LOCUS       NM_000222               5147 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens KIT proto-oncogene, receptor tyrosine kinase (KIT),
            transcript variant 1, mRNA.
ACCESSION   NM_000222
VERSION     NM_000222.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5147)
  AUTHORS   Zhang,Y., Gao,H., Zhang,L., Zhao,Y., Qiu,C. and Liu,X.
  TITLE     Novel Germline KIT Variants in Families With Severe Piebaldism:
            Case Series and Literature Review
  JOURNAL   J Clin Lab Anal 38 (11-12), e25073 (2024)
   PUBMED   38887855
  REMARK    GeneRIF: Novel Germline KIT Variants in Families With Severe
            Piebaldism: Case Series and Literature Review.
            Review article
REFERENCE   2  (bases 1 to 5147)
  AUTHORS   Jeong,H., Kim,R.I., Koo,H., Choi,Y.H., Kim,M., Roh,H., Park,S.G.,
            Sung,J.H., Kim,K.L. and Suh,W.
  TITLE     Stem cell factor and cKIT modulate endothelial glycolysis in
            hypoxia
  JOURNAL   Cardiovasc Res 120 (7), 745-755 (2024)
   PUBMED   38507654
  REMARK    GeneRIF: Stem cell factor and cKIT modulate endothelial glycolysis
            in hypoxia.
REFERENCE   3  (bases 1 to 5147)
  AUTHORS   Muhlenberg,T., Falkenhorst,J., Schulz,T., Fletcher,B.S., Teuber,A.,
            Krzeciesa,D., Klooster,I., Lundberg,M., Wilson,L., Lategahn,J., von
            Mehren,M., Grunewald,S., Tuns,A.I., Wardelmann,E., Sicklick,J.K.,
            Brahmi,M., Serrano,C., Schildhaus,H.U., Sievers,S., Treckmann,J.,
            Heinrich,M.C., Raut,C.P., Ou,W.B., Marino-Enriquez,A., George,S.,
            Rauh,D., Fletcher,J.A. and Bauer,S.
  TITLE     KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal
            Tumor: Emerging Mechanisms of Kinase Inhibitor Escape
  JOURNAL   J Clin Oncol 42 (12), 1439-1449 (2024)
   PUBMED   38408285
  REMARK    GeneRIF: KIT ATP-Binding Pocket/Activation Loop Mutations in GI
            Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape.
REFERENCE   4  (bases 1 to 5147)
  AUTHORS   Nishida,T., Naito,Y., Takahashi,T., Saito,T., Hisamori,S.,
            Manaka,D., Ogawa,K., Hirota,S. and Ichikawa,H.
  TITLE     Molecular and clinicopathological features of KIT/PDGFRA wild-type
            gastrointestinal stromal tumors
  JOURNAL   Cancer Sci 115 (3), 894-904 (2024)
   PUBMED   38178783
  REMARK    GeneRIF: Molecular and clinicopathological features of KIT/PDGFRA
            wild-type gastrointestinal stromal tumors.
REFERENCE   5  (bases 1 to 5147)
  AUTHORS   Bal,G., Schneikert,J., Li,Z., Franke,K., Tripathi,S.R.,
            Zuberbier,T. and Babina,M.
  TITLE     CREB Is Indispensable to KIT Function in Human Skin Mast Cells-A
            Positive Feedback Loop between CREB and KIT Orchestrates Skin Mast
            Cell Fate
  JOURNAL   Cells 13 (1), 42 (2023)
   PUBMED   38201246
  REMARK    GeneRIF: CREB Is Indispensable to KIT Function in Human Skin Mast
            Cells-A Positive Feedback Loop between CREB and KIT Orchestrates
            Skin Mast Cell Fate.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5147)
  AUTHORS   Spritz,R.A., Droetto,S. and Fukushima,Y.
  TITLE     Deletion of the KIT and PDGFRA genes in a patient with piebaldism
  JOURNAL   Am J Med Genet 44 (4), 492-495 (1992)
   PUBMED   1279971
REFERENCE   7  (bases 1 to 5147)
  AUTHORS   Giebel,L.B., Strunk,K.M., Holmes,S.A. and Spritz,R.A.
  TITLE     Organization and nucleotide sequence of the human KIT (mast/stem
            cell growth factor receptor) proto-oncogene
  JOURNAL   Oncogene 7 (11), 2207-2217 (1992)
   PUBMED   1279499
REFERENCE   8  (bases 1 to 5147)
  AUTHORS   Andre,C., Martin,E., Cornu,F., Hu,W.X., Wang,X.P. and Galibert,F.
