LOCUS       NM_004798               6116 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens kinesin family member 3B (KIF3B), mRNA.
ACCESSION   NM_004798
VERSION     NM_004798.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6116)
  AUTHORS   Heydari,R., Seresht-Ahmadi,M., Mirshahvaladi,S., Sabbaghian,M. and
            Mohseni-Meybodi,A.
  TITLE     KIF3B gene silent variant leading to sperm morphology and motility
            defects and male infertilitydagger
  JOURNAL   Biol Reprod 106 (4), 766-774 (2022)
   PUBMED   34918036
  REMARK    GeneRIF: KIF3B gene silent variant leading to sperm morphology and
            motility defects and male infertilitydagger.
REFERENCE   2  (bases 1 to 6116)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 6116)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6116)
  AUTHORS   Cogne,B., Latypova,X., Senaratne,L.D.S., Martin,L., Koboldt,D.C.,
            Kellaris,G., Fievet,L., Le Meur,G., Caldari,D., Debray,D.,
            Nizon,M., Frengen,E., Bowne,S.J., Cadena,E.L., Daiger,S.P.,
            Bujakowska,K.M., Pierce,E.A., Gorin,M., Katsanis,N., Bezieau,S.,
            Petersen-Jones,S.M., Occelli,L.M., Lyons,L.A., Legeai-Mallet,L.,
            Sullivan,L.S., Davis,E.E. and Isidor,B.
  CONSRTM   99 Lives Consortium
  TITLE     Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant
            Ciliopathy
  JOURNAL   Am J Hum Genet 106 (6), 893-904 (2020)
   PUBMED   32386558
  REMARK    GeneRIF: Mutations in the Kinesin-2 Motor KIF3B Cause an
            Autosomal-Dominant Ciliopathy.
REFERENCE   5  (bases 1 to 6116)
  AUTHORS   Gu,R., Li,X., Yan,X., Feng,Z. and Hu,A.
  TITLE     Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by
            Promoting KIF3B Expression
  JOURNAL   Technol Cancer Res Treat 19, 1533033820943217 (2020)
   PUBMED   33153390
  REMARK    GeneRIF: Circular RNA circ_0032462 Enhances Osteosarcoma Cell
            Progression by Promoting KIF3B Expression.
REFERENCE   6  (bases 1 to 6116)
  AUTHORS   Whitehead,J.L., Wang,S.Y., Bost-Usinger,L., Hoang,E., Frazer,K.A.
            and Burnside,B.
  TITLE     Photoreceptor localization of the KIF3A and KIF3B subunits of the
            heterotrimeric microtubule motor kinesin II in vertebrate retina
  JOURNAL   Exp Eye Res 69 (5), 491-503 (1999)
   PUBMED   10548469
REFERENCE   7  (bases 1 to 6116)
  AUTHORS   Navarro,E., Espinosa,L., Adell,T., Tora,M., Berrozpe,G. and
            Real,F.X.
  TITLE     Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of
            ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that
            include Alu repeated elements
  JOURNAL   Biochim Biophys Acta 1450 (3), 254-264 (1999)
   PUBMED   10395937
  REMARK    Erratum:[Biochim Biophys Acta 1999 Dec 9;1452(3):322]
REFERENCE   8  (bases 1 to 6116)
  AUTHORS   Shimizu,K., Shirataki,H., Honda,T., Minami,S. and Takai,Y.
  TITLE     Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated
            protein, with a human chromosome-associated polypeptide
  JOURNAL   J Biol Chem 273 (12), 6591-6594 (1998)
   PUBMED   9506951
REFERENCE   9  (bases 1 to 6116)
  AUTHORS   Nagata,Ki., Puls,A., Futter,C., Aspenstrom,P., Schaefer,E.,
            Nakata,T., Hirokawa,N. and Hall,A.
  TITLE     The MAP kinase kinase kinase MLK2 co-localizes with activated JNK
            along microtubules and associates with kinesin superfamily motor
            KIF3
  JOURNAL   EMBO J 17 (1), 149-158 (1998)
   PUBMED   9427749
REFERENCE   10 (bases 1 to 6116)
  AUTHORS   Yamazaki,H., Nakata,T., Okada,Y. and Hirokawa,N.
  TITLE     KIF3A/B: a heterodimeric kinesin superfamily protein that works as
            a microtubule plus end-directed motor for membrane organelle
            transport
  JOURNAL   J Cell Biol 130 (6), 1387-1399 (1995)
   PUBMED   7559760
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA805755.1, AB002357.1,
            BC136311.1, AL121897.32, AL354800.4 and AL353976.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004798.3.
