LOCUS       NM_145027               9085 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kinesin family member 6 (KIF6), transcript variant 1,
            mRNA.
ACCESSION   NM_145027
VERSION     NM_145027.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9085)
  AUTHORS   Takagishi,M., Yue,Y., Gray,R.S., Verhey,K.J. and Wallingford,J.B.
  TITLE     Motor protein Kif6 regulates cilia motility and polarity in brain
            ependymal cells
  JOURNAL   Dis Model Mech 17 (2) (2024)
   PUBMED   38235522
  REMARK    GeneRIF: Motor protein Kif6 regulates cilia motility and polarity
            in brain ependymal cells.
REFERENCE   2  (bases 1 to 9085)
  AUTHORS   Velasco,J.J., Li,Y., Ziganshin,B.A., Zafar,M.A., Rizzo,J.A., Ma,D.,
            Zang,H., Kalyanasundaram,A. and Elefteriades,J.A.
  TITLE     KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic
            Dissection
  JOURNAL   Genes (Basel) 14 (2), 252 (2023)
   PUBMED   36833179
  REMARK    GeneRIF: KIF6 Trp719Arg Genetic Variant Increases Risk for Thoracic
            Aortic Dissection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9085)
  AUTHORS   Barbieri,L., Verdoia,M., Suryapranata,H., Carugo,S. and De Luca,G.
  TITLE     Impact of 719Trp>Arg Polymorphism of KIF 6 Gene on Contrast Induced
            Nephropathy in Patients Undergoing Coronary Angiography or
            Percutaneous Coronary Intervention
  JOURNAL   Glob Heart 17 (1), 16 (2022)
   PUBMED   35342690
  REMARK    GeneRIF: Impact of 719Trp>Arg Polymorphism of KIF 6 Gene on
            Contrast Induced Nephropathy in Patients Undergoing Coronary
            Angiography or Percutaneous Coronary Intervention.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9085)
  AUTHORS   Wojciechowicz,B., Laguette,M.N., Sawczuk,M., Huminska-Lisowska,K.,
            Maciejewska-Skrendo,A., Ficek,K., Michalowska-Sawczyn,M.,
            Leonska-Duniec,A., Kaczmarczyk,M., Chycki,J., Trybek,G.,
            September,A.V. and Cieszczyk,P.
  TITLE     Are KIF6 and APOE polymorphisms associated with power and endurance
            athletes?
  JOURNAL   Eur J Sport Sci 21 (9), 1283-1289 (2021)
   PUBMED   32867607
  REMARK    GeneRIF: Are KIF6 and APOE polymorphisms associated with power and
            endurance athletes?
REFERENCE   5  (bases 1 to 9085)
  AUTHORS   Konjikusic,M.J., Yeetong,P., Boswell,C.W., Lee,C., Roberson,E.C.,
            Ittiwut,R., Suphapeetiporn,K., Ciruna,B., Gurnett,C.A.,
            Wallingford,J.B., Shotelersuk,V. and Gray,R.S.
  TITLE     Mutations in Kinesin family member 6 reveal specific role in
            ependymal cell ciliogenesis and human neurological development
  JOURNAL   PLoS Genet 14 (11), e1007817 (2018)
   PUBMED   30475797
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9085)
  AUTHORS   Shiffman,D., Chasman,D.I., Zee,R.Y., Iakoubova,O.A., Louie,J.Z.,
            Devlin,J.J. and Ridker,P.M.
  TITLE     A kinesin family member 6 variant is associated with coronary heart
            disease in the Women's Health Study
  JOURNAL   J Am Coll Cardiol 51 (4), 444-448 (2008)
   PUBMED   18222354
  REMARK    GeneRIF: Confirming and extending previous reports, carriers of the
            719Arg allele of KIF6 have 34% higher risk of myocardial infarction
            and 24% higher risk of CHD compared with noncarriers among 25,283
            women from the WHS.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[J Am Coll Cardiol. 2008 Mar 4;51(9):977]
REFERENCE   7  (bases 1 to 9085)
  AUTHORS   Iakoubova,O.A., Tong,C.H., Rowland,C.M., Kirchgessner,T.G.,
            Young,B.A., Arellano,A.R., Shiffman,D., Sabatine,M.S., Campos,H.,
            Packard,C.J., Pfeffer,M.A., White,T.J., Braunwald,E., Shepherd,J.,
            Devlin,J.J. and Sacks,F.M.
