LOCUS       NM_018240               7448 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens kirre like nephrin family adhesion molecule 1
            (KIRREL1), transcript variant 1, mRNA.
ACCESSION   NM_018240
VERSION     NM_018240.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7448)
  AUTHORS   Wang,T., Chen,S., Wang,Z., Li,S., Fei,X., Wang,T. and Zhang,M.
  TITLE     KIRREL promotes the proliferation of gastric cancer cells and
            angiogenesis through the PI3K/AKT/mTOR pathway
  JOURNAL   J Cell Mol Med 28 (1), e18020 (2024)
   PUBMED   37909722
  REMARK    GeneRIF: KIRREL promotes the proliferation of gastric cancer cells
            and angiogenesis through the PI3K/AKT/mTOR pathway.
REFERENCE   2  (bases 1 to 7448)
  AUTHORS   Gu,Y., Wang,Y., Sha,Z., He,C., Zhu,Y., Li,J., Yu,A., Zhong,Z.,
            Wang,X., Sun,Y., Lan,F. and Yu,F.X.
  TITLE     Transmembrane protein KIRREL1 regulates Hippo signaling via a
            feedback loop and represents a therapeutic target in YAP/TAZ-active
            cancers
  JOURNAL   Cell Rep 40 (9), 111296 (2022)
   PUBMED   36044856
  REMARK    GeneRIF: Transmembrane protein KIRREL1 regulates Hippo signaling
            via a feedback loop and represents a therapeutic target in
            YAP/TAZ-active cancers.
REFERENCE   3  (bases 1 to 7448)
  AUTHORS   Paul,A., Annunziato,S., Lu,B., Sun,T., Evrova,O., Planas-Paz,L.,
            Orsini,V., Terracciano,L.M., Charlat,O., Loureiro,Z.Y., Ji,L.,
            Zamponi,R., Sigoillot,F., Lei,H., Lindeman,A., Russ,C.,
            Reece-Hoyes,J.S., Nicholson,T.B., Tchorz,J.S. and Cong,F.
  TITLE     Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo
            signaling recruiting SAV1 to cell-cell contact sites
  JOURNAL   Nat Commun 13 (1), 930 (2022)
   PUBMED   35177623
  REMARK    GeneRIF: Cell adhesion molecule KIRREL1 is a feedback regulator of
            Hippo signaling recruiting SAV1 to cell-cell contact sites.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7448)
  AUTHORS   Chen,K., Zhao,R., Yao,G., Liu,Z., Shi,R. and Geng,J.
  TITLE     Overexpression of kin of IRRE-Like protein 1 (KIRREL) as a
            prognostic biomarker for breast cancer
  JOURNAL   Pathol Res Pract 216 (7), 153000 (2020)
   PUBMED   32534710
  REMARK    GeneRIF: Overexpression of kin of IRRE-Like protein 1 (KIRREL) as a
            prognostic biomarker for breast cancer.
            Review article
REFERENCE   5  (bases 1 to 7448)
  AUTHORS   Solanki,A.K., Widmeier,E., Arif,E., Sharma,S., Daga,A.,
            Srivastava,P., Kwon,S.H., Hugo,H., Nakayama,M., Mann,N.,
            Majmundar,A.J., Tan,W., Gee,H.Y., Sadowski,C.E., Rinat,C.,
            Becker-Cohen,R., Bergmann,C., Rosen,S., Somers,M., Shril,S.,
            Huber,T.B., Mane,S., Hildebrandt,F. and Nihalani,D.
  TITLE     Mutations in KIRREL1, a slit diaphragm component, cause
            steroid-resistant nephrotic syndrome
  JOURNAL   Kidney Int 96 (4), 883-889 (2019)
   PUBMED   31472902
  REMARK    GeneRIF: Mutations in KIRREL1, a slit diaphragm component, cause
            steroid-resistant nephrotic syndrome.
REFERENCE   6  (bases 1 to 7448)
  AUTHORS   Barletta,G.M., Kovari,I.A., Verma,R.K., Kerjaschki,D. and
            Holzman,L.B.
  TITLE     Nephrin and Neph1 co-localize at the podocyte foot process
            intercellular junction and form cis hetero-oligomers
  JOURNAL   J Biol Chem 278 (21), 19266-19271 (2003)
   PUBMED   12646566
REFERENCE   7  (bases 1 to 7448)
  AUTHORS   Huber,T.B., Schmidts,M., Gerke,P., Schermer,B., Zahn,A.,
            Hartleben,B., Sellin,L., Walz,G. and Benzing,T.
