LOCUS       NM_004984               5779 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens kinesin family member 5A (KIF5A), transcript variant
            1, mRNA.
ACCESSION   NM_004984
VERSION     NM_004984.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5779)
  AUTHORS   Cozzi,M., Magri,S., Tedesco,B., Patelli,G., Ferrari,V.,
            Casarotto,E., Chierichetti,M., Pramaggiore,P., Cornaggia,L.,
            Piccolella,M., Galbiati,M., Rusmini,P., Crippa,V., Mandrioli,J.,
            Pareyson,D., Pisciotta,C., D'Arrigo,S., Ratti,A., Nanetti,L.,
            Mariotti,C., Sarto,E., Pensato,V., Gellera,C., Di Bella,D.,
            Cristofani,R.M., Taroni,F. and Poletti,A.
  TITLE     Altered molecular and cellular mechanisms in KIF5A-associated
            neurodegenerative or neurodevelopmental disorders
  JOURNAL   Cell Death Dis 15 (9), 692 (2024)
   PUBMED   39333504
  REMARK    GeneRIF: Altered molecular and cellular mechanisms in
            KIF5A-associated neurodegenerative or neurodevelopmental disorders.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5779)
  AUTHORS   Wang,H., Guan,L., Ma,X., Wang,Y., Wang,J., Zhang,P. and Deng,M.
  TITLE     Whole-Genome Sequencing Identified a Novel Mutation in the
            N-Terminal Domain of KIF5A in Chinese Patients with Familial
            Amyotrophic Lateral Sclerosis
  JOURNAL   Genes (Basel) 15 (6), 680 (2024)
   PUBMED   38927616
  REMARK    GeneRIF: Whole-Genome Sequencing Identified a Novel Mutation in the
            N-Terminal Domain of KIF5A in Chinese Patients with Familial
            Amyotrophic Lateral Sclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5779)
  AUTHORS   Carrington,G., Fatima,U., Caramujo,I., Lewis,T., Casas-Mao,D. and
            Peckham,M.
  TITLE     A multiscale approach reveals the molecular architecture of the
            autoinhibited kinesin KIF5A
  JOURNAL   J Biol Chem 300 (3), 105713 (2024)
   PUBMED   38309508
  REMARK    GeneRIF: A multiscale approach reveals the molecular architecture
            of the autoinhibited kinesin KIF5A.
REFERENCE   4  (bases 1 to 5779)
  AUTHORS   Soustelle,L., Aimond,F., Lopez-Andres,C., Brugioti,V., Raoul,C. and
            Layalle,S.
  TITLE     ALS-Associated KIF5A Mutation Causes Locomotor Deficits Associated
            with Cytoplasmic Inclusions, Alterations of Neuromuscular
            Junctions, and Motor Neuron Loss
  JOURNAL   J Neurosci 43 (47), 8058-8072 (2023)
   PUBMED   37748861
  REMARK    GeneRIF: ALS-Associated KIF5A Mutation Causes Locomotor Deficits
            Associated with Cytoplasmic Inclusions, Alterations of
            Neuromuscular Junctions, and Motor Neuron Loss.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5779)
  AUTHORS   Rahman,A., Kamal,A., Roberts,E.A. and Goldstein,L.S.
  TITLE     Defective kinesin heavy chain behavior in mouse kinesin light chain
            mutants
  JOURNAL   J Cell Biol 146 (6), 1277-1288 (1999)
   PUBMED   10491391
REFERENCE   6  (bases 1 to 5779)
  AUTHORS   Reid,E., Dearlove,A.M., Rhodes,M. and Rubinsztein,D.C.
  TITLE     A new locus for autosomal dominant 'pure' hereditary spastic
            paraplegia mapping to chromosome 12q13, and evidence for further
            genetic heterogeneity
  JOURNAL   Am J Hum Genet 65 (3), 757-763 (1999)
   PUBMED   10441583
REFERENCE   7  (bases 1 to 5779)
  AUTHORS   Rahman,A., Friedman,D.S. and Goldstein,L.S.
