LOCUS       NM_001369769            3272 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens kinesin family member C2 (KIFC2), transcript variant
            2, mRNA.
ACCESSION   NM_001369769 XM_005272357
VERSION     NM_001369769.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3272)
  AUTHORS   Liu,X., Lin,Y., Long,W., Yi,R., Zhang,X., Xie,C., Jin,N., Qiu,Z.
            and Liu,X.
  TITLE     The kinesin-14 family motor protein KIFC2 promotes prostate cancer
            progression by regulating p65
  JOURNAL   J Biol Chem 299 (11), 105253 (2023)
   PUBMED   37716704
  REMARK    GeneRIF: The kinesin-14 family motor protein KIFC2 promotes
            prostate cancer progression by regulating p65.
REFERENCE   2  (bases 1 to 3272)
  AUTHORS   Chen,T., Chu,Y., Xu,H., Dai,H., Zhou,Y., Du,H. and Zhu,W.
  TITLE     Kinesin superfamily member KIFC2 as an independent prognostic
            biomarker of colon adenocarcinoma associated with poor immune
            response
  JOURNAL   Medicine (Baltimore) 102 (43), e35491 (2023)
   PUBMED   37904433
  REMARK    GeneRIF: Kinesin superfamily member KIFC2 as an independent
            prognostic biomarker of colon adenocarcinoma associated with poor
            immune response.
REFERENCE   3  (bases 1 to 3272)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   4  (bases 1 to 3272)
  AUTHORS   Bie,L., Zhao,G., Wang,Y.P. and Zhang,B.
  TITLE     Kinesin family member 2C (KIF2C/MCAK) is a novel marker for
            prognosis in human gliomas
  JOURNAL   Clin Neurol Neurosurg 114 (4), 356-360 (2012)
   PUBMED   22130050
  REMARK    GeneRIF: expression level of KIF2C mRNA could be a potential
            independent marker to evaluate patient prognosis
REFERENCE   5  (bases 1 to 3272)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 3272)
  AUTHORS   Hanlon,D.W., Yang,Z. and Goldstein,L.S.
  TITLE     Characterization of KIFC2, a neuronal kinesin superfamily member in
            mouse
  JOURNAL   Neuron 18 (3), 439-451 (1997)
   PUBMED   9115737
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY134032.1, BC017311.2, AC084125.9 and BM751216.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001369769.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645548.2/ ENSP00000494595.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                HY134032.1         2-19
            19-304              BC017311.2         1-286
            305-305             AC084125.9         161750-161750       c
            306-901             BC017311.2         288-883
            902-902             BM751216.1         465-465
            903-2201            BC017311.2         885-2183
            2202-3186           BC017311.2         2264-3248
            3187-3272           AC084125.9         154550-154635       c
FEATURES             Location/Qualifiers
     source          1..3272
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..3272
                     /gene="KIFC2"
                     /note="kinesin family member C2"
                     /db_xref="GeneID:90990"
                     /db_xref="HGNC:HGNC:29530"
                     /db_xref="MIM:615216"
     exon            1..182
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2459
                     /gene="KIFC2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kinesin-like protein KIFC2"
                     /codon_start=1
