LOCUS       NM_198525               4567 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens kinesin family member 7 (KIF7), mRNA.
ACCESSION   NM_198525 XM_351008
VERSION     NM_198525.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4567)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4567)
  AUTHORS   Blasius,T.L., Yue,Y., Prasad,R., Liu,X., Gennerich,A. and
            Verhey,K.J.
  TITLE     Sequences in the stalk domain regulate auto-inhibition and ciliary
            tip localization of the immotile kinesin-4 KIF7
  JOURNAL   J Cell Sci 134 (13) (2021)
   PUBMED   34114033
  REMARK    GeneRIF: Sequences in the stalk domain regulate auto-inhibition and
            ciliary tip localization of the immotile kinesin-4 KIF7.
REFERENCE   3  (bases 1 to 4567)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4567)
  AUTHORS   Terhune,E.A., Cuevas,M.T., Monley,A.M., Wethey,C.I., Chen,X.,
            Cattell,M.V., Bayrak,M.N., Bland,M.R., Sutphin,B., Trahan,G.D.,
            Taylor,M.R.G., Niswander,L.A., Jones,K.L., Baschal,E.E.,
            Antunes,L., Dobbs,M., Gurnett,C., Appel,B., Gray,R. and Hadley
            Miller,N.
  TITLE     Mutations in KIF7 implicated in idiopathic scoliosis in humans and
            axial curvatures in zebrafish
  JOURNAL   Hum Mutat 42 (4), 392-407 (2021)
   PUBMED   33382518
  REMARK    GeneRIF: Mutations in KIF7 implicated in idiopathic scoliosis in
            humans and axial curvatures in zebrafish.
REFERENCE   5  (bases 1 to 4567)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     KIF27 is one of orthologs for Drosophila Costal-2
  JOURNAL   Int J Oncol 25 (6), 1875-1880 (2004)
   PUBMED   15547729
REFERENCE   6  (bases 1 to 4567)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 4567)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   8  (bases 1 to 4567)
  AUTHORS   Bayoumi,R., Saar,K., Lee,Y.A., Nurnberg,G., Reis,A., Nur-E-Kamal,M.
            and Al-Gazali,L.I.
  TITLE     Localisation of a gene for an autosomal recessive syndrome of
            macrocephaly, multiple epiphyseal dysplasia, and distinctive facies
            to chromosome 15q26
  JOURNAL   J Med Genet 38 (6), 369-373 (2001)
   PUBMED   11389160
REFERENCE   9  (bases 1 to 4567)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
REFERENCE   10 (bases 1 to 4567)
  AUTHORS   Parisi,M. and Glass,I.
  TITLE     Joubert Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013787.15, BC042063.1,
            BC104044.1, BC112273.1, AY358384.1 and AW451733.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_198525.2.
            
            Summary: This gene encodes a cilia-associated protein belonging to
            the kinesin family. This protein plays a role in the sonic hedgehog
            (SHH) signaling pathway through the regulation of GLI transcription
            factors. It functions as a negative regulator of the SHH pathway by
            preventing inappropriate activation of GLI2 in the absence of
            ligand, and as a positive regulator by preventing the processing of
            GLI3 into its repressor form. Mutations in this gene have been
            associated with various ciliopathies. [provided by RefSeq, Oct
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3183965.1,
                                           SRR14038193.1406546.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394412.8/ ENSP00000377934.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC013787.15        132536-132551       c
