LOCUS       NM_012311               6360 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens Kin17 DNA and RNA binding protein (KIN), transcript
            variant 1, mRNA.
ACCESSION   NM_012311
VERSION     NM_012311.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6360)
  AUTHORS   Huang,X., Dai,Z., Zeng,B., Xiao,X., Zahid,K.R., Lin,X., Liu,T. and
            Zeng,T.
  TITLE     KIN17 functions in DNA damage repair and chemosensitivity by
            modulating RAD51 in hepatocellular carcinoma
  JOURNAL   Hum Cell 37 (5), 1489-1504 (2024)
   PUBMED   38935235
  REMARK    GeneRIF: KIN17 functions in DNA damage repair and chemosensitivity
            by modulating RAD51 in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 6360)
  AUTHORS   Dai,Z., Huang,Q., Huang,X., Zhu,C., Zahid,K.R., Liu,T., Li,Q.,
            Wu,C., Peng,M., Xiao,X., Raza,U., Yu,N. and Zeng,T.
  TITLE     KIN17 promotes cell migration and invasion through stimulating the
            TGF-beta/Smad2 pathway in hepatocellular carcinoma
  JOURNAL   Mol Carcinog 62 (3), 369-384 (2023)
   PUBMED   36468848
  REMARK    GeneRIF: KIN17 promotes cell migration and invasion through
            stimulating the TGF-beta/Smad2 pathway in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 6360)
  AUTHORS   de Lourenco,I.O., Seixas,F.A.V., Fernandez,M.A., Almeida,F.C.L.,
            Fossey,M.A., de Souza,F.P. and Caruso,I.P.
  TITLE     1H, 15N, and 13C resonance assignments of the SH3-like tandem
            domain of human KIN protein
  JOURNAL   Biomol NMR Assign 15 (2), 449-453 (2021)
   PUBMED   34417717
  REMARK    GeneRIF: [1]H, [15]N, and [13]C resonance assignments of the
            SH3-like tandem domain of human KIN protein.
REFERENCE   4  (bases 1 to 6360)
  AUTHORS   Gaspar,V.P., Ramos,A.C., Cloutier,P., Pattaro Junior,J.R., Duarte
            Junior,F.F., Bouchard,A., Seixas,F.A.V., Coulombe,B. and
            Fernandez,M.A.
  TITLE     Interactome Analysis of KIN (Kin17) Shows New Functions of This
            Protein
  JOURNAL   Curr Issues Mol Biol 43 (2), 767-781 (2021)
   PUBMED   34449532
  REMARK    GeneRIF: Interactome Analysis of KIN (Kin17) Shows New Functions of
            This Protein.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6360)
  AUTHORS   Huang,Q., Zahid,K.R., Chen,J., Pang,X., Zhong,M., Huang,H., Pan,W.,
            Yin,J., Raza,U., Zeng,J., Zhu,X. and Zeng,T.
  TITLE     KIN17 promotes tumor metastasis by activating EMT signaling in
            luminal-A breast cancer
  JOURNAL   Thorac Cancer 12 (13), 2013-2023 (2021)
   PUBMED   34008927
  REMARK    GeneRIF: KIN17 promotes tumor metastasis by activating EMT
            signaling in luminal-A breast cancer.
REFERENCE   6  (bases 1 to 6360)
  AUTHORS   Kannouche,P., Mauffrey,P., Pinon-Lataillade,G., Mattei,M.G.,
            Sarasin,A., Daya-Grosjean,L. and Angulo,J.F.
  TITLE     Molecular cloning and characterization of the human KIN17 cDNA
            encoding a component of the UVC response that is conserved among
            metazoans
  JOURNAL   Carcinogenesis 21 (9), 1701-1710 (2000)
   PUBMED   10964102
REFERENCE   7  (bases 1 to 6360)
  AUTHORS   Blattner,C., Kannouche,P., Litfin,M., Bender,K., Rahmsdorf,H.J.,
            Angulo,J.F. and Herrlich,P.
