LOCUS       NM_000899               5441 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens KIT ligand (KITLG), transcript variant b, mRNA.
ACCESSION   NM_000899
VERSION     NM_000899.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5441)
  AUTHORS   Jeong,H., Kim,R.I., Koo,H., Choi,Y.H., Kim,M., Roh,H., Park,S.G.,
            Sung,J.H., Kim,K.L. and Suh,W.
  TITLE     Stem cell factor and cKIT modulate endothelial glycolysis in
            hypoxia
  JOURNAL   Cardiovasc Res 120 (7), 745-755 (2024)
   PUBMED   38507654
  REMARK    GeneRIF: Stem cell factor and cKIT modulate endothelial glycolysis
            in hypoxia.
REFERENCE   2  (bases 1 to 5441)
  AUTHORS   Wang,X., Zhou,L., Xu,A., Nima,D. and Dong,Z.
  TITLE     Effects of stem cell factor in follicular fluid and granulosa cells
            on oocyte maturity and clinical pregnancy
  JOURNAL   Medicine (Baltimore) 102 (52), e36749 (2023)
   PUBMED   38206705
  REMARK    GeneRIF: Effects of stem cell factor in follicular fluid and
            granulosa cells on oocyte maturity and clinical pregnancy.
REFERENCE   3  (bases 1 to 5441)
  AUTHORS   Franke,K., Bal,G., Li,Z., Zuberbier,T. and Babina,M.
  TITLE     Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human
            Skin Mast Cells
  JOURNAL   Cells 12 (9), 1306 (2023)
   PUBMED   37174705
  REMARK    GeneRIF: Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling
            in Human Skin Mast Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5441)
  AUTHORS   Zhou,Y., Huangfu,S., Li,M., Tang,C., Qian,J., Guo,M., Zhou,Z.,
            Yang,Y. and Gu,C.
  TITLE     DAZAP1 facilitates the alternative splicing of KITLG to promote
            multiple myeloma cell proliferation via ERK signaling pathway
  JOURNAL   Aging (Albany NY) 14 (19), 7972-7985 (2022)
   PUBMED   36242590
  REMARK    GeneRIF: DAZAP1 facilitates the alternative splicing of KITLG to
            promote multiple myeloma cell proliferation via ERK signaling
            pathway.
REFERENCE   5  (bases 1 to 5441)
  AUTHORS   Huang,J.C., Chen,S.C., Chang,W.A., Hung,W.W., Wu,P.H., Wu,L.Y.,
            Chang,J.M., Hsu,Y.L. and Tsai,Y.C.
  TITLE     KITLG Promotes Glomerular Endothelial Cell Injury in Diabetic
            Nephropathy by an Autocrine Effect
  JOURNAL   Int J Mol Sci 23 (19), 11723 (2022)
   PUBMED   36233032
  REMARK    GeneRIF: KITLG Promotes Glomerular Endothelial Cell Injury in
            Diabetic Nephropathy by an Autocrine Effect.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5441)
  AUTHORS   Lu,H.S., Clogston,C.L., Wypych,J., Parker,V.P., Lee,T.D.,
            Swiderek,K., Baltera,R.F. Jr., Patel,A.C., Chang,D.C., Brankow,D.W.
            et al.
  TITLE     Post-translational processing of membrane-associated recombinant
            human stem cell factor expressed in Chinese hamster ovary cells
  JOURNAL   Arch Biochem Biophys 298 (1), 150-158 (1992)
   PUBMED   1381905
REFERENCE   7  (bases 1 to 5441)
  AUTHORS   Sharkey,A., Jones,D.S., Brown,K.D. and Smith,S.K.
  TITLE     Expression of messenger RNA for kit-ligand in human placenta:
            localization by in situ hybridization and identification of
            alternatively spliced variants
  JOURNAL   Mol Endocrinol 6 (8), 1235-1241 (1992)
   PUBMED   1383693
REFERENCE   8  (bases 1 to 5441)
  AUTHORS   Toyota,M., Hinoda,Y., Itoh,F., Tsujisaki,M., Imai,K. and Yachi,A.
  TITLE     Expression of two types of kit ligand mRNAs in human tumor cells
  JOURNAL   Int J Hematol 55 (3), 301-304 (1992)
   PUBMED   1379846
REFERENCE   9  (bases 1 to 5441)
  AUTHORS   Lev,S., Yarden,Y. and Givol,D.