            17-287              BC042063.1         1-271
            288-288             AC013787.15        129820-129820       c
            289-421             BC042063.1         273-405
            422-1194            BC042063.1         509-1281
            1195-1474           AC013787.15        125401-125680       c
            1475-2750           BC104044.1         1-1276
            2751-2751           AC013787.15        110285-110285       c
            2752-2965           BC104044.1         1278-1491
            2966-4185           BC112273.1         1383-2602
            4186-4468           AY358384.1         2739-3021
            4469-4567           AW451733.1         25-123              c
FEATURES             Location/Qualifiers
     source          1..4567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..4567
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /note="kinesin family member 7"
                     /db_xref="GeneID:374654"
                     /db_xref="HGNC:HGNC:30497"
                     /db_xref="MIM:611254"
     exon            1..69
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            70..421
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..4125
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /note="EQYK340"
                     /codon_start=1
                     /product="kinesin-like protein KIF7"
                     /protein_id="NP_940927.2"
                     /db_xref="CCDS:CCDS32325.2"
                     /db_xref="GeneID:374654"
                     /db_xref="HGNC:HGNC:30497"
                     /db_xref="MIM:611254"
                     /translation="MGLEAQRLPGAEEAPVRVALRVRPLLPKELLHGHQSCLQVEPGL
                     GRVTLGRDRHFGFHVVLAEDAGQEAVYQACVQPLLEAFFEGFNATVFAYGQTGSGKTY
                     TMGEASVASLLEDEQGIVPRAMAEAFKLIDENDLLDCLVHVSYLEVYKEEFRDLLEVG
                     TASRDIQLREDERGNVVLCGVKEVDVEGLDEVLSLLEMGNAARHTGATHLNHLSSRSH
                     TVFTVTLEQRGRAPSRLPRPAPGQLLVSKFHFVDLAGSERVLKTGSTGERLKESIQIN
                     SSLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLGGNAKTVMIACVSPSSSDFD
                     ETLNTLNYASRAQNIRNRATVNWRPEAERPPEETASGARGPPRHRSETRIIHRGRRAP
                     GPATASAAAAMRLGAECARYRACTDAAYSLLRELQAEPGLPGAAARKVRDWLCAVEGE
                     RSALSSASGPDSGIESASVEDQAAQGAGGRKEDEGAQQLLTLQNQVARLEEENRDFLA
                     ALEDAMEQYKLQSDRLREQQEEMVELRLRLELVRPGWGGPRLLNGLPPGSFVPRPHTA
                     PLGGAHAHVLGMVPPACLPGDEVGSEQRGEQVTNGREAGAELLTEVNRLGSGSSAASE
                     EEEEEEEPPRRTLHLRRNRISNCSQRAGARPGSLPERKGPELCLEELDAAIPGSRAVG
                     GSKARVQARQVPPATASEWRLAQAQQKIRELAINIRMKEELIGELVRTGKAAQALNRQ
                     HSQRIRELEQEAEQVRAELSEGQRQLRELEGKELQDAGERSRLQEFRRRVAAAQSQVQ
                     VLKEKKQATERLVSLSAQSEKRLQELERNVQLMRQQQGQLQRRLREETEQKRRLEAEM
                     SKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSLEQQQKIEEQKKW
                     LDQEMEKVLQQRRALEELGEELHKREAILAKKEALMQEKTGLESKRLRSSQALNEDIV
                     RVSSRLEHLEKELSEKSGQLRQGSAQSQQQIRGEIDSLRQEKDSLLKQRLEIDGKLRQ
                     GSLLSPEEERTLFQLDEAIEALDAAIEYKNEAITCRQRVLRASASLLSQCEMNLMAKL
                     SYLSSSETRALLCKYFDKVVTLREEQHQQQIAFSELEMQLEEQQRLVYWLEVALERQR
                     LEMDRQLTLQQKEHEQNMQLLLQQSRDHLGEGLADSRRQYEARIQALEKELGRYMWIN
                     QELKQKLGGVNAVGHSRGGEKRSLCSEGRQAPGNEDELHLAPELLWLSPLTEGAPRTR
                     EETRDLVHAPLPLTWKRSSLCGEEQGSPEELRQREAAEPLVGRVLPVGEAGLPWNFGP
                     LSKPRRELRRASPGMIDVRKNPL"
     exon            422..622