  TITLE     The carboxyl terminus of Neph family members binds to the PDZ
            domain protein zonula occludens-1
  JOURNAL   J Biol Chem 278 (15), 13417-13421 (2003)
   PUBMED   12578837
REFERENCE   8  (bases 1 to 7448)
  AUTHORS   Gerke,P., Huber,T.B., Sellin,L., Benzing,T. and Walz,G.
  TITLE     Homodimerization and heterodimerization of the glomerular podocyte
            proteins nephrin and NEPH1
  JOURNAL   J Am Soc Nephrol 14 (4), 918-926 (2003)
   PUBMED   12660326
REFERENCE   9  (bases 1 to 7448)
  AUTHORS   Sellin,L., Huber,T.B., Gerke,P., Quack,I., Pavenstadt,H. and
            Walz,G.
  TITLE     NEPH1 defines a novel family of podocin interacting proteins
  JOURNAL   FASEB J 17 (1), 115-117 (2003)
   PUBMED   12424224
REFERENCE   10 (bases 1 to 7448)
  AUTHORS   Donoviel,D.B., Freed,D.D., Vogel,H., Potter,D.G., Hawkins,E.,
            Barrish,J.P., Mathur,B.N., Turner,C.A., Geske,R., Montgomery,C.A.,
            Starbuck,M., Brandt,M., Gupta,A., Ramirez-Solis,R., Zambrowicz,B.P.
            and Powell,D.R.
  TITLE     Proteinuria and perinatal lethality in mice lacking NEPH1, a novel
            protein with homology to NEPHRIN
  JOURNAL   Mol Cell Biol 21 (14), 4829-4836 (2001)
   PUBMED   11416156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC109192.1, AL139010.29 and AA628934.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018240.6.
            
            Summary: NEPH1 is a member of the nephrin-like protein family,
            which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The
            cytoplasmic domains of these proteins interact with the C terminus
            of podocin (NPHS2; MIM 604766), and the genes are expressed in
            kidney podocytes, cells involved in ensuring size- and
            charge-selective ultrafiltration (Sellin et al., 2003 [PubMed
            12424224]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC109193.1, DRR138518.504189.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359209.11/ ENSP00000352138.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2839              BC109192.1         36-2874
            2840-7357           AL139010.29        161683-166200
            7358-7448           AA628934.1         7-97                c
FEATURES             Location/Qualifiers
     source          1..7448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..7448
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /note="kirre like nephrin family adhesion molecule 1"
                     /db_xref="GeneID:55243"
                     /db_xref="HGNC:HGNC:15734"
                     /db_xref="MIM:607428"
     exon            1..84
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2306
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; nephrin related; kin of IRRE-like protein 1;
                     nephrin-like protein 1; kin of irregular chiasm-like
                     protein 1; kin of IRRE like"
                     /codon_start=1
                     /product="kin of IRRE-like protein 1 isoform 1 precursor"
                     /protein_id="NP_060710.3"
                     /db_xref="CCDS:CCDS1172.2"
                     /db_xref="GeneID:55243"
                     /db_xref="HGNC:HGNC:15734"
                     /db_xref="MIM:607428"
                     /translation="MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVL
                     LNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQA
                     TEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDG
                     TQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELD
                     VHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNV
                     DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGN
                     PPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGP
                     PIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGS
                     GVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGASIL
                     LIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASVSTATR
                     VMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYAD
                     YRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTSQL
                     SYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTS
                     QHSDYGQRFQQRMQTHV"
     exon            85..234
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            235..384
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            385..542
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            543..693
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            694..799
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            800..948
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1076
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1203
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1304
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1503
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1611
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1751
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1829
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..7448
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6194..6199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /note="hexamer: ATTAAA"
     polyA_site      6221
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
     regulatory      7429..7434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /note="hexamer: TATAAA"
     polyA_site      7448
                     /gene="KIRREL1"
                     /gene_synonym="KIRREL; NEPH1; NPHS23"
                     /note="major polyA site"
ORIGIN      
        1 agccgcgggc gggcgcacgg cgggcggaca gcatgctgag cctcctcgtc tggatcctca
       61 ctctctccga tactttctcc caagggaccc agacccgctt cagccaggag ccagctgacc
      121 agacggtggt ggctggacag cgggccgtgc tcccctgtgt gctgctcaac tactctggaa
      181 ttgtgcaatg gaccaaggac gggctggccc tgggcatggg ccagggcctc aaagcctggc
      241 cacggtaccg ggttgtgggc tccgcagacg ctgggcagta caacctggag atcacagatg
      301 ctgagctctc tgacgacgcc tcttacgagt gccaggccac ggaggccgcc ctgcgctctc
      361 ggcgggccaa actcaccgtg ctcatccccc cagaggacac caggattgac ggaggccctg
      421 tgattctact gcaggcaggc accccccaca acctcacatg ccgggccttc aatgcgaagc
      481 ctgctgccac catcatctgg ttccgggacg ggacgcagca ggagggcgct gtggccagca
      541 cggaattgct gaaggatggg aagagggaga ccaccgtgag ccaactgctt attaacccca
      601 cggacctgga catagggcgt gtcttcactt gccgaagcat gaacgaagcc atccctagtg
      661 gcaaggagac ttccatcgag ctggatgtgc accaccctcc tacagtgacc ctgtccattg
      721 agccacagac ggtgcaggag ggtgagcgtg ttgtctttac ctgccaggcc acagccaacc
      781 ccgagatctt gggctacagg tgggccaaag ggggtttctt gattgaagac gcccacgaga
      841 gtcgctatga gacaaatgtg gattattcct ttttcacgga gcctgtgtct tgtgaggttc
      901 acaacaaagt gggaagcacc aatgtcagca ctttagtaaa tgtccacttt gctccccgga
      961 ttgtagttga ccccaaaccc acaaccacag acattggctc tgatgtgacc cttacctgtg
     1021 tctgggttgg gaatcccccc ctcactctca cctggaccaa aaaggactca aatatggtcc
     1081 tgagtaacag caaccagctg ctgctgaagt cggtgactca ggcagacgct ggcacctaca
     1141 cctgccgggc catcgtgcct cgaatcggag tggctgagcg ggaggtgccg ctctatgtga
     1201 acgggccccc catcatctcc agtgaggcag tgcagtatgc tgtgaggggt gacggtggca
     1261 aggtggagtg tttcattggg agcacaccac ccccagaccg catagcatgg gcctggaagg
     1321 agaacttctt ggaggtgggg accctggaac gctatacagt ggagaggacc aactcaggca
     1381 gtggggtgct atccacgctc accatcaaca atgtcatgga ggccgacttt cagactcact