  TITLE     UV-Induced stabilization of c-fos and other short-lived mRNAs
  JOURNAL   Mol Cell Biol 20 (10), 3616-3625 (2000)
   PUBMED   10779351
REFERENCE   8  (bases 1 to 6360)
  AUTHORS   Kannouche,P. and Angulo,J.F.
  TITLE     Overexpression of kin17 protein disrupts nuclear morphology and
            inhibits the growth of mammalian cells
  JOURNAL   J Cell Sci 112 (Pt 19), 3215-3224 (1999)
   PUBMED   10504327
REFERENCE   9  (bases 1 to 6360)
  AUTHORS   Biard,D.S., Saintigny,Y., Maratrat,M., Vozenin,M.C., Martin,M.,
            Daburon,F. and Angulo,J.F.
  TITLE     Differential expression of the HsKin17 protein during
            differentiation of in vitro reconstructed human skin
  JOURNAL   Arch Dermatol Res 289 (8), 448-456 (1997)
   PUBMED   9266022
REFERENCE   10 (bases 1 to 6360)
  AUTHORS   Angulo,J.F., Rouer,E., Mazin,A., Mattei,M.G., Tissier,A.,
            Horellou,P., Benarous,R. and Devoret,R.
  TITLE     Identification and expression of the cDNA of KIN17, a zinc-finger
            gene located on mouse chromosome 2, encoding a new DNA-binding
            protein
  JOURNAL   Nucleic Acids Res 19 (19), 5117-5123 (1991)
   PUBMED   1923796
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301789.1, AJ005273.1,
            AL158044.17 and AA768850.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012311.3.
            
            Summary: The protein encoded by this gene is a nuclear protein that
            forms intranuclear foci during proliferation and is redistributed
            in the nucleoplasm during the cell cycle. Short-wave ultraviolet
            light provokes the relocalization of the protein, suggesting its
            participation in the cellular response to DNA damage. Originally
            selected based on protein-binding with RecA antibodies, the mouse
            protein presents a limited similarity with a functional domain of
            the bacterial RecA protein, a characteristic shared by this human
            ortholog. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.8556.1,
                                           SRR1660805.187703.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379562.9/ ENSP00000368881.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK301789.1         35-58
            25-1516             AJ005273.1         30-1521
            1517-6345           AL158044.17        134602-139430       c
            6346-6360           AA768850.1         8-22                c
FEATURES             Location/Qualifiers
     source          1..6360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p14"
     gene            1..6360
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /note="Kin17 DNA and RNA binding protein"
                     /db_xref="GeneID:22944"
                     /db_xref="HGNC:HGNC:6327"
                     /db_xref="MIM:601720"
     exon            1..174
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1242
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /note="binding to curved DNA; KIN, antigenic determinant
                     of recA protein homolog"
                     /codon_start=1
                     /product="DNA/RNA-binding protein KIN17"
                     /protein_id="NP_036443.1"
                     /db_xref="CCDS:CCDS7080.1"
                     /db_xref="GeneID:22944"
                     /db_xref="HGNC:HGNC:6327"