                     /product="kinesin-like protein KIFC2 isoform 2"
                     /protein_id="NP_001356698.1"
                     /db_xref="CCDS:CCDS94366.1"
                     /db_xref="GeneID:90990"
                     /db_xref="HGNC:HGNC:29530"
                     /db_xref="MIM:615216"
                     /translation="MYAFYSLLIYIFYSLFRRDGGAAAAAEPGDPAQRARKPRGRRRP
                     DLPAPELWTELTGLAASSEPEDGSEGAAEGRAAAVSLEEALLRLAEFLSVQLGAEESC
                     GGPADLGQSGEVPSLLTVTSQLLALLAWLRSPRGRQALLQGTQPAPRVRPPSPDGSTS
                     QEESPSHFTAVPGEPLGDETQGQQPLQLEEDQRAWQRLEQLILGQLEELKQQLEQQEE
                     ELGRLRLGVGATDSEKRVQHLTLENEALKQSLSLMRDLLLHWGPGPPIRAPQEEAEAL
                     LELQGRLQEAQDTTEALRAQLGVQEVQLQGLQGALQQLQQETEQNCRRELQQMHGQLA
                     GLRARMASLRQGCGDLRGLVSTFTQSCQGSLSEARGQVSWALGALSSGGPGTQLPEGQ
                     QGPPAGCPGRLPELKGNIRVLCRLRPGTSSSLVSVEPGPGGTVTTCYRGRHRRFRLDW
                     VFPPDASQEEVFRELEPAVLSCLRGYSVCIFTYGQTGTGKTYSMEGPPEDPGIVPRAL
                     QSLFREMGAGRQHRVTLSMVEIYNEAVRDLLAPGPPERLAVRQGPEGQGGIQVAGLTH
                     WDVPNLETLHQMLKLGRSNRATAATAMNQRSSRSHALVTLTLRAASPPRAPGTAGTLH
                     LVDLAGSERARKAGAAGPPRGDPDGARRLREAQTINRSLLALGGVMAALRAHRPHVPF
                     RDSQLTRLLQPALGPGTTAVLLLQISTRPEDLGETVCSLKFADRVGQVELGPARRRRV
                     PRSSGTPSSLSTDTPLTGTPCTPTPSPGSPPCPSPDNGSGSALAPAEGLPL"
     exon            183..261
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            262..413
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..552
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            553..698
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..764
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..893
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..971
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1086
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1196
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1305
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1463
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1568
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1690
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1814
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1944
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2201
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..3272
                     /gene="KIFC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3166..3171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIFC2"
                     /note="hexamer: AATAAA"
     polyA_site      3186
                     /gene="KIFC2"
                     /note="major polyA site"
ORIGIN      
        1 ggcactgcgg cgggcgggcg ccgagtctgg gcgcggggac gcggggcggc gcgaagcggg
       61 gccctctgcc gccccgcgct cccatgtacg ccttttactc gttgctcatc tacatcttct
      121 acagcctctt ccgcagggat ggtggcgccg cggcggccgc ggagcccggg gaccccgccc
      181 agagagcccg caagccccgg ggtcgccggc gcccagacct gcccgcgcca gagctgtgga
      241 ccgagctgac cggcctggcc gccagctccg agcctgagga tgggtcggaa ggcgcagccg
      301 agggccgcgc ggccgcggtg tccctggaag aggccctact gcgcctcgcc gagttcctct
      361 ccgtccagct gggggcggaa gagagctgcg ggggcccggc ggacctgggc cagtctggcg
      421 aggtcccctc actgttgaca gtgaccagtc agctcttggc ccttctggca tggcttcgaa
      481 gccccagggg gaggcaggcc ctgctccagg ggactcagcc agcccctcgg gtccggcccc
      541 cctctccaga tggatccaca tcccaagaag aaagcccttc ccacttcacc gcagtcccag