  TITLE     Two kinesin light chain genes in mice. Identification and
            characterization of the encoded proteins
  JOURNAL   J Biol Chem 273 (25), 15395-15403 (1998)
   PUBMED   9624122
  REMARK    Erratum:[J Biol Chem 1998 Sep 11;273(37):24280]
REFERENCE   8  (bases 1 to 5779)
  AUTHORS   Hamlin,P.J., Jones,P.F., Leek,J.P., Bransfield,K., Lench,N.J.,
            Aldersley,M.A., Howdle,P.D., Markham,A.F. and Robinson,P.A.
  TITLE     Assignment of GALGT encoding beta-1,
            4N-acetylgalactosaminyl-transferase (GalNAc-T) and KIF5A encoding
            neuronal kinesin (D12S1889) to human chromosome band 12q13 by
            assignment to ICI YAC 26EG10 and in situ hybridization.
            medjph@stjames.leeds.ac.uk
  JOURNAL   Cytogenet Cell Genet 82 (3-4), 267-268 (1998)
   PUBMED   9858832
REFERENCE   9  (bases 1 to 5779)
  AUTHORS   Niclas,J., Navone,F., Hom-Booher,N. and Vale,R.D.
  TITLE     Cloning and localization of a conventional kinesin motor expressed
            exclusively in neurons
  JOURNAL   Neuron 12 (5), 1059-1072 (1994)
   PUBMED   7514426
REFERENCE   10 (bases 1 to 5779)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022506.38, AL707807.1,
            U06698.1, BM930000.1, AL118561.1 and CB243285.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004984.3.
            
            Summary: This gene encodes a member of the kinesin family of
            proteins. Members of this family are part of a multisubunit complex
            that functions as a microtubule motor in intracellular organelle
            transport. Mutations in this gene cause autosomal dominant spastic
            paraplegia 10. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB290174.1, SRR1803612.133167.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455537.7/ ENSP00000408979.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC022506.38        58023-58042         c
            21-517              AL707807.1         35-531
            518-2953            U06698.1           438-2873
            2954-2973           BM930000.1         130-149
            2974-3752           U06698.1           2894-3672
            3753-3881           AL118561.1         541-669
            3882-3917           U06698.1           3798-3833
            3918-5778           AC022506.38        21454-23314         c
            5779-5779           CB243285.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..5779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..5779
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /note="kinesin family member 5A"
                     /db_xref="GeneID:3798"
                     /db_xref="HGNC:HGNC:6323"
                     /db_xref="MIM:602821"
     exon            1..357
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..3327
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin, heavy chain, neuron-specific; KIF5A variant
                     protein; neuronal kinesin heavy chain; kinesin heavy chain
                     neuron-specific 1; neuron-specific kinesin heavy chain"
                     /codon_start=1
                     /product="kinesin heavy chain isoform 5A isoform 1"
                     /protein_id="NP_004975.2"
                     /db_xref="CCDS:CCDS8945.1"
                     /db_xref="GeneID:3798"
                     /db_xref="HGNC:HGNC:6323"
                     /db_xref="MIM:602821"
                     /translation="MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGG
                     KPYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHD
                     PQLMGIIPRIARDIFNHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDK
                     NRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENM
                     ETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSY
                     VPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASVN
                     LELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEEAALGAE
                     LCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQML
                     DQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEK
                     SQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVG
                     NGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGR
                     ELSSCQLLISQHEAKIRSLTEYMQSVELKKRHLEESYDSLSDELAKLQAQETVHEVAL
                     KDKEPDTQDADEVKKALELQMESHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQL
                     ELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLR
                     KLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRC
                     ELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSGKRGH
                     SAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNSLFQNYQNLYLQATPSSTSDMYFA
                     NSCTSSGATSSGGPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQAKLFPLHQETA
                     AS"
     exon            358..445
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            446..519
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            520..624
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            625..673
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            674..729
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            730..817
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            818..942
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1047
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1196
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1345
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1521
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1590
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1797
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1944
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2133
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2251
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2316
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2426
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2528
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2589
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2661
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2766
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2983
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3137
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3220
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3248
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3363
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..5779
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5758..5763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /note="hexamer: AATAAA"
     polyA_site      5779
                     /gene="KIF5A"
                     /gene_synonym="ALS25; D12S1889; MY050; NEIMY; NKHC; SPG10"
                     /note="major polyA site"
ORIGIN      
        1 agagagcccg aaaggaccag acgcccaggt cgcccgcatc ccgctgccgc aggagagaga
       61 cagcgcgccc cggccctgct ccccaggctt cgcccgggcg ccctcaactc tgtccccaga