                     /db_xref="MIM:601720"
                     /translation="MGKSDFLTPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCH
                     CMSESHQRQLLLASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHR
                     EHIHMNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELEKKKK
                     QDLDDEEKTAKFIEEQVRRGLEGKEQEVPTFTELSRENDEEKVTFNLSKGACSSSGAT
                     SSKSSTLGPSALKTIGSSASVKRKESSQSSTQSKEKKKKKSALDEIMEIEEEKKRTAR
                     TDYWLQPEIIVKIITKKLGEKYHKKKAIVKEVIDKYTAVVKMIDSGDKLKLDQTHLET
                     VIPAPGKRILVLNGGYRGNEGTLESINEKTFSATIVIETGPLKGRRVEGIQYEDISKL
                     A"
     exon            175..269
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     exon            270..313
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..436
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     exon            437..618
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     exon            619..667
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..728
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..858
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..909
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..978
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1078
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1179
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..6360
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1496..1501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /note="hexamer: ATTAAA"
     polyA_site      1516
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /note="major polyA site"
     regulatory      4088..4093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /note="hexamer: AATAAA"
     polyA_site      4113
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
     regulatory      6335..6340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
                     /note="hexamer: AATAAA"
     polyA_site      6360
                     /gene="KIN"
                     /gene_synonym="BTCD; KIN17; Rts2"
ORIGIN      
        1 ggttccgttt ccggctggct gagtactggg gtccagaaag tgatcgctgc cgtggtcgcc
       61 atggggaagt cggattttct tactcccaag gctatcgcca acaggatcaa gtccaagggg
      121 ctgcagaagc tacgctggta ttgccagatg tgccagaagc agtgccggga cgagaatggc
      181 tttaagtgtc attgtatgtc cgaatctcat cagagacaac tattgctggc ttcagaaaat
      241 cctcagcagt ttatggatta tttttcagag gaattccgaa atgactttct agaacttctc
      301 aggagacgct ttggcactaa aagggtccac aacaacattg tctacaacga atacatcagc
      361 caccgagagc acatccacat gaatgccact cagtgggaaa ctctgactga ttttactaag
      421 tggctgggca gagaaggctt gtgcaaagtg gacgagacac caaaaggctg gtatattcag
      481 tacatagaca gggacccaga aactatccgc cggcaactgg aactggagaa aaagaaaaag
      541 caggaccttg atgatgaaga aaaaactgcc aaatttattg aagagcaagt gagaagaggc
      601 ctggaaggga aggaacagga ggtccctact tttacggaat taagcagaga aaatgatgaa
      661 gagaaagtca cgtttaattt gagtaaagga gcatgtagct catccggagc aacatcttcc
      721 aagtcaagta ctctgggacc gagtgcactg aagacgatag gaagttcagc atcagtgaaa
      781 cgaaaagaat cttcccagag ctcaactcag tctaaagaaa agaagaaaaa gaaatctgca
      841 ctggatgaaa tcatggagat tgaagaggaa aagaaaagaa ctgcccgaac agactactgg
      901 ctacagcctg aaattattgt gaaaattata accaagaaac tgggagagaa atatcataag
      961 aaaaaggcta ttgttaagga agtaattgac aaatatacag ctgttgtgaa gatgattgat
