LOCUS       NM_002263               2391 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens kinesin family member C1 (KIFC1), mRNA.
ACCESSION   NM_002263 XM_371813
VERSION     NM_002263.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2391)
  AUTHORS   Lin,X., He,Y., Liu,Y., Zhou,H., Xu,X., Xu,J. and Zhou,K.
  TITLE     CDK1 promotes the phosphorylation of KIFC1 to regulate the
            tumorgenicity of endometrial carcinoma
  JOURNAL   J Gynecol Oncol 35 (5), e68 (2024)
   PUBMED   38456590
  REMARK    GeneRIF: CDK1 promotes the phosphorylation of KIFC1 to regulate the
            tumorgenicity of endometrial carcinoma.
REFERENCE   2  (bases 1 to 2391)
  AUTHORS   Garlapati,C., Joshi,S., Yang,C., Chandrashekar,D.S., Rida,P. and
            Aneja,R.
  TITLE     A novel role for KIFC1-MYH9 interaction in triple-negative breast
            cancer aggressiveness and racial disparity
  JOURNAL   Cell Commun Signal 22 (1), 312 (2024)
   PUBMED   38902769
  REMARK    GeneRIF: A novel role for KIFC1-MYH9 interaction in triple-negative
            breast cancer aggressiveness and racial disparity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2391)
  AUTHORS   Deng,X., Liu,Z., Wang,B., Ma,J. and Meng,X.
  TITLE     The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to
            the malignant behavior of pancreatic cancer
  JOURNAL   FASEB J 38 (7), e23581 (2024)
   PUBMED   38551642
  REMARK    GeneRIF: The DDX6/KIFC1 signaling axis, as regulated by YY1,
            contributes to the malignant behavior of pancreatic cancer.
REFERENCE   4  (bases 1 to 2391)
  AUTHORS   Zhang,S., Qin,O., Xu,H., Wu,S., Huang,W. and Song,H.
  TITLE     A comprehensive analysis of the prognostic and immunotherapeutic
            characteristics of KIFC1 in pan-cancer and its role in the
            malignant phenotype of pancreatic cancer
  JOURNAL   Aging (Albany NY) 15 (24), 14845-14863 (2023)
   PUBMED   38112634
  REMARK    GeneRIF: A comprehensive analysis of the prognostic and
            immunotherapeutic characteristics of KIFC1 in pan-cancer and its
            role in the malignant phenotype of pancreatic cancer.
REFERENCE   5  (bases 1 to 2391)
  AUTHORS   Jinna,N., Yuan,Y.C. and Rida,P.
  TITLE     Kinesin Family Member C1 (KIFC1/HSET) Underlies Aggressive Disease
            in Androgen Receptor-Low and Basal-Like Triple-Negative Breast
            Cancers
  JOURNAL   Int J Mol Sci 24 (22), 16072 (2023)
   PUBMED   38003261
  REMARK    GeneRIF: Kinesin Family Member C1 (KIFC1/HSET) Underlies Aggressive
            Disease in Androgen Receptor-Low and Basal-Like Triple-Negative
            Breast Cancers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2391)
  AUTHORS   Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E.,
            Fan,J.B., Abraham,R.T. and Jiang,W.
  TITLE     Functional analysis of human microtubule-based motor proteins, the
            kinesins and dyneins, in mitosis/cytokinesis using RNA interference
  JOURNAL   Mol Biol Cell 16 (7), 3187-3199 (2005)
   PUBMED   15843429
REFERENCE   7  (bases 1 to 2391)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 2391)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   9  (bases 1 to 2391)
  AUTHORS   Janitz,K., Wild,A., Beck,S., Savasta,S., Beluffi,G., Ziegler,A. and
            Volz,A.
  TITLE     Genomic organization of the HSET locus and the possible association
            of HLA-linked genes with immotile cilia syndrome (ICS)
  JOURNAL   Immunogenetics 49 (7-8), 644-652 (1999)
   PUBMED   10369922
REFERENCE   10 (bases 1 to 2391)
  AUTHORS   Ando,A., Kikuti,Y.Y., Kawata,H., Okamoto,N., Imai,T., Eki,T.,
            Yokoyama,K., Soeda,E., Ikemura,T., Abe,K. et al.
