LOCUS       NM_004522               6954 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens kinesin family member 5C (KIF5C), transcript variant
            1, mRNA.
ACCESSION   NM_004522 XM_938129 XM_943554
VERSION     NM_004522.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6954)
  AUTHORS   Tong,D. and Fan,L.
  TITLE     LncRNA ZNF667-AS1 Targets miR-523-3p/KIF5C Axis to Hinder Colon
            Cancer Progression
  JOURNAL   Mol Biotechnol 66 (6), 1464-1476 (2024)
   PUBMED   37322260
  REMARK    GeneRIF: LncRNA ZNF667-AS1 Targets miR-523-3p/KIF5C Axis to Hinder
            Colon Cancer Progression.
REFERENCE   2  (bases 1 to 6954)
  AUTHORS   Naim,A., Accogli,A., Amadori,E., D'Onofrio,G., Madia,F.,
            Tortora,D., Zara,F., Striano,P., Salpietro,V. and Severino,M.
  TITLE     Abnormal course of the corticospinal tracts in KIF5C-related
            encephalopathy
  JOURNAL   Eur J Med Genet 65 (11), 104622 (2022)
   PUBMED   36122673
  REMARK    GeneRIF: Abnormal course of the corticospinal tracts in
            KIF5C-related encephalopathy.
REFERENCE   3  (bases 1 to 6954)
  AUTHORS   Li,W., Cheng,T., Dong,X., Chen,H., Yang,L., Qiu,Z. and Zhou,W.
  TITLE     KIF5C deficiency causes abnormal cortical neuronal migration,
            dendritic branching, and spine morphology in mice
  JOURNAL   Pediatr Res 92 (4), 995-1002 (2022)
   PUBMED   34966180
  REMARK    GeneRIF: KIF5C deficiency causes abnormal cortical neuronal
            migration, dendritic branching, and spine morphology in mice.
REFERENCE   4  (bases 1 to 6954)
  AUTHORS   Diwaker,D., Murray,J.W., Barnes,J., Wolkoff,A.W. and Wilson,D.W.
  TITLE     Deletion of the Pseudorabies Virus gE/gI-US9p complex disrupts
            kinesin KIF1A and KIF5C recruitment during egress, and alters the
            properties of microtubule-dependent transport in vitro
  JOURNAL   PLoS Pathog 16 (6), e1008597 (2020)
   PUBMED   32511265
  REMARK    GeneRIF: Deletion of the Pseudorabies Virus gE/gI-US9p complex
            disrupts kinesin KIF1A and KIF5C recruitment during egress, and
            alters the properties of microtubule-dependent transport in vitro.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6954)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 6954)
  AUTHORS   Brickley,K., Smith,M.J., Beck,M. and Stephenson,F.A.
  TITLE     GRIF-1 and OIP106, members of a novel gene family of coiled-coil
            domain proteins: association in vivo and in vitro with kinesin
  JOURNAL   J Biol Chem 280 (15), 14723-14732 (2005)
   PUBMED   15644324
REFERENCE   7  (bases 1 to 6954)
  AUTHORS   Kanai,Y., Okada,Y., Tanaka,Y., Harada,A., Terada,S. and Hirokawa,N.
  TITLE     KIF5C, a novel neuronal kinesin enriched in motor neurons
  JOURNAL   J Neurosci 20 (17), 6374-6384 (2000)
   PUBMED   10964943
REFERENCE   8  (bases 1 to 6954)
  AUTHORS   Xia,Ch., Rahman,A., Yang,Z. and Goldstein,L.S.
  TITLE     Chromosomal localization reveals three kinesin heavy chain genes in
            mouse
  JOURNAL   Genomics 52 (2), 209-213 (1998)
   PUBMED   9782088
REFERENCE   9  (bases 1 to 6954)
  AUTHORS   Engelender,S., Sharp,A.H., Colomer,V., Tokito,M.K., Lanahan,A.,
            Worley,P., Holzbaur,E.L. and Ross,C.A.
