LOCUS       NM_001300792            6239 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens kinesin family member 3A (KIF3A), transcript variant
            2, mRNA.
ACCESSION   NM_001300792 XM_005271869
VERSION     NM_001300792.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6239)
  AUTHORS   Kim,M.H., Jeong,Y.J., Urm,S.H. and Seog,D.H.
  TITLE     The heterotrimeric kinesin-2 family member KIF3A directly binds to
            disabled-1 (Dab1)
  JOURNAL   BMB Rep 57 (10), 447-452 (2024)
   PUBMED   38919020
  REMARK    GeneRIF: The heterotrimeric kinesin-2 family member KIF3A directly
            binds to disabled-1 (Dab1).
REFERENCE   2  (bases 1 to 6239)
  AUTHORS   Wang,C. and Yang,X.
  TITLE     CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate
            bladder cancer cell proliferation, migration and invasion
  JOURNAL   Int Immunopharmacol 131, 111613 (2024)
   PUBMED   38489970
  REMARK    GeneRIF: CircRAPGEF5 sponges miR-582-3p and targets KIF3A to
            regulate bladder cancer cell proliferation, migration and invasion.
REFERENCE   3  (bases 1 to 6239)
  AUTHORS   Liu,R., Li,T. and Zhang,W.
  TITLE     Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem
            cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (8), 84-88 (2023)
   PUBMED   37715417
  REMARK    GeneRIF: Inhibitory mechanism of KIF3A gene on nasopharyngeal
            carcinoma stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6239)
  AUTHORS   Liu,S., He,Y., Li,S., Gao,X. and Yang,F.
  TITLE     Kinesin family member 3A induces related diseases via
            wingless-related integration site/beta-catenin signaling pathway
  JOURNAL   Sci Prog 106 (1), 368504221148340 (2023)
   PUBMED   36594221
  REMARK    GeneRIF: Kinesin family member 3A induces related diseases via
            wingless-related integration site/beta-catenin signaling pathway.
            Review article
REFERENCE   5  (bases 1 to 6239)
  AUTHORS   Huang,Y., Wang,L. and Liu,D.
  TITLE     lncRNA MIR600HG induces the proliferation and invasion of
            colorectal cancer cells via regulating miR-144-3p/KIF3A
  JOURNAL   Int Immunopharmacol 108, 108686 (2022)
   PUBMED   35378445
  REMARK    GeneRIF: lncRNA MIR600HG induces the proliferation and invasion of
            colorectal cancer cells via regulating miR-144-3p/KIF3A.
REFERENCE   6  (bases 1 to 6239)
  AUTHORS   Nagata,Ki., Puls,A., Futter,C., Aspenstrom,P., Schaefer,E.,
            Nakata,T., Hirokawa,N. and Hall,A.
  TITLE     The MAP kinase kinase kinase MLK2 co-localizes with activated JNK
            along microtubules and associates with kinesin superfamily motor
            KIF3
  JOURNAL   EMBO J 17 (1), 149-158 (1998)
   PUBMED   9427749
REFERENCE   7  (bases 1 to 6239)
  AUTHORS   Yamazaki,H., Nakata,T., Okada,Y. and Hirokawa,N.
  TITLE     KIF3A/B: a heterodimeric kinesin superfamily protein that works as
            a microtubule plus end-directed motor for membrane organelle
            transport
  JOURNAL   J Cell Biol 130 (6), 1387-1399 (1995)
   PUBMED   7559760
REFERENCE   8  (bases 1 to 6239)
  AUTHORS   Kondo,S., Sato-Yoshitake,R., Noda,Y., Aizawa,H., Nakata,T.,
            Matsuura,Y. and Hirokawa,N.
  TITLE     KIF3A is a new microtubule-based anterograde motor in the nerve
            axon
  JOURNAL   J Cell Biol 125 (5), 1095-1107 (1994)
   PUBMED   7515068
REFERENCE   9  (bases 1 to 6239)
  AUTHORS   Aizawa,H., Sekine,Y., Takemura,R., Zhang,Z., Nangaku,M. and
            Hirokawa,N.
  TITLE     Kinesin family in murine central nervous system
  JOURNAL   J Cell Biol 119 (5), 1287-1296 (1992)
   PUBMED   1447303
REFERENCE   10 (bases 1 to 6239)
  AUTHORS   Stanley,S.M.