  TITLE     A recombinant ectodomain of the receptor for the stem cell factor
            (SCF) retains ligand-induced receptor dimerization and antagonizes
            SCF-stimulated cellular responses
  JOURNAL   J Biol Chem 267 (15), 10866-10873 (1992)
   PUBMED   1375232
REFERENCE   10 (bases 1 to 5441)
  AUTHORS   Huang,E.J., Nocka,K.H., Buck,J. and Besmer,P.
  TITLE     Differential expression and processing of two cell associated forms
            of the kit-ligand: KL-1 and KL-2
  JOURNAL   Mol Biol Cell 3 (3), 349-362 (1992)
   PUBMED   1378327
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC320486.1, BC126166.1,
            AC024941.30 and AK025245.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000899.4.
            
            Summary: This gene encodes the ligand of the tyrosine-kinase
            receptor encoded by the KIT locus. This ligand is a pleiotropic
            factor that acts in utero in germ cell and neural cell development,
            and hematopoiesis, all believed to reflect a role in cell
            migration. In adults, it functions pleiotropically, while mostly
            noted for its continued requirement in hematopoiesis. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (b) encodes the longer isoform (b)
            which contains the primary proteolytic-cleavage site; as a result,
            isoform b is largely a soluble product.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.6956.1,
                                           SRR11853567.7581.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000644744.1/ ENSP00000495951.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                DC320486.1         3-45
            44-1652             BC126166.1         1-1609
            1653-5386           AC024941.30        132318-136051
            5387-5441           AK025245.1         1796-1850
FEATURES             Location/Qualifiers
     source          1..5441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.32"
     gene            1..5441
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /note="KIT ligand"
                     /db_xref="GeneID:4254"
                     /db_xref="HGNC:HGNC:6343"
                     /db_xref="MIM:184745"
     exon            1..208
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1015
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /EC_number="3.2.1.31"
                     /note="isoform b precursor is encoded by transcript
                     variant b; familial progressive hyperpigmentation 2; mast
                     cell growth factor; stem cell factor; steel factor; c-Kit
                     ligand"
                     /codon_start=1
                     /product="kit ligand isoform b precursor"
                     /protein_id="NP_000890.1"
                     /db_xref="CCDS:CCDS31868.1"
                     /db_xref="GeneID:4254"
                     /db_xref="HGNC:HGNC:6343"
                     /db_xref="MIM:184745"
                     /translation="MKKTQTWILTCIYLQLLLFNPLVKTEGICRNRVTNNVKDVTKLV
                     ANLPKDYMITLKYVPGMDVLPSHCWISEMVVQLSDSLTDLLDKFSNISEGLSNYSIID
                     KLVNIVDDLVECVKENSSKDLKKSFKSPEPRLFTPEEFFRIFNRSIDAFKDFVVASET
                     SDCVVSSTLSPEKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKAKNPPGDSSLHWAAM
                     ALPALFSLIIGFAFGALYWKKRQPSLTRAVENIQINEEDNEISMLQEKEREFQEV"
     exon            209..322
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /inference="alignment:Splign:2.1.0"
     exon            323..385
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /inference="alignment:Splign:2.1.0"
     exon            386..556
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /inference="alignment:Splign:2.1.0"
     exon            557..713
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /inference="alignment:Splign:2.1.0"
