LOCUS       NM_001300791            6311 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens kinesin family member 3A (KIF3A), transcript variant
            1, mRNA.
ACCESSION   NM_001300791 XM_005271868
VERSION     NM_001300791.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6311)
  AUTHORS   Kim,M.H., Jeong,Y.J., Urm,S.H. and Seog,D.H.
  TITLE     The heterotrimeric kinesin-2 family member KIF3A directly binds to
            disabled-1 (Dab1)
  JOURNAL   BMB Rep 57 (10), 447-452 (2024)
   PUBMED   38919020
  REMARK    GeneRIF: The heterotrimeric kinesin-2 family member KIF3A directly
            binds to disabled-1 (Dab1).
REFERENCE   2  (bases 1 to 6311)
  AUTHORS   Wang,C. and Yang,X.
  TITLE     CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate
            bladder cancer cell proliferation, migration and invasion
  JOURNAL   Int Immunopharmacol 131, 111613 (2024)
   PUBMED   38489970
  REMARK    GeneRIF: CircRAPGEF5 sponges miR-582-3p and targets KIF3A to
            regulate bladder cancer cell proliferation, migration and invasion.
REFERENCE   3  (bases 1 to 6311)
  AUTHORS   Liu,R., Li,T. and Zhang,W.
  TITLE     Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem
            cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (8), 84-88 (2023)
   PUBMED   37715417
  REMARK    GeneRIF: Inhibitory mechanism of KIF3A gene on nasopharyngeal
            carcinoma stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6311)
  AUTHORS   Liu,S., He,Y., Li,S., Gao,X. and Yang,F.
  TITLE     Kinesin family member 3A induces related diseases via
            wingless-related integration site/beta-catenin signaling pathway
  JOURNAL   Sci Prog 106 (1), 368504221148340 (2023)
   PUBMED   36594221
  REMARK    GeneRIF: Kinesin family member 3A induces related diseases via
            wingless-related integration site/beta-catenin signaling pathway.
            Review article
REFERENCE   5  (bases 1 to 6311)
  AUTHORS   Huang,Y., Wang,L. and Liu,D.
  TITLE     lncRNA MIR600HG induces the proliferation and invasion of
            colorectal cancer cells via regulating miR-144-3p/KIF3A
  JOURNAL   Int Immunopharmacol 108, 108686 (2022)
   PUBMED   35378445
  REMARK    GeneRIF: lncRNA MIR600HG induces the proliferation and invasion of
            colorectal cancer cells via regulating miR-144-3p/KIF3A.
REFERENCE   6  (bases 1 to 6311)
  AUTHORS   Nagata,Ki., Puls,A., Futter,C., Aspenstrom,P., Schaefer,E.,
            Nakata,T., Hirokawa,N. and Hall,A.
  TITLE     The MAP kinase kinase kinase MLK2 co-localizes with activated JNK
            along microtubules and associates with kinesin superfamily motor
            KIF3
  JOURNAL   EMBO J 17 (1), 149-158 (1998)
   PUBMED   9427749
REFERENCE   7  (bases 1 to 6311)
  AUTHORS   Yamazaki,H., Nakata,T., Okada,Y. and Hirokawa,N.
  TITLE     KIF3A/B: a heterodimeric kinesin superfamily protein that works as
            a microtubule plus end-directed motor for membrane organelle
            transport
  JOURNAL   J Cell Biol 130 (6), 1387-1399 (1995)
   PUBMED   7559760
REFERENCE   8  (bases 1 to 6311)
  AUTHORS   Kondo,S., Sato-Yoshitake,R., Noda,Y., Aizawa,H., Nakata,T.,
            Matsuura,Y. and Hirokawa,N.
  TITLE     KIF3A is a new microtubule-based anterograde motor in the nerve
            axon
  JOURNAL   J Cell Biol 125 (5), 1095-1107 (1994)
   PUBMED   7515068
REFERENCE   9  (bases 1 to 6311)
  AUTHORS   Aizawa,H., Sekine,Y., Takemura,R., Zhang,Z., Nangaku,M. and
            Hirokawa,N.
