LOCUS       NM_002256                714 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens KiSS-1 metastasis suppressor (KISS1), mRNA.
ACCESSION   NM_002256
VERSION     NM_002256.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 714)
  AUTHORS   Musa,E., Salazar-Petres,E., Vatish,M., Levitt,N.,
            Sferruzzi-Perri,A.N. and Matjila,M.J.
  TITLE     Kisspeptin signalling and its correlation with placental
            ultrastructure and clinical outcomes in pregnant South African
            women with obesity and gestational diabetes
  JOURNAL   Placenta 154, 49-59 (2024)
   PUBMED   38878622
  REMARK    GeneRIF: Kisspeptin signalling and its correlation with placental
            ultrastructure and clinical outcomes in pregnant South African
            women with obesity and gestational diabetes.
REFERENCE   2  (bases 1 to 714)
  AUTHORS   Stephen,S.B., Pauline,R., Velmurugan,S. and Subbaraj,G.K.
  TITLE     An association between fat mass and obesity-associated (FTO)
            (rs9939609) and kisspeptin-1 (KISS-1) (rs4889, rs372790354) gene
            polymorphisms with polycystic ovary syndrome: an updated
            meta-analysis and power analysis
  JOURNAL   J Assist Reprod Genet 41 (9), 2457-2475 (2024)
   PUBMED   39126595
  REMARK    GeneRIF: An association between fat mass and obesity-associated
            (FTO) (rs9939609) and kisspeptin-1 (KISS-1) (rs4889, rs372790354)
            gene polymorphisms with polycystic ovary syndrome: an updated
            meta-analysis and power analysis.
REFERENCE   3  (bases 1 to 714)
  AUTHORS   Panting,E.N., Weight,J.H., Sartori,J.A., Coall,D.A. and Smith,J.T.
  TITLE     The role of placental kisspeptin in trophoblast invasion and
            migration: an assessment in Kiss1r knockout mice, BeWo cell lines
            and human term placenta
  JOURNAL   Reprod Fertil Dev 36 (2024)
   PUBMED   38976640
  REMARK    GeneRIF: The role of placental kisspeptin in trophoblast invasion
            and migration: an assessment in Kiss1r knockout mice, BeWo cell
            lines and human term placenta.
REFERENCE   4  (bases 1 to 714)
  AUTHORS   Balraj,P., Ambhore,N.S., Ramakrishnan,Y.S., Borkar,N.A.,
            Banerjee,P., Reza,M.I., Varadharajan,S., Kumar,A., Pabelick,C.M.,
            Prakash,Y.S. and Sathish,V.
  TITLE     Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle
            Cell Migration
  JOURNAL   Am J Respir Cell Mol Biol 70 (6), 507-518 (2024)
   PUBMED   38512807
  REMARK    GeneRIF: Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth
            Muscle Cell Migration.
REFERENCE   5  (bases 1 to 714)
  AUTHORS   Yang,Y., Zhang,J., Li,D., Liu,C., Guo,R., Xiao,Y., Zhou,L., Tong,L.
            and Zhang,H.
  TITLE     [Notch1/Akt/Foxo1 Pathway Regulated by Kisspeptin Is Involved in
            Endometrial Decidualization in Patients With Recurrent Spontaneous
            Abortion]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (3), 542-551 (2024)
   PUBMED   38948287
  REMARK    GeneRIF: [Notch1/Akt/Foxo1 Pathway Regulated by Kisspeptin Is
            Involved in Endometrial Decidualization in Patients With Recurrent
            Spontaneous Abortion].
REFERENCE   6  (bases 1 to 714)
  AUTHORS   West,A., Vojta,P.J., Welch,D.R. and Weissman,B.E.
  TITLE     Chromosome localization and genomic structure of the KiSS-1
            metastasis suppressor gene (KISS1)
  JOURNAL   Genomics 54 (1), 145-148 (1998)
   PUBMED   9806840
REFERENCE   7  (bases 1 to 714)
  AUTHORS   Lee,J.H. and Welch,D.R.
  TITLE     Suppression of metastasis in human breast carcinoma MDA-MB-435
            cells after transfection with the metastasis suppressor gene,
            KiSS-1
  JOURNAL   Cancer Res 57 (12), 2384-2387 (1997)
   PUBMED   9192814
REFERENCE   8  (bases 1 to 714)
  AUTHORS   Lee,J.H. and Welch,D.R.
  TITLE     Identification of highly expressed genes in metastasis-suppressed
            chromosome 6/human malignant melanoma hybrid cells using
            subtractive hybridization and differential display
  JOURNAL   Int J Cancer 71 (6), 1035-1044 (1997)
   PUBMED   9185708
REFERENCE   9  (bases 1 to 714)
  AUTHORS   Lee,J.H., Miele,M.E., Hicks,D.J., Phillips,K.K., Trent,J.M.,
            Weissman,B.E. and Welch,D.R.