            
            Summary: The protein encoded by this gene acts as a heterodimer
            with kinesin family member 3A to aid in chromosome movement during
            mitosis and meiosis. The encoded protein is a plus end-directed
            microtubule motor and can interact with the SMC3 subunit of the
            cohesin complex. In addition, the encoded protein may be involved
            in the intracellular movement of membranous organelles. This
            protein and kinesin family member 3A form the kinesin II subfamily
            of the kinesin superfamily. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002357.1, SRR1660803.189755.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375712.4/ ENSP00000364864.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA805755.1         1-13
            14-2144             AB002357.1         1-2131
            2145-3028           BC136311.1         2038-2921
            3029-3445           AL121897.32        144890-145306
            3446-6096           AL354800.4         1-2651
            6097-6116           AL353976.1         212-231
FEATURES             Location/Qualifiers
     source          1..6116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..6116
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /note="kinesin family member 3B"
                     /db_xref="GeneID:9371"
                     /db_xref="HGNC:HGNC:6320"
                     /db_xref="MIM:603754"
     exon            1..115
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /inference="alignment:Splign:2.1.0"
     exon            116..1584
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2424
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /EC_number="5.6.1.3"
                     /note="microtubule plus end-directed kinesin motor 3B"
                     /codon_start=1
                     /product="kinesin-like protein KIF3B"
                     /protein_id="NP_004789.1"
                     /db_xref="CCDS:CCDS13200.1"
                     /db_xref="GeneID:9371"
                     /db_xref="HGNC:HGNC:6320"
                     /db_xref="MIM:603754"
                     /translation="MSKLKSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVK
                     NPKGTAHEMPKTFTFDAVYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGK
                     TYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQ
                     TKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAI
                     FVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALG
                     NVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYA
                     NRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGG
                     GEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKM
                     EDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRRERE
                     IQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKER
                     QELEQTQNELTRELKLKHLIIENFIPLEEKSKIMNRAFFDEEEDHWKLHPITRLENQQ
                     MMKRPVSAVGYKRPLSQHARMSMMIRPEARYRAENIVLLELDMPSRTTRDYEGPAIAP
                     KVQAALDAALQDEDEIQVDASSFESTANKKSKARPKSGRKSGSSSSSSGTPASQLYPQ
                     SRGLVPK"
     exon            1585..1686
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1809
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1928
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2042
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2148
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2327
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..6116
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6081..6086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /note="hexamer: AATAAA"
     polyA_site      6116
                     /gene="KIF3B"
                     /gene_synonym="FLA8; HH0048; KLP-11; OTSC12; RP89"