     1441 acaactgcac cgcctggaac agcttcgggc caggcacagc catcatccag ctggaagagc
     1501 gagaggtgtt acctgtgggc atcatagctg gggccaccat cggcgcgagc atcctgctca
     1561 tcttcttctt catcgccttg gtattcttcc tctaccggcg ccgcaaaggc agtcgcaaag
     1621 acgtgaccct gaggaagctg gatatcaagg tggagacagt gaaccgagag ccacttacga
     1681 tgcattctga ccgggaggat gacaccgcca gcgtctccac agcaacccgg gtcatgaagg
     1741 ccatctactc gtcgtttaag gatgatgtgg atctgaagca ggacctgcgc tgcgacacca
     1801 tcgacacccg ggaggagtat gagatgaagg accccaccaa tggctactac aacgtgcgtg
     1861 cccatgaaga ccgcccgtct tccagggcag tgctctatgc tgactaccgt gcccctggcc
     1921 ctgcccgctt cgacggccgc ccctcatccc gtctctccca ctccagcggc tatgcccagc
     1981 tcaacaccta tagccggggc cctgcctctg actatggccc tgagcccaca ccccctggcc
     2041 ctgctgcccc agctggcact gacacaacca gccagctgtc ctacgagaac tatgagaagt
     2101 tcaactccca tcccttccct ggggcagctg ggtaccccac ctaccgactg ggctaccccc
     2161 aggccccacc ctctggcctg gagcggaccc catatgaggc gtatgacccc attggcaagt
     2221 acgccacagc cactcgattc tcctacacct cccagcactc ggactacggc cagcgattcc
     2281 agcagcgcat gcagactcac gtgtaggggc cagagcctgg ctggggcatc tctgcggggc
     2341 agaggagaag gctttcacag ctgttccctg atattcaggg gcattgctca ttgctccctt
     2401 ctcggaccag ccttcttcct cccaccatgg caggtgggga gcaggtctcc cagaaacacc
     2461 ccgtcccgag gatggtgctc tgtgcatgcc ccagcctcct gggcctgccc ttccctcttc
     2521 ttcgggagga tgtgtctctt ctgacctgca ctcttgcctg accctagaat ggggacaggg
     2581 aaagtgaagg ttagggaaag cagagggggg cactttttag cattcccttt ctatcccacc
     2641 cctctgatct cccataagtg gaaatggggg tacccaggga tgggcaggct ttggcctagg
     2701 gacatgaagt atgggagtgg gtggctgtgg cacagacagg tggaaaacgg gatagcctgg
     2761 ccagtccctc tgttgtctgc attcgtgccc tgggtgcctc tctccttcct cagggtactg
     2821 cagaagggag cgaacagggt actgttcgct cttgtctaca gaacagccct ggcactgcat
     2881 tcaaatccag tcttcattca gctgggatca aaatgccagt caccttggct acccactgtg
     2941 gacagctgtc tgtcagcatg cagagggatc caggaatccc cccggcagca cggcccgctt
     3001 tccttctcct ccatgctggg ccagccagat aagtcagggt cctggtggag aaagaaaggc
     3061 taggaccatg tcctcattga cccagatact gctgtgtgct gcacagcagt gaaccaacac
     3121 tagagggagc cacacaagcc tcctctcccc agtctgcccc acttcctggc tttaactctt
     3181 gagctggttt ggggagtggt gaggtagggg tgggggtgct gtaggctctt tttcaaagaa
     3241 aacaaaaaac aatgaaaacc tcatttggga agaaaagctg tagggattcc cccacccaaa
     3301 tacaagtccc agtggaaagg aaaggtagta cctattcttc tccatggggt tcctaacacc
     3361 ctccattact ctttcagtct ccaagcactt tgaatccatt tttaaacatt caggttgcca
     3421 gacctgtcac acagtggact ctgatagggt tacggagggg gcctggctct cagtctctac
     3481 tctcctatgt cccatcagtt ggttggaggc caccttccag ggggtatggg agacaggttt
     3541 tggtttttaa gtgtcttttt tttttttctt ggaccaatca gattccttct tccactttca
     3601 gtgccttgag tgtcaagctt tggatgaccg accctatgtg ggcggttgtg tggggagtgg
     3661 gtacttgtga gcctcggaca cactgttaag tgttacagtg ttaggagaga gatgggtgag
     3721 gggacctgga gaggtaaggg gcctggaaat ggccctgaca gagaacttgt gctgaccggg
     3781 agaaggtggt gcggaagggc accgcaggca ttacacaggc catttctcct cctccatgtg
     3841 cacgcacatc caacacacac cttccatgtg actgcttctc agccaccact ttctgaccaa
     3901 agagaacagg cgctccaagg agaacctgta cccctgcccc agcctcgcct tcctaaaaag
     3961 cagtgtctgg agttggctgt ttcccgcctc cccagctgca tgtccagccc agtgggagac
     4021 agggcctctg gtgcagttcc caaaatgttc ctcgcccttt ctccgtggtc accattcata
     4081 attcatgttc gctttaatga gttacatgct tatcagccac aggccattac cacccttatg
     4141 gatgggtctg gggggcgaca ttcctggcca accccttgta ggaaggacca gataataccc
     4201 aggaagcaag tagctctaat tttaacttca caggaagtct gtgcatcctc cttcatttca
     4261 gcagggaaaa ctcctgtgga gtgggcccta tctggggcat ttacaggctt ccagctgtat
     4321 tccatccctg gaagctgata cctttctata gagtcctttt atgagagctc agtgggaagg
     4381 tctgtcaaga aattcaggtt cttgtacaga caaattcatg caaatttcta ttattttcac