  TITLE     Genomic organization of the human c-kit gene: evolution of the
            receptor tyrosine kinase subclass III
  JOURNAL   Oncogene 7 (4), 685-691 (1992)
   PUBMED   1373482
REFERENCE   9  (bases 1 to 5147)
  AUTHORS   Duronio,V., Welham,M.J., Abraham,S., Dryden,P. and Schrader,J.W.
  TITLE     p21ras activation via hemopoietin receptors and c-kit requires
            tyrosine kinase activity but not tyrosine phosphorylation of p21ras
            GTPase-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1587-1591 (1992)
   PUBMED   1371879
REFERENCE   10 (bases 1 to 5147)
  AUTHORS   Spritz,R.A., Giebel,L.B. and Holmes,S.A.
  TITLE     Dominant negative and loss of function mutations of the c-kit
            (mast/stem cell growth factor receptor) proto-oncogene in human
            piebaldism
  JOURNAL   Am J Hum Genet 50 (2), 261-269 (1992)
   PUBMED   1370874
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC376760.1, X06182.1 and
            BC071593.1.
            
            On Nov 30, 2019 this sequence version replaced NM_000222.2.
            
            Summary: This gene encodes a receptor tyrosine kinase. This gene
            was initially identified as a homolog of the feline sarcoma viral
            oncogene v-kit and is often referred to as proto-oncogene c-Kit.
            The canonical form of this glycosylated transmembrane protein has
            an N-terminal extracellular region with five immunoglobulin-like
            domains, a transmembrane region, and an intracellular tyrosine
            kinase domain at the C-terminus. Upon activation by its cytokine
            ligand, stem cell factor (SCF), this protein phosphorylates
            multiple intracellular proteins that play a role in in the
            proliferation, differentiation, migration and apoptosis of many
            cell types and thereby plays an important role in hematopoiesis,
            stem cell maintenance, gametogenesis, melanogenesis, and in mast
            cell development, migration and function. This protein can be a
            membrane-bound or soluble protein. Mutations in this gene are
            associated with gastrointestinal stromal tumors, mast cell disease,
            acute myelogenous leukemia, and piebaldism. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, May 2020].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the coding region, compared to variant 3, resulting
            in a shorter protein (isoform 1). Isoforms 1 and 7 have identical
            lengths but distinct sequences.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071593.1, SRR14038192.1813833.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288135.6/ ENSP00000288135.6
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DC376760.1         30-66
            38-4840             X06182.1           1-4803
            4841-5147           BC071593.1         4859-5165
FEATURES             Location/Qualifiers
     source          1..5147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..5147
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /note="KIT proto-oncogene, receptor tyrosine kinase"
                     /db_xref="GeneID:3815"
                     /db_xref="HGNC:HGNC:6342"
                     /db_xref="MIM:164920"
     exon            1..125
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2989
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; proto-oncogene tyrosine-protein kinase Kit;
                     v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like
                     protein; proto-oncogene c-Kit; p145 c-kit; piebald trait
                     protein; mast/stem cell growth factor receptor Kit; v-kit
                     Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;
                     c-Kit protooncogene"
                     /codon_start=1
                     /product="mast/stem cell growth factor receptor Kit
                     isoform 1 precursor"
                     /protein_id="NP_000213.1"
                     /db_xref="CCDS:CCDS3496.1"
                     /db_xref="GeneID:3815"
                     /db_xref="HGNC:HGNC:6342"
                     /db_xref="MIM:164920"
                     /translation="MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKS
                     DLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHG
                     LSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDL
                     RFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSK
                     ASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLT
                     ISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLI
                     VEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTF
                     LVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRC
                     SASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAF
                     KGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGN
                     NYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKM
                     LKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL
                     RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRR
                     SVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNI
                     LLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYG
                     IFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKR
                     PTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLV
                     HDDV"
     exon            126..395
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            396..677
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            678..814
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            815..983
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1173
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1289
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1404
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1598
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1705
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1832
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1937
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2048
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2199
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2291
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2419
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2542
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2654
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2754
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2860
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..5147
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5123..5128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /note="hexamer: AATAAA"
     polyA_site      5147
                     /gene="KIT"
                     /gene_synonym="C-Kit; CD117; MASTC; PBT; SCFR"
                     /note="major polyA site"
ORIGIN      
        1 gcacttgggc gagagctgga acgtggacca gagctcggat cccatcgcag ctaccgcgat
       61 gagaggcgct cgcggcgcct gggattttct ctgcgttctg ctcctactgc ttcgcgtcca
      121 gacaggctct tctcaaccat ctgtgagtcc aggggaaccg tctccaccat ccatccatcc
      181 aggaaaatca gacttaatag tccgcgtggg cgacgagatt aggctgttat gcactgatcc
      241 gggctttgtc aaatggactt ttgagatcct ggatgaaacg aatgagaata agcagaatga
      301 atggatcacg gaaaaggcag aagccaccaa caccggcaaa tacacgtgca ccaacaaaca
      361 cggcttaagc aattccattt atgtgtttgt tagagatcct gccaagcttt tccttgttga
      421 ccgctccttg tatgggaaag aagacaacga cacgctggtc cgctgtcctc tcacagaccc
      481 agaagtgacc aattattccc tcaaggggtg ccaggggaag cctcttccca aggacttgag
      541 gtttattcct gaccccaagg cgggcatcat gatcaaaagt gtgaaacgcg cctaccatcg
      601 gctctgtctg cattgttctg tggaccagga gggcaagtca gtgctgtcgg aaaaattcat
      661 cctgaaagtg aggccagcct tcaaagctgt gcctgttgtg tctgtgtcca aagcaagcta
      721 tcttcttagg gaaggggaag aattcacagt gacgtgcaca ataaaagatg tgtctagttc
      781 tgtgtactca acgtggaaaa gagaaaacag tcagactaaa ctacaggaga aatataatag
      841 ctggcatcac ggtgacttca attatgaacg tcaggcaacg ttgactatca gttcagcgag
      901 agttaatgat tctggagtgt tcatgtgtta tgccaataat acttttggat cagcaaatgt
      961 cacaacaacc ttggaagtag tagataaagg attcattaat atcttcccca tgataaacac
     1021 tacagtattt gtaaacgatg gagaaaatgt agatttgatt gttgaatatg aagcattccc
     1081 caaacctgaa caccagcagt ggatctatat gaacagaacc ttcactgata aatgggaaga
     1141 ttatcccaag tctgagaatg aaagtaatat cagatacgta agtgaacttc atctaacgag
     1201 attaaaaggc accgaaggag gcacttacac attcctagtg tccaattctg acgtcaatgc
     1261 tgccatagca tttaatgttt atgtgaatac aaaaccagaa atcctgactt acgacaggct
     1321 cgtgaatggc atgctccaat gtgtggcagc aggattccca gagcccacaa tagattggta
     1381 tttttgtcca ggaactgagc agagatgctc tgcttctgta ctgccagtgg atgtgcagac
     1441 actaaactca tctgggccac cgtttggaaa gctagtggtt cagagttcta tagattctag
     1501 tgcattcaag cacaatggca cggttgaatg taaggcttac aacgatgtgg gcaagacttc