                     /note="major polyA site"
ORIGIN      
        1 actgtctctc cccatccggg gcagcgggga atggctgagc caggggttcg ccgcccccgc
       61 cgccgccgcc gccgccgccg ccgccgccgc cgcccgcttt cggctcgggc ctcaggaccg
      121 tagcatcctg agacattttg aattgacact tctcaagatt tgactggatc agagttcatc
      181 atgtcaaagt tgaaaagctc agagtcagtc agggtggtgg ttcgctgtcg gcccatgaat
      241 ggcaaggaaa aggctgcttc gtatgacaaa gtggtggatg tggatgttaa gctggggcag
      301 gtgtctgtga agaaccccaa agggacggcc catgaaatgc ccaagacctt cacctttgat
      361 gccgtctatg actggaatgc caagcagttt gaactgtacg atgagacgtt ccgaccactt
      421 gttgactctg tcctgcaagg tttcaatgga accatttttg cctatggaca aactgggaca
      481 ggaaaaacct acaccatgga aggaatccgt ggtgaccctg aaaaaagagg agtcattcct
      541 aactcatttg accatatctt cacccacatc tctcgatccc agaatcaaca atacctggtc
      601 agggcttctt acttagagat ctaccaggag gagatccgag atttgctctc aaaggatcag
      661 accaaaaggc ttgagctcaa agagaggcct gacacaggag tgtatgtgaa agacctgtct
      721 tcctttgtca ccaagagtgt gaaggagata gagcatgtga tgaatgtggg gaaccagaac
      781 cgttctgtcg gtgctaccaa catgaacgag cacagctcgc gttctcatgc aattttcgtt
      841 atcactattg agtgcagcga ggtgggcctc gatggtgaaa accacatccg tgtaggaaaa
      901 ttgaaccttg tagatcttgc tggcagcgaa cggcaagcca agaccggcgc acaaggggag
      961 agattaaaag aagctaccaa gatcaacctc tccctttccg ctttgggtaa tgtcatctct
     1021 gctctagtgg acggcaaaag cactcacatt ccatatcggg actcaaagct taccaggctc
     1081 ctccaagatt cccttggtgg caatgccaag actgtgatgg tggccaacgt ggggcctgcc
     1141 tcttacaacg tagaagagac tctgaccact ctgcgatatg ccaaccgtgc caaaaacatt
     1201 aagaacaaac caagggtcaa tgaggacccc aaggatgccc tccttcgaga attccaggaa
     1261 gagattgctc ggctcaaggc ccagctggaa aaacggtcca ttggtaggag gaagaggcga
     1321 gagaagcgga gggaaggtgg tggcagtggt gggggtgggg aagaggagga ggaggaggga
     1381 gaagagggtg aggaggaagg ggatgataag gatgattact ggcgggaaca gcaagaaaaa
     1441 ctggagattg agaagcgggc cattgtagag gatcacagct tggttgcaga ggagaagatg
     1501 aggctgctga aggagaaaga gaaaaagatg gaggacctgc ggcgggagaa ggatgctgcc
     1561 gagatgctgg gcgccaagat caaggccatg gagagtaagt tgcttgttgg aggaaaaaat
     1621 atagtagatc atacgaatga acagcagaaa atcctggagc agaaacgaca ggaaattgca
     1681 gagcagaaac gtcgagaaag agaaatccag caacagatgg aaagtcgaga tgaggagacc
     1741 ttggaactta aagagacata cagctcattg cagcaagagg tggacatcaa gaccaaaaaa
     1801 ctcaaaaagc tcttctccaa gcttcaggca gtgaaggctg agatccatga cctccaagaa
     1861 gaacacatca aggagcgcca agagctagag cagactcaga atgagctcac cagggagctg
     1921 aaactcaagc atcttattat agaaaacttt atccctctgg aagaaaaaag taaaattatg
     1981 aatagagcct tctttgatga agaggaagat cattggaaac tacatcctat aaccagactg
     2041 gagaaccagc agatgatgaa gcggccagtc tcagccgtgg gatataagag accattgagc
     2101 cagcacgcaa gaatgtccat gatgattcgt ccagaggccc gatatagggc agaaaacatt
     2161 gtgctgttag agctggacat gcccagccgg accaccagag actatgaggg tccagccatt
     2221 gcccccaagg tccaggctgc attggatgcg gctctgcagg atgaagatga gatacaggtg
     2281 gatgcatcat catttgaaag cactgcaaat aagaaatcca aggccaggcc taaaagtgga
     2341 aggaagtcgg gatcctcctc ctcttcctca ggaacccctg catctcagct ttatccacag
     2401 tctcgggggc tggttccaaa gtaaagccag cttctcctct cccagggcgg aaacagcatt
     2461 tgccttctga gagaagagac tagcaaaaag ctgcagagag gattcggccc aaactcagaa
     2521 ctgttcccct gaggagaagc ggtggcctct ttgcagatca accaacttaa tctggttgaa
     2581 cgtgctgttc ctaatctggc actcagcccc tctgggaaac atcttttaat tagcatctca
     2641 gaaatgcatg ggtaaggtaa agtgcgatag ttcaagtgga aagcaagaga atgaccagtg
     2701 accttgcttc cttccccctt gccttcttct cccccttccc ctgtgctccc tttctctcct
     2761 ctctcctttt ctagcctgtt ctttacatgg ggctcccttc ttgttgaaca atagggcaga
     2821 atcaggagtc accttagcag gaccacatct ttggagcctc gggataaaat gacagtgagg
     2881 ttgaaaagtg aaaaccctag aacttgaata ggtgcctgtt cttgtaggga gaaatgagaa
     2941 atcgcatttg gatccaggcc ccaggtgggc accatcagca gtcttgcttc catgcacctc
     3001 agtaagaagt ggatctgcct ttgggacctg ctcagtgagg aaatctcttc caatttctgc