  TITLE     Association of the Trp719Arg polymorphism in kinesin-like protein 6
            with myocardial infarction and coronary heart disease in 2
            prospective trials: the CARE and WOSCOPS trials
  JOURNAL   J Am Coll Cardiol 51 (4), 435-443 (2008)
   PUBMED   18222353
  REMARK    GeneRIF: In both the CARE and the WOSCOPS trials, carriers of the
            KIF6 719Arg allele had an increased risk of coronary events, and
            pravastatin treatment substantially reduced that risk.
            GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 9085)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 9085)
  AUTHORS   Bare,L.A., Morrison,A.C., Rowland,C.M., Shiffman,D., Luke,M.M.,
            Iakoubova,O.A., Kane,J.P., Malloy,M.J., Ellis,S.G., Pankow,J.S.,
            Willerson,J.T., Devlin,J.J. and Boerwinkle,E.
  TITLE     Five common gene variants identify elevated genetic risk for
            coronary heart disease
  JOURNAL   Genet Med 9 (10), 682-689 (2007)
   PUBMED   18073581
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   10 (bases 1 to 9085)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161439.15, AK131471.1,
            BX649045.1, AL832634.2, AL136087.12 and AK123217.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_145027.5.
            
            Summary: This gene encodes a member of a family of molecular motors
            which are involved in intracellular transport of protein complexes,
            membrane organelles, and messenger ribonucleic acid along
            microtubules. Kinesins function as homodimeric molecules with two
            N-terminal head domains that move along microtubules and two
            C-terminal tail domains that interact with the transported cargo,
            either directly or indirectly, through adapter molecules. This gene
            is ubiquitously expressed in coronary arteries and other vascular
            tissue. A naturally occurring mutation in this gene is associated
            with coronary heart disease. [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287152.12/ ENSP00000287152.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL161439.15        92598-92600
            4-1624              AK131471.1         1-1621
            1625-2253           BX649045.1         1202-1830
            2254-3111           AL832634.2         487-1344
            3112-3453           AL136087.12        88482-88823         c
            3454-3975           AK123217.1         1848-2369
            3976-9085           AL136087.12        82850-87959         c
FEATURES             Location/Qualifiers
     source          1..9085
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..9085
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /note="kinesin family member 6"
                     /db_xref="GeneID:221458"
                     /db_xref="HGNC:HGNC:21202"
                     /db_xref="MIM:613919"
     exon            1..164
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2543
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin-like protein KIF6"
                     /codon_start=1
                     /product="kinesin-like protein KIF6 isoform 1"
                     /protein_id="NP_659464.3"
                     /db_xref="CCDS:CCDS4844.1"
                     /db_xref="GeneID:221458"
                     /db_xref="HGNC:HGNC:21202"
                     /db_xref="MIM:613919"
                     /translation="MVKQTIQIFARVKPPVRKHQQGIYSIDEDEKLIPSLEIILPRDL
                     ADGFVNNKRESYKFKFQRIFDQDANQETVFENIAKPVAGSVLAGYNGTIFAYGQTGSG