      121 gactgagcac ctgtcctccg cctcggcctc tgctgagagc cctctcctct ggagcacaca
      181 ccacccctgc agcccaagaa gagtcccagc cccacgccgg ctaccaccat ggcggagacc
      241 aacaacgaat gtagcatcaa ggtgctctgc cgattccggc ccctgaacca ggctgagatt
      301 ctgcggggag acaagttcat ccccattttc caaggggacg acagcgtcgt tattgggggg
      361 aagccatatg tttttgaccg tgtattcccc ccaaacacga ctcaagagca agtttatcat
      421 gcatgtgcca tgcagattgt caaagatgtc cttgctggct acaatggcac catttttgct
      481 tatggacaga catcctcagg gaaaacacat accatggagg gaaagctgca cgaccctcag
      541 ctgatgggaa tcattcctcg aattgcccga gacatcttca accacatcta ctccatggat
      601 gagaaccttg agttccacat caaggtttct tactttgaaa tttacctgga caaaattcgt
      661 gaccttctgg atgtgaccaa gacaaatctg tccgtgcacg aggacaagaa ccgggtgcca
      721 tttgtcaagg gttgtactga acgctttgtg tccagcccgg aggagattct ggatgtgatt
      781 gatgaaggga aatcaaatcg tcatgtggct gtcaccaaca tgaatgaaca cagctctcgg
      841 agccacagca tcttcctcat caacatcaag caggagaaca tggaaacgga gcagaagctc
      901 agtgggaagc tgtatctggt ggacctggca gggagtgaga aggtcagcaa gactggagca
      961 gagggagccg tgctggacga ggcaaagaat atcaacaagt cactgtcagc tctgggcaat
     1021 gtgatctccg cactggctga gggcactaaa agctatgttc catatcgtga cagcaaaatg
     1081 acaaggattc tccaggactc tctcggggga aactgccgga cgactatgtt catctgttgc
     1141 tcaccatcca gttataatga tgcagagacc aagtccaccc tgatgtttgg gcagcgggca
     1201 aagaccatta agaacactgc ctcagtaaat ttggagttga ctgctgagca gtggaagaag
     1261 aaatatgaga aggagaagga gaagacaaag gcccagaagg agacgattgc gaagctggag
     1321 gctgagctga gccggtggcg caatggagag aatgtgcctg agacagagcg cctggctggg
     1381 gaggaggcag ccctgggagc cgagctctgt gaggagaccc ctgtgaatga caactcatcc
     1441 atcgtggtgc gcatcgcgcc cgaggagcgg cagaaatacg aggaggagat ccgccgtctc
     1501 tataagcagc ttgacgacaa ggatgatgaa atcaaccaac aaagccaact catagagaag
     1561 ctcaagcagc aaatgctgga ccaggaagag ctgctggtgt ccacccgagg agacaacgag
     1621 aaggtccagc gggagctgag ccacctgcaa tcagagaacg atgccgctaa ggatgaggtg
     1681 aaggaagtgc tgcaggccct ggaggagctg gctgtgaact atgaccagaa gtcccaggag
     1741 gtggaggaga agagccagca gaaccagctt ctggtggatg agctgtctca gaaggtggcc
     1801 accatgctgt ccctggagtc tgagttgcag cggctacagg aggtcagtgg acaccagcga
     1861 aaacgaattg ctgaggtgct gaacgggctg atgaaggatc tgagcgagtt cagtgtcatt
     1921 gtgggcaacg gggagattaa gctgccagtg gagatcagtg gggccatcga ggaggagttc
     1981 actgtggccc gactctacat cagcaaaatc aaatcagaag tcaagtctgt ggtcaagcgg
     2041 tgccggcagc tggagaacct ccaggtggag tgtcaccgca agatggaagt gaccgggcgg
     2101 gagctctcat cctgccagct cctcatctct cagcatgagg ccaagatccg ctcgcttacg
     2161 gaatacatgc agagcgtgga gctaaagaag cggcacctgg aagagtccta tgactccttg
     2221 agcgatgagc tggccaagct ccaggcccag gaaactgtgc atgaagtggc cctgaaggac
     2281 aaggagcctg acactcagga tgcagatgaa gtgaagaagg ctctggagct gcagatggag
     2341 agtcaccggg aggcccatca ccggcagctg gcccggctcc gggacgagat caacgagaag
     2401 cagaagacca ttgatgagct caaagaccta aatcagaagc tccagttaga gctagagaag
     2461 cttcaggctg actacgagaa gctgaagagc gaagaacacg agaagagcac caagctgcag
     2521 gagctgacat ttctgtacga gcgacatgag cagtccaagc aggacctcaa gggtctggag
     2581 gagacagttg cccgggaact ccagaccctc cacaaccttc gcaagctgtt cgttcaagac
     2641 gtcacgactc gagtcaagaa aagtgcagaa atggagcccg aagacagtgg ggggattcac
     2701 tcccaaaagc agaagatttc ctttcttgag aacaacctgg aacagcttac aaaggttcac
     2761 aaacagctgg tacgtgacaa tgcagatctg cgttgtgagc ttcctaaatt ggaaaaacga
     2821 cttagggcta cggctgagag agttaaggcc ctggagggtg cactgaagga ggccaaggag
     2881 ggcgccatga aggacaagcg ccggtaccag caggaggtgg accgcatcaa ggaggccgtt
