LOCUS       NM_014970               2954 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens kinesin associated protein 3 (KIFAP3), transcript
            variant 1, mRNA.
ACCESSION   NM_014970
VERSION     NM_014970.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2954)
  AUTHORS   Du,L., Lu,Y., Wang,J., Zheng,Y., Li,H., Liu,Y., Wu,X., Zhou,J.,
            Wang,L., He,L., Shi,J., Xu,L., Li,X., Lu,Q. and Yin,X.
  TITLE     LncRNA KIFAP3-5:1 inhibits epithelial-mesenchymal transition of
            renal tubular cell through PRRX1 in diabetic nephropathy
  JOURNAL   Cell Biol Toxicol 40 (1), 47 (2024)
   PUBMED   38869718
  REMARK    GeneRIF: LncRNA KIFAP3-5:1 inhibits epithelial-mesenchymal
            transition of renal tubular cell through PRRX1 in diabetic
            nephropathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2954)
  AUTHORS   Gleason,N., Williams,C.L. and Kowluru,A.
  TITLE     Novel regulatory roles of small G protein GDP dissociation
            stimulator (smgGDS) in insulin secretion from pancreatic beta-cells
  JOURNAL   Mol Cell Endocrinol 580, 112104 (2024)
   PUBMED   38013223
  REMARK    GeneRIF: Novel regulatory roles of small G protein GDP dissociation
            stimulator (smgGDS) in insulin secretion from pancreatic
            beta-cells.
REFERENCE   3  (bases 1 to 2954)
  AUTHORS   Soda,T., Gen,Y., Terasaki,K., Iwai,N., Kitaichi,T., Dohi,O.,
            Taketani,H., Seko,Y., Umemura,A., Nishikawa,T., Yamaguchi,K.,
            Moriguchi,M., Konishi,H., Naito,Y., Itoh,Y. and Yasui,K.
  TITLE     Loss of KAP3 decreases intercellular adhesion and impairs
            intracellular transport of laminin in signet ring cell carcinoma of
            the stomach
  JOURNAL   Sci Rep 12 (1), 5050 (2022)
   PUBMED   35322078
  REMARK    GeneRIF: Loss of KAP3 decreases intercellular adhesion and impairs
            intracellular transport of laminin in signet ring cell carcinoma of
            the stomach.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2954)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2954)
  AUTHORS   Onodera,S., Morita,N., Nakamura,Y., Takahashi,S., Hashimoto,K.,
            Nomura,T., Katakura,A., Kosaki,K. and Azuma,T.
  TITLE     Novel alterations in IFT172 and KIFAP3 may induce basal cell
            carcinoma
  JOURNAL   Orphanet J Rare Dis 16 (1), 443 (2021)
   PUBMED   34674729
  REMARK    GeneRIF: Novel alterations in IFT172 and KIFAP3 may induce basal
            cell carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2954)
  AUTHORS   Khanna,H., Hurd,T.W., Lillo,C., Shu,X., Parapuram,S.K., He,S.,
            Akimoto,M., Wright,A.F., Margolis,B., Williams,D.S. and Swaroop,A.
  TITLE     RPGR-ORF15, which is mutated in retinitis pigmentosa, associates
            with SMC1, SMC3, and microtubule transport proteins
  JOURNAL   J Biol Chem 280 (39), 33580-33587 (2005)
   PUBMED   16043481
REFERENCE   7  (bases 1 to 2954)
  AUTHORS   Jimbo,T., Kawasaki,Y., Koyama,R., Sato,R., Takada,S., Haraguchi,K.
            and Akiyama,T.
  TITLE     Identification of a link between the tumour suppressor APC and the
            kinesin superfamily
  JOURNAL   Nat Cell Biol 4 (4), 323-327 (2002)
   PUBMED   11912492
REFERENCE   8  (bases 1 to 2954)
  AUTHORS   Shimizu,K., Shirataki,H., Honda,T., Minami,S. and Takai,Y.
  TITLE     Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated
            protein, with a human chromosome-associated polypeptide
  JOURNAL   J Biol Chem 273 (12), 6591-6594 (1998)
   PUBMED   9506951
REFERENCE   9  (bases 1 to 2954)
  AUTHORS   Nagata,Ki., Puls,A., Futter,C., Aspenstrom,P., Schaefer,E.,
            Nakata,T., Hirokawa,N. and Hall,A.
  TITLE     The MAP kinase kinase kinase MLK2 co-localizes with activated JNK
            along microtubules and associates with kinesin superfamily motor
            KIF3
  JOURNAL   EMBO J 17 (1), 149-158 (1998)
   PUBMED   9427749
REFERENCE   10 (bases 1 to 2954)
  AUTHORS   Shimizu,K., Kawabe,H., Minami,S., Honda,T., Takaishi,K.,
            Shirataki,H. and Takai,Y.
