LOCUS       NM_004521               5866 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kinesin family member 5B (KIF5B), mRNA.
ACCESSION   NM_004521
VERSION     NM_004521.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5866)
  AUTHORS   Marom,R., Zhang,B., Washington,M.E., Song,I.W., Burrage,L.C.,
            Rossi,V.C., Berrier,A.S., Lindsey,A., Lesinski,J., Nonet,M.L.,
            Chen,J., Baldridge,D., Silverman,G.A., Sutton,V.R., Rosenfeld,J.A.,
            Tran,A.A., Hicks,M.J., Murdock,D.R., Dai,H., Weis,M.,
            Jhangiani,S.N., Muzny,D.M., Gibbs,R.A., Caswell,R., Pottinger,C.,
            Cilliers,D., Stals,K., Eyre,D., Krakow,D., Schedl,T., Pak,S.C. and
            Lee,B.H.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Dominant negative variants in KIF5B cause osteogenesis imperfecta
            via down regulation of mTOR signaling
  JOURNAL   PLoS Genet 19 (11), e1011005 (2023)
   PUBMED   37934770
  REMARK    GeneRIF: Dominant negative variants in KIF5B cause osteogenesis
            imperfecta via down regulation of mTOR signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5866)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 5866)
  AUTHORS   Tunganuntarat,J., Kanjanasirirat,P., Khumpanied,T.,
            Benjaskulluecha,S., Wongprom,B., Palaga,T., Siregar,T.A.P.,
            Borwornpinyo,S., Chaiprasert,A., Palittapongarnpim,P. and
            Ponpuak,M.
  TITLE     BORC complex specific components and Kinesin-1 mediate autophagy
            evasion by the autophagy-resistant Mycobacterium tuberculosis
            Beijing strain
  JOURNAL   Sci Rep 13 (1), 1663 (2023)
   PUBMED   36717601
  REMARK    GeneRIF: BORC complex specific components and Kinesin-1 mediate
            autophagy evasion by the autophagy-resistant Mycobacterium
            tuberculosis Beijing strain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5866)
  AUTHORS   Flex,E., Albadri,S., Radio,F.C., Cecchetti,S., Lauri,A., Priolo,M.,
            Kissopoulos,M., Carpentieri,G., Fasano,G., Venditti,M.,
            Magliocca,V., Bellacchio,E., Welch,C.L., Colombo,P.C., Kochav,S.M.,
            Chang,R., Barrick,R., Trivisano,M., Micalizzi,A., Borghi,R.,
            Messina,E., Mancini,C., Pizzi,S., De Santis,F., Rosello,M.,
            Specchio,N., Compagnucci,C., McWalter,K., Chung,W.K., Del Bene,F.
            and Tartaglia,M.
  TITLE     Dominantly acting KIF5B variants with pleiotropic cellular
            consequences cause variable clinical phenotypes
  JOURNAL   Hum Mol Genet 32 (3), 473-488 (2023)
   PUBMED   36018820
  REMARK    GeneRIF: Dominantly acting KIF5B variants with pleiotropic cellular
            consequences cause variable clinical phenotypes.
REFERENCE   5  (bases 1 to 5866)
  AUTHORS   Charles Jacob,H.K., Signorelli,R., Charles Richard,J.L., Kashuv,T.,
            Lavania,S., Middleton,A., Gomez,B.A., Ferrantella,A., Amirian,H.,
            Tao,J., Ergonul,A.B., Boone,M.M., Hadisurya,M., Tao,W.A., Iliuk,A.,
            Kashyap,M.K., Garcia-Buitrago,M., Dawra,R. and Saluja,A.K.
  TITLE     Identification of novel early pancreatic cancer biomarkers KIF5B
            and SFRP2 from 'first contact' interactions in the tumor
            microenvironment
  JOURNAL   J Exp Clin Cancer Res 41 (1), 258 (2022)
   PUBMED   36002889
  REMARK    GeneRIF: Identification of novel early pancreatic cancer biomarkers
            KIF5B and SFRP2 from ''first contact'' interactions in the tumor
            microenvironment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5866)
  AUTHORS   Tanaka,Y., Kanai,Y., Okada,Y., Nonaka,S., Takeda,S., Harada,A. and
            Hirokawa,N.
  TITLE     Targeted disruption of mouse conventional kinesin heavy chain,
            kif5B, results in abnormal perinuclear clustering of mitochondria
  JOURNAL   Cell 93 (7), 1147-1158 (1998)
   PUBMED   9657148
REFERENCE   7  (bases 1 to 5866)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   8  (bases 1 to 5866)
  AUTHORS   Kull,F.J., Sablin,E.P., Lau,R., Fletterick,R.J. and Vale,R.D.
