LOCUS       NM_012310               4388 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kinesin family member 4A (KIF4A), mRNA.
ACCESSION   NM_012310
VERSION     NM_012310.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4388)
  AUTHORS   Zhang,C., Wang,M., Ying,Y., Meng,F., Gao,H., Zeng,S., Zhu,Y.,
            Liu,A., Zhang,Z. and Xu,C.
  TITLE     Knockdown of kinesin family member 4A inhibits cell proliferation,
            migration, and invasion while promoting apoptosis of urothelial
            bladder carcinoma cells
  JOURNAL   Cancer Med 12 (11), 12581-12592 (2023)
   PUBMED   37039264
  REMARK    GeneRIF: Knockdown of kinesin family member 4A inhibits cell
            proliferation, migration, and invasion while promoting apoptosis of
            urothelial bladder carcinoma cells.
REFERENCE   2  (bases 1 to 4388)
  AUTHORS   Zhang,D., Lu,W. and Samadi,N.
  TITLE     KIF4A knockdown inhibits tumor progression and promotes
            chemo-sensitivity via induction of P21 in lung cancer cells
  JOURNAL   Chem Biol Drug Des 101 (5), 1042-1047 (2023)
   PUBMED   36217900
  REMARK    GeneRIF: KIF4A knockdown inhibits tumor progression and promotes
            chemo-sensitivity via induction of P21 in lung cancer cells.
REFERENCE   3  (bases 1 to 4388)
  AUTHORS   Zhang,J., An,L., Zhao,R., Shi,R., Zhou,X., Wei,S., Zhang,Q.,
            Zhang,T., Feng,D., Yu,Z. and Wang,H.
  TITLE     KIF4A promotes genomic stability and progression of endometrial
            cancer through regulation of TPX2 protein degradation
  JOURNAL   Mol Carcinog 62 (3), 303-318 (2023)
   PUBMED   36468837
  REMARK    GeneRIF: KIF4A promotes genomic stability and progression of
            endometrial cancer through regulation of TPX2 protein degradation.
REFERENCE   4  (bases 1 to 4388)
  AUTHORS   Yang,M., Zhang,H., Gao,S. and Huang,W.
  TITLE     DEPDC1 and KIF4A synergistically inhibit the malignant biological
            behavior of osteosarcoma cells through Hippo signaling pathway
  JOURNAL   J Orthop Surg Res 18 (1), 145 (2023)
   PUBMED   36849972
  REMARK    GeneRIF: DEPDC1 and KIF4A synergistically inhibit the malignant
            biological behavior of osteosarcoma cells through Hippo signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4388)
  AUTHORS   Wu,J., Li,L., Zhong,H., Zhang,H.H., Li,J., Zhang,H.B., Zhao,Y.Q.,
            Xu,B. and Song,Q.B.
  TITLE     Bioinformatic and Experimental Analyses Reveal That KIF4A Is a
            Biomarker of Therapeutic Sensitivity and Predicts Prognosis in
            Cervical Cancer Patients
  JOURNAL   Curr Med Sci 42 (6), 1273-1284 (2022)
   PUBMED   36260268
  REMARK    GeneRIF: Bioinformatic and Experimental Analyses Reveal That KIF4A
            Is a Biomarker of Therapeutic Sensitivity and Predicts Prognosis in
            Cervical Cancer Patients.
REFERENCE   6  (bases 1 to 4388)
  AUTHORS   Oh,S., Hahn,H., Torrey,T.A., Shin,H., Choi,W., Lee,Y.M., Morse,H.C.
            and Kim,W.
  TITLE     Identification of the human homologue of mouse KIF4, a kinesin
            superfamily motor protein
  JOURNAL   Biochim Biophys Acta 1493 (1-2), 219-224 (2000)
   PUBMED   10978527
REFERENCE   7  (bases 1 to 4388)
  AUTHORS   Ha,M.J., Yoon,J., Moon,E., Lee,Y.M., Kim,H.J. and Kim,W.
