LOCUS       NM_002254               5342 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens kinesin family member 3C (KIF3C), mRNA.
ACCESSION   NM_002254
VERSION     NM_002254.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5342)
  AUTHORS   Chen,J., Xu,X., Chen,S., Lu,T., Zheng,Y., Gan,Z., Shen,Z., Ma,S.,
            Wang,D., Su,L., He,F., Shang,X., Xu,H., Chen,D., Zhang,L. and
            Xiong,F.
  TITLE     Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause
            hereditary gingival fibromatosis
  JOURNAL   Int J Oral Sci 15 (1), 46 (2023)
   PUBMED   37752101
  REMARK    GeneRIF: Double heterozygous pathogenic mutations in KIF3C and
            ZNF513 cause hereditary gingival fibromatosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5342)
  AUTHORS   Liu,H., Liu,R., Hao,M., Zhao,X. and Li,C.
  TITLE     Kinesin family member 3C (KIF3C) is a novel non-small cell lung
            cancer (NSCLC) oncogene whose expression is modulated by
            microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p)
  JOURNAL   Bioengineered 12 (1), 3077-3088 (2021)
   PUBMED   34193018
  REMARK    GeneRIF: Kinesin family member 3C (KIF3C) is a novel non-small cell
            lung cancer (NSCLC) oncogene whose expression is modulated by
            microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
REFERENCE   3  (bases 1 to 5342)
  AUTHORS   Gao,Y., Zheng,H., Li,L., Zhou,C., Chen,X., Zhou,X. and Cao,Y.
  TITLE     KIF3C Promotes Proliferation, Migration, and Invasion of Glioma
            Cells by Activating the PI3K/AKT Pathway and Inducing EMT
  JOURNAL   Biomed Res Int 2020, 6349312 (2020)
   PUBMED   33150178
  REMARK    GeneRIF: KIF3C Promotes Proliferation, Migration, and Invasion of
            Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5342)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5342)
  AUTHORS   Gao,Y., Li,L., Zheng,H., Zhou,C., Chen,X., Hao,B. and Cao,Y.
  TITLE     KIF3C is associated with favorable prognosis in glioma patients and
            may be regulated by PI3K/AKT/mTOR pathway
  JOURNAL   J Neurooncol 146 (3), 513-521 (2020)
   PUBMED   32020481
  REMARK    GeneRIF: KIF3C is associated with favorable prognosis in glioma
            patients and may be regulated by PI3K/AKT/mTOR pathway.
REFERENCE   6  (bases 1 to 5342)
  AUTHORS   Camargo,L.M., Collura,V., Rain,J.C., Mizuguchi,K., Hermjakob,H.,
            Kerrien,S., Bonnert,T.P., Whiting,P.J. and Brandon,N.J.
  TITLE     Disrupted in Schizophrenia 1 Interactome: evidence for the close
            connectivity of risk genes and a potential synaptic basis for
            schizophrenia
  JOURNAL   Mol Psychiatry 12 (1), 74-86 (2007)
   PUBMED   17043677
REFERENCE   7  (bases 1 to 5342)
  AUTHORS   Muresan,V., Abramson,T., Lyass,A., Winter,D., Porro,E., Hong,F.,
            Chamberlin,N.L. and Schnapp,B.J.
  TITLE     KIF3C and KIF3A form a novel neuronal heteromeric kinesin that
            associates with membrane vesicles
  JOURNAL   Mol Biol Cell 9 (3), 637-652 (1998)
   PUBMED   9487132
REFERENCE   8  (bases 1 to 5342)
  AUTHORS   Sardella,M., Navone,F., Rocchi,M., Rubartelli,A., Viggiano,L.,
            Vignali,G., Consalez,G.G., Sitia,R. and Cabibbo,A.
  TITLE     KIF3C, a novel member of the kinesin superfamily: sequence,
            expression, and mapping to human chromosome 2 at 2p23
  JOURNAL   Genomics 47 (3), 405-408 (1998)
   PUBMED   9480755
REFERENCE   9  (bases 1 to 5342)
  AUTHORS   Yang,Z. and Goldstein,L.S.
  TITLE     Characterization of the KIF3C neural kinesin-like motor from mouse
  JOURNAL   Mol Biol Cell 9 (2), 249-261 (1998)
   PUBMED   9450952
REFERENCE   10 (bases 1 to 5342)
  AUTHORS   Telford,E.A., Wightman,P., Leek,J., Markham,A.F., Lench,N.J. and
            Bonthron,D.T.