  TITLE     Crystal structure of the kinesin motor domain reveals a structural
            similarity to myosin
  JOURNAL   Nature 380 (6574), 550-555 (1996)
   PUBMED   8606779
REFERENCE   9  (bases 1 to 5866)
  AUTHORS   Niclas,J., Navone,F., Hom-Booher,N. and Vale,R.D.
  TITLE     Cloning and localization of a conventional kinesin motor expressed
            exclusively in neurons
  JOURNAL   Neuron 12 (5), 1059-1072 (1994)
   PUBMED   7514426
REFERENCE   10 (bases 1 to 5866)
  AUTHORS   Navone,F., Niclas,J., Hom-Booher,N., Sparks,L., Bernstein,H.D.,
            McCaffrey,G. and Vale,R.D.
  TITLE     Cloning and expression of a human kinesin heavy chain gene:
            interaction of the COOH-terminal domain with cytoplasmic
            microtubules in transfected CV-1 cells
  JOURNAL   J Cell Biol 117 (6), 1263-1275 (1992)
   PUBMED   1607388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP361225.1, DC399931.1, BC065267.1, X65873.1, AL161932.15 and
            BU633712.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004521.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.674711.1,
                                           SRR14038193.375442.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302418.5/ ENSP00000307078.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BP361225.1         19-26
            9-25                DC399931.1         20-36
            26-433              BC065267.1         1-408
            434-3664            X65873.1           295-3525
            3665-5339           AL161932.15        34648-36322         c
            5340-5866           BU633712.1         22-548              c
FEATURES             Location/Qualifiers
     source          1..5866
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.22"
     gene            1..5866
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /note="kinesin family member 5B"
                     /db_xref="GeneID:3799"
                     /db_xref="HGNC:HGNC:6324"
                     /db_xref="MIM:602809"
     exon            1..578
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..3344
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /note="kinesin 1 (110-120kD); kinesin heavy chain;
                     ubiquitous kinesin heavy chain; conventional kinesin heavy
                     chain; epididymis secretory protein Li 61"
                     /codon_start=1
                     /product="kinesin-1 heavy chain"
                     /protein_id="NP_004512.1"
                     /db_xref="CCDS:CCDS7171.1"
                     /db_xref="GeneID:3799"
                     /db_xref="HGNC:HGNC:6324"
                     /db_xref="MIM:602809"
                     /translation="MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASK
                     PYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDP
                     EGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKN
                     RVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQ
                     TEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVP
                     YRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVE
                     LTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTV
                     DKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
                     TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQE
                     VEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIG
                     IAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEE
                     NEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHE
                     MEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKM
                     MLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHN
                     LRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADL
                     RCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARR
                     GHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGGKQV"
     exon            579..666
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            667..740
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            741..845
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            846..894
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            895..950
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1038