  TITLE     A theory of evolution above the species level
  JOURNAL   Proc Natl Acad Sci U S A 72 (2), 646-650 (1975)
   PUBMED   1054846
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC045542.1, AB209780.1, AC004039.1 and AW086059.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001300792.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, compared to variant 1. The resulting isoform (2)
            lacks an internal segment, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313359.1, BC045542.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BC045542.1         27-46
            21-2593             AB209780.1         1-2573
            2594-5842           AC004039.1         10453-13701
            5843-6239           AW086059.1         14-410              c
FEATURES             Location/Qualifiers
     source          1..6239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..6239
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="kinesin family member 3A"
                     /db_xref="GeneID:11127"
                     /db_xref="HGNC:HGNC:6319"
                     /db_xref="MIM:604683"
     exon            1..133
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2236
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="isoform 2 is encoded by transcript variant 2;
                     kinesin family protein 3A; kinesin-like protein KIF3A;
                     microtubule plus end-directed kinesin motor 3A"
                     /codon_start=1
                     /product="kinesin-like protein KIF3A isoform 2"
                     /protein_id="NP_001287721.1"
                     /db_xref="CCDS:CCDS75295.1"
                     /db_xref="GeneID:11127"
                     /db_xref="HGNC:HGNC:6319"
                     /db_xref="MIM:604683"
                     /translation="MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRG
                     TITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQT
                     GTGKTFTMEGVRAIPELRGIIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDL
                     LGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSS
                     RSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLS
                     LSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETIS
                     TLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDD
                     DEEGEVGEDGEKRKKRRDQAGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKA
                     RAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELE
                     ERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADL
                     QQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRDYQEMIENYVHWNEDIGEWQLKC
                     VAYTGNNMRKQTPVPDKKEKDPFEVDLSHVYLAYTEESLRQSLMKLERPRTSKGKARP
                     KTGRRKRSAKPETVIDSLLQ"
     exon            134..407
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            408..552
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            553..637
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            638..743
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            744..883
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1081
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1256
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1355
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1364
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1521
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1702
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1813
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1939
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..1993
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2062
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2187
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..6239
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2258..2263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="hexamer: AATAAA"
     polyA_site      2280