  TITLE     cDNA cloning, genomic organization, and chromosomal localization of
            a novel human gene that encodes a kinesin-related protein highly
            similar to mouse Kif3C
  JOURNAL   Biochem Biophys Res Commun 242 (2), 407-412 (1998)
   PUBMED   9446808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013449.8, KF456639.1 and AC064847.4.
            
            On Aug 31, 2019 this sequence version replaced NM_002254.7.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX571741.1, BC130423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264712.8/ ENSP00000264712.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1685              AC013449.8         51399-53083         c
            1686-1773           KF456639.1         1-88                c
            1774-2125           AC013449.8         50959-51310         c
            2126-2227           AC013449.8         26929-27030         c
            2228-2350           AC013449.8         26127-26249         c
            2351-2469           AC013449.8         24853-24971         c
            2470-2586           AC013449.8         22375-22491         c
            2587-2695           AC013449.8         541-649             c
            2696-2758           AC013449.8         1-63                c
            2759-2868           AC064847.4         136819-136928       c
            2869-5342           AC064847.4         134112-136585       c
FEATURES             Location/Qualifiers
     source          1..5342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..5342
                     /gene="KIF3C"
                     /note="kinesin family member 3C"
                     /db_xref="GeneID:3797"
                     /db_xref="HGNC:HGNC:6321"
                     /db_xref="MIM:602845"
     exon            1..2125
                     /gene="KIF3C"
                     /inference="alignment:Splign:2.1.0"
     CDS             581..2962
                     /gene="KIF3C"
                     /note="KIF3C variant protein"
                     /codon_start=1
                     /product="kinesin-like protein KIF3C"
                     /protein_id="NP_002245.4"
                     /db_xref="CCDS:CCDS1719.1"
                     /db_xref="GeneID:3797"
                     /db_xref="HGNC:HGNC:6321"
                     /db_xref="MIM:602845"
                     /translation="MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTL
                     RNPRAAPGELPKTFTFDAVYDASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTG
                     KTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKE
                     PGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGNQTRAVGSTHMNEVSSRSHA
                     IFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNTAGGAATPSSGGGGGGG
                     GSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRLLQDSLGGNA
                     KTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARLKA
                     QLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILE
                     SALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATE
                     LLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEE
                     TMELRGTYTSLQQEVEVKTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQT
                     RELKLKYLIIENFIPPEEKNKIMNRLFLDCEEEQWKFQPLVPAGVSSSQMKKRPTSAV
                     GYKRPISQYARVAMAMGSHPRYRAENIMFLELDVSPPAVFEMEFSHDQEQDPRALHME
                     RLMRLDSFLERPSTSKVRKSRSWCQSPQRPPPSTTHASLASASLRPATVADHE"
     exon            2126..2227
                     /gene="KIF3C"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2350
                     /gene="KIF3C"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2469
