LOCUS       NM_032551               1624 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens KISS1 receptor (KISS1R), mRNA.
ACCESSION   NM_032551
VERSION     NM_032551.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1624)
  AUTHORS   Musa,E., Salazar-Petres,E., Vatish,M., Levitt,N.,
            Sferruzzi-Perri,A.N. and Matjila,M.J.
  TITLE     Kisspeptin signalling and its correlation with placental
            ultrastructure and clinical outcomes in pregnant South African
            women with obesity and gestational diabetes
  JOURNAL   Placenta 154, 49-59 (2024)
   PUBMED   38878622
  REMARK    GeneRIF: Kisspeptin signalling and its correlation with placental
            ultrastructure and clinical outcomes in pregnant South African
            women with obesity and gestational diabetes.
REFERENCE   2  (bases 1 to 1624)
  AUTHORS   Shen,S., Wang,D., Liu,H., He,X., Cao,Y., Chen,J., Li,S., Cheng,X.,
            Xu,H.E. and Duan,J.
  TITLE     Structural basis for hormone recognition and distinctive Gq protein
            coupling by the kisspeptin receptor
  JOURNAL   Cell Rep 43 (7), 114389 (2024)
   PUBMED   38935498
  REMARK    GeneRIF: Structural basis for hormone recognition and distinctive
            Gq protein coupling by the kisspeptin receptor.
REFERENCE   3  (bases 1 to 1624)
  AUTHORS   Panting,E.N., Weight,J.H., Sartori,J.A., Coall,D.A. and Smith,J.T.
  TITLE     The role of placental kisspeptin in trophoblast invasion and
            migration: an assessment in Kiss1r knockout mice, BeWo cell lines
            and human term placenta
  JOURNAL   Reprod Fertil Dev 36 (2024)
   PUBMED   38976640
  REMARK    GeneRIF: The role of placental kisspeptin in trophoblast invasion
            and migration: an assessment in Kiss1r knockout mice, BeWo cell
            lines and human term placenta.
REFERENCE   4  (bases 1 to 1624)
  AUTHORS   Balraj,P., Ambhore,N.S., Ramakrishnan,Y.S., Borkar,N.A.,
            Banerjee,P., Reza,M.I., Varadharajan,S., Kumar,A., Pabelick,C.M.,
            Prakash,Y.S. and Sathish,V.
  TITLE     Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle
            Cell Migration
  JOURNAL   Am J Respir Cell Mol Biol 70 (6), 507-518 (2024)
   PUBMED   38512807
  REMARK    GeneRIF: Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth
            Muscle Cell Migration.
REFERENCE   5  (bases 1 to 1624)
  AUTHORS   Zhang,J., Jin,L., Kong,L., Nie,L. and Yuan,D.
  TITLE     Physiological and pathological roles of locally expressed
            kisspeptin and KISS1R in the endometrium
  JOURNAL   Hum Reprod 38 (7), 1253-1260 (2023)
   PUBMED   37105233
  REMARK    GeneRIF: Physiological and pathological roles of locally expressed
            kisspeptin and KISS1R in the endometrium.
            Review article
REFERENCE   6  (bases 1 to 1624)
  AUTHORS   Muir,A.I., Chamberlain,L., Elshourbagy,N.A., Michalovich,D.,
            Moore,D.J., Calamari,A., Szekeres,P.G., Sarau,H.M., Chambers,J.K.,
            Murdock,P., Steplewski,K., Shabon,U., Miller,J.E., Middleton,S.E.,
            Darker,J.G., Larminie,C.G., Wilson,S., Bergsma,D.J., Emson,P.,
            Faull,R., Philpott,K.L. and Harrison,D.C.
  TITLE     AXOR12, a novel human G protein-coupled receptor, activated by the
            peptide KiSS-1
  JOURNAL   J Biol Chem 276 (31), 28969-28975 (2001)
   PUBMED   11387329
REFERENCE   7  (bases 1 to 1624)
  AUTHORS   Clements,M.K., McDonald,T.P., Wang,R., Xie,G., O'Dowd,B.F.,
            George,S.R., Austin,C.P. and Liu,Q.
