LOCUS       NM_001130100            3359 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens kinesin family member C3 (KIFC3), transcript variant
            2, mRNA.
ACCESSION   NM_001130100
VERSION     NM_001130100.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3359)
  AUTHORS   He,Y., He,P., Lu,S. and Dong,W.
  TITLE     KIFC3 Regulates the progression and metastasis of gastric cancer
            via Notch1 pathway
  JOURNAL   Dig Liver Dis 55 (9), 1270-1279 (2023)
   PUBMED   36890049
  REMARK    GeneRIF: KIFC3 Regulates the progression and metastasis of gastric
            cancer via Notch1 pathway.
REFERENCE   2  (bases 1 to 3359)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3359)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3359)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3359)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3359)
  AUTHORS   Xu,Y., Takeda,S., Nakata,T., Noda,Y., Tanaka,Y. and Hirokawa,N.
  TITLE     Role of KIFC3 motor protein in Golgi positioning and integration
  JOURNAL   J Cell Biol 158 (2), 293-303 (2002)
   PUBMED   12135985
REFERENCE   7  (bases 1 to 3359)
  AUTHORS   Noda,Y., Okada,Y., Saito,N., Setou,M., Xu,Y., Zhang,Z. and
            Hirokawa,N.
  TITLE     KIFC3, a microtubule minus end-directed motor for the apical
            transport of annexin XIIIb-associated Triton-insoluble membranes
  JOURNAL   J Cell Biol 155 (1), 77-88 (2001)
   PUBMED   11581287
REFERENCE   8  (bases 1 to 3359)
  AUTHORS   Hoang,E., Bost-Usinger,L. and Burnside,B.
  TITLE     Characterization of a novel C-kinesin (KIFC3) abundantly expressed
            in vertebrate retina and RPE
  JOURNAL   Exp Eye Res 69 (1), 57-68 (1999)
   PUBMED   10375449
REFERENCE   9  (bases 1 to 3359)
  AUTHORS   Hoang,E.H., Whitehead,J.L., Dose,A.C. and Burnside,B.
  TITLE     Cloning of a novel C-terminal kinesin (KIFC3) that maps to human
            chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl
            syndrome
  JOURNAL   Genomics 52 (2), 219-222 (1998)
   PUBMED   9782090
REFERENCE   10 (bases 1 to 3359)
  AUTHORS   Diu,A., Moebius,U., Ferradini,L., Genevee,C., Roman-Roman,S.,
            Claudon,M., Delorme,D., Meuer,S., Hercend,T. and Praz,F.
  TITLE     Limited T-cell receptor diversity in liver-infiltrating lymphocytes
            from patients with primary biliary cirrhosis
  JOURNAL   J Autoimmun 6 (5), 611-619 (1993)
   PUBMED   8240664
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA989120.1, AB209290.1,
            AK291737.1 and BC008014.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001130100.1.
            
            Summary: This gene encodes a member of the kinesin-14 family of
            microtubule motors. Members of this family play a role in the
            formation, maintenance and remodeling of the bipolar mitotic
            spindle. The protein encoded by this gene has cytoplasmic functions
            in the interphase cells. It may also be involved in the final
            stages of cytokinesis. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and uses a downstream start codon,
            compared to variant 4. It encodes isoform 2, which has a shorter
            N-terminus, compared to isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB209290.1, AK307846.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000445690.7/ ENSP00000401696.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DA989120.1         98-126
            30-859              AB209290.1         1-830
            860-3148            AK291737.1         735-3023
            3149-3359           BC008014.1         2121-2331
FEATURES             Location/Qualifiers
     source          1..3359
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..3359
                     /gene="KIFC3"