                     KTFTITGGAERYSDRGIIPRTLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPR
                     HEASSLEDLPKVTILEDPDQNIHLKNLTLHQATTEEEALNLLFLGDTNRMIAETPMNQ
                     ASTRSHCIFTIHLSSKEPGSATVRHAKLHLVDLAGSERVAKTGVGGHLLTEAKYINLS
                     LHYLEQVIIALSEKHRSHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLEKRNLDESIS
                     TCRFAQRVALIKNEAVLNEEINPRLVIKRLQKEIQELKDELAMVTGEQRTEALTEAEL
                     LQLEKLITSFLEDQDSDSRLEVGADMRKVHHCFHHLKKLLNDKKILENNTVSSESKDQ
                     DCQEPLKEEEYRKLRDILKQRDNEINILVNMLKKEKKKAQEALHLAGMDRREFRQSQS
                     PPFRLGNPEEGQRMRLSSAPSQAQDFSILGKRSSLLHKKIGMREEMSLGCQEAFEIFK
                     RDHADSVTIDDNKQILKQRFSEAKALGESINEARSKIGHLKEEITQRHIQQVALGISE
                     NMAVPLMPDQQEEKLRSQLEEEKRRYKTMFTRLKALKVEIEHLQLLMDKAKVKLQKEF
                     EVWWAEEATNLQVNSPAVNSLDHTKPFLQTSDSQHEWSQLLSNKSSGGWEVQDQGTGR
                     FDVCDVNARKILPSPCPSPHSQKQSSTSTPLEDSIPKRPVSSIPLTGDSQTDSDIIAF
                     IKARQSILQKQCLGSN"
     exon            165..274
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..349
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..497
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..607
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..737
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..944
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1088
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1175
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1279
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1385
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1524
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1743
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1852
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1908
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1959
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2044
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2180
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2278
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2329
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2419
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2526
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..9085
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2894..2899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /note="hexamer: AATATA"
     polyA_site      2921
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /note="major polyA site"
     regulatory      9064..9069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /note="hexamer: AATAAA"
     polyA_site      9085
                     /gene="KIF6"
                     /gene_synonym="C6orf102; dJ1043E3.1; dJ137F1.4; dJ188D3.1"
                     /note="major polyA site"
ORIGIN      
        1 actgttgcta agactgtggg tcgccggagg tggtgggagt tagttttggc agcccgggcc
       61 tgagagaggt caagggtcat tgcagagcca gggaggagat ggtgaagcag actatccaga
      121 tattcgcgag ggtgaagccc cctgtccgga agcaccaaca agggatttat tccatagatg
      181 aagatgaaaa attaatacct agcttggaaa tcatcttacc acgtgatttg gcagatgggt
      241 ttgtgaataa taagcgagaa agctacaaat ttaaatttca aagaattttt gatcaggatg
      301 caaaccaaga gaccgttttt gaaaacattg ccaaaccagt tgctgggagt gtcctggcag
      361 gttacaatgg taccatcttt gcatatgggc aaacaggcag cgggaagaca ttcactatca
      421 cagggggtgc agagcgttac agtgacagag gcattatccc aaggacactg tcatacattt
      481 ttgaacagtt acaaaaggac agcagcaaaa tatatacaac acacatttcc tatttggaaa
      541 tctacaatga atgtggttat gatcttttgg atccaagaca tgaagcctcc agtttggaag