  TITLE     KiSS-1, a novel human malignant melanoma metastasis-suppressor gene
  JOURNAL   J Natl Cancer Inst 88 (23), 1731-1737 (1996)
   PUBMED   8944003
  REMARK    Erratum:[J Natl Cancer Inst 1997 Oct 15;89(20):1549]
REFERENCE   10 (bases 1 to 714)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592114.13 and BC022819.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002256.3.
            
            Summary: This gene is a metastasis suppressor gene that suppresses
            metastases of melanomas and breast carcinomas without affecting
            tumorigenicity. The encoded protein may inhibit chemotaxis and
            invasion and thereby attenuate metastasis in malignant melanomas.
            Studies suggest a putative role in the regulation of events
            downstream of cell-matrix adhesion, perhaps involving cytoskeletal
            reorganization. A protein product of this gene, kisspeptin,
            stimulates gonadotropin-releasing hormone (GnRH)-induced
            gonadotropin secretion and regulates the pubertal activation of
            GnRH neurons. A polymorphism in the terminal exon of this mRNA
            results in two protein isoforms. An adenosine present at the
            polymorphic site represents the third position in a stop codon.
            When the adenosine is absent, a downstream stop codon is utilized
            and the encoded protein extends for an additional seven amino acid
            residues. [provided by RefSeq, Jun 2022].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022819.1, AF218017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367194.5/ ENSP00000356162.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AL592114.13        35357-35472         c
            117-257             AL592114.13        31755-31895         c
            258-714             BC022819.1         253-709
FEATURES             Location/Qualifiers
     source          1..714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..714
                     /gene="KISS1"
                     /gene_synonym="HH13; KiSS-1"
                     /note="KiSS-1 metastasis suppressor"
                     /db_xref="GeneID:3814"
                     /db_xref="HGNC:HGNC:6341"
                     /db_xref="MIM:603286"
     exon            1..116
                     /gene="KISS1"
                     /gene_synonym="HH13; KiSS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..257
                     /gene="KISS1"
                     /gene_synonym="HH13; KiSS-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..571
                     /gene="KISS1"
                     /gene_synonym="HH13; KiSS-1"
                     /note="metastin; prepro-kisspeptin;
                     metastasis-suppressor-1; malignant melanoma
                     metastasis-suppressor; kisspeptin-1"
                     /codon_start=1
                     /product="metastasis-suppressor KiSS-1 preproprotein"
                     /protein_id="NP_002247.3"
                     /db_xref="CCDS:CCDS41454.1"
                     /db_xref="GeneID:3814"
                     /db_xref="HGNC:HGNC:6341"
                     /db_xref="MIM:603286"
                     /translation="MNSLVSWQLLLFLCATHFGEPLEKVASVGNSRPTGQQLESLGLL
                     APGEQSLPCTERKPAATARLSRRGTSLSPPPESSGSPQQPGLSAPHSRQIPAPQGAVL
                     VQREKDLPNYNWNSFGLRFGKREAAPGNHGRSAGRG"
     exon            258..714
                     /gene="KISS1"
                     /gene_synonym="HH13; KiSS-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      690..695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KISS1"
                     /gene_synonym="HH13; KiSS-1"
                     /note="hexamer: AATAAA"
     polyA_site      714
                     /gene="KISS1"
                     /gene_synonym="HH13; KiSS-1"
                     /note="major polyA site"
ORIGIN      
        1 gagaactctt gagaccggga gcccagctgc ccaccctctg gacattcacc cagccaggtg
       61 gtctcgtcac ctcagaggct ccgccagact cctgcccagg ccaggactga ggcaagcctc
      121 aaggcacttc taggacctgc ctcttctcac caagatgaac tcactggttt cttggcagct
      181 actgcttttc ctctgtgcca cccactttgg ggagccatta gaaaaggtgg cctctgtggg
      241 gaattctaga cccacaggcc agcagctaga atccctgggc ctcctggccc ccggggagca
      301 gagcctgccg tgcaccgaga ggaagccagc tgctactgcc aggctgagcc gtcgggggac
      361 ctcgctgtcc ccgccccccg agagctccgg gagcccccag cagccgggcc tgtccgcccc
      421 ccacagccgc cagatccccg caccccaggg cgcggtgctg gtgcagcggg agaaggacct
      481 gccgaactac aactggaact ccttcggcct gcgcttcggc aagcgggagg cggcaccagg
      541 gaaccacggc agaagcgctg ggcggggctg agggcgcagg tgcggggcag tgaacttcag
      601 accccaaagg agtcagagca tgcggggcgg gggcgggggg cggggacgta gggctaaggg
      661 agggggcgct ggagcttcca acccgaggca ataaaagaaa tgttgcgtaa ctca
//