     1021 tctggagaca agctgaaact tgaccagact catttagaga cagtaattcc agcaccagga
     1081 aaaagaattc tagttttaaa tggaggctac agaggaaatg aaggtaccct agaatccatc
     1141 aatgagaaga ctttttcagc tactatcgtc attgaaactg gccctttaaa aggacgcaga
     1201 gttgaaggaa ttcaatatga agacatttct aaacttgcct gagtttgaaa atttgttaac
     1261 aatacattaa aatcttaaag catcaaattg gtgttcgcca aggcattatg agactctact
     1321 gtgttagggt atattctttt gtataaaaca aacaggtttt tgaaaatatt actgtatagt
     1381 tgttcagcta aactttgaga agaatttaat tatgtctcat gaggtatcaa actatgtaat
     1441 tttgtccttg ttatttttgt ttcctttgta atttacttga tgagtttata tcttcattaa
     1501 agaatgttat tataaagtgt tttatctatg acaatttaga atcatgtaat tggaggaaat
     1561 ccttcataca ctctatattt tcagtagtag agtagtaaag ttgaactcta agtgtgacta
     1621 aattttaaat gtcaaactat aaatatagaa gcagctttat tgtggtaata attcatatac
     1681 catacagttc actcatttaa aatatacata caattcagtg gtttttagta tttttgcaga
     1741 attgtgcagc catcaccact gtctgatttt aaaacacttt cataccccaa aatgaaaccc
     1801 tttaatagtc aatcgctatt tttcccctct gccctagccc tagacagcca ctaatgtact
     1861 ttctgtctct atggatttgc cctttctgga catttcttat aaatggaatc atataatatg
     1921 tgatctttta tgactggctt cttacactta gcatcatgtt ttcaaggttt atccatgcag
     1981 tagcatgtag gcgtgcttca tttgttttta tggctgctta atattccact gtatggatgt
     2041 accgtatttt gtttgtccat tcatcagctg ataaacattt agattgtttc tactttttgg
     2101 ctattgtgaa taatgctgcc atgatcaccc atttacagga ttttatgtga acagaagctt
     2161 tcgcttctgc caaactcttc cagagcagct ataccatttt acagtcctac cagcaatgtt
     2221 gaactatagt tttatttgtt tttaattttt ttacttttag agacatggtc tcactgtgtt
     2281 gcccaggctg ctgtcaaact cctgggctca agtgatcctc ctgcctcagc ctcccaaagt
     2341 gctaggattg caggtgtgag ccacagcacc ctgcctaacc atacagtttg aaataagtag
     2401 ggcagtgtat tattagggaa tgcaaaagac aggaaaccca catttgcctg tgccaaagga
     2461 aaaacgaagg gatatttgta gtgcacatga ctgaaaggag cagacgctag cttccagggc
     2521 agcgggaccg ggtgtgaaca gccttccctg ggcttccgct ctgtctctgg ctcctgtgct
     2581 ggctctctac atttacattc ttgagcactc taggtttaca tcttaccctt cagcagcacc
     2641 gggaagagag agatgatcta tcttttcttt ttcttttttt ttttttttct gacacagagt
     2701 ctcactctgt cacccaggct gattgcagta gtgcaatctc ggctcactgc aacctccacc
     2761 tcccgggttc aagccattct cctgcctcag cctcctgagt agctgggact acaggcatgc
     2821 gccaccacgc ccagctaatt tttgtaattt tagaagagat gaggtttcac catgttggcc
     2881 aggatggtct cgatctcttg accttatgat ctgcccgcct cagcctccca aagtgctggg
     2941 attacaggca tgagccacta cgcctctttt tttttgttct gttttttgag atagggtctt
     3001 gctctgtcat ccagcctgga gtgcagtggc acaatcatgg ctcactgcag cctcgtcctc
     3061 ctgggcttag gtcattgatt ctcccacctc agcctcccga gtagctggga ctacaggcat
     3121 gcactaccat gcctggctaa tttttttgat ttttagtaga gatgaggtct tgctatgttg
     3181 cccaggctgg tctcaaactc ttgagctcaa gcaatcctcc tgcctcggcc ttctaaaatg
     3241 ttgtgattac aggtgtgagc taccacgcct tgcctgagtt gatcttctac aagagttcaa
     3301 acaaaaaaca gaccatacca ggatgatcac ttcaaacatg aggatgggta taagctgacg
     3361 tcagacacag gtatggtgcc aaaccctggg atctctctct ttaactgaga gtcagggagg
     3421 gctgattgct tctattctca gaagatggga gaacgtatgc tgttagcaga aatgtaagag
     3481 gcagtaaaga aatactaata ggatgatggc agaagcttta cagaaaatgt tcctcaggga
     3541 tgaattaagg tttttccaaa gtaacctgac agcacattat ggaaagcaac tgggttttgg
     3601 gtgtgggcag tctttagatc aaattctggc agttctgttc attggctttg taatattaga
