggacat ccagtttctg caggacatca
     2581 cccgcctgag ctcccccacg cgcctggctg tgattccctg gggggtgcgc aagctgctgc
     2641 ggtgggtccg gaggaactac ggcgacatgg acatttacat caccgccagt ggcatcgacg
     2701 accaggctct ggaggatgac cggctccgga agtactacct agggaagtac cttcaggagg
     2761 tgctgaaagc atacctgatt gataaagtca gaatcaaagg ctattatgca ttcaaactgg
     2821 ctgaagagaa atctaaaccc agatttggat tcttcacatc tgattttaaa gctaaatcct
     2881 caatacaatt ttacaacaaa gtgatcagca gcaggggctt cccttttgag aacagtagtt
     2941 ctagatgcag tcagacccaa gaaaatacag agtgcactgt ctgcttattc cttgtgcaga
     3001 agaaaccact gatattcctg ggttgttgct tcttctccac cctggttcta ctcttatcaa
     3061 ttgccatttt tcaaaggcag aagagaagaa agttttggaa agcaaaaaac ttacaacaca
     3121 taccattaaa gaaaggcaag agagttgtta gctaaactga tctgtctgca tgatagacag
     3181 tttaaaaatt catcccagtt ccatatgctg gtaacttaca ggagatatac ctgtattata
     3241 gaaagacaat ctgagataca gctgtaacca aggtgatgac aattgtctct gctgtgtggt
     3301 tcaaagaaca ttcccttagg tgttgacatc agtgaactca gttcttggat gtaaacataa
     3361 aggcttcatc ctgacagtaa gctatgagga ttacatgcta cattgcttct taaagtttca
     3421 tcaactgtat tccatcattc tgctttagct ttcatctcta ccaatagcta cttgtggtac
     3481 aataaattat ttttaagaag taaaactctg gggctggacg ctgtggctca cacctgtaat
     3541 ctcagcactt tgggaggccg aggcggggag atcacctgag gtgaggagtt cgagaccagc
     3601 ctggccaaca tggtgaaacc atgtctctac taaaaataca aaaaattagc caggcgtggt
     3661 gacagtggca cctgtaatcc cagctacttg ggaggctgag gcagaagttt gaacccagga
     3721 aacaggttac agtaggccaa aattgcgcca ctgcactcca gcctaggcga caacagcaag
     3781 actgtgtcca aaaaaaaaaa aaaaagcaaa agcaaaactt tgttttgtta gactctacag
     3841 cagagattta acacccttct ttaaactggg tagtcagtga tagataatat atattctgtc
     3901 acttctaata aggtgccttc tcctttaggt cagggtggtt ctaaaatgga aagaaaacac
     3961 aatagggtaa gtagtgcttg tctaagccag ttacaacaca gactcttaaa gaggatcaag
     4021 cccttcattt ttctaacaac aaaaaatcac ctatagaata tctaatttgt gatcttttac
     4081 tagatctgat tttttaaaat aatgtaattt ccggccaggc acggtggcac cgcctgtaat
     4141 cccagcactt tgggaggcca aggcaggtgg atcacctgag gttaggagtt cgagactagc
     4201 ctggccaaca tggcaaaacc ccatctctac taaaaataca aaagttagcc gggcatggtg
     4261 gtgggcacct gtaatcccag ctactcagga ggccgaggca ggagaatcgc ttgaacccga
     4321 gaggcagagg ttgcaatgag ccaagatcgt gccattgcac tccagcctgg gggacagggc
     4381 aagactgtct ctcaaaataa aaaaaaataa taaaaataaa aataaaagta atttccaaaa
     4441 cctcatctca tggaaagatc acaggatgaa ggaaagctag actcaactct gtgaatagaa
     4501 gttgctatac tgtaagtaaa gcaacaattc agaatactga atgagtttaa attgttttat
     4561 atagcaccct tttgggctag ggttaattac tagatctgac ttggataatt tgacactttg
     4621 ggaaatgaac tctgttcttg agacttgttc agtgtatttt aaacatctga ggaagaaaac
     4681 ttaaatatgc acctatttat acctattctt tctttaggtc aacatttaac acccactgca
     4741 tacattaatt tgtccttgtc tgctcactcc agcaatttag accttaacag tcacaagaga
     4801 cgttcttctg ttacaaagcc ttagtaaatt aaggcagttt tgattatatt ctaggtccac
     4861 ctatgtctga agctaaattc agtatctaac tgctaatgaa caagtttcca aaatactgta
     4921 aaaatacaat tagtcaattt gagtaaatgc aaatatgatg agaaatcaat ttgctatttg
     4981 gcctggcaaa tgggaacagt aaaattctgc tttactcttc tctagtctcc ttgccccagc
     5041 tgcacccact accccaaagt tggcagtttt gaggtatgat tttcaaggaa tttttttagt
     5101 attaacatct ccctctgaga actatgtacc taaggtcacg catacaacta gtcaattctg
     5161 tttttattac tctaactatg tagaaacagt aagtcactta aaacaatcac ttggctgggt
     5221 tttttcccct ttgtgccaca ttgattcacc ctgacccaag aactccaggg aaaattcttt
     5281 aatgtcaact gggcaactca ttaacctctc tttaacatca agggcttggg aaaaaaaaaa
     5341 aaaaggttag ccacaggaat aacaaaaacc tggaatttat ctttcaggtt ttgctttctc
     5401 tttctcactt tgtttaaagt atctcgtact cacagttcac aaattaacct tcactgtctc
     5461 tttcacatta agagcttatg cttaaagcat gccccccttt tctaacttgc tggtttacca
     5521 taaactcccc taagtaataa aattcctaac ccagtactga gagtcctcct tctctgccac
     5581 ttgggcatta ttttactagt ttttaagcca tcatcgcaca agaatccaaa aacccttaaa
     5641 ttttttaacc actggcaaat atgtacagca aattaggtta agcatttaat ctggctcatg
     5701 ctctatcata ctaaatattc aggtttatca taaactcctt aaaaaccatc aaaggtcaac
     5761 cagaaactga taactcttga aaggagcaaa caggtaagat ctttggagtt taagcttttc
     5821 tgagatgtgt tgtgaaaaat ctaacgtgtt tatcgtatat tcaatgtaac aacctggaga
     5881 atcacaacta tatttaaaga gcctctggaa aatgaggcca gtacagtgtg actacatgtt
     5941 taattttcaa tgtaatttat tccaaataaa ctggttcatg ctgaccactt gtattcaact
     6001 aa
//