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            623..1016
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1536
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1653
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1881
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2015
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2131
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2284
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2487
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2685
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2811
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2988
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3204
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3411
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3610
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..3757
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..4567
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4358
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
     regulatory      4544..4549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /note="hexamer: AATAAA"
     polyA_site      4567
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /note="major polyA site"
ORIGIN      
        1 atcggagcgc gccgcactgg ggatggaaac ctgactgcct ggcccgggac ggcgcttgca
       61 gccaggcagg gcccagagca gtcctccctc ggcatggggc tggaggctca gaggctgcca
      121 ggggctgagg aggccccagt gcgggttgcc ctgcgagttc gaccactgct gcccaaggag
      181 ctgctgcacg ggcatcagag ctgcctgcag gtggagccag ggcttggccg cgtcactctg
      241 ggccgtgacc gacactttgg cttccacgtg gtgctggccg aggatgcggg gcaggaggcc
      301 gtgtaccagg cctgcgttca gcccctcctt gaggccttct tcgagggctt caatgccact
      361 gtctttgcct atggtcagac gggctcaggg aagacataca ccatggggga ggccagtgtg
      421 gcctccctcc ttgaggatga gcagggcatt gtcccgaggg ccatggccga ggccttcaag
      481 ctcatcgatg agaacgacct gcttgactgt ctggtacatg tgtcctacct ggaagtgtac
      541 aaggaggagt tccgagacct gctcgaggtg ggcactgcca gccgtgacat ccagctccgg
      601 gaagatgagc gcgggaatgt tgtgctgtgc ggggtgaagg aggtcgacgt ggagggcctg
      661 gatgaggtgc tgagcctcct ggagatgggc aacgcggcgc ggcacacggg agccacgcac
      721 ctcaaccacc tgtctagccg ctcacacacg gtcttcaccg tgaccctgga gcagcggggg
      781 cgcgccccca gccgcctacc ccgccccgcc ccgggccagc tgctcgtctc caagttccac
      841 ttcgtggacc tggcgggctc agagagggtg ctcaagacgg gcagcaccgg cgagcggctc
      901 aaggagagca tccagatcaa cagcagcctc ctggcgctgg gcaacgtcat cagcgccctg
      961 ggggaccctc agcgccgggg cagccacata ccctaccgcg actccaagat cacccggatc
     1021 ctcaaagact cgctgggcgg gaacgccaag acggtgatga tcgcctgcgt cagcccttcc
     1081 tcctccgact tcgacgagac cctcaacacc ctcaactacg ccagccgcgc ccagaacatc
     1141 cgcaaccgcg ccacggtcaa ctggcggccc gaggccgagc ggccacccga agagacggcg
     1201 agcggcgcgc ggggtccgcc acggcaccgc tccgagaccc gcatcatcca ccgcggccgg
     1261 cgcgccccag gcccagccac cgcctccgcg gcggccgcca tgcgcctggg cgccgagtgc
     1321 gcgcgctacc gggcctgcac cgacgccgcc tacagcctct tgcgcgagct gcaggccgag
     1381 cccgggctgc ccggcgccgc cgcccgcaag gtgcgcgact ggctgtgcgc cgtcgagggc
     1441 gagcgcagcg ccctgagctc cgcctccggg cccgatagcg gcatcgagag cgcctccgtc
     1501 gaggaccagg cggcgcaggg ggccggcggg cgaaaggagg atgagggggc gcagcagctg
     1561 ctgaccctgc agaaccaggt ggcgcggctg gaggaggaga accgagactt tctggctgcg
     1621 ctggaggacg ccatggagca gtacaaactg cagagcgacc ggctgcgtga gcagcaggag
     1681 gagatggtgg aactgcggct gcggttagag ctggtgcggc caggctgggg gggcccgcgg
     1741 ctcctgaatg gcctgcctcc cgggtccttt gtgcctcgac ctcatacagc ccccctgggg