     3661 atgttaatgt tcttgaattg caatgttttt aatgtataaa ttgtcaaaat gtttttcagc
     3721 agggttgatg ggagacctac agaaaataca tataaatcat cagacatgaa gtccagcaca
     3781 tagtaggtat tgaataaatg gcagtgagtg gtcatgtcca gaaatgaagc caagaagttg
     3841 agcctggact actaagaatc tggtctgaag aatttcaaaa aggagaatgg ttctccctga
     3901 taacaaatag tgatgagtaa aaccagacaa attacatatg cctcccccaa gtatgtacgt
     3961 ttggaatcaa cttggtggtt ttcttcagag aaaaaatgtt tcatgtctgc ctcccacatt
     4021 taattctcca acgtctttct gaaattattt cagaatgaaa tgaggcagca tacttgaggt
     4081 taaattcaat aaaaaatatc tgaagcataa aaatacgatt atagacttca cagtagtttt
     4141 ttccctctga gtctgtagaa cttgatagag tttatgctaa gcaaaatgac tgcagataac
     4201 taacaacagg tctcatatta gactttgatt tttgaagtat cataagctat ttttctttat
     4261 ttcaaacata gactttactt tttagagcag tctctgtggg ttttgacaaa tgtataatga
     4321 catgcatctg ccactgtagt atcacacaga acagtttcac tgccctagaa gtttcctgtg
     4381 ttctgtctgt tccctgtctc cccccaaatc cctgctgacc gctgatcttt ttactgtctc
     4441 cctagttttg tctccatcga aggtcatata gttggagtca cacagggtgt agctttttca
     4501 gattggcttc tttcacctgg tagaacatat gcatgtaagg ttcctccatg ttgttttggt
     4561 taggtttttg tggctcgata gcgcacttca ttttagcact gcatattcta ttgtctgaat
     4621 gcaccacagt ttatgcactc acctactgaa ggatatcttg gttgcttaca aggtttggaa
     4681 attatgagta aagctgctac aaacatctgt gcgcaggttt tttgtggata gacgttttca
     4741 acttatttac gtaacgacca aagagcacaa ttgctggatc atatgccagg agtcttctga
     4801 gaaactacca acctgtcttc cagagtgact gtaccatttt gtattcaaac gagcagtgaa
     4861 tgagagttcc tgctgctctg catctccgtc agcatttgat gttgtcagtg ttctggattt
     4921 tggccatctt aatagctgta cagtgggatc ttgtcattgc tttaatttgc atttctttga
     4981 tgaagtatga tgtggagcat cttttcatgg gcttatttgc cacctgtata tcttctctgg
     5041 tgagatgtct ttcaggtttt ttgcccatta tttaattggg ttactcattt tcttattgtt
     5101 gaattttaag agttgtttgt atatttcagt tgtgttcttt atcgaatgtg tcttttgcaa
     5161 gtattttctc tcagtcagtg gcctgtcttc tcattttgtt ttaagctatt cttttttaac
     5221 accccaagat tttcatcgtt actttttttt tttttttttt tttttttttt tttttttttt
     5281 gagacggagt ctcgctctgt cgcccaggcc ggactgcgga ctgcagtggc gcaatctcgg
     5341 ctcactgcaa gctccgcttc ccgggttcac gccattctcc tgcctcagcc tcccgagtag
     5401 ctgggactac aggcgcccgc caccgcgccc ggctaatttt ttgtattttt agtacatcgt
     5461 tacttttaag accactgtgc acacataaaa tactaaaagc taaacttaat atctgcaggt
     5521 agaagtttta aattcaagat tttaaccaaa taacagagtt aatgctaaaa tctcactttt
     5581 gaagtttatg ttgaatatta gcattctaat atttaatatt tttctatttt tgaaatagga
     5641 aatggaaaag atgcagtagg tttttcaaaa gggtatcata ggtgagcact tcttatagaa
     5701 gaagaaaact aagaggtagt gctatttacc tcttcagcac taagtttatc tttattttta
     5761 tttatttcta taaagagatg ggagtctcac tgtgttgctt aggctggtct tgaactcctg
     5821 gcctccagtg atgctcctgc cttggcctcc gagagtgctg ggattatagg catgaggcac
     5881 cacacccagc cagtaatctt tagcttctag aaacaatcag atttccttaa gattttgcaa
     5941 ttaggtttag aggagctcac ttgctttttc aaatatgggt tggatatgtc caaaaaaaga
     6001 gttttgcctc tacaatgaaa aatgattttt accagattat ggaaaggaag attcataaaa
     6061 atgtgccttt aaaaagcttt tttaaagtgc aagttcacca atttgacttt tgaaaatacg
     6121 ttcattttag gaattgattt tttaaggaaa gttgtaaaca cagcaaagca cagaattaca
     6181 ctggttcaga cttgcatctt agcaccaaaa tccactatac aaatgcagac agcataaagt
     6241 aacctagttt cgctttaaat ttgttgctta ttttattctc ccttataaat gtcattggtc
     6301 ttttgttaga acataattta ctactttatt ttgaaataaa gtctaagatt tagcatgtaa
//