     1561 tgcctatttt aactttgcat ttaaaggtaa caacaaagag caaatccatc cccacaccct
     1621 gttcactcct ttgctgattg gtttcgtaat cgtagctggc atgatgtgca ttattgtgat
     1681 gattctgacc tacaaatatt tacagaaacc catgtatgaa gtacagtgga aggttgttga
     1741 ggagataaat ggaaacaatt atgtttacat agacccaaca caacttcctt atgatcacaa
     1801 atgggagttt cccagaaaca ggctgagttt tgggaaaacc ctgggtgctg gagctttcgg
     1861 gaaggttgtt gaggcaactg cttatggctt aattaagtca gatgcggcca tgactgtcgc
     1921 tgtaaagatg ctcaagccga gtgcccattt gacagaacgg gaagccctca tgtctgaact
     1981 caaagtcctg agttaccttg gtaatcacat gaatattgtg aatctacttg gagcctgcac
     2041 cattggaggg cccaccctgg tcattacaga atattgttgc tatggtgatc ttttgaattt
     2101 tttgagaaga aaacgtgatt catttatttg ttcaaagcag gaagatcatg cagaagctgc
     2161 actttataag aatcttctgc attcaaagga gtcttcctgc agcgatagta ctaatgagta
     2221 catggacatg aaacctggag tttcttatgt tgtcccaacc aaggccgaca aaaggagatc
     2281 tgtgagaata ggctcataca tagaaagaga tgtgactccc gccatcatgg aggatgacga
     2341 gttggcccta gacttagaag acttgctgag cttttcttac caggtggcaa agggcatggc
     2401 tttcctcgcc tccaagaatt gtattcacag agacttggca gccagaaata tcctccttac
     2461 tcatggtcgg atcacaaaga tttgtgattt tggtctagcc agagacatca agaatgattc
     2521 taattatgtg gttaaaggaa acgctcgact acctgtgaag tggatggcac ctgaaagcat
     2581 tttcaactgt gtatacacgt ttgaaagtga cgtctggtcc tatgggattt ttctttggga
     2641 gctgttctct ttaggaagca gcccctatcc tggaatgccg gtcgattcta agttctacaa
     2701 gatgatcaag gaaggcttcc ggatgctcag ccctgaacac gcacctgctg aaatgtatga
     2761 cataatgaag acttgctggg atgcagatcc cctaaaaaga ccaacattca agcaaattgt
     2821 tcagctaatt gagaagcaga tttcagagag caccaatcat atttactcca acttagcaaa
     2881 ctgcagcccc aaccgacaga agcccgtggt agaccattct gtgcggatca attctgtcgg
     2941 cagcaccgct tcctcctccc agcctctgct tgtgcacgac gatgtctgag cagaatcagt
     3001 gtttgggtca cccctccagg aatgatctct tcttttggct tccatgatgg ttattttctt
     3061 ttctttcaac ttgcatccaa ctccaggata gtgggcaccc cactgcaatc ctgtctttct
     3121 gagcacactt tagtggccga tgatttttgt catcagccac catcctattg caaaggttcc
     3181 aactgtatat attcccaata gcaacgtagc ttctaccatg aacagaaaac attctgattt
     3241 ggaaaaagag agggaggtat ggactggggg ccagagtcct ttccaaggct tctccaattc
     3301 tgcccaaaaa tatggttgat agtttacctg aataaatggt agtaatcaca gttggccttc
     3361 agaaccatcc atagtagtat gatgatacaa gattagaagc tgaaaaccta agtcctttat
     3421 gtggaaaaca gaacatcatt agaacaaagg acagagtatg aacacctggg cttaagaaat
     3481 ctagtatttc atgctgggaa tgagacatag gccatgaaaa aaatgatccc caagtgtgaa
     3541 caaaagatgc tcttctgtgg accactgcat gagcttttat actaccgacc tggtttttaa
     3601 atagagtttg ctattagagc attgaattgg agagaaggcc tccctagcca gcacttgtat
     3661 atacgcatct ataaattgtc cgtgttcata catttgaggg gaaaacacca taaggtttcg
     3721 tttctgtata caaccctggc attatgtcca ctgtgtatag aagtagatta agagccatat
     3781 aagtttgaag gaaacagtta ataccatttt ttaaggaaac aatataacca caaagcacag
     3841 tttgaacaaa atctcctctt ttagctgatg aacttattct gtagattctg tggaacaagc
     3901 ctatcagctt cagaatggca ttgtactcaa tggatttgat gctgtttgac aaagttactg
     3961 attcactgca tggctcccac aggagtggga aaacactgcc atcttagttt ggattcttat
     4021 gtagcaggaa ataaagtata ggtttagcct ccttcgcagg catgtcctgg acaccgggcc
     4081 agtatctata tatgtgtatg tacgtttgta tgtgtgtaga caaatatttg gaggggtatt
     4141 tttgccctga gtccaagagg gtcctttagt acctgaaaag taacttggct ttcattatta
     4201 gtactgctct tgtttctttt cacatagctg tctagagtag cttaccagaa gcttccatag
     4261 tggtgcagag gaagtggaag gcatcagtcc ctatgtattt gcagttcacc tgcacttaag
     4321 gcactctgtt atttagactc atcttactgt acctgttcct tagaccttcc ataatgctac
     4381 tgtctcactg aaacatttaa attttaccct ttagactgta gcctggatat tattcttgta
     4441 gtttacctct ttaaaaacaa aacaaaacaa aacaaaaaac tccccttcct cactgcccaa
     4501 tataaaaggc aaatgtgtac atggcagagt ttgtgtgttg tcttgaaaga ttcaggtatg
     4561 ttgcctttat ggtttccccc ttctacattt cttagactac atttagagaa ctgtggccgt
     4621 tatctggaag taaccatttg cactggagtt ctatgctctc gcacctttcc aaagttaaca
     4681 gattttgggg ttgtgttgtc acccaagaga ttgttgtttg ccatactttg tctgaaaaat
     4741 tcctttgtgt ttctattgac ttcaatgata gtaagaaaag tggttgttag ttatagatgt
     4801 ctaggtactt caggggcact tcattgagag ttttgtcttg gatattcttg aaagtttata
     4861 tttttataat tttttcttac atcagatgtt tctttgcagt ggcttaatgt ttgaaattat
     4921 tttgtggctt tttttgtaaa tattgaaatg tagcaataat gtcttttgaa tattcccaag
     4981 cccatgagtc cttgaaaata ttttttatat atacagtaac tttatgtgta aatacataag
     5041 cggcgtaagt ttaaaggatg ttggtgttcc acgtgtttta ttcctgtatg ttgtccaatt
     5101 gttgacagtt ctgaagaatt ctaataaaat gtacatatat aaatcaa
//