  TITLE     Kinesin family in murine central nervous system
  JOURNAL   J Cell Biol 119 (5), 1287-1296 (1992)
   PUBMED   1447303
REFERENCE   10 (bases 1 to 6311)
  AUTHORS   Stanley,S.M.
  TITLE     A theory of evolution above the species level
  JOURNAL   Proc Natl Acad Sci U S A 72 (2), 646-650 (1975)
   PUBMED   1054846
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC045542.1, AK295089.1, AC004039.1 and AW086059.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001300791.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK295089.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403231.6/ ENSP00000385808.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BC045542.1         27-36
            11-2276             AK295089.1         1-2266
            2277-5914           AC004039.1         10064-13701
            5915-6311           AW086059.1         14-410              c
FEATURES             Location/Qualifiers
     source          1..6311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..6311
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="kinesin family member 3A"
                     /db_xref="GeneID:11127"
                     /db_xref="HGNC:HGNC:6319"
                     /db_xref="MIM:604683"
     exon            1..133
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2308
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin family protein 3A; kinesin-like protein KIF3A;
                     microtubule plus end-directed kinesin motor 3A"
                     /codon_start=1
                     /product="kinesin-like protein KIF3A isoform 1"
                     /protein_id="NP_001287720.1"
                     /db_xref="CCDS:CCDS75296.1"
                     /db_xref="GeneID:11127"
                     /db_xref="HGNC:HGNC:6319"
                     /db_xref="MIM:604683"
                     /translation="MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRG
                     TITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQT
                     GTGKTFTMEGVRAIPELRGIIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDL
                     LGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSS
                     RSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLS
                     LSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETIS
                     TLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDD
                     DEEGEVGEDGEKRKKRRGSSSSSSSDSTCSVIEKPLDKFLPNQAGKKKVSPDKMIEMQ
                     AKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIV
                     GGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEA
                     QGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIP
                     RDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKEKDPFEVDLSHVYLAY
                     TEESLRQSLMKLERPRTSKGKARPKTGRRKRSAKPETVIDSLLQ"
     exon            134..407
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            408..552
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            553..637
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            638..743
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            744..883
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1081
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1256
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1355
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1427
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1436
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1593
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1774
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1885
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2011