  TITLE     Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued
            subunit of dynactin
  JOURNAL   Hum Mol Genet 6 (13), 2205-2212 (1997)
   PUBMED   9361024
REFERENCE   10 (bases 1 to 6954)
  AUTHORS   Niclas,J., Navone,F., Hom-Booher,N. and Vale,R.D.
  TITLE     Cloning and localization of a conventional kinesin motor expressed
            exclusively in neurons
  JOURNAL   Neuron 12 (5), 1059-1072 (1994)
   PUBMED   7514426
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW162840.1, AB011103.1,
            DA085551.1 and AB209191.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004522.2.
            
            Summary: The protein encoded by this gene is a kinesin heavy chain
            subunit involved in the transport of cargo within the central
            nervous system. The encoded protein, which acts as a tetramer by
            associating with another heavy chain and two light chains,
            interacts with protein kinase CK2. Mutations in this gene have been
            associated with complex cortical dysplasia with other brain
            malformations-2. Two transcript variants, one protein-coding and
            the other non-protein coding, have been found for this gene.
            [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011103.1, SRR1803612.248336.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435030.6/ ENSP00000393379.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AW162840.1         5-27
            24-4752             AB011103.1         1-4729
            4753-5048           DA085551.1         275-570
            5049-6954           AB209191.1         2932-4837
FEATURES             Location/Qualifiers
     source          1..6954
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.1-q23.2"
     gene            1..6954
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /note="kinesin family member 5C"
                     /db_xref="GeneID:3800"
                     /db_xref="HGNC:HGNC:6325"
                     /db_xref="MIM:604593"
     exon            1..517
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..3265
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /note="kinesin heavy chain neuron-specific 2;
                     neuron-specific kinesin heavy chain 2; kinesin-1"
                     /codon_start=1
                     /product="kinesin heavy chain isoform 5C"
                     /protein_id="NP_004513.1"
                     /db_xref="CCDS:CCDS74586.1"
                     /db_xref="GeneID:3800"
                     /db_xref="HGNC:HGNC:6325"
                     /db_xref="MIM:604593"
                     /translation="MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQG
                     KPYVFDRVLPPNTTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHD
                     PQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDK
                     NRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENV
                     ETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTH
                     VPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVN
                     LELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLEP
                     CDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQSQLAEKLKQQML
                     DQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDK
                     TRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIG
                     TNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASER
                     ELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSF
                     QDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQ
                     KLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTL
                     HNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNA
                     DLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQEVDRIKEAVRAKNMA
                     RRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNSTHYQK"
     exon            518..608
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..682
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            683..787
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..836
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..892
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..980
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1105
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1210
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1359
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1508
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1684
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1753
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1960
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2107
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2296
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2414
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2491
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2601
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2703
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2764
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2836
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2837..2941
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3158
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3272
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..6954
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6933..6938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /note="hexamer: AATAAA"
     polyA_site      6954
                     /gene="KIF5C"
                     /gene_synonym="CDCBM2; KINN; NKHC; NKHC-2; NKHC2"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgct ggtgctgatg caggatggct gagcgcgcag gagcccggga ggtctgagcc
       61 gggcgaggct cgctccctgc gcatcgcctc ctccgcccgc cgcgtggtcg cgggcaggtg
      121 ggccgggggg cgctgggcag gggcggggca gggccagggc aggccggtct gcagccggag
      181 gggccggagc ggagaagctg cccaccttcc cgggctcgga gcggccgggg ctgctcagcc
      241 ggccgggctc gcgatgacct gctgagaagc gtcgtcggag gctgcaggag gcggcctagc
      301 tgtgggcggt gcagctcgcg gcctcctccc tcgtcgttcc cggccccggc cccccaccca
      361 tccccgtgcc ccctccctac cgccggccga gatggcggat ccagccgaat gcagcatcaa
      421 agtgatgtgc cggttccggc ccctcaacga agcggagatc ctccgcgggg acaaattcat
      481 ccccaaattt aaaggcgatg agaccgtggt gatcgggcaa gggaagccat atgtcttcga
      541 cagagtgcta cctcccaaca cgacccaaga gcaggtttac aatgcatgtg cgaagcaaat
      601 tgtcaaagat gtccttgaag gttataacgg gacgattttt gcgtatgggc agacttcatc
      661 aggaaaaacc cacaccatgg aggggaagct gcatgacccc cagctcatgg ggatcatccc
      721 acgaattgcc catgatatct ttgaccatat ctactccatg gatgagaacc tggagtttca
      781 cataaaggtt tcctattttg agatctactt ggacaaaata agggacttac ttgatgtatc
      841 caagaccaac ttggctgttc atgaagataa aaacagagtc ccgtatgtaa aggggtgcac
      901 tgagcggttt gtgtcgagcc ctgaggaagt catggatgta atagatgaag gcaaagcaaa
      961 ccgacacgtg gctgtgacaa acatgaatga acacagctct agaagtcaca gtatcttcct
     1021 gataaatatt aaacaagaga atgtagagac tgaaaaaaaa ctcagtggga aactttattt
     1081 ggttgatttg gctgggagcg aaaaggtcag caaaactggt gccgagggag ctgttcttga
     1141 cgaagctaaa aatatcaata agtctttgtc tgctcttgga aatgtgatct ctgctttggc