      601 atttgccgaa agtgacaata ctggaggatc ctgatcagaa cattcacctg aaaaacttga
      661 ctctccatca ggcaaccaca gaggaagaag ctctgaattt gcttttttta ggagacacca
      721 accgaatgat tgcagagact cctatgaacc aagcttcaac ccgttcccac tgcattttca
      781 ccattcattt gtcaagcaag gaaccaggat ctgcaactgt acgacatgcc aaactccatc
      841 tggttgacct ggctggttca gagcgagttg caaagactgg agtagggggc catcttctaa
      901 cagaggccaa gtatatcaac ttgtcactac attacttaga acaggttatc attgcccttt
      961 cagaaaagca ccgttcgcac attccttata gaaactccat gatgaccagt gtcctaagag
     1021 acagtttggg agggaactgc atgacaacta tgattgcaac actctccttg gagaaaagga
     1081 atcttgatga gtctatatca acctgcagat ttgcacagcg agtggcactc ataaagaatg
     1141 aagctgttct taatgaagaa attaacccca gattagtgat taaacgccta caaaaggaaa
     1201 tccaggaact gaaggatgaa ctggccatgg tcactgggga gcagaggaca gaggcactca
     1261 cagaagcaga gctccttcag ctggaaaaac taataacatc ctttttggaa gaccaggatt
     1321 cagacagtag attagaggtt ggcgcggata tgcgtaaagt tcatcactgt tttcatcatt
     1381 taaagaaact attgaatgac aagaagatcc ttgaaaacaa tacagtctcc tctgaaagca
     1441 aagaccaaga ttgtcaagaa ccattaaaag aagaagaata tagaaagcta cgagatattc
     1501 tgaaacagag agataacgaa atcaatatcc tggtcaacat gttaaaaaaa gaaaagaaga
     1561 aagctcagga ggctctccac ttggctggca tggatagacg tgaattcaga cagtcccaga
     1621 gcccaccctt ccgcctagga aacccagaag aaggtcaaag aatgcgacta tcctcagctc
     1681 cctcacaggc ccaggacttc agcattttgg ggaaaagatc cagtttgctc cacaagaaaa
     1741 taggaatgag agaggaaatg tcattaggat gccaggaggc ttttgaaatc ttcaagaggg
     1801 accacgctga cagcgttacc atcgatgaca acaaacagat tctgaaacag agattttctg
     1861 aagccaaggc cctgggagaa agtataaatg aagcaagaag taaaattggt cacctgaagg
     1921 aagaaatcac ccagcggcat atacagcaag tagccctagg aatctcggaa aacatggccg
     1981 tgcctctgat gccagaccag caggaggaga agctgcgatc acaactggag gaagaaaaga
     2041 gaaggtataa aacaatgttc actcgcctga aagccctgaa ggtggagatc gagcacttgc
     2101 agctgctcat ggacaaagcc aaggtgaagc tacagaaaga gtttgaagtc tggtgggcag
     2161 aggaggccac caacctgcag gtaaattctc cagcagtgaa ttcactcgat cacacgaagc
     2221 catttctcca gacatctgac tcccagcatg aatggtccca actcctctct aacaaaagtt
     2281 ctggaggctg ggaagtccaa gatcaaggca ctggcagatt cgatgtctgt gatgtgaatg
     2341 ccaggaaaat cctgccctcg ccttgcccca gtccacacag ccagaaacag agcagcacca
     2401 gcaccccact ggaagacagc atccccaaga ggccagtgtc gtccatccct ctcaccggag
     2461 acagccagac ggactcggac atcatcgcct tcatcaaggc cagacagagc attctgcaga
     2521 agcaatgttt gggaagcaat tgaatttcca ggaaatatcc atccatgaat tatgccagca
     2581 agaatgaagc acagatgaag gcagcgcccc tcacttgctc tggcttcaga agtgaactat
     2641 gggctgctgg gagcaactag tgactttgat tcccatggag gggactgtgt ttctttaagg
     2701 atgctgacct ggaggccacc gagaggctgg ggctggggct gaccacaaca tccttcctgt
     2761 ggttgctgga gctgctggca gggccaggca aggccagagt gctaggggca gggtgaaggc
     2821 ttcagctcac tgttgtagtg acgttttgtg tagatcttta taagcttttg agaatgtgaa
     2881 atagcaccat caaaatataa tgtcagagga tgctcacacc agtggaatgt ggggggaata
     2941 tttttatttt taacgatttg ccagctctct cccttggccc gtgctctggt ttggaagccc
     3001 agaaatggcc atgacaggtc caggcaggat gtcccagcca caggcaaggc agtggaatgc
     3061 agggcatcct gaaggccaat cctgatctcc cagaccacat ctttcaccat cagcctcttg
     3121 gccaggatga cctggaggca gtgcctgaac agctgtgtct ccagggagcc atctgccctg
     3181 cagggtctaa ggacatcata gcacccagag aacagtgggc agctcccagg ggctctgctg
     3241 agagcttgag agagggcagt gtgggtacct tgggcctcac aaccttcacc cagccacttg
     3301 ggaggatttg ggctgacact ccccacttcc acagggaaaa acatagctgc ctgggggtct
     3361 tgtctccatg ggccctctcc atgacagatc caagggaagg tgggcagccc tcaaggaggt