                     /note="kinesin family member C3"
                     /db_xref="GeneID:3801"
                     /db_xref="HGNC:HGNC:6326"
                     /db_xref="MIM:604535"
     exon            1..122
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            123..333
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2642
                     /gene="KIFC3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kinesin-like protein KIFC3"
                     /codon_start=1
                     /product="kinesin-like protein KIFC3 isoform 2"
                     /protein_id="NP_001123572.1"
                     /db_xref="CCDS:CCDS45493.1"
                     /db_xref="GeneID:3801"
                     /db_xref="HGNC:HGNC:6326"
                     /db_xref="MIM:604535"
                     /translation="MVPSRRTWNLGATPSLRGLWRVGRAPEPEPGMARPAPAPASPAA
                     RPFPHTGPGRLRTGRGKDTPVCGDEDSSARSAARPALAQCRALSVDWAGPGSPHGLYL
                     TLQVEHLKEKLISQAQEVSRLRSELGGTDLEKHRDLLMVENERLRQEMRRCEAELQEL
                     RTKPAGPCPGCEHSQESAQLRDKLSQLQLEMAESKGMLSELNLEVQQKTDRLAEVELR
                     LKDCLAEKAQEEERLSRRLRDSHETIASLRAQSPPVKYVIKTVEVESSKTKQALSESQ
                     ARNQHLQEQVAMQRQVLKEMEQQLQSSHQLTARLRAQIAMYESELERAHGQMLEEMQS
                     LEEDKNRAIEEAFARAQVEMKAVHENLAGVRTNLLTLQPALRTLTNDYNGLKRQVRGF
                     PLLLQEALRSVKAEIGQAIEEVNSNNQELLRKYRRELQLRKKCHNELVRLKGNIRVIA
                     RVRPVTKEDGEGPEATNAVTFDADDDSIIHLLHKGKPVSFELDKVFSPQASQQDVFQE
                     VQALVTSCIDGFNVCIFAYGQTGAGKTYTMEGTAENPGINQRALQLLFSEVQEKASDW
                     EYTITVSAAEIYNEVLRDLLGKEPQEKLEIRLCPDGSGQLYVPGLTEFQVQSVDDINK
                     VFEFGHTNRTTEFTNLNEHSSRSHALLIVTVRGVDCSTGLRTTGKLNLVDLAGSERVG
                     KSGAEGSRLREAQHINKSLSALGDVIAALRSRQGHVPFRNSKLTYLLQDSLSGDSKTL
                     MVVQVSPVEKNTSETLYSLKFAERVRSVELGPGLRRAELGSWSSQEHLEWEPACQTPQ
                     PSARAHSAPSSGTSSRPGSIRRKLQPSA"
     exon            334..476
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            477..542
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            543..686
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            687..926
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1100
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1248
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1379
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1491
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1673
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1778
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1909
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2033
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2163
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2393
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2528
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2637
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2666
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..3359
                     /gene="KIFC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3336..3341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIFC3"
                     /note="hexamer: AATAAA"
     polyA_site      3359
                     /gene="KIFC3"
                     /note="major polyA site"
ORIGIN      
        1 aggggcgcga gcgggctggc cgaggaggag gcggcggcgt ggagctgcct cctgccggcg
       61 ggccgggccg ggccgagccc cgggcgctgc ggcgacgcct ggatcctgcc tccgccaggc
      121 cggctgcctg gtgccccgag gaggctgctg agccccaggc catggtcccc tctcgcagga
      181 cgtggaacct gggagccacg ccctcgctgc ggggcctgtg gagagtgggc cgggccccgg
      241 agcccgagcc ggggatggct cgccccgccc cagccccagc cagcccggcc gcccgccctt
      301 tcccacacac cggcccgggg aggttgagaa ctgggcgtgg aaaagatacc ccagtctgcg