  TITLE     SMAP, an Smg GDS-associating protein having arm repeats and
            phosphorylated by Src tyrosine kinase
  JOURNAL   J Biol Chem 271 (43), 27013-27017 (1996)
   PUBMED   8900189
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA144269.1, AK315586.1,
            BC028679.2 and AI085654.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014970.3.
            
            Summary: The small G protein GDP dissociation stimulator (smg GDS)
            is a regulator protein having two activities on a group of small G
            proteins including the Rho and Rap1 family members and Ki-Ras; one
            is to stimulate their GDP/GTP exchange reactions, and the other is
            to inhibit their interactions with membranes. The protein encoded
            by this gene contains 9 'Armadillo' repeats and interacts with the
            smg GDS protein through these repeats. This protein, which is
            highly concentrated around the endoplasmic reticulum, is
            phosphorylated by v-src, and this phosphorylation reduces the
            affinity of the protein for smg GDS. It is thought that this
            protein serves as a linker between human chromosome-associated
            polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in
            the nucleus, and that it plays a role in the interaction of
            chromosomes with an ATPase motor protein. Several transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028679.2, SRR1803617.55536.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361580.7/ ENSP00000354560.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                DA144269.1         47-89
            44-1745             AK315586.1         1-1702
            1746-2849           BC028679.2         1746-2849
            2850-2952           AI085654.1         1-103               c
            2953-2954           BC028679.2         2953-2954
FEATURES             Location/Qualifiers
     source          1..2954
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..2954
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /note="kinesin associated protein 3"
                     /db_xref="GeneID:22920"
                     /db_xref="HGNC:HGNC:17060"
                     /db_xref="MIM:601836"
     exon            1..260
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2607
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /note="isoform 1 is encoded by transcript variant 1; smg
                     GDS-associated protein; small G protein GDP dissociation
                     stimulator"
                     /codon_start=1
                     /product="kinesin-associated protein 3 isoform 1"
                     /protein_id="NP_055785.2"
                     /db_xref="CCDS:CCDS1288.1"
                     /db_xref="GeneID:22920"
                     /db_xref="HGNC:HGNC:17060"
                     /db_xref="MIM:601836"
                     /translation="MQGEDARYLKRKVKGGNIDVHPSEKALIVHYEVEATILGEMGDP
                     MLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLNEVEQLLYYLQNRRDS
                     LSGKEKKEKSSKPKDPPPFEGMEIDEVANINDMDEYIELLYEDIPDKVRGSALILQLA
                     RNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSQFHGLITHYK
                     IGALCMNIIDHELKRHELWQEELSKKKKAVDEDPENQTLRKDYEKTFKKYQGLVVKQE
                     QLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFM
                     ENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTA
                     LLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCI
                     NLAANKRNVQLICEGNGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDL
                     AAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKPGAAEDDLVL
                     EVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQAT
                     RDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQ
                     WLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDLFYNSDGLIASEGAISPDFFN
                     DYHLQNGDVVGQHSFPGSLGMDGFGQPVGILGRPATAYGFRPDEPYYYGYGS"
     exon            261..392
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            393..547
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            548..603
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            604..745
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            746..845
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            846..970
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1069
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1248
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1411
