LOCUS       NM_001099293            4387 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kinesin family member 4B (KIF4B), mRNA.
ACCESSION   NM_001099293 XM_209695
VERSION     NM_001099293.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4387)
  AUTHORS   Marques,A.C., Dupanloup,I., Vinckenbosch,N., Reymond,A. and
            Kaessmann,H.
  TITLE     Emergence of young human genes after a burst of retroposition in
            primates
  JOURNAL   PLoS Biol 3 (11), e357 (2005)
   PUBMED   16201836
REFERENCE   2  (bases 1 to 4387)
  AUTHORS   Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E.,
            Fan,J.B., Abraham,R.T. and Jiang,W.
  TITLE     Functional analysis of human microtubule-based motor proteins, the
            kinesins and dyneins, in mitosis/cytokinesis using RNA interference
  JOURNAL   Mol Biol Cell 16 (7), 3187-3199 (2005)
   PUBMED   15843429
REFERENCE   3  (bases 1 to 4387)
  AUTHORS   Oh,S., Hahn,H., Torrey,T.A., Shin,H., Choi,W., Lee,Y.M., Morse,H.C.
            and Kim,W.
  TITLE     Identification of the human homologue of mouse KIF4, a kinesin
            superfamily motor protein
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 219-224 (2000)
   PUBMED   10978527
REFERENCE   4  (bases 1 to 4387)
  AUTHORS   Ha,M.J., Yoon,J., Moon,E., Lee,Y.M., Kim,H.J. and Kim,W.
  TITLE     Assignment of the kinesin family member 4 genes (KIF4A and KIF4B)
            to human chromosome bands Xq13.1 and 5q33.1 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 41-42 (2000)
   PUBMED   10773663
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK302388.1 and AC008410.6.
            
            On May 17, 2019 this sequence version replaced NM_001099293.2.
            
            Summary: This gene is an intronless retrocopy of kinesin family
            member 4A. The protein encoded by this gene is a microtubule-based
            motor protein that plays vital roles in anaphase spindle dynamics
            and cytokinesis. [provided by RefSeq, Jul 2016].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK302388.1, SRR6380202.92267.3
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435029.6/ ENSP00000387875.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1783              AK302388.1         1-1783
            1784-1784           AC008410.6         58427-58427         c
            1785-1843           AK302388.1         1785-1843
            1844-1844           AC008410.6         58367-58367         c
            1845-2155           AK302388.1         1845-2155
            2156-2156           AC008410.6         58055-58055         c
            2157-4378           AK302388.1         2157-4378
            4379-4387           AC008410.6         55824-55832         c
FEATURES             Location/Qualifiers
     source          1..4387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.2"
     gene            1..4387
                     /gene="KIF4B"
                     /note="kinesin family member 4B"
                     /db_xref="GeneID:285643"
                     /db_xref="HGNC:HGNC:6322"
                     /db_xref="MIM:609184"
     exon            1..4387
                     /gene="KIF4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..3810
                     /gene="KIF4B"
                     /note="chromokinesin KIF4B; chromokinesin-B"
                     /codon_start=1
                     /product="chromosome-associated kinesin KIF4B"
                     /protein_id="NP_001092763.1"
                     /db_xref="CCDS:CCDS47324.1"
                     /db_xref="GeneID:285643"
                     /db_xref="HGNC:HGNC:6322"
                     /db_xref="MIM:609184"