  TITLE     Assignment of the kinesin family member 4 genes (KIF4A and KIF4B)
            to human chromosome bands Xq13.1 and 5q33.1 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 41-42 (2000)
   PUBMED   10773663
REFERENCE   8  (bases 1 to 4388)
  AUTHORS   Tang,Y., Winkler,U., Freed,E.O., Torrey,T.A., Kim,W., Li,H.,
            Goff,S.P. and Morse,H.C. 3rd.
  TITLE     Cellular motor protein KIF-4 associates with retroviral Gag
  JOURNAL   J Virol 73 (12), 10508-10513 (1999)
   PUBMED   10559369
REFERENCE   9  (bases 1 to 4388)
  AUTHORS   Yan,R.T. and Wang,S.Z.
  TITLE     Increased chromokinesin immunoreactivity in retinoblastoma cells
  JOURNAL   Gene 189 (2), 263-267 (1997)
   PUBMED   9168136
REFERENCE   10 (bases 1 to 4388)
  AUTHORS   Sekine,Y., Okada,Y., Noda,Y., Kondo,S., Aizawa,H., Takemura,R. and
            Hirokawa,N.
  TITLE     A novel microtubule-based motor protein (KIF4) for organelle
            transports, whose expression is regulated developmentally
  JOURNAL   J Cell Biol 127 (1), 187-201 (1994)
   PUBMED   7929562
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357752.19 and AL139398.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_012310.4.
            
            Summary: This gene encodes a member of the kinesin 4 subfamily of
            kinesin related proteins. The encoded protein is an ATP dependent
            microtubule-based motor protein that is involved in the
            intracellular transport of membranous organelles. This protein also
            associates with condensed chromosome arms and may be involved in
            maintaining chromosome integrity during mitosis. This protein may
            also be involved in the organization of the central spindle prior
            to cytokinesis. A pseudogene of this gene is found on chromosome
            X.[provided by RefSeq, Mar 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF071592.2, AB208797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374403.4/ ENSP00000363524.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL357752.19        89439-89485         c
            48-188              AL357752.19        89011-89151         c
            189-303             AL357752.19        88784-88898         c
            304-494             AL357752.19        82401-82591         c
            495-584             AL357752.19        80387-80476         c
            585-751             AL357752.19        77523-77689         c
            752-846             AL357752.19        77191-77285         c
            847-963             AL357752.19        50068-50184         c
            964-1139            AL357752.19        49257-49432         c
            1140-1201           AL357752.19        45900-45961         c
            1202-1334           AL357752.19        37658-37790         c
            1335-1393           AL357752.19        35828-35886         c
            1394-1499           AL357752.19        35607-35712         c
            1500-1556           AL357752.19        26933-26989         c
            1557-1742           AL357752.19        25782-25967         c
            1743-1846           AL357752.19        5335-5438           c
            1847-1991           AL357752.19        4241-4385           c
            1992-2102           AL357752.19        3379-3489           c
            2103-2186           AL139398.20        9030-9113
            2187-2300           AL139398.20        9596-9709
            2301-2456           AL139398.20        18083-18238
            2457-2557           AL139398.20        18361-18461
            2558-2687           AL139398.20        24978-25107
            2688-2858           AL139398.20        26276-26446