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1163
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1268
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1414
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1563
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1757
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1826
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2033
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2177
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2366
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2484
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2546
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2656
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2758
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2819
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2891
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..2996
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3213
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3364
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..5866
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5843..5848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /note="hexamer: AATAAA"
     polyA_site      5866
                     /gene="KIF5B"
                     /gene_synonym="HEL-S-61; KINH; KNS; KNS1; UKHC"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcccaac ggcggcctca ggagtgatcg ggcagcagtc ggccggccag cggacggcag
       61 agcgggcgga cgggtaggcc cggcctgctc ttcgcgagga ggaagaaggt ggccactctc
      121 ccggtcccca gaacctcccc agcccccgca gtccgcccag accgtaaagg gggacgctga
      181 ggagccgcgg acgctctccc cggtgccgcc gccgctgccg ccgccatggc tgccatgatg
      241 gatcggaagt gagcattagg gttaacggct gccggcgccg gctcttcaag tcccggctcc
      301 ccggccgcct ccacccgggg aagcgcagcg cggcgcagct gactgctgcc tctcacggcc
      361 ctcgcgacca caagccctca ggtccggcgc gttccctgca agactgagcg gcggggagtg
      421 gctcccggcc gccggccccg gctgcgagaa agatggcgga cctggccgag tgcaacatca
      481 aagtgatgtg tcgcttcaga cctctcaacg agtctgaagt gaaccgcggc gacaagtaca
      541 tcgccaagtt tcagggagaa gacacggtcg tgatcgcgtc caagccttat gcatttgatc
      601 gggtgttcca gtcaagcaca tctcaagagc aagtgtataa tgactgtgca aagaagattg
      661 ttaaagatgt acttgaagga tataatggaa caatatttgc atatggacaa acatcctctg
      721 ggaagacaca cacaatggag ggtaaacttc atgatccaga aggcatggga attattccaa
      781 gaatagtgca agatattttt aattatattt actccatgga tgaaaatttg gaatttcata
      841 ttaaggtttc atattttgaa atatatttgg ataagataag ggacctgtta gatgtttcaa
      901 agaccaacct ttcagttcat gaagacaaaa accgagttcc ctatgtaaag gggtgcacag
      961 agcgttttgt atgtagtcca gatgaagtta tggataccat agatgaagga aaatccaaca
     1021 gacatgtagc agttacaaat atgaatgaac atagctctag gagtcacagt atatttctta
     1081 ttaatgtcaa acaagagaac acacaaacgg aacaaaagct gagtggaaaa ctttatctgg
     1141 ttgatttagc tggtagtgaa aaggttagta aaactggagc tgaaggtgct gtgctggatg
     1201 aagctaaaaa catcaacaag tcactttctg ctcttggaaa tgttatttct gctttggctg
     1261 agggtagtac atatgttcca tatcgagata gtaaaatgac aagaatcctt caagattcat
     1321 taggtggcaa ctgtagaacc actattgtaa tttgctgctc tccatcatca tacaatgagt
     1381 ctgaaacaaa atctacactc ttatttggcc aaagggccaa aacaattaag aacacagttt
     1441 gtgtcaatgt ggagttaact gcagaacagt ggaaaaagaa gtatgaaaaa gaaaaagaaa
     1501 aaaataagat cctgcggaac actattcagt ggcttgaaaa tgagctcaac agatggcgta
     1561 atggggagac ggtgcctatt gatgaacagt ttgacaaaga gaaagccaac ttggaagctt
     1621 tcacagtgga taaagatatt actcttacca atgataaacc agcaaccgca attggagtta
     1681 taggaaattt tactgatgct gaaagaagaa agtgtgaaga agaaattgct aaattataca
     1741 aacagcttga tgacaaggat gaagaaatta accagcaaag tcaactggta gagaaactga
     1801 agacgcaaat gttggatcag gaggagcttt tggcatctac cagaagggat caagacaata
     1861 tgcaagctga gctgaatcgc cttcaagcag aaaatgatgc ctctaaagaa gaagtgaaag
     1921 aagttttaca ggccctagaa gaacttgctg tcaattatga tcagaagtct caggaagttg
     1981 aagacaaaac taaggaatat gaattgctta gtgatgaatt gaatcagaaa tcggcaactt
     2041 tagcgagtat agatgctgag cttcagaaac ttaaggaaat gaccaaccac cagaaaaaac
     2101 gagcagctga gatgatggca tctttactaa aagaccttgc agaaatagga attgctgtgg
     2161 gaaataatga tgtaaagcag cctgagggaa ctggcatgat agatgaagag ttcactgttg
     2221 caagactcta cattagcaaa atgaagtcag aagtaaaaac catggtgaaa cgttgcaagc
     2281 agttagaaag cacacaaact gagagcaaca aaaaaatgga agaaaatgaa aaggagttag
     2341 cagcatgtca gcttcgtatc tctcaacatg aagccaaaat caagtcattg actgaatacc