     exon            714..797
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /inference="alignment:Splign:2.1.0"
     exon            798..907
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /inference="alignment:Splign:2.1.0"
     exon            908..975
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1052
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..5441
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5418..5423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /note="hexamer: AATAAA"
     polyA_site      5441
                     /gene="KITLG"
                     /gene_synonym="DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF;
                     SCF; SF; SHEP7; SLF; WS2F"
                     /note="major polyA site"
ORIGIN      
        1 gcttcgctcg ccgcctcgcg ccgagactag aagcgctgcg ggaagcaggg acagtggaga
       61 gggcgctgcg ctcgggctac ccaatgcgtg gactatctgc cgccgctgtt cgtgcaatat
      121 gctggagctc cagaacagct aaacggagtc gccacaccac tgtttgtgct ggatcgcagc
      181 gctgcctttc cttatgaaga agacacaaac ttggattctc acttgcattt atcttcagct
      241 gctcctattt aatcctctcg tcaaaactga agggatctgc aggaatcgtg tgactaataa
      301 tgtaaaagac gtcactaaat tggtggcaaa tcttccaaaa gactacatga taaccctcaa
      361 atatgtcccc gggatggatg ttttgccaag tcattgttgg ataagcgaga tggtagtaca
      421 attgtcagac agcttgactg atcttctgga caagttttca aatatttctg aaggcttgag
      481 taattattcc atcatagaca aacttgtgaa tatagtggat gaccttgtgg agtgcgtgaa
      541 agaaaactca tctaaggatc taaaaaaatc attcaagagc ccagaaccca ggctctttac
      601 tcctgaagaa ttctttagaa tttttaatag atccattgat gccttcaagg actttgtagt
      661 ggcatctgaa actagtgatt gtgtggtttc ttcaacatta agtcctgaga aagattccag
      721 agtcagtgtc acaaaaccat ttatgttacc ccctgttgca gccagctccc ttaggaatga
      781 cagcagtagc agtaatagga aggccaaaaa tccccctgga gactccagcc tacactgggc
      841 agccatggca ttgccagcat tgttttctct tataattggc tttgcttttg gagccttata
      901 ctggaagaag agacagccaa gtcttacaag ggcagttgaa aatatacaaa ttaatgaaga
      961 ggataatgag ataagtatgt tgcaagagaa agagagagag tttcaagaag tgtaattgtg
     1021 gcttgtatca acactgttac tttcgtacat tggctggtaa cagttcatgt ttgcttcata
     1081 aatgaagcag ctttaaacaa attcatattc tgtctggagt gacagaccac atctttatct
     1141 gttcttgcta cccatgactt tatatggatg attcagaaat tggaacagaa tgttttactg
     1201 tgaaactggc actgaattaa tcatctataa agaagaactt gcatggagca ggactctatt
     1261 ttaaggactg cgggacttgg gtctcattta gaacttgcag ctgatgttgg aagagaaagc
     1321 acgtgtctca gactgcatgt accatttgca tggctccaga aatgtctaaa tgctgaaaaa
     1381 acacctagct ttattcttca gatacaaact gcagcctgta gttatcctgg tctctgcaag
     1441 tagatttcag cttggatagt gagggtaaca atttttctca aagggatctg gaaaaaatgt
     1501 ttaaaactca gtagtgtcag ccactgtaca gtgtagaaag cagtgggaac tgtgattgga
     1561 tttggcaaca tgtcagcttt atagttgccg attagtgata tgggtctgat ttcgatctct
     1621 tcctgatgta aaccatgctc acccatatcc cactatacaa atgcaaatgg ttgcctggtt
     1681 ccatttatgc aagggagcca gtactgaatt atgccttggc agaggggaga ctccaaaaga
     1741 gtcatcgcag gaagaagtta agaacactga acatcagaac agtctgccaa gaaggacatt
     1801 ggcatcctgg gaaagtccgc cttttccctt gaccactata gggtgtataa atcgtgtttg
     1861 caaaatgtgt tatgatgtgt ttatattcta aaactattac agagctatgt aaagggactt
     1921 aggagaaaat gctgaatgta agatggtccc atttcaattt ccaccatggg agagcctaaa
     1981 aataaattat gacatttagt atctaaggtt agaaaaccac gcccacatgc taatatgggt
     2041 gttgaaaact aggttactta taatgcaagg aatcaggaaa ctttagttat ttatagtata
     2101 atcaccatta tctgtttaaa ggatccattt agttaaaatc gggcactcta tattcattaa
     2161 ggtttatgaa ttaaaaagaa agctttatgt agttatgcat gtcagtttgc tatttaaaat
     2221 gtgtgacagt gtttgtcata ttaagagtga atttggcagg aattcccaag atggacattg
     2281 tgcttttaaa ctagaacttg taagacatta tgtgaatatc ccttgccaat tttttttata
     2341 ataagaaaac atctgactaa agtcaaagaa tgatttctta tggtttattt tgatgaaagt