      601 gcgagccact gggggatgag acccagggac agcagcccct ccagttggag gaggatcaga
      661 gggcgtggca gcggctggag cagctcatcc tgggacagct ggaggagctg aagcagcagc
      721 tggaacagca ggaggaggag ttgggtcgac tgcgcctggg cgtgggggcg acggactcag
      781 agaaaagggt tcagcatctg actctggaga acgaggccct gaagcagagc ctgagtctca
      841 tgcgggacct cctgctgcac tggggccccg ggccccccat cagggctccg caggaggagg
      901 cagaggcatt gctagagctc cagggccggc ttcaggaggc ccaagacacc acagaagccc
      961 tccgagccca gctgggggtg caggaggtgc agctgcaggg ccttcaaggg gccctccagc
     1021 agctccagca ggagacggag cagaactgca ggcgtgagct acagcagatg catgggcagc
     1081 tggcaggact tcgggcacgg atggccagcc tgcgtcaggg ctgcggggac ctccgaggtt
     1141 tggtcagcac ctttacccag agctgtcagg gttcgctgag tgaggcccgg ggccaggtgt
     1201 cctgggcctt gggggcactg tcatctggag ggcctggcac tcagctccct gaggggcagc
     1261 aagggccccc agccggatgc ccagggcggc tgccagaact caagggaaat atccgtgtgc
     1321 tgtgtcggct gaggccaggg acatcttcta gccttgtgag tgtggagcct ggcccagggg
     1381 gcaccgtcac cacctgctac cgggggcgcc atcgtcgatt ccgcctagac tgggtcttcc
     1441 ctccagacgc cagccaggag gaggtcttca gagagctgga acctgcggtg ctgtcctgcc
     1501 tccgaggcta cagcgtctgc atcttcacct atggccagac aggcaccggg aagacctaca
     1561 gcatggaggg ccctcctgag gaccccggca tagttcctag ggcgctgcag tcgctgttcc
     1621 gggagatggg ggccggccgg cagcaccggg tgacactcag catggtggag atctacaatg
     1681 aggctgtcag ggacctcctt gctccagggc ctcccgagcg cctggccgtg aggcagggcc
     1741 cagaaggcca gggcgggatc caggtggctg gcctcaccca ctgggacgtg cccaacctgg
     1801 agacattgca ccagatgctg aaactgggga ggagcaaccg ggccaccgcc gccaccgcca
     1861 tgaaccagcg cagctcccgc tcgcatgccc tggtcacgct gacgctgcgc gcggcgtctc
     1921 caccgcgcgc tccaggcacc gcaggcacgc tgcacctggt ggacctggcg ggatccgaac
     1981 gcgcacggaa ggcaggggcg gccggcccgc cgcggggaga cccagacggc gcccggcgcc
     2041 tgcgggaggc ccagaccata aaccgctcgc tgctggcgct aggaggcgtg atggccgcac
     2101 tgcgggccca ccggccgcac gtgcccttcc gcgactcgca gctcacgcga ctgctgcagc
     2161 cggcgctggg cccaggcacc accgcggtgc tgctgctgca gatctccacg cggccggagg
     2221 atctcgggga gacagtctgc tccctcaagt tcgccgaccg agtgggtcaa gtggagctgg
     2281 ggccagcccg gcgccgcagg gtcccgcgct cctccgggac gccttcttcc ctcagcaccg
     2341 acactccgct caccgggacc ccctgcaccc ctacgccgtc ccctggcagt cctccatgcc
     2401 ccagtcccga caacggctcg ggctcggctc tcgcgcccgc agagggcctg cccctctagt
     2461 cctgggtcgc ggccctgccc atggggtctc aggccaggtc tctgctggca gaggcggtag
     2521 taaagtccct gtaccccgtc tcccagggca caagctccct agcctctttg gatccattgc
     2581 ccctgagctc ccagagtcac ccctccacct ccgcagccag tgaagtgtgt tgtgcctgct
     2641 gaagtgatca ccccccgccc ccagccctgc atcaggccac aggtcttggc tttctcctta
     2701 tcaccatttg ctgttatcac ggcacacagc agggaatccc aggccccccc gccaagtggt
     2761 tacccaagtc accactcctg acccaaaaat caggcatggc attaaaacgt tgcaaattcc
     2821 tttactgtta tcccccccac caccaggacc atgtagggtg cagtctttac tccctaaccc
     2881 gtttcccgaa aaaggtgcta cctcctttcc agacagatga gagagggcag gacttcaggc
     2941 tggatccacc actgggctct ccctccccca gcctggagca cgggagggga ggtgacggct
     3001 ggtgactgat ggatgggtag tgggctgaga agaggggact aggaagggct attccaggct
     3061 cagccctgct cctgcagctt tgccgctgag tgtaggaaaa acaggcatga cagaccaggg
     3121 tgagggttgt gcccagctgg gccacggcca tgcgtggggt ggcccaataa acaccgtgga
     3181 ctcccagcaa ggctgctgcc tggtgtttcg aggctgctgt ggtcgcagac agccgcctcg
     3241 ccttggctcc ctgtcaacaa ggtgggggtg gg
//