     3421 tcttgaagaa ctgccccctg ggccaggggg ttccaaccca gctgcagcca gggaggggca
     3481 gcggagggtg agcaggagtg gcacctggaa atgaagctaa ctggataaaa gtgctggtcc
     3541 actgctcctg gtgtctctgt cctataaata caggacctga tgaccctgga ggggagcaga
     3601 gtggtaatat agtataattg gcttgatttt ctttttcgtt ttttaggact gggtaacagg
     3661 atcatgcagg agaagattaa accattacat ttctaagcta ggcaggccca tcgagctcct
     3721 ctaatccaca cccctatttt atataattag aaggccagag tgaaggggag attcagcttg
     3781 ctgttctatg ccactgacaa atgtcccctc ttcagggggc ttcccctgac cactccatct
     3841 cgagtcaccc cctagttatc ccctatccca ttaccatttt ttctgcatca ctatctgaca
     3901 tgttatcctt ccgaacttgc ctatttttga aatacctgca accccccata atactaagag
     3961 ctccaatgca acagggacct gtttgtcttg ctcattgctg tgtcccaagc acagagtcgc
     4021 tgttcagtaa acggtccttc agttcatgag tagacgagcc agaacccaga tgtgtttctc
     4081 aggctggtgt cactctgact tcccccaggc tctgactgaa tcccatcggg acaggggcca
     4141 gcatctctgg tccactcctg gccctcacag ttcaatggaa catagtaagc cctctgtaaa
     4201 gtctgtagaa ccagaggaag accaaattct gattctagaa gcctccccaa gagtccatgg
     4261 aacacacatg taactgcaca cacacacaca catacacaca cacactctca agagccctga
     4321 agatggcatg gcatttgccc cagtccccta tgtagcagca gcagtattct tggcatgcct
     4381 tagtgccctc agccctctag agctgggtag agtctactaa cttttatttt cttttatttt
     4441 tactttcttt tatttatttt ttgagatggg gggggtctct gtcagccagg ctggggtgca
     4501 gtggtgcgac catacctcac tagtcagcct ccaactcctg ggctcaagcc atactcagcc
     4561 tccaactcct gggctcaagc gatcctctca cctcagcctc caaagtagct ggaactacag
     4621 gcatgcacca ccacacctag ctcgttttaa attttttgta gagacagggt ctcactgtgt
     4681 ggctcaggat ggtctcaaat tcctggcctt aagcgatgct cccgccttgg cctcccaaag
     4741 tgctgggatt gcaggcatga gccacatacc ctgccagagt ctttcaacat tagatctccc
     4801 actgagacat catctcctgg atccaaaggc cttactgaca gagatgtgtg gcatggcccc
     4861 atgcggggtg tgaaccagcc tcctggggca atcactaaga caggaaagga aatgaagaca
     4921 gaaaaacaca caacatggga tctggggcca ctggtgtcca gagcatatgc aaagtgtgtg
     4981 cagcaactgg ccaaggggcc ttttgctccg aacatcccct aatggaagcc cagcctttga
     5041 tatggacaca tgcttgacag cagtgcacct tcccagagtt cactggcctc tgcaaatggg
     5101 agaaattgat gcaatgtttt gaaaagactt tccagcaatc cacctgggat cagtggagcc
     5161 acggatgaca agaagtatct gagttcactc taggccaaaa tgtgggattt tcaaaaacat
     5221 tttctggaaa gcagcctagc cagtgactcc agcccagtcc ctgctagaat tcaactggct
     5281 ctaccaatcc cttgacaaga agtagggtgg acggaggttg gaggagggaa gttaaaatgt
     5341 agcttgccca gatcttgcta aaaaggagtt ttagaaagca gatagagaaa ttgtggtata
     5401 ctgaatacat cattttaatt cttcaccacc agtatagaat tacacatcca aagctttgtc
     5461 atggcccact ttgactaatg tggtgttggc aaacctgatc caggcagagg cttgaattgt
     5521 gctctcatgg ttgagcttgc ctcttgctcc agtgatctct cttgggatga acatgccatg
     5581 ggtagctgct gccccttcag cctggaacat ccagagagca gacctgagcc cagtctacag
     5641 cctggagcag agcctcccag gcaagcccag cccagatcag ctgaactatg gctcacccaa
     5701 agacctattg gcatgagaat atatgctgct tgtcataaac cactgaggtt tagagtggtt
     5761 tgttatatag cattaattgt agcaatagca gactggcaca gaaattggaa cccagagaca
     5821 gtatatgact ggatctagga tttctcagtg cagagttcat tgtctctcca tgcagcctgt
     5881 ggaaaggcac tgagagcatc ctgtatatgg aaaagcagga ccaccaccta cagccatgat
     5941 gaagcaacaa ggacctgatt taccctcctg ctttaaatga ctaaaaatga gacaaaatcc
     6001 tctatacaaa ccaatggttt tcagccattg gataacaagc aatatagggt atgattgatc
     6061 cgcaagagaa gggaaacaag tgaggggagc cctatgattg ctccaactta ctgcctgcag
     6121 tgagttttca ggctgcagcc caggaagggg gaaccaggta gagcccagtg gtttccctga
     6181 gttgaggaaa tggagctggg aatccaggga ggacaaagtg gcttaaattt gcaaggcaga
