LOCUS       NM_013289               1871 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens killer cell immunoglobulin like receptor, three Ig
            domains and long cytoplasmic tail 1 (KIR3DL1), transcript variant 1
            (reference allele), mRNA.
ACCESSION   NM_013289 NM_014514 XM_005277260 XM_498425
VERSION     NM_013289.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Wobser,M., Appenzeller,S., Roth,S., Siedel,C., Goebeler,M.,
            Geissinger,E., Rosenwald,A. and Maurus,K.
  TITLE     Oncogenic alterations in KIR3DL1 in cutaneous acral CD8+
            lymphoproliferative disorder
  JOURNAL   Br J Dermatol 191 (5), 816-822 (2024)
   PUBMED   38924750
  REMARK    GeneRIF: Oncogenic alterations in KIR3DL1 in cutaneous acral CD8+
            lymphoproliferative disorder.
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Wang,R., Sun,Y., Kuang,B.H., Yan,X., Lei,J., Lin,Y.X., Tian,J.,
            Li,Y., Xie,X., Chen,T., Zhang,H., Zeng,Y.X., Zhao,J. and Feng,L.
  TITLE     HLA-Bw4 in association with KIR3DL1 favors natural killer
            cell-mediated protection against severe COVID-19
  JOURNAL   Emerg Microbes Infect 12 (1), 2185467 (2023)
   PUBMED   36849422
  REMARK    GeneRIF: HLA-Bw4 in association with KIR3DL1 favors natural killer
            cell-mediated protection against severe COVID-19.
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Muriuki,B.M., Forconi,C.S., Kirwa,E.K., Maina,T.K., Ariera,B.O.,
            Bailey,J.A., Ghansah,A., Moormann,A.M. and Ong'echa,J.M.
  TITLE     Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan
            children with endemic Burkitt lymphoma
  JOURNAL   PLoS One 18 (8), e0275046 (2023)
   PUBMED   37647275
  REMARK    GeneRIF: Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in
            Kenyan children with endemic Burkitt lymphoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Shaukat,S.N., Nasir,F., Raza,A., Khanani,R., Uddin,S. and
            Kazmi,S.U.
  TITLE     Expression profile of KIR3DS1/KIR3DL1 receptors in association with
            immunological responses in TB, HIV and HIV/TB infected patients
  JOURNAL   Microb Pathog 180, 106145 (2023)
   PUBMED   37169313
  REMARK    GeneRIF: Expression profile of KIR3DS1/KIR3DL1 receptors in
            association with immunological responses in TB, HIV and HIV/TB
            infected patients.
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Naruse,T.K., Konishi-Takemura,M., Yanagida,R., Sharma,G.,
            Vajpayee,M., Terunuma,H., Mehra,N.K., Kaur,G. and Kimura,A.
  TITLE     Killer cell immunoglobulin-like receptor three domains long
            cytoplasmic tail 1 gene *007 may modulate disease progression of
            human immunodeficiency virus-1 infection in the Japanese population
  JOURNAL   Int J Immunogenet 50 (2), 48-52 (2023)
   PUBMED   36807537
  REMARK    GeneRIF: Killer cell immunoglobulin-like receptor three domains
            long cytoplasmic tail 1 gene *007 may modulate disease progression
            of human immunodeficiency virus-1 infection in the Japanese
            population.
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Dohring,C., Samaridis,J. and Colonna,M.
  TITLE     Alternatively spliced forms of human killer inhibitory receptors
  JOURNAL   Immunogenetics 44 (3), 227-230 (1996)
   PUBMED   8662091
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   D'Andrea,A., Chang,C., Franz-Bacon,K., McClanahan,T., Phillips,J.H.
            and Lanier,L.L.
  TITLE     Molecular cloning of NKB1. A natural killer cell receptor for HLA-B
            allotypes
  JOURNAL   J Immunol 155 (5), 2306-2310 (1995)
   PUBMED   7650366
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   Wagtmann,N., Biassoni,R., Cantoni,C., Verdiani,S., Malnati,M.S.,
            Vitale,M., Bottino,C., Moretta,L., Moretta,A. and Long,E.O.
  TITLE     Molecular clones of the p58 NK cell receptor reveal
            immunoglobulin-related molecules with diversity in both the extra-
            and intracellular domains
  JOURNAL   Immunity 2 (5), 439-449 (1995)
   PUBMED   7749980
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Colonna,M. and Samaridis,J.
  TITLE     Cloning of immunoglobulin-superfamily members associated with HLA-C
            and HLA-B recognition by human natural killer cells
  JOURNAL   Science 268 (5209), 405-408 (1995)
   PUBMED   7716543
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Litwin,V., Gumperz,J., Parham,P., Phillips,J.H. and Lanier,L.L.
  TITLE     NKB1: a natural killer cell receptor involved in the recognition of
            polymorphic HLA-B molecules
  JOURNAL   J Exp Med 180 (2), 537-543 (1994)
   PUBMED   8046332
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245128.3.