                     /gene="KIF3C"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2586
                     /gene="KIF3C"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2695
                     /gene="KIF3C"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2868
                     /gene="KIF3C"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..5342
                     /gene="KIF3C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5317..5322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF3C"
                     /note="hexamer: AATAAA"
     polyA_site      5342
                     /gene="KIF3C"
                     /note="major polyA site"
ORIGIN      
        1 gtttttctct ctcattctcc agtggcggcg gcggggaagg cggaggcaga ggcagcagca
       61 gccgcgctgg ctgcaatgaa tgatccccca gcttgggggg aggactccag gtgagcctct
      121 gccctcggga ggcccgggac ccccggccgc ccacgaccgg cagcccacgc tatggatccc
      181 tagaggaagg aggagaagac agctcgccgc ccacccccat cccattttcc tcttccttta
      241 tctcattgtt gccgaagctg tttacggcag cgctccctct gctcctgcat ggggcgggct
      301 ccgggcacgg ctgctcggca ggcgctgctc ccgcggcgac tgggggattc tgcctaattc
      361 acctcccagc cggtgcagag aggaccggag agcggtggag gcccggactg cagcagcgtt
      421 ggggccacct cccagcgtcc ccaccctagg aggctgcatg cggattgaag agctgcgcct
      481 gggggctggg ccggccccgc tgatcccgac ctagcgagca ggatagcagg accgcccagg
      541 ctgcggaggg gctcgggggc aggaaggtca gagcagcaag atggccagta agaccaaggc
      601 cagcgaggcc ctcaaggtgg tggcccggtg ccgccccctc agcaggaagg aggaggctgc
      661 tggtcacgag cagatcctga ccatggacgt gaaactgggc caggtgaccc tgcggaaccc
      721 ccgcgccgcc ccgggggagc tgcccaagac cttcaccttt gacgccgtgt atgatgccag
      781 ctccaagcag gccgacctgt atgacgaaac cgtgaggccc ctgatagact ccgtgctcca
      841 gggtttcaat ggcacggtgt ttgcctatgg ccagacgggc actggcaaga cctataccat
      901 gcaggggacc tgggtggagc ccgagctgcg cggggtcatc ccgaatgcct ttgagcacat
      961 cttcacccac atctcccgct cccagaacca acagtacctg gtccgggcct cctatttgga
     1021 gatctaccag gaagagattc gagacctgct ctccaaggag ccgggcaaga ggctagagct
     1081 gaaagagaac cccgagactg gcgtctacat caaggacctc tcctccttcg tcaccaagaa
     1141 tgtcaaggag attgagcatg tgatgaacct ggggaaccag acccgggctg tgggcagcac
     1201 ccacatgaat gaggtcagct cccgctccca tgccatcttc atcatcactg tggagtgcag
     1261 cgaacgtggc tctgatggcc aggaccacat ccgagtgggc aagctcaacc tcgtggacct
     1321 ggctggcagc gagaggcaga acaaggcagg ccccaacaca gcgggagggg cagccacacc
     1381 atcctcgggt ggcggtggtg gcggtggagg cagtggtggt ggtgctggtg gagagaggcc
     1441 taaggaagcc tccaaaatca acctctcatt atctgccctg ggcaacgtga ttgctgccct
     1501 ggcgggcaac aggagcaccc acattcccta ccgggactcc aagctgaccc ggctgctcca
     1561 ggactccctg ggggggaatg ccaagaccat catggtagcc acactggggc cagcttctca
     1621 cagctacgat gagagcctct ccaccttgcg ctttgccaac cgagccaaga acatcaagaa
     1681 caagccccgg gtgaacgagg accccaagga cacactgctg cgggaattcc aagaggagat
     1741 tgcccgcctg aaggcccagc tggagaagag ggggatgctg gggaagcggc cccggaggaa
     1801 gagcagccgc aggaagaagg ccgtgtccgc cccgcctggg taccctgagg gcccagtgat
     1861 tgaggcctgg gtggcagaag aggaggatga caacaacaac aaccaccgcc cgccccagcc
     1921 catcctggag tcagccttgg agaagaacat ggagaattac ctgcaggaac agaaggagcg
     1981 gctggaggag gagaaggcag ccatccagga tgaccgcagc ctggtgagcg aggagaagca
     2041 gaagctgctg gaggagaagg agaagatgct ggaggacctg cggcgggaac agcaggccac
     2101 agagctgctt gcggccaagt acaaggccat ggagagcaag ctcctcatcg ggggcaggaa
     2161 catcatggat cacaccaacg aacagcagaa gatgttggaa ctgaagaggc aggagattgc
     2221 cgagcagaaa cgtcgtgagc gggagatgca gcaggagatg atgctccggg acgaggagac
     2281 tatggagctc cggggcacct acacatccct gcagcaggag gtggaggtca aaaccaagaa
     2341 actcaagaag ctctacgcca agctgcaggc ggtgaaggcg gagatccagg accagcatga