     2401 ttcaaaatgt ggaacaaaag aaaagacagt tggaggaatc tgtcgatgcc ctcagtgaag
     2461 aactagtcca gcttcgagca caagagaaag tccatgaaat ggaaaaggag cacttaaata
     2521 aggttcagac tgcaaatgaa gttaagcaag ctgttgaaca gcagatccag agccatagag
     2581 aaactcatca aaaacagatc agtagtttga gagatgaagt agaagcaaaa gcaaaactta
     2641 ttactgatct tcaagaccaa aaccagaaaa tgatgttaga gcaggaacgt ctaagagtag
     2701 aacatgagaa gttgaaagcc acagatcagg aaaagagcag aaaactacat gaacttacgg
     2761 ttatgcaaga tagacgagaa caagcaagac aagacttgaa gggtttggaa gagacagtgg
     2821 caaaagaact tcagacttta cacaacctgc gcaaactctt tgttcaggac ctggctacaa
     2881 gagttaaaaa gagtgctgag attgattctg atgacaccgg aggcagcgct gctcagaagc
     2941 aaaaaatctc ctttcttgaa aataatcttg aacagctcac taaagtgcac aaacagttgg
     3001 tacgtgataa tgcagatctc cgctgtgaac ttcctaagtt ggaaaagcga cttcgagcta
     3061 cagctgagag agtgaaagct ttggaatcag cactgaaaga agctaaagaa aatgcatctc
     3121 gtgatcgcaa acgctatcag caagaagtag atcgcataaa ggaagcagtc aggtcaaaga
     3181 atatggccag aagagggcat tctgcacaga ttgctaaacc tattcgtccc gggcaacatc
     3241 cagcagcttc tccaactcac ccaagtgcaa ttcgtggagg aggtgcattt gttcagaaca
     3301 gccagccagt ggcagtgcga ggtggaggag gcaaacaagt gtaatcgttt atacataccc
     3361 acaggtgtta aaaagtaatc gaagtacgaa gaggacatgg tatcaagcag tcattcaatg
     3421 actataacct ctactccctt gggattgtag aattataact tttaaaaaaa atgtataaat
     3481 tatacctggc ctgtacagct gtttcctacc tactcttctt gtaaactctg ctgcttccca
     3541 acacaactag agtgcaattt tggcatctta ggagggaaaa aggacagttt acaactgtgg
     3601 ccctatttat tacacagttt gtctatcgtg tcttaaattt agtctttact gtgccaagct
     3661 aactgtacct tataggactg tactttttgt attttttgtg tatgtttatt ttttaatctc
     3721 agtttaaatt acctagctgc tactgcttct tgtttttctt ttcctattaa aacgtcttcc
     3781 tttttttttc ttaagagaaa atggaacatt taggttaaat gtctttaaat tttaccactt
     3841 aacaacacta catgcccata aaatatatcc agtcagtact gtattttaaa atcccttgaa
     3901 atgatgatat cagggttaaa attacttgta ttgtttctga agtttgctcc tgaaaactac
     3961 tgtttgagca ctgaaacgtt acaaatgcct aataggcatt tgagactgag caaggctact
     4021 tgttatctca tgaaatgcct gttgccgagt tattttgaat agaaatattt taaagtatca
     4081 aaagcagatc ttagtttaag ggagtttgga aaaggaatta tatttctctt tttcctgatt
     4141 ctgtactcaa caagtcttga tggaattaaa atactctgct ttattctggt gagcctgcta
     4201 gctaatataa gtattggaca ggtaataatt tgtcatcttt aatattagta aaatgaatta
     4261 agatattata ggattaaaca taattttata cggttagtac tttattggcc gacctaaatt
     4321 tatagcgtgt ggaaattgag aaaaatgaag aaacaggaca gatatatgat gaattaaaaa
     4381 tatatatagg tcaattttgg tctgaaatcc ctgaggtgtt tttaacctgc tacactaatt
     4441 tgtacactaa tttatttctt tagtctagaa atagtaaatt gtttgcaagt cactaataat
     4501 cattagataa attattttct tggccatagc cgataatttt gtaatcagta ctaagtgtat
     4561 acgtattttt gccacttttt cctcagatga ttaaagtaag tcaacagctt attttaggaa
     4621 actgtaaaag taatagggaa agagatttca ctatttgctt catcagtggt aggggggcgg
     4681 tgactgcaac tgtgttagca gaaattcaca gagaatgggg atttaaggtt agcagagaaa
     4741 cttggaaagt tctgtgttag gatcttgctg gcagaattaa ctttttgcaa aagttttata
     4801 cacagatatt tgtattaaat ttggagccat agtcagaaga ctcagatcat aattggctta
     4861 tttttctatt tccgtaacta ttgtaatttc cacttttgta ataattttga tttaaaatat
     4921 aaatttattt atttattttt ttaatagtca aaaatctttg ctgttgtagt ctgcaacctc
     4981 taaaatgatt gtgttgcttt taggattgat cagaagaaac actccaaaaa ttgagatgaa
     5041 atgttggtgc agccagttat aagtaatata gttaacaagc aaaaaaagtg ctgccacctt
     5101 ttatgatgat tttctaaatg gagaaacatt tggctgcatc cacatagacc tttatgtttt
     5161 gttttcagtt gaaaacttgc ctcctttggc aacattcgta aatgaagcag aatttttttt
     5221 tctctttttt ccaaatatgt tagttttgtt cttgtaagat gtatcatggg tattggtgct
     5281 gtgtaatgaa caacgaattt taattagcat gtggttcaga atatacaatg ttaggttttt
     5341 aaaaagtatc ttgatggttc ttttctattt ataatttcag actttcataa agtgtaccaa
     5401 gaatttcata aatttgtttt cagtgaactg ctttttgcta tggtaggtca ttaaacacag
     5461 cacttactct taaaaatgaa aatttctgat catctaggat attgacacat ttcaatttgc
     5521 agtgtctttt tgactggata tattaacgtt cctctgaatg gcattgatag atggttcaga
     5581 agagaaactc aatgaaataa agagaatatt tattcatggc gattaattaa attatttgcc
     5641 taacttaaga aaactactgt gcgtaactct cagtttgtgc ttaactccat ttgacatgag
     5701 gtgacagaag agagtctgag tctacctgtg gaatatgttg gtttattttc agtgcttgaa
     5761 gatacattca caaatacttg gtttgggaag acaccgttta attttaagtt aacttgcatg
     5821 ttgtaaatgc gttttatgtt taaataaaga ggaaaatttt ttgaaa
//