            
            On Mar 2, 2023 this sequence version replaced NM_013289.3.
            
            Summary: Killer cell immunoglobulin-like receptors (KIRs) are
            transmembrane glycoproteins expressed by natural killer cells and
            subsets of T cells. The KIR genes are polymorphic and highly
            homologous and they are found in a cluster on chromosome 19q13.4
            within the 1 Mb leukocyte receptor complex (LRC). The gene content
            of the KIR gene cluster varies among haplotypes, although several
            'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
            KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of
            extracellular immunoglobulin domains (2D or 3D) and by whether they
            have a long (L) or short (S) cytoplasmic domain. KIR proteins with
            the long cytoplasmic domain transduce inhibitory signals upon
            ligand binding via an immune tyrosine-based inhibitory motif
            (ITIM), while KIR proteins with the short cytoplasmic domain lack
            the ITIM motif and instead associate with the TYRO protein tyrosine
            kinase binding protein to transduce activating signals. The ligands
            for several KIR proteins are subsets of HLA class I molecules;
            thus, KIR proteins are thought to play an important role in
            regulation of the immune response. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the reference
            genome allele of the KIR3DL1 gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L41269.1, BC028206.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391728.8/ ENSP00000375608.4
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC245128.3         118092-118158
            68-103              AC245128.3         119158-119193
            104-388             AC245128.3         119939-120223
            389-688             AC245128.3         121337-121636
            689-982             AC245128.3         123189-123482
            983-1033            AC245128.3         126652-126702
            1034-1138           AC245128.3         130985-131089
            1139-1191           AC245128.3         131552-131604
            1192-1871           AC245128.3         131723-132402
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1871
                     /gene="KIR3DL1"
                     /gene_synonym="CD158E1; KIR; KIR2DL5B; KIR3DL1/S1; NKAT-3;
                     NKAT3; NKB1; NKB1B"
                     /note="killer cell immunoglobulin like receptor, three Ig
                     domains and long cytoplasmic tail 1"
                     /db_xref="GeneID:3811"
                     /db_xref="HGNC:HGNC:6338"
                     /db_xref="MIM:604946"
     exon            1..67
                     /gene="KIR3DL1"
                     /gene_synonym="CD158E1; KIR; KIR2DL5B; KIR3DL1/S1; NKAT-3;
                     NKAT3; NKB1; NKB1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1368
                     /gene="KIR3DL1"
                     /gene_synonym="CD158E1; KIR; KIR2DL5B; KIR3DL1/S1; NKAT-3;
                     NKAT3; NKB1; NKB1B"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1 (reference allele); natural killer-associated
                     transcript 3; killer cell immunoglobulin-like receptor,
                     three domains, long cytoplasmic tail, 1; p70 killer cell
                     inhibitory receptor; killer cell immunoglobulin-like
                     receptor 3DL1; KIR antigen 3DL1; p70 NK receptor
                     CL-2/CL-11; CD158 antigen-like family member E;
                     HLA-BW4-specific inhibitory NK cell receptor; p70 natural
                     killer cell receptor clones CL-2/CL-11"
                     /codon_start=1
                     /product="killer cell immunoglobulin-like receptor 3DL1
                     isoform 1 precursor"
                     /protein_id="NP_037421.2"
                     /db_xref="CCDS:CCDS42621.1"
                     /db_xref="GeneID:3811"
                     /db_xref="HGNC:HGNC:6338"
                     /db_xref="MIM:604946"
                     /translation="MSLMVVSMACVGLFLVQRAGPHMGGQDKPFLSAWPSAVVPRGGH
                     VTLRCHYRHRFNNFMLYKEDRIHIPIFHGRIFQESFNMSPVTTAHAGNYTCRGSHPHS
                     PTGWSAPSNPVVIMVTGNHRKPSLLAHPGPLVKSGERVILQCWSDIMFEHFFLHKEGI
                     SKDPSRLVGQIHDGVSKANFSIGPMMLALAGTYRCYGSVTHTPYQLSAPSDPLDIVVT