     2401 tgagtatatc cgcgtgcggc aggacctgga ggaggcgcag aacgagcaga cccgcgaact
     2461 caagctcaag tacctaatca tcgagaactt catcccgccg gaggagaaga acaagatcat
     2521 gaaccggctt ttcctggact gtgaggagga gcagtggaag ttccagccac tggtgccagc
     2581 cggcgtcagt agcagccaga tgaagaagcg gccaacatct gcagtgggct acaagaggcc
     2641 tatcagccag tatgctcggg ttgccatggc aatggggtcc caccccaggt acagggctga
     2701 aaacataatg tttctggagt tggatgtgtc ccctccagct gtctttgaga tggaattctc
     2761 tcacgaccaa gaacaagacc ctcgtgcgct acacatggag aggctcatgc gattggacag
     2821 ctttctggaa agaccttcca cgtctaaagt ccgaaagtcc agatcctggt gccagagtcc
     2881 tcagcggcct ccaccttcca ccacacatgc ctccctggcc tctgcttctc tgcgccctgc
     2941 aacagtggcg gaccatgagt gacaaccatc acgtcaggct gcccatccaa tagactcctg
     3001 ggatggggca gccaaccctg gctcatctca tctgccgctt ggtgcgtgtg cgtgtgcgtg
     3061 catgtgcgtg tgcgtgtgtg caggggtgag aatctggcag atggtgcctc tgcctgctct
     3121 tcttcgcctc ctttatttaa ttcatgttat ttattcgcgg agctctgttc gtgttgggga
     3181 gatgccctcg cctgagccgt ctgggcctac cgtggtcact gcgtagcctc tttttcttct
     3241 gacttgagag ctcccccagt cagatctcag gcttgtcccc ctgtcagctg cctccagaag
     3301 ggaaggtagc cagtgcctga gaagacagtc ccttttctac ccaccgcact ccataacctc
     3361 catcttctcc cacactgatg gcgagcagcc cctgagcact ttctgggact gggagactgc
     3421 ttggtgttcc ctgaggacaa gagacatcct gacagtgttg ggcatctgct ccccgtggac
     3481 acagccccac tctccacttt ctgagcctca gacaacctca ttcagcctct tgggctcctt
     3541 ttcaaggaca ttaataacct caccaacata gctcatgccc ttcagctttg acaagaactc
     3601 acagcttccc aaactctgct ttctgcccac cttggatggg aactgtggac caagcaatta
     3661 ccatcgcctt ggaacctgca ggaaatggaa cagcaattga gacaacttga acagtcatca
     3721 acggaagtcc ctccactgga ttcctttgtt tctgtcccct ccgaggagtc attttggtcg
     3781 acaggctctc aaggcaactc cccattttca agaggctgct cctgcctgct tcgatcattt
     3841 ctccctgcag ctgcctagac cccgttcaca gtgggaggag tcaatgtcat tctacccctc
     3901 gctaaacgaa gatattaaca tctattgctt tttcccttca tctgtcacag gaaacagaag
     3961 cccaggcaca atcttttcca gctttgcctg ttacccctgt ttctgaattg catctttaag
     4021 gtattatttt gttgaaaata gatcctttat tcactagtta cgcaaattgg ttcctagggg
     4081 gatactcctt accttccttt gtgatggccc aaaatgtctc taggtatctc aagtgataag
     4141 taaatttcta caaaaaaaaa tggttaatgt tcattgactg gctttttaag tgtatatttt
     4201 ggaggacggg tgaagaggtc ataacgaaag caagcgagtg aattaggatt tcaaagtgcc
     4261 ctaatagtgt gagtctccag ttcctagaat atgaagagtg ctgtcgttgg ggtgaaacca
     4321 tgagactgac agatctgcct gaaatggggg gtgtgggagg tggtggcggg ggttattctc
     4381 tttccttcag gaaatgaacc cttcttacat cattcaagtt ctgctctgag gatcaagctt
     4441 gggtctgatt taactcagcg acactgtcat ttctgcttca ttactggact agagggttga
     4501 gccacccact tgccatttgc tcctgtcctt ccaggaaatc acaattttca tcagagccca
     4561 agagattatt tgagactcag gattcagatc agaggttcga ctgtggctgg gacaggagtt
     4621 gtgtgtagaa attcaccagg tggcctgagc gcagggggac ctccagggct gcgttgagca
     4681 gcctctccca ctgacctctt tctcgtttgt ggacaaagca gcacgtatca cctcattcat
     4741 cacttggaca catcgccttt gcattgtctt gtcacacctc cctcacagtc ttatagcaca
     4801 atatacccaa atcagccccc ccagtccgag ggctgggccc gaggtatggt cggaggagga
     4861 gctcctgcct gcggttttgt gtatgtgtgt atgtgtgtgc gtgtttgtgt gcgtgtttac
     4921 ctccacaggg gacactctac actcagtgta agatctgctg ggaacagggc caccaggagt
     4981 ggctggatct cagtctctct gtctctcttt ctctcctttt ccttttggtg tatcaaatat
     5041 ttgattgaca aagtaagggc cttgattagg accaaattct cgtgtgttgc tatggtcttt
     5101 atttaggaca acaattaaca atgcagtggc ccattcttgt cactctacac atatgactat
     5161 acgggacata tgtaatatat aaatatatat ataaaacatt cccctctgtc cccttggctt
     5221 cggatggagg cctttctgtt gagctgaaat gcacctgcag ctgggtgctg ccagcagctt
     5281 gcaggcccca gccctgttcc aatcaatgca gttgacaata aaggaatgag tatcgtcacg
     5341 ga
//