            2859-2966           AL139398.20        27127-27234
            2967-3044           AL139398.20        28240-28317
            3045-3140           AL139398.20        28671-28766
            3141-3323           AL139398.20        29305-29487
            3324-3440           AL139398.20        40300-40416
            3441-3563           AL139398.20        42073-42195
            3564-4388           AL139398.20        42474-43298
FEATURES             Location/Qualifiers
     source          1..4388
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..4388
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /note="kinesin family member 4A"
                     /db_xref="GeneID:24137"
                     /db_xref="HGNC:HGNC:13339"
                     /db_xref="MIM:300521"
     exon            1..47
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            48..188
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..3767
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /note="chromokinesin-A; chromokinesin KIF4A"
                     /codon_start=1
                     /product="chromosome-associated kinesin KIF4A"
                     /protein_id="NP_036442.3"
                     /db_xref="CCDS:CCDS14401.1"
                     /db_xref="GeneID:24137"
                     /db_xref="HGNC:HGNC:13339"
                     /db_xref="MIM:300521"
                     /translation="MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGEPQVVVG
                     TDKSFTYDFVFDPSTEQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAY
                     TAEQENEPTVGVIPRVIQLLFKEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQ
                     INIREDPKEGIKIVGLTEKTVLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTI
                     SLEQRKKSDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISA
                     LGDDKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRAR
                     KIKNKPIVNIDPQTAELNHLKQQVQQLQVLLLQAHGGTLPGSITVEPSENLQSLMEKN
                     QSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHAACKLDLQKL
                     VETLEDQELKENVEIICNLQQLITQLSDETVACMAAAIDTAVEQEAQVETSPETSRSS
                     DAFTTQHALRQAQMSKELVELNKALALKEALARKMTQNDSQLQPIQYQYQDNIKELEL
                     EVINLQKEKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSKLLK
                     LKESTERTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKR
                     QYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQREVADKRKETQSRGMEGTA
                     ARVKNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQLKEKKESGENPPPKLRRR
                     TFSLTEVRGQVSESEDSITKQIESLETEMEFRSAQIADLQQKLLDAESEDRPKQRWEN
                     IATILEAKCALKYLIGELVSSKIQVSKLESSLKQSKTSCADMQKMLFEERNHFAEIET
                     ELQAELVRMEQQHQEKVLYLLSQLQQSQMAEKQLEESVSEKEQQLLSTLKCQDEELEK
                     MREVCEQNQQLLRENEIIKQKLTLLQVASRQKHLPKDTLLSPDSSFEYVPPKPKPSRV
                     KEKFLEQSMDIEDLKYCSEHSVNEHEDGDGDDDEGDDEEWKPTKLVKVSRKNIQGCSC
                     KGWCGNKQCGCRKQKSDCGVDCCCDPTKCRNRQQGKDSLGTVERTQDSEGSFKLEDPT
                     EVTPGLSFFNPVCATPNSKILKEMCDVEQVLSKKTPPAPSPFDLPELKHVATEYQENK
                     APGKKKKRALASNTSFFSGCSPIEEEAH"
     exon            189..303
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            304..494
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            495..584
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            585..751
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            752..846
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            847..963