  TITLE     FMRFamide-related neuropeptides are agonists of the orphan
            G-protein-coupled receptor GPR54
  JOURNAL   Biochem Biophys Res Commun 284 (5), 1189-1193 (2001)
   PUBMED   11414709
REFERENCE   8  (bases 1 to 1624)
  AUTHORS   Ohtaki,T., Shintani,Y., Honda,S., Matsumoto,H., Hori,A.,
            Kanehashi,K., Terao,Y., Kumano,S., Takatsu,Y., Masuda,Y.,
            Ishibashi,Y., Watanabe,T., Asada,M., Yamada,T., Suenaga,M.,
            Kitada,C., Usuki,S., Kurokawa,T., Onda,H., Nishimura,O. and
            Fujino,M.
  TITLE     Metastasis suppressor gene KiSS-1 encodes peptide ligand of a
            G-protein-coupled receptor
  JOURNAL   Nature 411 (6837), 613-617 (2001)
   PUBMED   11385580
REFERENCE   9  (bases 1 to 1624)
  AUTHORS   Lee,D.K., Nguyen,T., O'Neill,G.P., Cheng,R., Liu,Y., Howard,A.D.,
            Coulombe,N., Tan,C.P., Tang-Nguyen,A.T., George,S.R. and
            O'Dowd,B.F.
  TITLE     Discovery of a receptor related to the galanin receptors
  JOURNAL   FEBS Lett 446 (1), 103-107 (1999)
   PUBMED   10100623
REFERENCE   10 (bases 1 to 1624)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005379.1 and BC141812.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032551.4.
            
            Summary: The protein encoded by this gene is a galanin-like G
            protein-coupled receptor that binds metastin, a peptide encoded by
            the metastasis suppressor gene KISS1. The tissue distribution of
            the expressed gene suggests that it is involved in the regulation
            of endocrine function, and this is supported by the finding that
            this gene appears to play a role in the onset of puberty. Mutations
            in this gene have been associated with hypogonadotropic
            hypogonadism and central precocious puberty. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141812.1, AY253982.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968540,
                                           SAMEA2142853 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234371.10/ ENSP00000234371.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC005379.1         11887-11895
            10-1624             BC141812.1         1-1615
FEATURES             Location/Qualifiers
     source          1..1624
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1624
                     /gene="KISS1R"
                     /gene_synonym="AXOR12; CPPB1; GPR54; HH8; HOT7T175;
                     KISS-1R"
                     /note="KISS1 receptor"
                     /db_xref="GeneID:84634"
                     /db_xref="HGNC:HGNC:4510"
                     /db_xref="MIM:604161"
     exon            1..414
                     /gene="KISS1R"
                     /gene_synonym="AXOR12; CPPB1; GPR54; HH8; HOT7T175;
                     KISS-1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1367
                     /gene="KISS1R"
                     /gene_synonym="AXOR12; CPPB1; GPR54; HH8; HOT7T175;
                     KISS-1R"
                     /note="metastin receptor; G protein-coupled receptor 54;
                     hypogonadotropin-1; kisspeptins receptor; G-protein
                     coupled receptor OT7T175"
                     /codon_start=1
                     /product="kiSS-1 receptor"
                     /protein_id="NP_115940.2"
                     /db_xref="CCDS:CCDS12049.1"
                     /db_xref="GeneID:84634"
                     /db_xref="HGNC:HGNC:4510"
                     /db_xref="MIM:604161"
                     /translation="MHTVATSGPNASWGAPANASGCPGCGANASDGPVPSPRAVDAWL
                     VPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALL
                     YPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLAL
                     AVSLSIWVGSAAVSAPVLALHRLSPGPRAYCSEAFPSRALERAFALYNLLALYLLPLL
