LOCUS       NM_015868               1592 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens killer cell immunoglobulin like receptor, two Ig
            domains and long cytoplasmic tail 3 (KIR2DL3), mRNA.
ACCESSION   NM_015868
VERSION     NM_015868.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1592)
  AUTHORS   Li,Y. and Deng,Z.
  TITLE     A single nucleotide substitution in exon 5 generated the novel
            KIR2DL3*00112 allele
  JOURNAL   HLA 103 (6), e15557 (2024)
   PUBMED   38837671
  REMARK    GeneRIF: A single nucleotide substitution in exon 5 generated the
            novel KIR2DL3*00112 allele.
REFERENCE   2  (bases 1 to 1592)
  AUTHORS   Teshnizi,S.H., Mirzazadeh,S., Mashhadi,N., Meri,S., Kabelitz,D. and
            Kalantar,K.
  TITLE     Association study between killer immunoglobulin-like receptor
            polymorphisms and susceptibility to COVID-19 disease: a systematic
            review and meta-analysis
  JOURNAL   Immunol Res 72 (2), 175-184 (2024)
   PUBMED   37874432
  REMARK    GeneRIF: Association study between killer immunoglobulin-like
            receptor polymorphisms and susceptibility to COVID-19 disease: a
            systematic review and meta-analysis.
            Review article
REFERENCE   3  (bases 1 to 1592)
  AUTHORS   Sezgin,G., Goruroglu Ozturk,O., Ozkan,A., Kupeli,S. and Bayram,I.
  TITLE     Clinical Impact of KIR2DS3 and KIR2DL3 Genes in Neuroblastoma
            Patients
  JOURNAL   Med Princ Pract 31 (6), 532-539 (2022)
   PUBMED   35537400
  REMARK    GeneRIF: Clinical Impact of KIR2DS3 and KIR2DL3 Genes in
            Neuroblastoma Patients.
REFERENCE   4  (bases 1 to 1592)
  AUTHORS   Palamarchuk,A.I., Alekseeva,N.A., Streltsova,M.A.,
            Ustiuzhanina,M.O., Kobyzeva,P.A., Kust,S.A., Grechikhina,M.V.,
            Boyko,A.A., Shustova,O.A., Sapozhnikov,A.M. and Kovalenko,E.I.
  TITLE     Increased Susceptibility of the CD57- NK Cells Expressing KIR2DL2/3
            and NKG2C to iCasp9 Gene Retroviral Transduction and the
            Relationships with Proliferative Potential, Activation Degree, and
            Death Induction Response
  JOURNAL   Int J Mol Sci 22 (24), 13326 (2021)
   PUBMED   34948123
  REMARK    GeneRIF: Increased Susceptibility of the CD57(-) NK Cells
            Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral
            Transduction and the Relationships with Proliferative Potential,
            Activation Degree, and Death Induction Response.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1592)
  AUTHORS   Moradi,S., Stankovic,S., O'Connor,G.M., Pymm,P., MacLachlan,B.J.,
            Faoro,C., Retiere,C., Sullivan,L.C., Saunders,P.M., Widjaja,J.,
            Cox-Livingstone,S., Rossjohn,J., Brooks,A.G. and Vivian,J.P.
  TITLE     Structural plasticity of KIR2DL2 and KIR2DL3 enables altered
            docking geometries atop HLA-C
  JOURNAL   Nat Commun 12 (1), 2173 (2021)
   PUBMED   33846289
  REMARK    GeneRIF: Structural plasticity of KIR2DL2 and KIR2DL3 enables
            altered docking geometries atop HLA-C.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1592)
  AUTHORS   Olcese,L., Lang,P., Vely,F., Cambiaggi,A., Marguet,D., Blery,M.,
            Hippen,K.L., Biassoni,R., Moretta,A., Moretta,L., Cambier,J.C. and
            Vivier,E.
  TITLE     Human and mouse killer-cell inhibitory receptors recruit PTP1C and
            PTP1D protein tyrosine phosphatases
  JOURNAL   J Immunol 156 (12), 4531-4534 (1996)
   PUBMED   8648092
REFERENCE   7  (bases 1 to 1592)
  AUTHORS   Burshtyn,D.N., Scharenberg,A.M., Wagtmann,N., Rajagopalan,S.,
            Berrada,K., Yi,T., Kinet,J.P. and Long,E.O.