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1512
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1621
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1734
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1900
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2026
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2125
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2211
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2401
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2501
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2954
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2929..2934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /note="hexamer: ATTAAA"
     polyA_site      2954
                     /gene="KIFAP3"
                     /gene_synonym="dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP;
                     Smg-GDS"
                     /note="major polyA site"
ORIGIN      
        1 aggcgactct gggcgggtct gggccgctcc agtgttttgg ggcacagaag ctgtgggagg
       61 agctggaggc ttcaccgtgg taaccacagc gccgctgctg ccccgccttg caggcctcag
      121 gactgtcatc gcctctgggt gtgagggtac tttggccacc gtccccggaa ataaccgcgc
      181 ctgcctctca agatacccca tcctctccac gccgctgccg ctgccgccat gcaaggggag
      241 gacgccagat acctcaaaag gaaagttaaa ggagggaata tagatgtaca tccatcagaa
      301 aaagcactca ttgttcacta tgaagtggaa gctaccattc ttggagaaat gggggacccc
      361 atgttgggag aacgaaaaga atgtcaaaaa atcattcgac ttaagagtct caatgccaac
      421 acagatataa cttccctggc aaggaaggtg gttgaagaat gtaaactcat tcatccttca
      481 aaactaaatg aggtagaaca gctgttgtac tatctacaga accgccgtga ttcattgtca
      541 ggaaaagaga aaaaagaaaa atcaagcaag cctaaagatc cacctccttt tgaaggaatg
      601 gagattgatg aagttgctaa cattaatgac atggatgaat atattgagtt attatatgaa
      661 gatattcctg acaaagttcg gggttctgct ttgatcctgc agcttgctcg aaatcctgat
      721 aacttggaag aactactatt gaatgaaact gcccttggtg cattagcaag ggtcctgaga
      781 gaagactgga agcaaagtgt cgagttagct acaaacataa tttacatctt tttttgtttc
      841 tccagctttt ctcaatttca tggacttatt actcactata aaattggagc tctgtgtatg
      901 aatattattg atcatgagtt aaaaagacat gagctttggc aagaagaact ctcaaagaag
      961 aagaaagctg ttgatgaaga ccctgaaaac caaaccttga gaaaggatta tgaaaaaacc
     1021 tttaaaaagt accaggggct tgtggtaaaa caggaacagc tattacgagt tgctctttat
     1081 ttgcttctga atcttgctga ggatactcgt accgaactga aaatgaggaa caagaacata
     1141 gttcacatgt tggtgaaagc ccttgatcgg gacaattttg agctgctaat tttagttgtg
     1201 tcattcttga agaaactcag catttttatg gagaataaaa atgatatggt ggaaatggat
     1261 attgttgaaa aactggtgaa aatgatacct tgtgagcatg aagacctgct gaatatcacc
     1321 ctccgacttt tactaaacct atcctttgac acaggactga ggaataagat ggtacaagtt
     1381 ggactgcttc ccaagctcac tgcactccta ggcaatgaca actacaaaca aatagcaatg
     1441 tgtgttcttt accacataag catggatgac cgctttaaat caatgtttgc atacactgac
     1501 tgtataccac agttaatgaa gatgctgttt gaatgttcag atgaacgaat tgacttggaa
     1561 ctcatttctt tctgcattaa tcttgctgct aacaaaagaa atgtacagct tatctgtgaa
     1621 ggaaatgggc tgaagatgct catgaagagg gctctgaagt ttaaggatcc attgctgatg
     1681 aaaatgatta gaaacatttc tcagcatgat ggaccaacta aaaatctgtt tattgattat
     1741 gttggggacc ttgcagccca gatctctaat gatgaagaag aggagtttgt gattgaatgt
     1801 ttgggaactc ttgcaaactt gaccattcca gacttagact gggaattggt tcttaaagaa
     1861 tataagttgg ttccatacct caaggataaa ctaaaaccag gtgctgcaga agatgatctt
     1921 gttttagaag tggttataat gattggaact gtatccatgg atgactcttg tgctgcattg
     1981 ctagccaaat ctggcataat ccctgcactc attgaattgc taaatgctca acaagaagat
     2041 gatgaatttg tgtgtcagat aatttatgtc ttctaccaga tggttttcca ccaagccaca
     2101 agagacgtca taatcaagga aacacaggct ccagcatatc tcatagacct aatgcatgat
     2161 aagaataatg aaatccgaaa ggtctgtgat aatacattag atattatagc ggaatatgat
     2221 gaagaatggg ctaagaaaat tcagagtgaa aagtttcgct ggcataactc tcagtggctg
     2281 gagatggtag agagtcgtca gatggatgag agtgagcagt acttgtatgg tgatgatcga
     2341 attgagccat acattcatga aggagatatt ctcgaaagac ctgacctttt ctacaactca
     2401 gatggattaa ttgcctctga aggagccata agtcccgatt tcttcaatga ttaccacctt
     2461 caaaatggag atgttgttgg gcagcattca tttcctggca gccttggaat ggatggcttt
     2521 ggccaaccag ttggcattct tggacgccct gccacagcat atggattccg ccctgatgaa
     2581 ccttactact atggctatgg atcttgataa agtatctgtt tccatgtgta atctcagctt
     2641 agaagaaatc tgtgtgggtt gggttaattt tggatctttg cctaataatg catgttgatg
     2701 ttattgtggg tctgtgtttg tttttatttt tatatgttgt tagctgcaga ttaaccccag
     2761 cccctctgtc ttctgttaag tacagttgat actgacattg ttcactcatc aaaccacatc
     2821 ttgatgctaa gtaacatttc ccatgagcca caaaactgaa tgctgaaaag ctactagact
     2881 ggaaaacaaa cactgcatta tgtatgttaa gtgactaatt taatttcaat taaaaagcgt
     2941 aaagtgaaaa tgaa
//