                     /translation="MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGETQVVVG
                     TDKSFTYDFVFDPCTEQEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAY
                     TAEQENEPTVGIIPRVIQLLFKEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQ
                     INIREDPKEGIKIVGLTEKTVLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTI
                     SIEQRKKSDKNCSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISA
                     LGDDKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLSTLRYADRAR
                     KIKNKPIVNIDPHTAELNHLKQQVQQLQVLLLQAHGGTLPGSINAEPSENLQSLMEKN
                     QSLVEENEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEELRQHVACKLDLQKL
                     VETLEDQELKENVEIICNLQQLITQLSDETVACTAAAIDTAVEEEAQVETSPETSRSS
                     DAFTTQHALHQAQMSKEVVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLEL
                     EVINLQKEKEELVRELQTAKKNVNQAKLSEHRHKLLQELEGQIADLKKKLNEQSKLLK
                     LKESTERTVSKLNQEIWMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKR
                     QYELLKLERNFQKQSSVLRRKTEEAAAANKRLKDALQKQREVTDKRKETQSHGKEGIA
                     ARVRNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVVQLKEKKESRENPPPKLRKC
                     TFSLSEVHGQVLESEDCITKQIESLETEMELRSAQIADLQQKLLDAESEDRPKQCWEN
                     IATILEAKCALKYLIGELVSSKIHVTKLENSLRQSKASCADMQKMLFEEQNHFSEIET
                     ELQAELVRMEQQHQEKVLYLVSQLQESQMAEKQLEKSASEKEQQLVSTLQCQDEELEK
                     MREVCEQNQQLLQENEIIKQKLILLQVASRQKHLPNDTLLSPDSSFEYIPPKPKPSRV
                     KEKFLEQSMDIEDLKYCSEHSVNEHEDGDGDGDSDEGDDEEWKPTKLVKVSRKNIQGC
                     SCKGWCGNKQCGCRKQKSDCGVDCSCDPTKCRNRQQGKDSLGTVEQTQDSEGSFKLED
                     PTEVTPGLSFFNPVCATPNSKILKEMCDMEQVLSKKTAPAPSPFDLPESKHGATEYQQ
                     NKPPGKKKKRALASNTSFFSGCSPIEEEAH"
ORIGIN      
        1 ggatttgaaa cttggcggtt aaagctccgg ctgggacagg gcggcgggag accccgggtg
       61 aacggggaag ggacatttag tttgagacgg tgctgagata ggatcatgaa ggaagaggtg
      121 aagggaattc ctgtaagagt ggcactgcgt tgtcgccctc tggtccccaa agagattagc
      181 gagggctgcc agatgtgcct ttccttcgtg cccggggaga ctcaggtggt ggttggtact
      241 gataaatcct tcacctacga ttttgtgttt gacccctgta ctgagcagga agaagtcttc
      301 aataaagcag tagcgccgct cataaaaggc atatttaaag gatataatgc aacggtcctg
      361 gcctatgggc agactggctc tggaaaaacc tattcaatgg gaggtgcata cactgcggag
      421 caggagaatg aaccaacagt tggcattatt cctagggtaa tacaactgct cttcaaagaa
      481 attgataaaa agagtgactt tgaatttact ctgaaagtgt cttacttaga gatttacaat
      541 gaagaaattt tggatcttct atgcccatct cgtgagaaag ctcaaataaa tatacgggag
      601 gatcctaagg aaggcataaa gattgtggga ctcactgaga agactgtttt agttgccttg
      661 gatactgttt cctgtttgga gcagggcaac aactctagga ctgtggcctc cacagctatg
      721 aactcccagt cgtcccgatc tcatgccatc tttacaatct ccatagagca aagaaagaaa
      781 agtgacaaga attgcagctt tcgctccaag ctgcatcttg tagatctcgc tggatcagaa
      841 agacagaaga aaaccaaggc tgaaggggat cgtctaaaag agggtattaa tattaaccga
      901 ggcctcctat gcttgggaaa tgtaatcagt gctcttggag atgacaaaaa gggtagcttt
      961 gtgccctaca gagattccaa gttaactcga ctgctgcaag attctctagg aggtaacagc
     1021 cacactctta tgatagcctg tgtgagtcct gctgactcca atctagagga aacattaagt
     1081 acccttcgct atgctgacag agcaagaaaa atcaagaaca aacctattgt taatattgat
     1141 ccccacacag ctgaacttaa tcatctaaag caacaggtac aacagctaca agtcttgttg
     1201 ctacaagccc atggaggtac cctgcctgga tctataaatg cagaaccatc agagaatcta
     1261 caatccctga tggagaagaa tcagtccctg gtagaggaga atgaaaaatt aagtcgttgt
     1321 ctgagcaagg cagctggtca gacagcccag atgttggaga ggatcatttt gacagagcaa
     1381 gtgaatgaaa aactgaacgc caagctagaa gagctcaggc agcatgtggc ctgcaagctg