     1801 ggtgcccacg cccatgtgct gggcatggtg ccgcctgcct gcctccctgg agatgaagtt
     1861 ggctctgagc agaggggaga gcaggtgaca aatggcaggg aggctggagc tgagttgctg
     1921 actgaggtga acaggctggg aagtggctct tcagctgctt cagaggagga agaggaggag
     1981 gaggagccgc ccaggcggac cttacacctg cgcagaaata ggatcagcaa ctgcagtcag
     2041 agggcggggg cacgcccagg gagtctgcca gagaggaagg gcccagagct ttgccttgag
     2101 gagttggatg cagccattcc agggtccaga gcagttggtg ggagcaaggc ccgagttcag
     2161 gcccgccagg tcccccctgc cacagcctca gagtggcggc tggcccaggc ccagcagaag
     2221 atccgggagc tggctatcaa catccgcatg aaggaggagc ttattggcga gctggtccgc
     2281 acaggaaagg cagctcaggc cctgaaccgc cagcacagcc agcgtatccg ggagctggag
     2341 caggaggcag agcaggtgcg ggccgagctg agtgaaggcc agaggcagct gcgggagctc
     2401 gagggcaagg agctccagga tgctggcgag cggtctcggc tccaggagtt ccgcaggagg
     2461 gtcgctgcgg cccagagcca ggtgcaggtg ctgaaggaga agaagcaggc tacggagcgg
     2521 ctggtgtcac tgtcggccca gagtgagaag cgactgcagg agctcgagcg gaacgtgcag
     2581 ctcatgcggc agcagcaggg acagctgcag aggcggcttc gcgaggagac ggagcagaag
     2641 cggcgcctgg aggcagaaat gagcaagcgg cagcaccgcg tcaaggagct ggagctgaag
     2701 catgagcaac agcagaagat cctgaagatt aagacggaag agatcgcggc attccagagg
     2761 aagaggcgca gtggcagcaa cggctctgtg gtcagcctgg aacagcagca gaagattgag
     2821 gagcagaaga agtggctgga ccaggagatg gagaaggtgc tacagcagcg gcgggcgctg
     2881 gaggagctgg gggaggagct ccacaagcgg gaggccatcc tggccaagaa ggaggccctg
     2941 atgcaggaga agacggggct ggagagcaag cgcctgagat ccagccaggc cctcaacgag
     3001 gacatcgtgc gagtgtccag ccggctggag cacctggaga aggagctgtc cgagaagagc
     3061 gggcagctgc ggcagggcag cgcccagagc cagcagcaga tccgcgggga gatcgacagc
     3121 ctgcgccagg agaaggactc gctgctcaag cagcgcctgg agatcgacgg caagctgagg
     3181 caggggagtc tgctgtcccc cgaggaggag cggacgctgt tccagttgga tgaggccatc
     3241 gaggccctgg atgctgccat tgagtataag aatgaggcca tcacatgccg ccagcgggtg
     3301 cttcgggcct cagcctcgtt gctgtcccag tgcgagatga acctcatggc caagctcagc
     3361 tacctctcat cctcagagac cagagccctc ctctgcaagt attttgacaa ggtggtgacg
     3421 ctccgagagg agcagcacca gcagcagatt gccttctcgg aactggagat gcagctggag
     3481 gagcagcaga ggctggtgta ctggctggag gtggccctgg agcggcagcg cctggagatg
     3541 gaccgccagc tgaccctgca gcagaaggag cacgagcaga acatgcagct gctcctgcag
     3601 cagagtcgag accacctcgg tgaagggtta gcagacagca ggaggcagta tgaggcccgg
     3661 attcaagctc tggagaagga actgggccgt tacatgtgga taaaccagga actgaaacag
     3721 aagctcggcg gtgtgaacgc tgtaggccac agcaggggtg gggagaagag gagcctgtgc
     3781 tcggagggca gacaggctcc tggaaatgaa gatgagctcc acctggcacc cgagcttctc
     3841 tggctgtccc ccctcactga gggggccccc cgcacccggg aggagacgcg ggacttggtc
     3901 cacgctccgt tacccttgac ctggaaacgc tcgagcctgt gtggtgagga gcaggggtcc
     3961 cccgaggaac tgaggcagcg ggaggcggct gagcccctgg tggggcgggt gcttcctgtg
     4021 ggtgaggcag gcctgccctg gaactttggg cctttgtcca agccccggcg ggaactgcga
     4081 cgagccagcc cggggatgat tgatgtccgg aaaaaccccc tgtaagccct cggggcagac
     4141 cctgccttgg agggagactc cgagcctgct gaaaggggca gctgcctgtt ttgcttctgt
     4201 gaagggcagt ccttaccgca caccctaaat ccaggccctc atctgtaccc tcactgggat
     4261 caacaaattt gggccatggc ccaaaagaac tggaccctca tttaacaaaa taatatgcaa
     4321 attcccacca cttacttcca tgaagctgtg gtacccaatt gccgccttgt gtcttgctcg
     4381 aatctcagga caattctggt ttcaggcgta aatggatgtg cttgtagttc aggggtttgg
     4441 ccaagaatca tcacgaaagg gtcggtggta accaggttgt ggtttaaatg gtcttatgta
     4501 tataggggaa actgggagac tttaggatct taaaaaacca tttaataaaa aaaaatcttt
     4561 gaaggga
//