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1139
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1201
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1334
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1393
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1499
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1556
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1742
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1846
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1991
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2102
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2186
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2300
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2456
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2557
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2687
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2858
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2966
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3044
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3140
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3323
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3440
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3563
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..4388
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4309..4314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /note="hexamer: AATAAA"
     polyA_site      4326
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /note="major polyA site"
     regulatory      4363..4368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
                     /note="hexamer: AATAAA"
     polyA_site      4388
                     /gene="KIF4A"
                     /gene_synonym="KIF4; KIF4G1; MRX100; TMDI; XLID100"
ORIGIN      
        1 agggcggcgg gaggcccagg gagaacgggg aagggacatt tagtttgaga cggtgctgag
       61 ataggatcat gaaggaagag gtgaagggaa ttcccgtaag agtggcgctg cgttgtcgcc
      121 ctctggtccc caaagagatt agcgagggct gccagatgtg cctttccttc gtgcccggag
      181 agcctcaggt ggtggttggt acagataaat ccttcaccta cgattttgta tttgatccct
      241 ctactgaaca ggaagaagtc ttcaatacag cagtagcgcc actcataaaa ggtgtattta
      301 aaggatataa tgcaacggtc ctggcctatg ggcagactgg ctctggaaaa acctattcaa
      361 tgggaggtgc atatactgca gagcaagaga atgaaccaac agttggggtt attcctaggg
      421 taatacaact gctcttcaaa gaaattgata aaaagagtga ctttgaattt actctgaaag
      481 tgtcttactt agagatttac aatgaagaaa ttttggatct tctatgccca tctcgtgaga
      541 aagctcaaat aaatatacga gaggatccta aggaaggcat aaagattgtg ggactcactg
      601 agaagactgt tttggttgcc ttggatactg tttcctgttt ggaacagggc aacaactcta
      661 ggactgtggc ctccacggct atgaactccc agtcgtcccg atctcatgcc atctttacaa
      721 tctccttaga gcaaagaaag aaaagtgaca agaatagcag ctttcgctcc aagctgcatc
      781 ttgtagacct cgctggatca gaaagacaga agaaaaccaa ggctgaaggg gatcgtctaa
      841 aagagggtat taatattaac cgaggcctcc tatgcttggg aaatgtaatc agtgctcttg
      901 gagatgacaa aaagggtggc tttgtgccct acagagattc caagttgact cgactgcttc
      961 aagattctct aggaggtaat agccatactc ttatgatagc ctgtgtgagt cctgctgact
     1021 ccaatctaga ggaaacatta aatacccttc gctatgctga cagagcaaga aaaatcaaga
     1081 acaaacctat tgttaatatt gatccccaga cagctgaact taatcatcta aagcaacagg
     1141 tacaacagct acaagtcttg ttgctacagg cccatggagg taccctgcct ggatctataa
     1201 ctgtggaacc atcagagaat ctacaatccc tgatggagaa gaatcagtcc ctggtagagg
     1261 agaatgaaaa attaagtcgt ggtctgagcg aggcagctgg tcagacagcc cagatgttgg
     1321 agaggatcat tttgacagag caagcgaatg aaaaaatgaa cgccaagcta gaagagctca
     1381 ggcagcatgc ggcctgcaaa ctggatcttc aaaagctagt ggagactttg gaagaccagg
     1441 aattgaaaga aaatgtagag ataatttgta acctgcagca attgattacc cagttatcgg