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2065
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2134
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2259
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..6311
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2330..2335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="hexamer: AATAAA"
     polyA_site      2352
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="major polyA site"
     regulatory      6292..6297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="hexamer: AATAAA"
     polyA_site      6311
                     /gene="KIF3A"
                     /gene_synonym="FLA10; KLP-20"
                     /note="major polyA site"
ORIGIN      
        1 gagaagccgc agtctcgaga gcgtcaacga ggtgtttcgg tagtctctgg ccatcctttc
       61 tgcgcacccg gtgtcgctgg gctgcacccc gggcggggac gtccgccggg cacgggaggg
      121 ggccaagatg ccgatcaata aatcagagaa gccagaaagc tgcgataatg tgaaggttgt
      181 tgttaggtgc cggcccctca atgagagaga gaaatcaatg tgctacaaac aggctgtcag
      241 tgtggatgag atgaggggaa ctatcactgt acataagact gattcttcca atgaacctcc
      301 aaagacattt acttttgata ctgtttttgg accagagagt aaacaacttg atgtttataa
      361 cttaactgca agacctatta ttgattctgt acttgaaggc tacaatggga ctatttttgc
      421 atatggacaa accggaacag gcaaaacttt taccatggaa ggtgttcgag ctattcctga
      481 acttagagga ataattccca attcatttgc tcacatattt ggtcatattg caaaagcgga
      541 gggtgataca agatttttgg ttcgagtgtc ttatttggaa atatataatg aagaagttcg
      601 tgaccttttg ggcaaggatc agacacaaag gttagaggtt aaagaaagac ctgatgtggg
      661 agtttatatc aaagatttat cagcttatgt ggtaaataat gctgatgata tggatagaat
      721 tatgacgcta ggccacaaaa atcgttctgt tggtgcaact aatatgaacg aacatagttc
      781 ccgttcccat gccatcttta caattactat agaatgcagt gaaaaaggca ttgatggtaa
      841 catgcatgtc aggatgggga agctccatct tgtagatctt gctggttcag aaagacaggc
      901 aaaaactgga gctactggac agcgcctaaa ggaagctaca aaaatcaatc tttcactttc
      961 cacccttggt aatgtaattt ctgccttggt tgatggaaaa agcactcatg tgccttatcg
     1021 taactctaaa ctgactcgtc ttcttcagga ttccttagga ggaaattcaa aaaccatgat
     1081 gtgtgcaaat attgggccag cagattacaa ttatgatgaa actatcagta cattacggta
     1141 tgccaatcgt gctaagaata ttaaaaataa agctagaatt aatgaagatc caaaggatgc
     1201 tttgctgcgt cagttccaga aagaaataga agaactgaaa aagaagcttg aagaaggaga
     1261 agaaatatca ggctctgata tcagtgggtc agaggaagat gatgatgaag agggtgaggt
     1321 tggagaagat ggagagaaaa ggaaaaaaag aaggggcagt agcagcagca gtagttcaga
     1381 ctccacatgt tctgtcatag agaaacctct ggataagttc ttgcctaatc aagcaggaaa
     1441 aaagaaagtc tccccagaca agatgattga aatgcaagca aaaattgatg aggagagaaa
     1501 agcacttgaa acaaagctcg acatggaaga agaagaaaga aacaaggcta gagctgaatt
     1561 agagaaacgg gaaaaagatc ttcttaaagc ccaacaagag catcagtctt tgctggaaaa
     1621 attatctgcc ctggaaaaga aggtaattgt tggtggggtt gacttgttgg ccaaagctga
     1681 ggaacaagag aaacttcttg aagaatctaa catggaactg gaagaaagga ggaaaagagc
     1741 agagcaactt cgcagagaac ttgaggaaaa agagcaagaa cgcttggata ttgaagaaaa
     1801 atataccagt ttgcaagagg aagcacaggg aaagaccaag aagttaaaga aagtttggac
     1861 tatgctgatg gctgcaaagt cagagatggc tgatctccaa caagaacatc agagggaaat
     1921 tgaaggccta ctggagaaca ttcggcaact tagccgggag cttcgacttc agatgcttat
     1981 tattgataac tttatacctc gggattatca ggaaatgatt gaaaactatg tccattggaa
     2041 tgaagacata ggagaatggc agctaaaatg tgttgcttat acaggaaata acatgaggaa
     2101 gcaaacccca gtacctgata aaaaggagaa agatcccttt gaggtggacc tttctcacgt
     2161 gtatcttgcc tatactgagg agagtctgcg tcagtctttg atgaaactag aaagaccacg
     2221 aacttcaaag gggaaagcaa ggccaaagac agggagaaga aagcgttctg caaagcctga
     2281 aactgtaatt gactctttac tgcagtaaat gttacagact taaagtcaca ataaaaatta