     1201 agaagggaca aaaacacatg tgccataccg ggacagcaag atgactcgga ttcttcagga
     1261 ctctttgggt gggaactgca gaaccaccat cgtcatttgc tgttctcctt ctgtcttcaa
     1321 tgaggctgag accaagtcca cactgatgtt cggacagaga gctaagacca tcaagaatac
     1381 agtctctgtg aacctagaac tgacagcaga agaatggaag aagaaatatg aaaaagagaa
     1441 agagaaaaac aagactttga agaatgttat ccagcatctg gagatggagc taaacaggtg
     1501 gaggaatgga gaagctgtgc ctgaggatga acagatcagt gccaaggacc agaagaacct
     1561 ggagccttgt gataacaccc ccatcataga caatattgct cctgttgttg ctggcatctc
     1621 tacagaggag aaagagaagt acgatgagga gatctccagt ctctacagac aactggatga
     1681 caaggatgat gaaattaacc agcagagcca gctggctgaa aagctgaagc aacagatgtt
     1741 ggatcaggat gagcttttag cttccacaag aagagactat gagaagatac aggaggagct
     1801 gacacgtctc cagattgaaa atgaggcagc caaggatgag gtgaaagaag ttctccaggc
     1861 cctggaggag ctggctgtca attatgacca gaaatcacag gaagtggagg ataagacccg
     1921 ggccaatgag cagctgacag acgagctggc ccagaaaacg actacattga caaccacaca
     1981 gagagagctg agccagctac aagagcttag caaccaccag aagaaaaggg caactgagat
     2041 cctgaatttg ctgttgaaag atctggggga gataggtgga attattggca ccaatgatgt
     2101 gaaaactttg gcagatgtga atggagtcat tgaggaggag tttaccatgg cccgcctgta
     2161 catcagcaag atgaagtcag aggtcaagtc cctggtgaac cgcagcaaac agctcgagag
     2221 cgcccagatg gactccaaca ggaagatgaa tgccagcgag cgggagctgg cagcctgcca
     2281 gctgctcatc tcccagcacg aagccaagat caagtctctg acagactaca tgcagaacat
     2341 ggaacagaag aggaggcagc tagaagagtc ccaggactcg ctcagcgaag agctggcaaa
     2401 gctccgagcc caggaaaaaa tgcacgaagt cagcttccag gataaggaga aggaacatct
     2461 gacgcggttg caggatgctg aagaaatgaa gaaggcgctg gagcagcaga tggagagcca
     2521 ccgggaagct caccagaagc agctgtccag actccgagac gaaattgagg agaagcagaa
     2581 aatcattgat gagattcggg atttgaatca gaaactgcaa ctggaacagg agaagcttag
     2641 ttctgattat aacaagctga aaatagagga ccaagagaga gaaatgaagc tggaaaagct
     2701 cttattgctc aacgataaaa gggaacaagc cagagaagac ctcaaagggc tggaggagac
     2761 agtgtctaga gaattgcaga cactgcacaa ccttcggaaa ctctttgtcc aggatctgac
     2821 cacccgagtt aaaaaaagtg tggagttgga caacgatgat ggagggggca gtgctgccca
     2881 gaagcagaaa atttccttct tggagaataa cctggagcag ctcaccaaag ttcacaagca
     2941 gctggtccgg gacaacgcag acctgcgctg tgaactgccc aagctggaga agcggctgcg
     3001 tgccacggcg gagcgcgtca aggctctgga gagcgcgctg aaggaggcca aggagaacgc
     3061 catgcgggac cgtaagcgct accagcagga ggtggatcgt atcaaggagg ccgtgcgggc
     3121 caagaacatg gccagaaggg cccattcagc ccagatcgcc aagcccatcc gccccggaca
     3181 ctacccggcc tcatctccaa cggccgtcca tgccattcga gggggaggag gcagctcttc
     3241 aaattccact cactaccaga aataaataca aaatatgact ccacgtagca tgtcaaggac
     3301 tacattaatc accaattcct ttatttttcc ccccctacag tttccatttt ttttttatac
     3361 ttgcttactc cagccatctg cagtacacca gtttcaggtc ttttgagctg tgtagagttt
     3421 ctgtgtgtac agatgtgtgc tcggactttt ctctttttga gaaatctgaa ggagatggtt
     3481 gcagaagatc cacttactac tgagaaccat taccaccgac tcggcctccg gggtgttggg
     3541 tggtttctgg gtggttcctg gagcctcctc tgggcagtgc actgtcccat ctgtacgccc
     3601 taatgtgcca ttccctagag gggaacaacc aagtgccgtg gaggcagatg atcatggtct
     3661 gcctcaactg tctggtttcc tgtaaaataa acacattgtt ttatattttt agggaacaaa
     3721 aagtgctgct atagggttca aagttttcct tctgaacact tttccgaaac aaattacccc
     3781 aaagacacat tttgaatatc ctggtcacat ctttggatct gtaaaatata ccttttagta
     3841 tggcacctgt taaaatgcaa agcaaatttc tttggggcag aaaaacaatc tgacagtagc
     3901 agtgtagaat ttgttcattc aaatacatct gtgtaaatgc aaaaagtcat aaaattcacc
     3961 tccgagctgc ttgcttttga acctgcagca actagtctta gccggcccgg tttgaacatc
     4021 gttctttcag aagtgctgaa aatgctgcaa agttggataa gtggaaatgt ggctgcccct