                     ATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAGAVRAKVSRLVAAVVLLFAACW
                     GPIQLFLVLQALGPAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAF
                     RRVCPCAPRRPRRPRRPGPSDPAAPHAELLRLGSHPAPARAQKPGSSGLAARGLCVLG
                     EDNAPL"
     exon            415..539
                     /gene="KISS1R"
                     /gene_synonym="AXOR12; CPPB1; GPR54; HH8; HOT7T175;
                     KISS-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            540..675
                     /gene="KISS1R"
                     /gene_synonym="AXOR12; CPPB1; GPR54; HH8; HOT7T175;
                     KISS-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            676..908
                     /gene="KISS1R"
                     /gene_synonym="AXOR12; CPPB1; GPR54; HH8; HOT7T175;
                     KISS-1R"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1624
                     /gene="KISS1R"
                     /gene_synonym="AXOR12; CPPB1; GPR54; HH8; HOT7T175;
                     KISS-1R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1563..1568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KISS1R"
                     /gene_synonym="AXOR12; CPPB1; GPR54; HH8; HOT7T175;
                     KISS-1R"
                     /note="hexamer: ATTAAA"
     polyA_site      1582
                     /gene="KISS1R"
                     /gene_synonym="AXOR12; CPPB1; GPR54; HH8; HOT7T175;
                     KISS-1R"
                     /note="major polyA site"
     polyA_site      1624
                     /gene="KISS1R"
                     /gene_synonym="AXOR12; CPPB1; GPR54; HH8; HOT7T175;
                     KISS-1R"
ORIGIN      
        1 agaggagccg ccgagcccag cacagctgcc ctctggaccc tgcggacccc agccgagccc
       61 cttcctgagt tccacaggcg cagcccccgg gcggtcgggc ggaggggtcc ccggggcggt
      121 gccagggcgc aatcctggag ggcggccggg aggaggaggt gcgcgcggcc atgcacaccg
      181 tggctacgtc cggacccaac gcgtcctggg gggcaccggc caacgcctcc ggctgcccgg
      241 gctgtggcgc caacgcctcg gacggcccag tcccttcgcc gcgggccgtg gacgcctggc
      301 tcgtgccgct cttcttcgcg gcgctgatgc tgctgggcct ggtggggaac tcgctggtca
      361 tctacgtcat ctgccgccac aagccgatgc ggaccgtgac caacttctac atcgccaacc
      421 tggcggccac ggacgtgacc ttcctcctgt gctgcgtccc cttcacggcc ctgctgtacc
      481 cgctgcccgg ctgggtgctg ggcgacttca tgtgcaagtt cgtcaactac atccagcagg
      541 tctcggtgca ggccacgtgt gccactctga ccgccatgag tgtggaccgc tggtacgtga
      601 cggtgttccc gttgcgcgcc ctgcaccgcc gcacgccccg cctggcgctg gctgtcagcc
      661 tcagcatctg ggtaggctct gcggcggtgt ctgcgccggt gctcgccctg caccgcctgt
      721 cacccgggcc gcgcgcctac tgcagtgagg ccttccccag ccgcgccctg gagcgcgcct
      781 tcgcactgta caacctgctg gcgctgtacc tgctgccgct gctcgccacc tgcgcctgct
      841 atgcggccat gctgcgccac ctgggccggg tcgccgtgcg ccccgcgccc gccgatagcg
      901 ccctgcaggg gcaggtgctg gcagagcgcg caggcgccgt gcgggccaag gtctcgcggc
      961 tggtggcggc cgtggtcctg ctcttcgccg cctgctgggg ccccatccag ctgttcctgg
     1021 tgctgcaggc gctgggcccc gcgggctcct ggcacccacg cagctacgcc gcctacgcgc
     1081 ttaagacctg ggctcactgc atgtcctaca gcaactccgc gctgaacccg ctgctctacg
     1141 ccttcctggg ctcgcacttc cgacaggcct tccgccgcgt ctgcccctgc gcgccgcgcc
     1201 gcccccgccg cccccgccgg cccggaccct cggaccccgc agccccacac gcggagctgc
     1261 tccgcctggg gtcccacccg gcccccgcca gggcgcagaa gccagggagc agtgggctgg
     1321 ccgcgcgcgg gctgtgcgtc ctgggggagg acaacgcccc tctctgagcg gacccggtgg
     1381 gaatccgagc ggctccctcg ggagcgggga ctgctggaac agcggctatt cttctgttat
     1441 tagtattttt cttactgtcc aagatcaact gtggaaatat tttggtctct tgtgacgttc
     1501 ggtgcagttt cgttgtgaag tttgctattg atattgaaat tatgacttct gtgtttcctg
     1561 aaattaaaca tgtgtcaaca caggactttc tggatcattc cagaaagtgt cagacgtttt
     1621 ctca
//