                     GPYEKPSLSAQPGPKVQAGESVTLSCSSRSSYDMYHLSREGGAHERRLPAVRKVNRTF
                     QADFPLGPATHGGTYRCFGSFRHSPYEWSDPSDPLLVSVTGNPSSSWPSPTEPSSKSG
                     NPRHLHILIGTSVVIILFILLLFFLLHLWCSNKKNAAVMDQEPAGNRTANSEDSDEQD
                     PEEVTYAQLDHCVFTQRKITRPSQRPKTPPTDTILYTELPNAKPRSKVVSCP"
     exon            68..103
                     /gene="KIR3DL1"
                     /gene_synonym="CD158E1; KIR; KIR2DL5B; KIR3DL1/S1; NKAT-3;
                     NKAT3; NKB1; NKB1B"
                     /inference="alignment:Splign:2.1.0"
     exon            104..388
                     /gene="KIR3DL1"
                     /gene_synonym="CD158E1; KIR; KIR2DL5B; KIR3DL1/S1; NKAT-3;
                     NKAT3; NKB1; NKB1B"
                     /inference="alignment:Splign:2.1.0"
     exon            389..688
                     /gene="KIR3DL1"
                     /gene_synonym="CD158E1; KIR; KIR2DL5B; KIR3DL1/S1; NKAT-3;
                     NKAT3; NKB1; NKB1B"
                     /inference="alignment:Splign:2.1.0"
     exon            689..982
                     /gene="KIR3DL1"
                     /gene_synonym="CD158E1; KIR; KIR2DL5B; KIR3DL1/S1; NKAT-3;
                     NKAT3; NKB1; NKB1B"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1033
                     /gene="KIR3DL1"
                     /gene_synonym="CD158E1; KIR; KIR2DL5B; KIR3DL1/S1; NKAT-3;
                     NKAT3; NKB1; NKB1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1138
                     /gene="KIR3DL1"
                     /gene_synonym="CD158E1; KIR; KIR2DL5B; KIR3DL1/S1; NKAT-3;
                     NKAT3; NKB1; NKB1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1191
                     /gene="KIR3DL1"
                     /gene_synonym="CD158E1; KIR; KIR2DL5B; KIR3DL1/S1; NKAT-3;
                     NKAT3; NKB1; NKB1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1871
                     /gene="KIR3DL1"
                     /gene_synonym="CD158E1; KIR; KIR2DL5B; KIR3DL1/S1; NKAT-3;
                     NKAT3; NKB1; NKB1B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcgcagc cgcctgtctg caccggcagc accatgtcgc tcatggtcgt cagcatggcg
       61 tgtgttgggt tgttcttggt ccagagggcc ggtccacaca tgggtggtca ggacaaaccc
      121 ttcctgtctg cctggcccag cgctgtggtg cctcgaggag gacacgtgac tcttcggtgt
      181 cactatcgtc ataggtttaa caatttcatg ctatacaaag aagacagaat ccacattccc
      241 atcttccatg gcagaatatt ccaggagagc ttcaacatga gccctgtgac cacagcacat
      301 gcagggaact acacatgtcg gggttcacac ccacactccc ccactgggtg gtcggcaccc
      361 agcaaccccg tggtgatcat ggtcacagga aaccacagaa aaccttccct cctggcccac
      421 ccaggtcccc tggtgaaatc aggagagaga gtcatcctgc aatgttggtc agatatcatg
      481 tttgagcact tctttctgca caaagagggg atctctaagg acccctcacg cctcgttgga
      541 cagatccatg atggggtctc caaggccaat ttctccatcg gtcccatgat gcttgccctt
      601 gcagggacct acagatgcta cggttctgtt actcacaccc cctatcagtt gtcagctccc
      661 agtgatcccc tggacatcgt ggtcacaggt ccatatgaga aaccttctct ctcagcccag
      721 ccgggcccca aggttcaggc aggagagagc gtgaccttgt cctgtagctc ccggagctcc
      781 tatgacatgt accatctatc cagggagggg ggagcccatg aacgtaggct ccctgcagtg
      841 cgcaaggtca acagaacatt ccaggcagat ttccctctgg gccctgccac ccacggaggg
      901 acctacagat gcttcggctc tttccgtcac tctccctacg agtggtcaga cccgagtgac
      961 ccactgcttg tttctgtcac aggaaaccct tcaagtagtt ggccttcacc cacagaacca
     1021 agctccaaat ctggtaaccc cagacacctg cacattctga ttgggacctc agtggtcatc
     1081 atcctcttca tcctcctcct cttctttctc cttcatctct ggtgctccaa caaaaaaaat
     1141 gctgctgtaa tggaccaaga gcctgcaggg aacagaacag ccaacagcga ggactctgat
     1201 gaacaagacc ctgaggaggt gacatacgca cagttggatc actgcgtttt cacacagaga
     1261 aaaatcactc gcccttctca gaggcccaag acacccccta cagataccat cttgtacacg
     1321 gaacttccaa atgctaagcc cagatccaaa gttgtctcct gcccatgagc accacagtca
     1381 ggccttgagg acgtcttcta gggagacaac agccctgtct caaaaccgag ttgccagctc
     1441 ccatgtacca gcagctggaa tctgaaggcg tgagtcttca tcttagggca tcgctcctcc
     1501 tcacgccaca aatctggtgc ctctctcttg cttacaaatg tctaggtccc cactgcctgc
     1561 tggaaagaaa acacactcct ttgcttagcc cacagttctc catttcactt gacccctgcc
     1621 cacctctcca acctaactgg cttacttcct agtctacttg aggctgcaat cacactgagg
     1681 aactcacaat tccaaacata caagaggctc cctcttgacg tggcacttac ccacgtgctg
     1741 ttccaccttc cctcatgctg tttcaccttt cttcggacta ttttccagcc ttctgtcagc
     1801 agtgaaactt ataaaatttt ttgtgatttc aatgtagctg tctcctcttc aaataaacat
     1861 gtctgccctc a
//