     4441 aaaaaccaga aaccatgggg gaatccaaag acttgaagtc taaagatggt ggcttttaaa
     4501 acatgcatat tccaaaaaga attcattttt gttttgggtt tggctagatt ctcttattta
     4561 tcccctttta gcttaagtat tagtttcatt ctactgaaat gatggagaga gggcctaagg
     4621 ttactaggta attgagctga tggtgcaggg agaattgttg agaaaggaag cctagtttcc
     4681 agaagcctga cacagagcta cttcactgtc ctctactcct taacaaggta actggagcct
     4741 cttgggtgtc aaacaagcac cctggaaggc acagggaagc atcagcaacc aaggtagtct
     4801 ctgccctctg taacttacgt gttggtgcat cagaatctga attggaacct acctgatggg
     4861 cccagtggaa tagcttttct ggggagtgga aggcgtcctt gatcacagag ctttgctgtc
     4921 gaatcctgga gtcctgcaac atggtgatgc ctcagtagtt ggtgatcctg atcacctttg
     4981 gtggcttgtt ttagtggaaa gagcaaggga ctaaaggtca ggagacccag gacccagtcc
     5041 tgaagctgca aaggttagat ctcggcctaa ctttctgttc attgccccca atttgtctgg
     5101 cctgtaaaat gaagggggag ggttgcataa acctaaaact attctggttt tgttataccc
     5161 atagggttgg gggtagggat gggactgccc attgctggca aggaactggg aacagtagca
     5221 agcatggtga gggctggaga gctggctggg ggggttctct cctgttcaaa gaagctttca
     5281 ccatgggctt cattatcttg tcagaagtga attagtttcc accagggacc cctttatccc
     5341 aaacagcaac acaaaataca ccctaaacct cagagtaaaa ttgatgtggg gctatccttt
     5401 ggctatcggg tcatctgtgc tgctccccac tcatttctga tgggtttgca aaggtgcctt
     5461 ttgccagggc aggacatagt atgcacatag ggatattgtt atgtgcctag gtttcaggca
     5521 ctccttctgt aggggaaaat gggaggagcc ttcctccacc ctgatcctta ggaacattcc
     5581 tctggcccag ggacagcttg ttcttctcac caaacaggtg aagcctgcag tccaaggtgc
     5641 ctggagccag aggtcgggga gtaagcacag ctgcccctgc ctgagaagga gcagcttgca
     5701 aggggagccg gtggagggaa aggggtacaa cagctttgga atacattctg gatcttgagg
     5761 aggatcttgt gattttggct gagccacggt cacttccctc gtgaaggacc cgccctatat
     5821 cctaaattct ggatccctca aagtccagcc acagagtttg catgaagcaa aaagcctagt
     5881 aagtgagaaa ggaaaggggc cagggatggg agcagtgctg tgctgttatc actgtcttgc
     5941 ttggaatgaa aacatctgag caccctgtct tcaagcggta cgctctcccc ttattccagc
     6001 agggctactt tcctcttcac tctgatgagg ggagctttat ctgctttcaa aatggagcac
     6061 gtcgcactgg agtttcgtgc cctctcgtta acctgtcagg agccacaggg ctccataaaa
     6121 cggaatcagt gtctcaatat acatgaccta tgttcatagc aatgttcagc catttgggtt
     6181 tgaagaaaac cacattaaag ccaagacccg tttggagcga actgccttgt tctttgctgt
     6241 gtggaaggtt ctgtccctac tgctgaactc cagttcctcc ccaagcaccc tggcctcaga
     6301 aatcctggct tccccaagtt agtgctgtct gacctgagcc aggccactgc ttggtgcctc
     6361 tacaggccac tgtgcatgtt gagaattgcc caaaaggatt agtgaagctc ctgaccctgg
     6421 cgaggccata atgaacactg aagtgcacag gccaagggat gtaattgaaa ggcatttatt
     6481 tttgtgaaga tgctgtaaaa ttagcattta aatatcccat tcccttctct tggcctcctc
     6541 ctatccccct atggtatttc tcctcctctc ctcaaggcca ggctttttgt gaaaggcatt
     6601 ggctcatctt tgtcagcgtg gtcctgacgt tcacctctgg gctgctggag aggactgaga
     6661 gatgtgtggt ttggtaggaa gggggtgtgt gtgggggtta gtggggaatc ccattttttt
     6721 gcatcactgt gaggtagctt caggccctgt ccctggagaa ataattgctg cgcagaagtc
     6781 acaggccata ctgggcagtt ctggtacaaa cctgccctta ttaataataa caataataat
     6841 aataactcca tttgcataga actgtcactc attcctgcca gtctgctgtc cctaccctgg
     6901 ttttttgctg gccccaacca ctggccttgt tgagtatcga tgggccctga gctcttctgt
     6961 ttgcttttgg agctcttcag atgctgtccc ccctgagaat accctaactc tggggaaaga
     7021 gcagccaaaa tcccaataca gtaaaactcc acacaatctt gttagcaaca gtgacccaga
     7081 aaattttgag aagtccaatt tcaccagaag aggcccaggg ctccctgtgg tcacattttc
     7141 tacccagcca ttcttggcat tgcaacctcc atttctagct cctgttgaat tttctccacc
     7201 cagaccccaa aaataaatgg atccatgatg ataattaaga gaagagaaaa aaagatatta
     7261 tttttgttag gacaaaccat tgtaggtttt tagcaatgtg tatctgtgtg tccctcacac
     7321 cttttcctat tctacttttt tttccttttt ttaaaaatat tatgtactat atttttagtc
     7381 tcaaacacac tatatattat atatatttaa tttttttata tatataaata taaatgtttt
     7441 aaaaagta
//