     1441 gatcttcaaa agctagtgga gactttggaa gaccaggaat tgaaagaaaa tgtagagata
     1501 atttgtaacc tgcagcaact gattacccag ttatcagatg aaactgttgc ttgcacggct
     1561 gcagccattg atactgcggt agaagaagaa gctcaagtgg aaaccagtcc agagacaagc
     1621 aggtcttctg acgcttttac cactcagcat gctctccatc aagctcagat gtctaaggag
     1681 gtggttgagt tgaataacgc ccttgcactg aaagaggccc tagttaggaa gatgactcag
     1741 aacgacaacc aactacagcc cattcagttt caataccagg ataacataaa aaatctagaa
     1801 ttagaagtca tcaatctgca aaaggaaaag gaagaattgg ttcgtgaact tcagacagca
     1861 aagaagaatg tcaaccaagc caagctgagt gagcaccgcc acaaacttct ccaggagctg
     1921 gagggtcaaa tagctgatct gaagaagaaa ctgaatgagc agtccaaact tctgaaacta
     1981 aaggaatcca cagagcgtac tgtctccaag ctgaaccaag agatatggat gatgaaaaac
     2041 cagcgggtac agttaatgcg tcaaatgaaa gaggatgctg agaagtttag acaatggaag
     2101 cagaaaaaag acaaagaagt aatacagttg aaagaacgag accgtaagag gcaatatgag
     2161 ctgctcaaac ttgaaagaaa cttccagaaa caatccagtg tgctcagacg taaaacggaa
     2221 gaggcagcag ctgccaacaa gcgactcaag gatgctctcc agaaacaacg agaggtcaca
     2281 gataagcgga aagagactca gagccatgga aaggaaggta ttgcagctcg agtgaggaat
     2341 tggcttggaa atgaaattga ggttatggtc agtactgagg aagccaaacg ccatctgaat
     2401 gacctccttg aagacagaaa gatcctggct caggatgtgg ttcaactcaa agaaaaaaag
     2461 gaatctcggg agaatccacc tcctaaactc cggaagtgta cattctccct ttctgaggtg
     2521 catggtcaag ttttggagtc agaagattgt attacaaaac agattgaaag cctagagact
     2581 gaaatggaac tcaggagtgc tcagattgct gacctacagc agaagctgct ggatgcagaa
     2641 agtgaagata ggccaaaaca atgctgggag aatattgcca ccattctgga agccaagtgt
     2701 gccctgaaat atttgattgg agagctggtc tcctccaaaa tacatgtcac caaacttgaa
     2761 aacagcctga gacagagcaa ggccagctgt gctgacatgc agaagatgct atttgaggaa
     2821 caaaatcatt tttctgagat agagacagag ttacaagctg agctggtcag aatggagcaa
     2881 cagcaccaag agaaggtgct ataccttgtc agccagctgc aggaaagcca aatggcagag
     2941 aagcagttag agaaatcagc cagtgaaaag gaacaacagc tggtgagcac actgcagtgt
     3001 caggatgaag aacttgagaa gatgcgagaa gtgtgtgagc aaaatcagca gcttctccaa
     3061 gagaatgaaa tcatcaagca gaaactgatc ctcctccagg tagccagcag acagaaacat
     3121 cttcctaatg atacccttct atctccagac tcttcttttg aatatatccc acctaagcca
     3181 aaaccttctc gtgttaaaga aaagtttctg gagcaaagca tggacatcga ggatctaaaa
     3241 tattgttcag agcattctgt gaatgagcat gaagatggtg atggtgatgg cgacagtgat
     3301 gagggggatg atgaggaatg gaagccaaca aaattagtca aggtgtccag gaagaacatc
     3361 caagggtgtt cctgcaaggg ctggtgtggg aacaagcagt gtgggtgcag gaagcaaaag
     3421 tcagactgtg gtgtggactg tagctgtgac cccacaaagt gtcggaaccg ccagcaaggc
     3481 aaggatagct tgggcactgt tgaacagacc caggattccg aaggctcctt caaactggag
     3541 gatcctaccg aggtgacccc aggattgagc ttctttaacc ctgtctgtgc cacccccaat
     3601 agcaagatcc tgaaagagat gtgtgacatg gagcaggtgc tgtcaaagaa gactgctcca
     3661 gctccctccc cttttgacct cccagagtcg aaacatggag caacagaata ccaacaaaat
     3721 aagcctccag ggaagaaaaa gaaacgagct ctggctagca acaccagctt cttctctggc
     3781 tgctccccta tcgaagaaga ggcccactga agttggagtc atcatctcta cccccaatct
     3841 ggcttgggag atgctttcca gttgcagcca gaaggggttt tttaaatgac ttctctggat
     3901 ttcaggtttc ttgccgttga aaaaaaggaa caaagcatta ctaaaaagaa ggtaaccttt
     3961 gttggatgtt gtccctcagt ctccatcccc agactactgc tctctgctct ctagaaggct
     4021 gctaaaccac ctgctgaaga gagaaccaac agactttcct aatgactcat caggaaccag
     4081 tcctcagtat gatcaagttc cttcttattt gtgagcagtt caggctatct cctgatgggg
     4141 atgaggccaa ggctttctta tcttttggtt gtctctgctt aatggaggag cctggcctag
     4201 gatggaggtc tggctcagat ctttcactcc acctcgggaa tggggttgtg atctttcctg
     4261 tcctgacccc ctctgaattg taagtgtttc aatagtactc ttgattgtat gccatgttgt
     4321 tgaagtaaat gaattatttt taaatgttaa gtaaataaac cttagcccat ctactgttaa
     4381 aaaaaaa
//