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="major polyA site"
     regulatory      6220..6225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="hexamer: AATAAA"
     polyA_site      6239
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="major polyA site"
ORIGIN      
        1 gagaagccgc agtctcgaga gcgtcaacga ggtgtttcgg tagtctctgg ccatcctttc
       61 tgcgcacccg gtgtcgctgg gctgcacccc gggcggggac gtccgccggg cacgggaggg
      121 ggccaagatg ccgatcaata aatcagagaa gccagaaagc tgcgataatg tgaaggttgt
      181 tgttaggtgc cggcccctca atgagagaga gaaatcaatg tgctacaaac aggctgtcag
      241 tgtggatgag atgaggggaa ctatcactgt acataagact gattcttcca atgaacctcc
      301 aaagacattt acttttgata ctgtttttgg accagagagt aaacaacttg atgtttataa
      361 cttaactgca agacctatta ttgattctgt acttgaaggc tacaatggga ctatttttgc
      421 atatggacaa accggaacag gcaaaacttt taccatggaa ggtgttcgag ctattcctga
      481 acttagagga ataattccca attcatttgc tcacatattt ggtcatattg caaaagcgga
      541 gggtgataca agatttttgg ttcgagtgtc ttatttggaa atatataatg aagaagttcg
      601 tgaccttttg ggcaaggatc agacacaaag gttagaggtt aaagaaagac ctgatgtggg
      661 agtttatatc aaagatttat cagcttatgt ggtaaataat gctgatgata tggatagaat
      721 tatgacgcta ggccacaaaa atcgttctgt tggtgcaact aatatgaacg aacatagttc
      781 ccgttcccat gccatcttta caattactat agaatgcagt gaaaaaggca ttgatggtaa
      841 catgcatgtc aggatgggga agctccatct tgtagatctt gctggttcag aaagacaggc
      901 aaaaactgga gctactggac agcgcctaaa ggaagctaca aaaatcaatc tttcactttc
      961 cacccttggt aatgtaattt ctgccttggt tgatggaaaa agcactcatg tgccttatcg
     1021 taactctaaa ctgactcgtc ttcttcagga ttccttagga ggaaattcaa aaaccatgat
     1081 gtgtgcaaat attgggccag cagattacaa ttatgatgaa actatcagta cattacggta
     1141 tgccaatcgt gctaagaata ttaaaaataa agctagaatt aatgaagatc caaaggatgc
     1201 tttgctgcgt cagttccaga aagaaataga agaactgaaa aagaagcttg aagaaggaga
     1261 agaaatatca ggctctgata tcagtgggtc agaggaagat gatgatgaag agggtgaggt
     1321 tggagaagat ggagagaaaa ggaaaaaaag aagggatcaa gcaggaaaaa agaaagtctc
     1381 cccagacaag atgattgaaa tgcaagcaaa aattgatgag gagagaaaag cacttgaaac
     1441 aaagctcgac atggaagaag aagaaagaaa caaggctaga gctgaattag agaaacggga
     1501 aaaagatctt cttaaagccc aacaagagca tcagtctttg ctggaaaaat tatctgccct
     1561 ggaaaagaag gtaattgttg gtggggttga cttgttggcc aaagctgagg aacaagagaa
     1621 acttcttgaa gaatctaaca tggaactgga agaaaggagg aaaagagcag agcaacttcg
     1681 cagagaactt gaggaaaaag agcaagaacg cttggatatt gaagaaaaat ataccagttt
     1741 gcaagaggaa gcacagggaa agaccaagaa gttaaagaaa gtttggacta tgctgatggc
     1801 tgcaaagtca gagatggctg atctccaaca agaacatcag agggaaattg aaggcctact
     1861 ggagaacatt cggcaactta gccgggagct tcgacttcag atgcttatta ttgataactt
     1921 tatacctcgg gattatcagg aaatgattga aaactatgtc cattggaatg aagacatagg
     1981 agaatggcag ctaaaatgtg ttgcttatac aggaaataac atgaggaagc aaaccccagt
     2041 acctgataaa aaggagaaag atccctttga ggtggacctt tctcacgtgt atcttgccta
     2101 tactgaggag agtctgcgtc agtctttgat gaaactagaa agaccacgaa cttcaaaggg
     2161 gaaagcaagg ccaaagacag ggagaagaaa gcgttctgca aagcctgaaa ctgtaattga
     2221 ctctttactg cagtaaatgt tacagactta aagtcacaat aaaaattagt gatattctca
     2281 tgcctggaca aaatctttaa ttaaaacagt gaagacttct ctataatttc aattaatgga
     2341 agttgtagat caatgaataa gactggaaat aataatttgc ttaagaactt ttagtctaca
     2401 tatattaata taacattaaa attgtacaac tggtgattgt tcaaattgtt gtactactac
     2461 tcttcaattg tactgtgcag ggaagttggg ggaacagttc atactataga gagttacagt
     2521 ttagatgtat gtgtaaatcg attagctatt tatccaacta ctgtatattt aggtaactag
     2581 aatttcaaaa tagaaaaaaa aaaactgtgt cctgttttgc acatagaaag aagcagatca
     2641 gattgtccta tgttgcgctg ttatatatga atgtttggac tgtacatcta aagaatgatt
     2701 ccgtcctaac acccacccag cctgtttgaa cacattctaa ttgtctaaca tttgttgcat
     2761 tttaagtatg agatgactga tcttatgaat gttttgtaga aaatgttata atttaacagt
     2821 ctttgcgagt atacatgttt tttaacaagt tgaaaatgtt tcatctgaac ctttcctaac
     2881 ttttttttgc cagtttgagt tcaaatcaaa tacaccttaa gttctggttt catgttctct
     2941 tgaaacattg aattgtacgt aaatataaag gatctactgt tgcggaaaat taagaagcta