     1501 atgaaactgt tgcttgcatg gctgcagcca ttgatactgc ggtggagcaa gaagcccaag
     1561 tagaaaccag tccagagacg agcaggtctt ctgacgcttt taccactcag catgctctcc
     1621 gtcaagcgca gatgtctaag gagctggttg agttgaataa agcgcttgca ctgaaagagg
     1681 ccctggctag gaagatgact cagaatgaca gccaactgca gcccattcag taccaatacc
     1741 aggataacat aaaagagcta gaattagaag tcatcaatct gcaaaaggaa aaggaagaat
     1801 tggttcttga acttcagaca gcaaagaagg atgccaacca agccaagttg agtgagcgcc
     1861 gccgcaaacg tctccaggag ctggagggtc aaattgctga tctgaagaag aaactgaatg
     1921 agcagtccaa acttctgaaa ctaaaggaat ccacagagcg tactgtctcc aaactgaacc
     1981 aggagatacg gatgatgaaa aaccagcggg tacagttaat gcgtcaaatg aaagaagatg
     2041 ctgagaagtt tagacagtgg aagcagaaaa aagacaaaga agtaatacag ttaaaagaac
     2101 gagaccgtaa gaggcaatat gagctgctga aacttgaaag aaacttccag aaacaatcca
     2161 atgtgctcag acgtaaaacg gaggaggcag cagctgccaa caagcgtctc aaggatgctc
     2221 tccagaaaca acgggaggtt gcagataagc ggaaagagac tcagagccgt ggaatggaag
     2281 gcactgcagc tcgagtgaag aattggcttg gaaacgaaat tgaggttatg gtcagtactg
     2341 aggaagccaa acgccatctg aatgacctcc ttgaagatag aaagatcctg gctcaagatg
     2401 tggctcaact caaagaaaaa aaggaatctg gggagaatcc acctcctaaa ctccggaggc
     2461 gtacattctc ccttactgaa gtgcgtggtc aagtttcgga gtcagaagat tctattacaa
     2521 agcagattga aagcctagag actgaaatgg aattcaggag tgctcagatt gctgacctac
     2581 agcagaagct gctggatgca gaaagtgaag acagaccaaa acaacgctgg gagaatattg
     2641 ccaccattct ggaagccaag tgtgccctga aatatttgat tggagagctg gtctcctcca
     2701 aaatacaggt cagcaaactt gaaagcagcc tgaaacagag caagaccagc tgtgctgaca
     2761 tgcagaagat gctgtttgag gaacgaaatc attttgccga gatagagaca gagttacaag
     2821 ctgagctggt cagaatggag caacagcacc aagagaaggt gctgtacctt ctcagccagc
     2881 tgcagcaaag ccaaatggca gagaagcagt tagaggaatc agtcagtgaa aaggaacagc
     2941 agctgctgag cacactgaag tgtcaggatg aagaacttga gaaaatgcga gaagtgtgtg
     3001 agcaaaatca gcagcttctc cgagagaatg aaatcatcaa gcagaaactg accctcctcc
     3061 aggtagccag cagacagaaa catcttccta aggataccct tctatctcca gactcttctt
     3121 ttgaatatgt cccacctaag ccaaaacctt ctcgtgttaa agaaaagttc ctggagcaaa
     3181 gcatggacat cgaggatcta aaatattgtt cagagcattc tgtgaatgag catgaggatg
     3241 gtgatggtga tgatgatgag ggggatgacg aggaatggaa gccaacaaaa ttagttaagg
     3301 tgtccaggaa gaacatccaa gggtgttcct gcaagggctg gtgtggaaac aagcagtgtg
     3361 ggtgcaggaa gcaaaagtca gactgtggtg tggactgttg ctgtgacccc acaaagtgtc
     3421 ggaaccgcca gcaaggcaag gatagcttgg gcactgttga acggacccag gattccgaag
     3481 gctccttcaa actggaggat cctaccgagg tgaccccagg attgagcttc tttaatcccg
     3541 tctgtgccac ccccaatagc aagatcctga aagagatgtg cgatgtggag caggtgctgt
     3601 caaagaagac tcccccagct ccctcccctt ttgacctccc agagttgaaa catgtagcaa
     3661 cagaatacca agaaaacaag gctccaggga agaaaaagaa acgggctctg gccagcaaca
     3721 ccagcttctt ctctggctgc tcccctatcg aagaagaggc ccactgaagt tggagtcatc
     3781 atctctaccc ccagtctggc ttgggagatg ctttcaggtt gcagccagaa ggggtttttt
     3841 aaatgacttc tctggatttc aggtttcttg ctgttgaaaa aaggaacaaa gcgttactga
     3901 aaagaaggta acctttgttg gatgtgggcc ttagcctcca ggtccagact actactctat
     3961 gttctccaga agggtgctaa gtcacctact gaagagagaa ccaactgact ttcctattga
     4021 ctcatcagga accagtcctc agtctggtca agttgtttct tatttgtgag cagttcaggc
     4081 tatctcctga tggggatgag gccaaggctt tcttatcttt tggttgtctc tgcttaatgg
     4141 aggagcctgg cctaggatgg aggcctggct tagatctttc attccacctc aggaatgagg
     4201 ttgtgatctt tcctgtcctg accctctctg aattatgttt caatagtact cttgattgtc
     4261 tgccatgttg ttgaagcaaa tgaattattt ttaaatgtta agtaagtaaa taaaccttag
     4321 cccgtctact gtttgggaag atccttctgt gctagaggga gaaataaaat ttcaacctgt
     4381 gttcctca
//