  TITLE     Recruitment of tyrosine phosphatase HCP by the killer cell
            inhibitor receptor
  JOURNAL   Immunity 4 (1), 77-85 (1996)
   PUBMED   8574854
REFERENCE   8  (bases 1 to 1592)
  AUTHORS   Wagtmann,N., Biassoni,R., Cantoni,C., Verdiani,S., Malnati,M.S.,
            Vitale,M., Bottino,C., Moretta,L., Moretta,A. and Long,E.O.
  TITLE     Molecular clones of the p58 NK cell receptor reveal
            immunoglobulin-related molecules with diversity in both the extra-
            and intracellular domains
  JOURNAL   Immunity 2 (5), 439-449 (1995)
   PUBMED   7749980
REFERENCE   9  (bases 1 to 1592)
  AUTHORS   Colonna,M. and Samaridis,J.
  TITLE     Cloning of immunoglobulin-superfamily members associated with HLA-C
            and HLA-B recognition by human natural killer cells
  JOURNAL   Science 268 (5209), 405-408 (1995)
   PUBMED   7716543
REFERENCE   10 (bases 1 to 1592)
  AUTHORS   Luria,S., Gross,G., Horowitz,M. and Givol,D.
  TITLE     Promoter and enhancer elements in the rearranged alpha chain gene
            of the human T cell receptor
  JOURNAL   EMBO J 6 (11), 3307-3312 (1987)
   PUBMED   3501368
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L41268.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_015868.2.
            
            Summary: Killer cell immunoglobulin-like receptors (KIRs) are
            transmembrane glycoproteins expressed by natural killer cells and
            subsets of T cells. The KIR genes are polymorphic and highly
            homologous and they are found in a cluster on chromosome 19q13.4
            within the 1 Mb leukocyte receptor complex (LRC). The gene content
            of the KIR gene cluster varies among haplotypes, although several
            'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
            KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of
            extracellular immunoglobulin domains (2D or 3D) and by whether they
            have a long (L) or short (S) cytoplasmic domain. KIR proteins with
            the long cytoplasmic domain transduce inhibitory signals upon
            ligand binding via an immune tyrosine-based inhibitory motif
            (ITIM), while KIR proteins with the short cytoplasmic domain lack
            the ITIM motif and instead associate with the TYRO protein tyrosine
            kinase binding protein to transduce activating signals. The ligands
            for several KIR proteins are subsets of HLA class I molecules;
            thus, KIR proteins are thought to play an important role in
            regulation of the immune response. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L41268.1, BC050730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2153031
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342376.4/ ENSP00000342215.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1592              L41268.1           5-1596
FEATURES             Location/Qualifiers
     source          1..1592
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1592
                     /gene="KIR2DL3"
                     /gene_synonym="CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b;
                     KIR-K7c; KIR2DL; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A;
                     NKAT2B; p58"
                     /note="killer cell immunoglobulin like receptor, two Ig
                     domains and long cytoplasmic tail 3"
                     /db_xref="GeneID:3804"
                     /db_xref="HGNC:HGNC:6331"
                     /db_xref="MIM:604938"
     exon            1..67
                     /gene="KIR2DL3"
                     /gene_synonym="CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b;
                     KIR-K7c; KIR2DL; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A;
                     NKAT2B; p58"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1059
                     /gene="KIR2DL3"
                     /gene_synonym="CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b;
                     KIR-K7c; KIR2DL; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A;
                     NKAT2B; p58"
                     /note="natural killer associated transcript 2; killer cell
                     immunoglobulin-like receptor, two domains, short
                     cytoplasmic tail, 5; p58.2 MHC class-I specific NK
                     receptor; killer cell immunoglobulin-like receptor 2DL3;
                     natural killer cell inhibitory receptor KIR2DL3; NKAT-2;
                     killer cell immunoglobulin-like receptor two domains long
                     cytoplasmic tail 3; p58 NK receptor CL-6; killer
                     inhibitory receptor cl 2-3; CD158 antigen-like family
                     member B2; p58 natural killer cell receptor clone CL-6"
                     /codon_start=1
                     /product="killer cell immunoglobulin-like receptor 2DL3
                     precursor"
                     /protein_id="NP_056952.2"