     3001 aatactgctc agttatcttt gcctgcgtgt atatttttaa aaattcactc tgaagtgtta
     3061 tggatgcttt tctttgagtt ctaaattttg gtgggaatta ctttatgtct cccagttaag
     3121 aagagtctcc attttccaga aaatacagct aagcaagaaa aatatctttt aaatactttg
     3181 cctttaaaac acttttttat tttgtttttc tattttaaaa ataaaatatt attttctgaa
     3241 tttcttctat tgggtaatcc agttagacca tattcctcta caaataaaaa ctatgttgat
     3301 ttcatagtaa agtaagttgt aatagagata attatttttt tctgttgtta gctgcttatg
     3361 aaacttttat tgtatttttt taaagttatg ctactcctgg ccgggcatgg tggctcacgc
     3421 ctgtaatccc agcactttgg gaggccgagg cacgtggatc acttgatgtc aggagttcga
     3481 gaccagcctg gctaacatgg tgaaaccctg tctccagtac aaatacaata attagctggg
     3541 tgtggtggcg cacacctgta atcccagcta cttgggaggc tgaggcagga gaatcacttg
     3601 aacctgggag gcggaggttg cagtgagctg agatggcatc actgcactcc agcctgggtg
     3661 acagggtgac actccacctc aaaaaataaa aataaaataa aaataaagtt atgctactcc
     3721 taaaccactt aatatatgtt ttgtggtttt caaaattatg taatcagccc tgaaacacat
     3781 tggttgaaaa tattttgaga ctttataagt tagtatttat taaattaata ttattttaat
     3841 aagttttgtt aaatcctagt ttaaatgaca aagctgtgta tagagtaggg gtgagtgaag
     3901 gtggagtact cttgaggtgg cgataaaaat gtacccataa atttaaagtc cattctgtaa
     3961 ttggaatact gaatgtcctg tgtgtggtga acattttcta ggtgattaga attgcatttc
     4021 actggctgca tttgtttgtg gtatgtaaga tagctagaaa tttattactt aactctgtgg
     4081 ggcattgttt agatactgtg aagagttgag gtaaatatgt gtcttgtaaa agctttgtgt
     4141 gatcagaata ttttggtaat tataaaatgt ttttgatgat acacatttaa ctctgttagt
     4201 aattactcta aagaaatctt aattttacca gtttaaaaaa aacgcttctt tttaaaagtt
     4261 catgtttcta acctttaaca attcagttaa taggaaagga gtaactttta aatcaagctt
     4321 taaaacatgg aaatttaagc cagtatgtta gatatttttt ctatcccacc ctaccatgat
     4381 aataaaaata aatctataaa aagtcaaaat aaaaagccga tctataaaaa gtcaattgag
     4441 aagttctaaa agcaggctac tatagcaggg gtgtttgttt tttgtttgga gacggagtct
     4501 ggctctatta cctaggctgg agtgcagtgg gacaatctcg gctcactgta acctctgtct
     4561 cttcagcctc ctgagttgct ggaactacag ctgtatgcca tcatgctcgg ctaatttttg
     4621 tatttttttg tagagatggg gttttgccat gttgcccggg cctgtcttga actcctagag
     4681 cttaagtgat ccacccgcct caggctcccg aagtgctggg attacaggca tgattatagg
     4741 cctgagccac cacaccccgc ctactatagc agttttttaa aaaaagcatt atgttaaaac
     4801 tgattatacc agatggacat taaatatcca tctcagaaat accaaaattt gatacataag
     4861 cctggcctga atatcttttt tttttttttg agacggagtc ttactctgtc gcccaggctg
     4921 gagtgcagtg gcgcgatctc ggctcactgc aacctctgcc tcctgggttc aagggattct
     4981 cctgcctcag cctcttgagt agctgggatt acaggtttgc gccaccacac ccagctaatt
     5041 tttgtatttt ttttttagta gagaccgggt ttcaccatgt tggccaggct ggtctcacct
     5101 gactttgtga tccgcccgcc tcagcctccc aaagtgctgg gattacaggt gtgagccacc
     5161 acgcctggcc tcaagcctgg tctgaatatc tatatgcaaa tatgggacac tgacttcaga
     5221 gctattcatt tagctccagt catagcaatt ctgtagtttc ctcacattta ctgtgtcttt
     5281 gtccacaaat gaaatatgtt gtaaggtcag tgttaatttc gtgagacgat atagatgaac
     5341 acacttgctc attttttgaa ataaatatgc agatttaaaa tgagtggcac atatatataa
     5401 ataggttatt gaatgggtat tctcttttcc ctttaattta aaaagtgata tttatttatt
     5461 aaaaggagca ttggtagaat tattggttta tagtatcttc tttaataatc cttacaatta
     5521 catatactaa taggatgtta aaattatcat cgtgtttcct atttgtgttt agattcttat
     5581 aaagcatgag atgagtaatc aagggaaggg tcgcatctcc atgtttgccc catgaataga
     5641 atccatttga caagccattt catttccttt ctggagaaag ggagttgttt tttttttctt
     5701 tttacagcaa aaatttaagg ttttattggg ggagggggtg gtgctacttc ctctgtaaca
     5761 tgtttttaaa actatgatta tggtttttgg ttgttttttg ttttgtttgt ttccttttag
     5821 tctgttttta atatccttcc ccttaactct taaggaaagt cttctttcct acagggctgt
     5881 gaattaagga atgggtagcg tttacattta agtacaccaa tgtctgccca atttcctaat
     5941 gtatacattt gttttatttt aaattatttt ttgttcttaa aaatactaga agaaaacata
     6001 gatgtttcta gtgcctttga acttatactg tagtctgact aatttaatga ataacttcag
     6061 tagcattact ataatactgt atgctggcca aaattacaaa ttacagtttg ttgcatcagt
     6121 ttcaaaagcc atgctttcat tgtattttat gtataaattg tatttgttca agttgtatat
     6181 attggtattg tatgtataca tgcagcatgg ttaaataaga ataaaaatct tttacctaa
//