     2941 cgctacaaga gctcgggcaa acggggccat tctgcccaga ttgccaaacc cgtccggcct
     3001 ggccactacc cagcatcctc acccaccaac ccctatggca cccggagccc tgagtgcatc
     3061 agttacacca acagcctctt ccagaactac cagaatctct acctgcaggc cacacccagc
     3121 tccacctcag atatgtactt tgcaaactcc tgtaccagca gtggagccac atcttctggc
     3181 ggccccttgg cttcctacca gaaggccaac atggacaatg gaaatgccac agatatcaat
     3241 gacaatagga gtgacctgcc gtgtggctat gaggctgagg accaggccaa gcttttccct
     3301 ctccaccaag agacagcagc cagctaatct cccacaccca cggctgcata cctgcacttt
     3361 cagtttctaa gagggactga ggcctcttct cagcatgctg caaacctgtg gtctctgata
     3421 ctaactccct ccccaacccc tgttgttgga ctgtactatg tttgatgtct tctcttactt
     3481 actctgtatc tctttgtact ctgtatctat atatcaaaag ctgctgctat gtctctcttc
     3541 tgtcttattc tcaagtatct actgatgtat ttagcaattt caaagcatag tctaccttcc
     3601 ttatttgggg caatagggag gagggtgaat gtttcttctt tctcatctac tcgtctcaca
     3661 ctgagtggtg ttagtcactg agtagaggtc acagagatga caaaaggaaa aatgggagct
     3721 agagggttgt gacccttcat acacacacgc acgcacgcac acaaacatgc acacacgcat
     3781 gcacacacac aaagccttaa gcagaagaat gtcttagcat catgagacag agaaatagac
     3841 tcttcctccc tcctctttca catatagcac aggggaaggt aaaatggaag ggctgctaat
     3901 tgagacatat aattttcttc atacacccct caccttaatc aaaggattca ggtgttactt
     3961 ctgccctaca aagtctgcct tttgcctccc tcttcctgtt ttcccctgga ctgagaaatg
     4021 ggttgctcaa gggaccattt ccctttttct tcaagctcct tttgatattc cctgccccag
     4081 agctcatgac cagaacccag agctgattta aaatattttg aaaaatggag gaggcagact
     4141 gctcccagca gcctgtcaat ggctgctcat ctgtccatgg agatggttac aggcaggtgt
     4201 agtcaaaatg attgattcct tgggtttggg ggtgaatagg ctgggaaatt tctgagcctt
     4261 ttttttttgt cacagtgccc tcaagttgaa gtgatgagct ggatttcttt cttgttccat
     4321 actgggcggc atgctcctcc catctccacc ccttggtttg ggggcttcca gctcattggc
     4381 aaaatctctc tagttgcctt cctttcaagc tggagcctga cttttcccca atgtacattt
     4441 tttttttctc cacaaagagt tccttctcta atgtccccat ctggtattaa gtgcacttta
     4501 aagaaagggg cagggtggat tttcaagagg tgggaagctc taaggcttga ccctgagggg
     4561 tcttctccca gccattctca gcccatatgc agcaccctcc atactgaaga ggactgttgt
     4621 tttagtttca gacggtcctt tccttccaca tggtgctaag gtggttttct aggtaactgc
     4681 agggatggag gtcactagcc attccaaacc aggagagaaa gtctggtgtc ctgatatcca
     4741 gtcttttcta ggaggaagac caagattctc cagcggcagg gcagcctatc acccaacttc
     4801 taagtcagga aaggaagctg agtgggaatg ccagctggta agcgcaggct gcactggccc
     4861 atgactcctt caaggaaaag aggccctgct ccctttacct gctgagctcc ttttagcagt
     4921 tagggagaac tgcaggggga aaaataccag tggagtgtgg aataaatcca aagcagtgat
     4981 ttttaaatgt ttttcaaaaa caaatcttac atagaacccc aatataaaaa ataaagtaat
     5041 gcagacctgg gcagtttgca tttttttttt tttttttttt tggtggaaga agtctcagcg
     5101 tctcttagga ctgactgttc aaaggctcct cagcaaatga gcccttgaac agtcctaaga
     5161 gaccctgagg attctgtgga gtagtttgaa aaccattgtt ctgaggaagg gggtccaatc
     5221 tggctcctct gcactaaagc tgcaactcat ggaaaagagg gcaacggtgg ggtagacaag
     5281 ccatgctgtc tccagaccca ctagggtgga aggaaggttc ctgtgggcct gtggacttag
     5341 gctaatattt gctgtcagca gggcacttaa gaatccaggg ggttttatgt aatgttgcca
     5401 ccacatggtt cttttaaaaa cacataagga aatgtgaggg tgtagcgcag atgaggagag
     5461 agatgacaca gagggagcag ccttctcttt agcaagatgt aagggaaata taattcactt
     5521 acataaaaaa gaaacaacac acacgcaaac ccttcaccag aagcttcaca ctacatcctc
     5581 ctcctcctcc tgctccccac cttcaccgca tccctttcag agccagggtc actgcaaggg
     5641 gcacctggcc tgcccactca catctgccaa aatgttgcat gccagcgtgg aagacaaacc
     5701 aaactgcgca accccctgtg tgtatttact tggtgtacat agataacttt aaaataaaat
     5761 aaattcaatg ataactcta
//