                     /db_xref="CCDS:CCDS33107.1"
                     /db_xref="GeneID:3804"
                     /db_xref="HGNC:HGNC:6331"
                     /db_xref="MIM:604938"
                     /translation="MSLMVVSMVCVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEET
                     VILQCWSDVRFQHFLLHREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYG
                     SVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHL
                     SREGEAHERRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLV
                     SVTGNPSNSWPSPTEPSSETGNPRHLHVLIGTSVVIILFILLLFFLLHRWCCNKKNAV
                     VMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQRKITRPSQRPKTPPTDIIVYT
                     ELPNAEP"
     exon            68..103
                     /gene="KIR2DL3"
                     /gene_synonym="CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b;
                     KIR-K7c; KIR2DL; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A;
                     NKAT2B; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            104..403
                     /gene="KIR2DL3"
                     /gene_synonym="CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b;
                     KIR-K7c; KIR2DL; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A;
                     NKAT2B; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            404..697
                     /gene="KIR2DL3"
                     /gene_synonym="CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b;
                     KIR-K7c; KIR2DL; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A;
                     NKAT2B; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            698..748
                     /gene="KIR2DL3"
                     /gene_synonym="CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b;
                     KIR-K7c; KIR2DL; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A;
                     NKAT2B; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            749..853
                     /gene="KIR2DL3"
                     /gene_synonym="CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b;
                     KIR-K7c; KIR2DL; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A;
                     NKAT2B; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            854..906
                     /gene="KIR2DL3"
                     /gene_synonym="CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b;
                     KIR-K7c; KIR2DL; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A;
                     NKAT2B; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1592
                     /gene="KIR2DL3"
                     /gene_synonym="CD158b; CD158B2; GL183; KIR-023GB; KIR-K7b;
                     KIR-K7c; KIR2DL; KIR2DS5; KIRCL23; NKAT; NKAT2; NKAT2A;
                     NKAT2B; p58"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcgcggc cgcctgtctg cacagacagc accatgtcgc tcatggtcgt cagcatggtg
       61 tgtgttgggt tcttcttgct gcagggggcc tggccacatg agggagtcca cagaaaacct
      121 tccctcctgg cccacccagg tcccctggtg aaatcagaag agacagtcat cctgcaatgt
      181 tggtcagatg tcaggtttca gcacttcctt ctgcacagag aagggaagtt taaggacact
      241 ttgcacctca ttggagagca ccatgatggg gtctccaagg ccaacttctc catcggtccc
      301 atgatgcaag accttgcagg gacctacaga tgctacggtt ctgttactca ctccccctat
      361 cagttgtcag ctcccagtga ccctctggac atcgtcatca caggtctata tgagaaacct
      421 tctctctcag cccagccggg ccccacggtt ctggcaggag agagcgtgac cttgtcctgc
      481 agctcccgga gctcctatga catgtaccat ctatccaggg agggggaggc ccatgaacgt
      541 aggttctctg cagggcccaa ggtcaacgga acattccagg ccgactttcc tctgggccct
      601 gccacccacg gaggaaccta cagatgcttc ggctctttcc gtgactctcc atacgagtgg
      661 tcaaactcga gtgacccact gcttgtttct gtcacaggaa acccttcaaa tagttggcct
      721 tcacccactg aaccaagctc cgaaaccggt aaccccagac acctgcatgt tctgattggg
      781 acctcagtgg tcatcatcct cttcatcctc ctcctcttct ttctccttca tcgctggtgc
      841 tgcaacaaaa aaaatgctgt tgtaatggac caagagcctg cagggaacag aacagtgaac
      901 agggaggact ctgatgaaca agaccctcag gaggtgacat atgcacagtt gaatcactgc
      961 gttttcacac agagaaaaat cactcgccct tctcagaggc ccaagacacc cccaacagat
     1021 atcatcgtgt acacggaact tccaaatgct gagccctgat ccaaagttgt ctcctgccca
     1081 tgagcaccac agtcaggcct tgaggggatc ttctagggag acaacagccc tgtctcaaaa
     1141 ctgggttgcc agctccaatg taccagcagc tggaatctga aggcgtgagt ctgcatctta
     1201 gggcatcgct cttcctcaca ccacaaatct gaacgtgcct ctcccttgct tacaaatgtc
     1261 taaggtcccc actgcctgct ggagagaaaa cacactcctt tgcttagccc acaattctcc
     1321 atttcacttg acccctgccc acctctccaa cctaactggc ttacttccta gtctacttga
     1381 ggctgcaatc acactgagga actcacaatt ccaaacatac aagaggctcc ctcttaacac
     1441 ggcacttaga cacgtgctgt tccaccttcc ctcatgctgt tccacctccc ctcagactag
     1501 ctttcagcct tctgtcagca gtaaaactta tatatttttt aaaataattt caatgtagtt
     1561 ttccctcctt caaataaaca tgtctgccct ca
//