     3061 ttctgaatga ttcaatgttg ggagcaatag aaataacatt ccctttgcct tctctgagtg
     3121 tttagggaaa tagcttcttt aaaacctcaa aaccatgacc atcctgtcaa agacctaagt
     3181 ctgtaagctg gtgccatgtc catacaccat gtcactttac tcttcatttg tcaccatctt
     3241 ttcccatgca cgcatactct gaacatcctt gtgtgggccc atcctctgca tccagagcat
     3301 gctctgcagt gggcctgttt tgtggaagaa aggaggctgt ctctgccttc tctgatggga
     3361 ctggagttga gggaaggagc tgtattgtgg cacttctgaa ttccccgttt tgttccatat
     3421 tggtatagag agcagaagag tagctaggca gatgcagaga tggagacatg agactcagtg
     3481 cagtgggcag ggaagacata acagatggaa gcaaaggaat cctgcctgcc ttcagcagag
     3541 aattcaccga atcctagaac tgtggctccc tccaggcaga gcctaagatg ctggtgaaga
     3601 atagctgtgt gattgaatag gctcaaagga gagttcagaa ttcccattta catattacta
     3661 gtttggtttg taagttttag ttccttgtat tattgagatt cagagcttca ttttatgttg
     3721 gtcattaggt gaatattact cattttccct caagagaagc tcataagtgt gtgtgggtgt
     3781 gagagcacga tggtgcctgt gttctgtgaa tgtgtccata tgtgtctgta agagagacag
     3841 agaccaagaa cttgcccaat tttagaaata cactaatgtg cagttgttgc cttttgtctg
     3901 tattgaaggc ccattgaatg actaatccag gctggaagca ttcccatgtg ggtgtctgag
     3961 tccatgagcc aagcctgagg ggacagtgag tctccaggtc tgccacactg gtgcaccttg
     4021 ctggcacggt gcctcaggaa ggtggcgact caggtgggcc ttgagttata ttttaactca
     4081 gctgctcagt tcccagggca catttctgga tcagaaccca tgggaaacag gaggtactaa
     4141 gtgcaatgtc ttagcattct gcaaaatgga gatctgttgt ccagcggctt atctcctttt
     4201 tagtaaccct tctttctgaa cccagggccc ttttcagcct tccctcatat tttcttgaga
     4261 tcaaacttta cttctttctt atttactaag aatttgcctg tttgaataag aacaaaacgc
     4321 taaggtgggt agcctaagct gattttctgc tggttacacg tgtctctcac accacatttc
     4381 ctcaaagcta atctgaattc tgtaggctaa aaatattcat gtagcaaatc tgagaattga
     4441 aaactgcaga taaccggccg ggtatggtga ctcatgcctg taatcctagc actttgggag
     4501 gccgaggtgg gtggaccacc tgaggttagg acttcaagac cagcctggcc aacatggtga
     4561 aaccccatct gtactaaaaa tacaaaaatt tgcctggtgt ggtggtgcat gcctctagtc
     4621 ctagctactc gggaggctga ggcacgagaa tcacttgaac ctgggaggcg gaggttgcag
     4681 tgagtcgaga taacactact gcattccagc ctgggtgaca gagtgagact ccccctcaaa
     4741 aaaaaaaaaa aaaaaaaaaa aaacagaaag aaagaaaaag aaaactgcag ataaccctat
     4801 acattaatac tggtatctcg aggtgactct tctgaccaag ggtggttaag tgacacatag
     4861 aacttttcta agagaagaca gacaagttga caggcatgcc ttgtactcag ctgtgttcat
     4921 gtggtggtct gtggaaagaa aagaagactc atttggaaat gaagctgtcc ctttccaagc
     4981 agtctctggt gcttttcttc tctcaaaatg gatccgataa atatttgaat agagcagatt
     5041 gtagaatgtc gtgctgtcac cagaaagctg ctgttttggg ttctgcattg agccaaatat
     5101 gtagaggacc taccaagccc actgagggac taggttttca tgtctctagt catacctaga
     5161 atgttctgag ccgtctgagg gccttcatgc cggcagcagc tagcaaagcc agaaagcaag
     5221 tctaacagga tctaagatga ccatcaggag aaggagtttg agactgtgta tgcaaccccc
     5281 aatagacccc cttttactct gatctggaga atgtatctgg cttcatattt tcaagtcaca
     5341 tgtctctcag acccctggat tcagaaccca aggccacaaa tcataggcat gaagcacttt
     5401 cttaagactg acctaacgct ggattatttc ccgtccaatg cctgcatgct gcttgaattg
     5461 ctccacccac acctccatga ccaagggcgc cagagtgctg caactggggc gtgggccgct
     5521 ctctgctttt cctgtctgac tctgacaagt cctccctcac tgaatgtaga atcgttgcca
     5581 agtttctgag aagtgtcgat tccctgttaa catggatatc agttctgcct cacatttccc
     5641 acttgaggtt gaggcgtact ggagacaaca cctcagacca tctgaacccc atcagtggac
     5701 gaaaatgggg ctgttaatat actctaaaag ccatactaaa aatgctctga gggaactggc
     5761 taagaatagt gggcctggtg attgtctatc acgcaaggct ttgttttgta ctgttcagaa
     5821 atctgtcacc tttctgcctg cccttgtttc ctgaatgaaa tgcttctggg gttatttatg
     5881 aaaggagtga tcctggggca ggcaggaggc agtgggcttc atggctcctt gaagttatta
     5941 ctgatcttga ccttctcttt ggctaccttt agacaaagaa tacgccaatc aatacttggg
     6001 gctctaagtt ttacaattga tatttatttg tatcatctct ttgtctagga atgtaaaagt
     6061 gattctaaac taagatgtgt aataaaaatc aatcagattt attgtaccta caaaaa
//