     4081 ctcctcacta cttcctctct gatcgttctg aagcttgcat tgggaatggc tgctttctct
     4141 aaccattttc agcttgagtg ggtattgctg aagaaatcca acatcattcc agcagttgaa
     4201 aaaggaagcc ttcgggagaa agtgcttgtc aaaattttgt tctttgtgct tgtgtatgag
     4261 taagttgcca tgaataagtt attattttaa cccataattg gcgactgttt atatgaattc
     4321 tttctttggc accaaatagg tttcatcttc ttaggcacaa ttagaaaaaa tccacataga
     4381 tggatatttt acatttagtt attgctttat ccaaatacat gaatctaaag ctgaatcaac
     4441 ccttacttcc agttgtgctt attaagaaga tcaatttcca agtagtaaag ttttcaggga
     4501 aactgactgt gctgctattt gttttgacaa atttgggggt aagtcaatga caaccaaacc
     4561 aatctcggtg gaaactccta tcctatcatg ttgtgtgccc aagatgagtg agctggcact
     4621 gtgccctgaa gctttcacca ctgtaatgaa atatatgcca ggggagactt tgggcttttc
     4681 tcatgactgt gtgggtcgaa ggtagctcaa gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4741 gtgtgtgtgt gtgtgtatgt gtgtaaagtg ctaagaactg tgcattgaca tccaaacatt
     4801 tcttgtacaa aatttcccta gcaaagcaaa cctgctttga cttaatttat ttgttaaatg
     4861 ttgcactttg tttatgtatg ttttgttttt ggtggggaat aaggagagag aggacgacaa
     4921 attctattga agtatttatt ttgtgaagat ggcaattttg catttgttta aatttttttc
     4981 attctttaat tttgttatca gtgccagccc aatatacctg ctctaccatt atttgcggtc
     5041 tgataaaagg gtccttgtgg ggcaggtttt gcaaagctta tcaggtaata acatatgcca
     5101 cataaccttg ttgatatgtt tgcttctgat ttgggaagct aaacattggt gtttgagagg
     5161 attgccaatt attaattgtc attaccacta ctctccatta ctttttgttt ggaaattgaa
     5221 caaaggtcag taatggtttt tggctcttgt taatatccat cataaaatag attgttttag
     5281 attctttcca gggtgatttt tccctgggta ccccgtttct acttctaaag aattgcttgg
     5341 cactttcatg tttcaaaggg aaacattcgc ttgtagttcc attttacttg atctctacaa
     5401 gggactgaca acatttgctt tacttttatt cacagagaaa gttggctttg atgtctctta
     5461 aagataattc tgctagttgc tgatcagcca gtcagttcac ctagcttcaa tctttatagg
     5521 acttctaatc taattttcct atagtgtgac taaaagggag gcaaattatt ggaacggatt
     5581 attcaaatgg atccttaaat attgctatgt ataataagcc agttattata tcaggaccat
     5641 gttctctgta ggccactttc taaaaaagcc acatatgtgc aattttcagg tttttagact
     5701 attgctccct gtactttaaa tgtaaaaacc acacttctga acaactaagc tcatgaatat
     5761 gattttggtt atatgcagct tttgactagc atgtattgtg tctttttctc ctctatgaat
     5821 aattttatat ttcatgctac ttcttgaaag tttactcttt gatgctctaa gagaacagcc
     5881 agatggttta tatgaataat ctttatctgc aggatggtgg attggtaaat taggagaatg
     5941 ttgtttgaga tatcaagatt tatgtctggg aactaaaata tataatgcca aatgtgtttt
     6001 tgtcaattac tagagaattc tgtgcaaaca tatcatctct tcaaatgctg cacactttgc
     6061 ttttgttaaa cagcaggtag tagacagaac aataacagtt tcgcgttaag acttttaaag
     6121 gaaatagaat cgtgattaag aaatcagaat ttatagatat attgggataa atgaagaaat
     6181 aaaaatgttt gtctagaatg tagcatctag tgacttttta aagccctaac gtttacataa
     6241 agaagctcta gttcttatag aaataacaaa gcaaataaaa gttcttaaca atcccctctt
     6301 tcgaagtgca tttttttaaa gcagggcagg agacatttgg actctagcta tatgacatac
     6361 tgggaaaggc agagggtgga gggaagattt cacttcattg tctagcccag aatcttgagc
     6421 aagctaaaga aaccatcata atctaaaatt gcttcattta acactaacaa tttagacttt
     6481 ttaaaccaag cattgaataa tggctggata actgccgaag taagcgccgc tccatgaagt
     6541 ctgcttactt atttaaaaat tgtgtatcag ttttaaatac tgttcattgt gtgcagatat
     6601 aaggggaata gggcattctg tagaattata catgtctagt ttgtaaagtg tgtcctgtgt
     6661 actgcagatg tgtgttctct gggctttatg tatctgtaca gtagctttca cattaaaaaa
     6721 attgtggaca aacttgtccg gggggtttga ggggagaatg gtggtttata tcaataacga
     6781 tgctgtacta tagtccatgt aacaaaagat ctggaagtca ccctcctctg gcccacggaa
     6841 aattttggta atcttctagg ttctaaaatg aagatgtatg ggtactctgg cagactgcat
     6901 gttgtataat ttgaaaaata ctaaaagtgg aaaataaaat tgaattaaac tttg
//