      361 gtgacgagga ctccagtgcc cgaagtgcag ctcgcccagc cctagctcag tgccgagccc
      421 ttagcgtgga ctgggctggc cccggaagcc cccacgggct ctacctgacc ctgcaggtag
      481 aacacctgaa ggagaagctc attagccagg cccaggaagt gagccgactg cgatctgagc
      541 tggggggcac cgacttggag aagcaccggg acctgctgat ggtggagaat gagcgactga
      601 ggcaggagat gcggcgctgt gaggccgagc tgcaagagct gcgcacaaag ccagcaggtc
      661 cctgcccagg ttgtgagcac agccaggaga gcgcccagct ccgtgacaag ctgtcccagc
      721 tgcagctgga gatggcggaa agcaaaggca tgctgtcaga gctgaaccta gaggtgcagc
      781 agaagaccga ccggctggct gaggtggagc tgcgactcaa ggactgcctg gctgagaagg
      841 cacaggagga ggagcggctt agtcggcgcc tgcgtgacag ccacgagacc attgccagcc
      901 tgcgggccca gtccccacct gtcaagtatg tcatcaagac agtggaggtg gagtcgtcca
      961 agaccaagca ggccctcagc gagtcccagg cccggaacca gcacctgcag gagcaggtgg
     1021 ctatgcagag gcaggtgctg aaggagatgg aacagcagct gcagagctca caccagctga
     1081 ccgcgcggct ccgggcgcag attgccatgt acgagtcaga gctggagcgg gcccatgggc
     1141 agatgctgga ggagatgcag tccctggaag aggacaagaa ccgggccatt gaggaggcct
     1201 ttgccagagc ccaggtggag atgaaggctg tgcacgagaa tctagcaggc gtccggacca
     1261 acttgctgac cttgcagccg gcactgcgga ccctcaccaa cgactacaat gggctcaagc
     1321 ggcaggtgcg cggcttccca ctgctgctgc aggaggccct caggagtgtc aaggccgaga
     1381 taggccaggc catcgaggag gtcaacagca acaaccagga gctgctgcgc aagtaccgcc
     1441 gcgagctgca gctgcgtaag aagtgccaca atgagctcgt gcggctgaaa gggaacatcc
     1501 gagtgattgc tcgtgtccgg ccagtcacca aagaggatgg ggaaggacct gaggccacca
     1561 atgctgtgac tttcgatgcc gacgacgact ccatcatcca cctgctgcac aagggcaagc
     1621 ctgtgtcctt cgagctggac aaggtcttct ccccacaggc ctcgcagcag gacgtgttcc
     1681 aggaggtgca ggccctggtc acctcttgca ttgatggctt caatgtctgc atctttgcgt
     1741 acggccagac gggcgccggc aagacgtaca cgatggaggg gaccgctgag aacccaggta
     1801 tcaaccagcg ggccctgcag ctgctcttct ccgaggtgca ggagaaggcg tctgactggg
     1861 agtacaccat caccgtcagc gctgcggaga tctacaatga ggtcctcagg gacctgctag
     1921 ggaaagagcc tcaggaaaaa ctggagatcc ggctgtgccc agacggcagt gggcagctgt
     1981 atgtaccagg gctgactgag ttccaagtgc agagcgtgga cgacatcaac aaggtgtttg
     2041 agtttggcca cactaatcgc acgaccgagt tcaccaacct gaacgagcac agctcccgct
     2101 cgcacgcgct gctcatcgtg acggtgcgag gcgtggactg cagcacaggc ctccgcacca
     2161 cggggaagct gaacctggtg gacttggctg gctcggagcg cgtgggcaag tcgggggccg
     2221 agggcagccg cctgcgggag gcgcagcaca tcaacaagtc gctgtcggct ctgggggacg
     2281 tcattgctgc cctgcgctcc cgccagggcc acgtgccctt ccgcaactcc aagctcacct
     2341 acctgctgca ggattcgctt agtggtgaca gcaagaccct catggtggta caggtgtccc
     2401 ccgtggagaa gaacactagc gagacgctct attccctcaa gtttgctgag agggtgcgct
     2461 ctgtggagct ggggcctggg ctacgcaggg cagagcttgg gtcctggtca agccaggagc
     2521 atctagagtg ggagccggct tgtcagacgc cacagccctc ggcacgggcc cactcagccc
     2581 ccagctctgg gaccagtagc cgccctggat ccatccggag gaagctgcag ccctcggcct
     2641 gacggctggg gctgcagagt ctctagggaa gtcgcggcca ctgcctgtgt gacggatgtg
     2701 accccgctgg gcctgaagct gggccctcac tggcctgtcc ctgctgcagc gccaggaccc
     2761 ccggaggtag aggcgagagt ggaggctctt cttctgcccc gtctcccctc aaagatgaga
     2821 aacatgttca gaaggaaacg gtgtctctcg gctgtggctc tgagtgcaaa ttgcatgggc
     2881 ggaaaggcgg gggtggctgc tcttcctggc aggcctgggc catcagcgaa ctgggccccg
     2941 tgaggagggc gggagtgtgg aggagggtgg gcctctcacc caggctttct cggcccctct
     3001 cctcagcttg cagagctggc cagccccctc cttagggggt gggcgaggag cctctgggca
     3061 gacccaagaa ccatggggac tggggtgggt tggtggcacc aatggcagcc ctccccgccc
     3121 ctctccttca aggagggttc ccgcagctgg ggggtgtgcg gaggcgcatg gcctcccgcc
     3181 acggggccgt gctgtgttta tggctggcag aggcagccag cgggtggggg attctgctgc
     3241 tcgctcacct gcctggctcg ctggtctctc gaattttctt ccctctgaaa tcctatttaa
     3301 gaacttttgg aagcttagcc atttttactt attaaaataa aagaagcctt tttacacaa
//