     6241 gtcccaggga tgagagagag agaaggagag agagaggaga aaaaagagag agaaagagag
     6301 agagcatgct ctggagatct tcagagggtt acccttgagt cttcagctaa ctaccgatca
     6361 acatctgcat gtgaagaaat tacccaaggc aggggaaaga accaccagga ggaagcaggt
     6421 ggaataattt cctgagataa cactgtgttg ggaagagttc atgtttccaa cagccagagt
     6481 ggagaaacct cccaaaacag tcattgtata gagacacata aggtactgcc tcagaagtgg
     6541 ggccaaatta gtcctagatg atagattgct ctggtcccac ctaacaaagc ttaaaaagcc
     6601 agccccaaag gagtcaaatt gtttccagta agtttccaag taacttcaat gagtcccaaa
     6661 acaaagcttc aaaatatcta aaggaatatg aaaaacaaac caaaaagaaa ccagcatcca
     6721 acaatataga atccacaatg tctggtgtcc attaaaaaat aatcaggcat gcaaagaagc
     6781 aggaaaatat gggccatgag aggagaaaaa accatcaata gaaatagagg ccgggtgtgg
     6841 tggctcactc ctataatccc agcactttgg gaggccgagg caggaggatc acctgaggtc
     6901 aggagttcaa gaacagcctg ttcaacatgg ggaaaccccg tctctactaa aaatacaaaa
     6961 aatagccggg catggtgttg cgtacctgta atcccagcta ctcagaggct gaggcaggag
     7021 aattgcttga gcccaggagg cagaggttac agtgagccga aattgtgcca ttgcactcca
     7081 gcttgggcaa caagagtgaa actctgtctc aaaaaaaaaa aaaagaaaaa acaaatagaa
     7141 acagccccag gcatggcaca gttgatagag taaatagaca gaaacatttt ttaaaatgca
     7201 atgggtgtgt gtttcaaatc taggcagaaa aaatgctcct tgtaattcct taaacataag
     7261 catgtctcat tcatctggtc attgttttga caaggatgtg ccatccattg tgctaagttc
     7321 tgaggagtca gaggtgacag agacagagaa agtgccagca ttcttggaac cttctaacga
     7381 aggagaggga caagccaggc atggtggctc acgcctgtaa tcccaacact ttgggagact
     7441 gaggctggcg gatcacgagg tcaggagttt gagaccaacc tggccaacat ggcgaaaccc
     7501 catcgctact aaaaatacaa aaattagctg ggtgtggtgg tgcgcacctg taatcccagc
     7561 tactctggag gctgaggcag gacaatcact tgaaccctgg aggcagagtt tgcagtgagc
     7621 tgagatcgtg ccactgcact ccaacctggg caacaagagc gagactcctt ctctgaaaaa
     7681 aaaaaaaaga gagggacaat aaacaagtaa gcaagacaat ctgattaaga aggagttggg
     7741 gttagctggg catggtagca agcgcctgta gtctcagcta ctcgggaggc tgaggtggga
     7801 ggatccttga acccaggagg ttaaggctgc agtgagctgt gatcacacca ctgcactcca
     7861 gcctggatga cagagcaaga ccctgtctca gaaaaagaag aaggagttgg gggtggggta
     7921 ggatgggctt ggactcacta tcaaggtggg tgggagtgtg agaacccggc aaggtgcaaa
     7981 gagagaagca gggaagggaa gcttaggaca atgatggcag gttgggtatt gggtgatggg
     8041 aagaggcaaa ggacgtggag cttggcaaaa aggggacttg tggggatttg ggccatgtga
     8101 gcatgtgggg gagacagtgt tccttccata acacgtgtcc agggactgcc agggctccga
     8161 ggcagagcag gtgtagagag gttggctgtg aatgttggat gttgaaaaca tatgtgtcaa
     8221 atgtgggagg aaaaagcagt gtttccttga atacaagctc ctcctcacct tgcgaaaagt
     8281 ggcctctgag tgtagccctg aatgcatctc ccaaggaata ggaggaagca gcaacctttt
     8341 cagagttaac tgctttattt gggttttcca tggcctcgtg ccagccagca gggctgagcc
     8401 agtttcaccc acactgagag ggaactcagc aaagagcaag cagcatgcca gctggtactc
     8461 ttccctctcc attcactcag ctcctgatct caggagggca gcccctcccc aggccagcac
     8521 ccctcccctt ctggccccag gtgtgggatg ttgttgtttt cttttctccg aaacatctcc
     8581 tgggtttgtc ttttccatca ctgtctttag actgaggcaa gcagtcccca tgccttcagc
     8641 cccatgtttt gggggtaacc tgtgctttga catgctttgc taaaaacttt ctaagtctcc
     8701 ctctggtgct gggaccagcc atgaccaaca acgtcatcca tgcaggccac ccctaacata
     8761 gtccaggcct catgtgggtc tcagttccct tttcttcttt caggaagttc tccagtgcat
     8821 gcatagggtt gaccagatgt cccaaggtgc tctaggactt atgcctatga agctgtttta
     8881 gggcttccta gtcagtccct ggttccagga aagcagcctg atgaggagat cattcccgct
     8941 ggctggtgtg gcatttcttt tatggcacta cctgggattg ggccaccaga cctgcgctaa
     9001 catgctgatt tgatggactc ttaacatcat aggacaaaga atcgtcatgt gaaccaatta
     9061 gacaataaac aaatgcctaa gtgcc
//