     2401 tcttttaaca tgtcttgaat gtacacataa aggaatccaa agctttccat tctaacttaa
     2461 tctttgtgat aacattattg ccatgttcta caaccgtaag atgacagttt tcaatgtagt
     2521 gacacaaaag ggcatgaaaa actaactgct agctttcctt tcatttcaaa agtccaagaa
     2581 tttctagtat atttggattt tagcttctgt tcaaagcaaa tccagatgca actccagtaa
     2641 gtggcctttg ctcttttttg taccaaagag cccagatgat tcctacagtc cctttcttct
     2701 ctaacatgct gtggttcctt aaatatgagt aatttctcta agatataacc caggtgcttt
     2761 gagaagctgc attaaggtgt tcaggccctc agatatcaca tggtacactt gattagtaat
     2821 aaaaccagag atcaatttaa attgctgata ggtcctgtct cagtgtgtgg cattgactgt
     2881 tttcaggaaa atagatacag attaatatga gttatgcgtg taggttgtgt atagattgag
     2941 aagatagata cttctcaatc tagtagtttg atttatttaa ccaatggttt cagtttgctt
     3001 gagcatatga aaatcctgct taatgtgctt aagagtataa taaatgtgta cttttgtcct
     3061 caaacctagt agctgggttt taacactcat ggacatggtc ttaatcaatg gagttaaata
     3121 aacaaattca gcaagttatt aaatctgaca tggtaggaga ggggagatgt gtcctgctta
     3181 ttaaatgtgt tggtccattg aaagttacat ggattgccaa tttttaaaac actaaagttg
     3241 aataaaatgc atgaacaata gaaaaatgct gaacattatt ttggatgcta gctgcttgga
     3301 cattaactgt gttatttctg ctttgagatg aaaatatata tttatctttg cttattttat
     3361 cccagatgtg ttctgaatat ccttcttcat aaatcatgga aaactcactg ctgagatagt
     3421 aaaccatgaa atcgcctttt cagttggtgc catgtatctg acagttccat cttggaaggt
     3481 ttcaaaatta ccttttaaaa tgatctcaga agtctgtaga ttctcaatga tactgaaagc
     3541 tttgcacctc tttggtagaa accaggtcta tttagaaaat ggctttatga taaatgttgc
     3601 ctcctgagtg ataatgaagt gttcctggat attgtattgt aatttaatgt gcttaccaca
     3661 ctgccacatt ttaatgagtc agagaaaaat taatttttct tcaatacaat aatagaacaa
     3721 gtagcctatt ctcttaaaaa gtatgtgaaa agaaaattat gaaaaaatat gcatacctaa
     3781 tgaagtattg gttttagtaa gaattaaata catttcattg agctttaaag tactttggag
     3841 aaactttggg gcacgttttc ctactctaat tcaactaaag ttataaataa agagaaaaac
     3901 tcattcagaa atcatggatt ttaaaaatat tttactgcag ccaagttttc atttcaaaat
     3961 gtaatttcag tttggagctt ttaggcatta tgtatattta aaaaatatat tcttcaaaaa
     4021 tgcattttgg catggtggga tggatgttgc aaaagatatc cggagcctcc agtctgtcat
     4081 taactgatat ggtaaatcac ctctcttctt tgggtctcaa ttttttattt atctatatgg
     4141 taaactcaga gatcactcct taggggtgag tcctattgca atatgaccga caaagaagac
     4201 aaaatagcat tgaaactaac ccatacaaaa tatccaactc tggattctgt gaataagtat
     4261 cttgaccata aaaagtcatt gctgttcttg tttctaatgt aaatagtgtc cattagtaaa
     4321 agtgaaattc agtcttaagt agggtgaatt ggatcaccat ttacacaaga gatggctttt
     4381 tcctttgctt gaataaacat tttggatcac ctccaaagaa tgaaaaccag tagtacgttt
     4441 tagtcatatt agtcaggatg agaaactata agatgtgtgt aacatttgga aatgcaccaa
     4501 agtgagcgtt taaatcttct cattttattg aaaactaaga gcagaaaatg taaaatgctc
     4561 atgaaggttt tgaatgccaa aagatatttt agaatcaatt tataaagggg taattcatta
     4621 attacacttt aaaattggaa agtgggataa gaaatctaaa gtaaaccagc ttatctttga
     4681 aacaatatta ttttgaaatt ggctttaaaa taaaaccatt cagattgaaa ttctaattag
     4741 ctcatttgtg gagtttgatc acacaattca taatgttgct gctttccatt aactagtctt
     4801 gaaatgcctt tgtttgtaaa aataaaataa tggtactttc attttataac aaggtgtttt
     4861 tttcaagaaa taatccatgc taaaatggat atttgtgatc ctgaaatgtt tactaagcat
     4921 tgtaaattta tttataactg ccatctccaa ctacatcctt atgatgtttt taacaataaa
     4981 attaaaacaa ctgttaaact aaaaaccaca ccgttttcca gtacttgatc tctgagctac
     5041 aatactcact aaatataatt ttccaatcaa aatattctat tctatattct aagggttaat
     5101 atgtgattat agtgtccact tgccaccatt tttttaaatc aatggacttg aaaagtatta
     5161 atttagatgg atgcgcagat ataccctcag ttcagtcata gattggagtt tgcatataat
     5221 aatgtaaatg tatgtcgaca ctattctaaa tagttctatt atgactgaaa tttaattaaa
     5281 taaaaaaggt tgtaaaatgt gatgtgtatg tgtatatact gtatgtgtac tttttaaaat
     5341 aggtgtatgt cccaaccctt ttttatacag gtttgaattt aaaattacat gatatataca
     5401 tatactttat tgttctaaat aaagaatttt atgcactctc a
//