  TITLE     Cloning of a new kinesin-related gene located at the centromeric
            end of the human MHC region
  JOURNAL   Immunogenetics 39 (3), 194-200 (1994)
   PUBMED   8276466
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE885900.1, BC063567.1 and AI990093.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002263.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098438.1, BC073878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428849.7/ ENSP00000393963.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BE885900.1         288-342
            56-2243             BC063567.1         1-2188
            2244-2391           AI990093.1         44-191              c
FEATURES             Location/Qualifiers
     source          1..2391
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..2391
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /note="kinesin family member C1"
                     /db_xref="GeneID:3833"
                     /db_xref="HGNC:HGNC:6389"
                     /db_xref="MIM:603763"
     exon            1..175
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2185
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /note="kinesin-like 2; kinesin-related protein HSET;
                     kinesin-like protein 2"
                     /codon_start=1
                     /product="kinesin-like protein KIFC1"
                     /protein_id="NP_002254.2"
                     /db_xref="CCDS:CCDS34430.1"
                     /db_xref="GeneID:3833"
                     /db_xref="HGNC:HGNC:6389"
                     /db_xref="MIM:603763"
                     /translation="MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMED
                     GLEPEKKRTRGLGATTKITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATG
                     LKNQKPVPAVPVQKSGTSGVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTL
                     DQENQQLQDQLRDAQQQVKALGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEE
                     RLSTQEGLVQELQKKQVELQEERRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQET
                     VAQAALLTEREERLHGLEMERRRLHNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLF
                     PSGPGGPSDPPTRLSLSRSDERRGTLSGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIA
                     MLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPGGDPQLEGLIPRALRHLFSVAQELSG
                     QGWTYSFVASYVEIYNETVRDLLATGTRKGQGGECEIRRAGPGSEELTVTNARYVPVS
                     CEKEVDALLHLARQNRAVARTAQNERSSRSHSVFQLQISGEHSSRGLQCGAPLSLVDL
                     AGSERLDPGLALGPGERERLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLL
                     QNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANRK"
     exon            176..313
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            314..413
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..467
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..518
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..919
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1699
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1990
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2064
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2140
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2391
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2364..2369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /note="hexamer: AATAAA"
     polyA_site      2391
                     /gene="KIFC1"
                     /gene_synonym="HSET; KNSL2"
                     /note="major polyA site"
ORIGIN      
        1 ggaattcaaa agtggcgggt gtggcgcggg gctggtagcg gccggagccg tgcgagttct
       61 ctaccctgct tcgcgagcgg gcgagagaac gcgagtccca ggatccccgg cacccagttc
      121 tcttccactg cattcccccg gcgcgtgtgg gaccgaggtg gacatggatc cgcagaggtc
      181 ccccctattg gaagtaaagg ggaacataga actgaagaga cctctgatta aggccccttc
      241 ccagctgcct ctctcaggaa gcagactcaa gaggaggcct gaccagatgg aagatggcct
      301 ggagcctgag aagaaacgga caagaggcct gggtgcaacg accaaaatta ccacatccca
      361 cccaagagtt ccatccctca ctacagtgcc acagacacaa ggccagacca cagctcaaaa
      421 agtttccaag aagacaggac cccggtgttc cacagctatt gccacagggt tgaagaacca
      481 gaagccagtt cctgctgttc ctgtccagaa gtctggcaca tcaggtgttc ctcccatggc
      541 aggagggaag aaacccagca aacgtccagc ctgggactta aagggtcagt tatgtgacct
      601 aaatgcagaa ctaaaacggt gccgtgagag gactcaaacg ttggaccaag agaaccagca
      661 gcttcaggac cagctcagag atgcccagca gcaggtcaag gccctgggga cagagcgcac
      721 aacactggag gggcatttag ccaaggtaca ggcccaggct gagcagggcc aacaggagct
      781 gaagaacttg cgtgcttgtg tcctggagct ggaagagcgg ctgagcacgc aggagggctt
      841 ggtgcaagag cttcagaaaa aacaggtgga attgcaggaa gaacggaggg gactgatgtc
      901 ccaactagag gagaaggaga ggaggctgca gacatcagaa gcagccctgt caagcagcca
      961 agcagaggtg gcatctctgc ggcaggagac tgtggcccag gcagccttac tgactgagcg
     1021 ggaagaacgt cttcatgggc tagaaatgga gcgccggcga ctgcacaacc agctgcagga
     1081 actcaagggc aacatccgtg tattctgccg ggtccgccct gtcctgccgg gggagcccac
     1141 tccaccccct ggcctcctcc tgtttccctc tggccctggt gggccctctg atcctccaac
     1201 ccgccttagc ctctcccggt ctgacgagcg gcgtgggacc ctgagtgggg caccagctcc
     1261 cccaactcgc catgattttt cctttgaccg ggtattccca ccaggaagtg gacaggatga
     1321 agtgtttgaa gagattgcca tgcttgtcca gtcagccctg gatggctatc cagtatgcat
     1381 ctttgcctat ggccagacag gcagtggcaa gaccttcaca atggagggtg ggcctggggg
     1441 agacccccag ttggaggggc tgatccctcg ggccctgcgg cacctcttct ctgtggctca
     1501 ggagctgagt ggtcagggct ggacctacag ctttgtagca agctacgtag agatctacaa
     1561 tgagactgtc cgggacctgc tggccactgg aacccggaag ggtcaagggg gcgagtgtga
     1621 gattcgccgt gcagggccag ggagtgagga gctcactgtc accaatgctc gatatgtccc
     1681 tgtctcctgt gagaaagaag tggacgccct gcttcatctg gcccgccaga atcgggctgt
     1741 ggcccgcaca gcccagaatg aacggtcatc acgcagccac agtgtattcc agctacagat
     1801 ttctggggag cactccagcc gaggcctgca gtgtggggcc cccctcagtc ttgtggacct
     1861 ggccgggagt gagcgacttg accccggctt agccctcggc cccggggagc gggaacgcct
     1921 tcgggaaaca caggccatta acagcagcct gtccacgctg gggctggtta tcatggccct
     1981 gagcaacaag gagtcccacg tgccttaccg gaacagcaaa ctgacctacc tgctgcagaa
     2041 ctctctgggt ggtagtgcta agatgctcat gtttgtgaac atttctccac tggaagagaa
     2101 cgtctccgag tccctcaact ctctacgctt tgcctccaag gtgaaccagt gtgttattgg
     2161 tactgctcag gccaacagga agtgaagacg gatccagatc tgtgtgtgtg tgtgtgtgtg
     2221 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtc cctatgtcta tgtatcgggt gaggggtggg
     2281 agggttgctg gagggtgctt tattgggtgg agggcaccat gtcccagggc tatcaaataa
     2341 agaatagttt ggtttttttt ttaaataaag gttttattag catttgccca a
//