     2341 gtgatattct catgcctgga caaaatcttt aattaaaaca gtgaagactt ctctataatt
     2401 tcaattaatg gaagttgtag atcaatgaat aagactggaa ataataattt gcttaagaac
     2461 ttttagtcta catatattaa tataacatta aaattgtaca actggtgatt gttcaaattg
     2521 ttgtactact actcttcaat tgtactgtgc agggaagttg ggggaacagt tcatactata
     2581 gagagttaca gtttagatgt atgtgtaaat cgattagcta tttatccaac tactgtatat
     2641 ttaggtaact agaatttcaa aatagaaaaa aaaaaactgt gtcctgtttt gcacatagaa
     2701 agaagcagat cagattgtcc tatgttgcgc tgttatatat gaatgtttgg actgtacatc
     2761 taaagaatga ttccgtccta acacccaccc agcctgtttg aacacattct aattgtctaa
     2821 catttgttgc attttaagta tgagatgact gatcttatga atgttttgta gaaaatgtta
     2881 taatttaaca gtctttgcga gtatacatgt tttttaacaa gttgaaaatg tttcatctga
     2941 acctttccta actttttttt gccagtttga gttcaaatca aatacacctt aagttctggt
     3001 ttcatgttct cttgaaacat tgaattgtac gtaaatataa aggatctact gttgcggaaa
     3061 attaagaagc taaatactgc tcagttatct ttgcctgcgt gtatattttt aaaaattcac
     3121 tctgaagtgt tatggatgct tttctttgag ttctaaattt tggtgggaat tactttatgt
     3181 ctcccagtta agaagagtct ccattttcca gaaaatacag ctaagcaaga aaaatatctt
     3241 ttaaatactt tgcctttaaa acactttttt attttgtttt tctattttaa aaataaaata
     3301 ttattttctg aatttcttct attgggtaat ccagttagac catattcctc tacaaataaa
     3361 aactatgttg atttcatagt aaagtaagtt gtaatagaga taattatttt tttctgttgt
     3421 tagctgctta tgaaactttt attgtatttt tttaaagtta tgctactcct ggccgggcat
     3481 ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcacgtgga tcacttgatg
     3541 tcaggagttc gagaccagcc tggctaacat ggtgaaaccc tgtctccagt acaaatacaa
     3601 taattagctg ggtgtggtgg cgcacacctg taatcccagc tacttgggag gctgaggcag
     3661 gagaatcact tgaacctggg aggcggaggt tgcagtgagc tgagatggca tcactgcact
     3721 ccagcctggg tgacagggtg acactccacc tcaaaaaata aaaataaaat aaaaataaag
     3781 ttatgctact cctaaaccac ttaatatatg ttttgtggtt ttcaaaatta tgtaatcagc
     3841 cctgaaacac attggttgaa aatattttga gactttataa gttagtattt attaaattaa
     3901 tattatttta ataagttttg ttaaatccta gtttaaatga caaagctgtg tatagagtag
     3961 gggtgagtga aggtggagta ctcttgaggt ggcgataaaa atgtacccat aaatttaaag
     4021 tccattctgt aattggaata ctgaatgtcc tgtgtgtggt gaacattttc taggtgatta
     4081 gaattgcatt tcactggctg catttgtttg tggtatgtaa gatagctaga aatttattac
     4141 ttaactctgt ggggcattgt ttagatactg tgaagagttg aggtaaatat gtgtcttgta
     4201 aaagctttgt gtgatcagaa tattttggta attataaaat gtttttgatg atacacattt
     4261 aactctgtta gtaattactc taaagaaatc ttaattttac cagtttaaaa aaaacgcttc
     4321 tttttaaaag ttcatgtttc taacctttaa caattcagtt aataggaaag gagtaacttt
     4381 taaatcaagc tttaaaacat ggaaatttaa gccagtatgt tagatatttt ttctatccca
     4441 ccctaccatg ataataaaaa taaatctata aaaagtcaaa ataaaaagcc gatctataaa
     4501 aagtcaattg agaagttcta aaagcaggct actatagcag gggtgtttgt tttttgtttg
     4561 gagacggagt ctggctctat tacctaggct ggagtgcagt gggacaatct cggctcactg
     4621 taacctctgt ctcttcagcc tcctgagttg ctggaactac agctgtatgc catcatgctc
     4681 ggctaatttt tgtatttttt tgtagagatg gggttttgcc atgttgcccg ggcctgtctt
     4741 gaactcctag agcttaagtg atccacccgc ctcaggctcc cgaagtgctg ggattacagg
     4801 catgattata ggcctgagcc accacacccc gcctactata gcagtttttt aaaaaaagca
     4861 ttatgttaaa actgattata ccagatggac attaaatatc catctcagaa ataccaaaat
     4921 ttgatacata agcctggcct gaatatcttt tttttttttt tgagacggag tcttactctg
     4981 tcgcccaggc tggagtgcag tggcgcgatc tcggctcact gcaacctctg cctcctgggt
     5041 tcaagggatt ctcctgcctc agcctcttga gtagctggga ttacaggttt gcgccaccac
     5101 acccagctaa tttttgtatt ttttttttag tagagaccgg gtttcaccat gttggccagg
     5161 ctggtctcac ctgactttgt gatccgcccg cctcagcctc ccaaagtgct gggattacag
     5221 gtgtgagcca ccacgcctgg cctcaagcct ggtctgaata tctatatgca aatatgggac
     5281 actgacttca gagctattca tttagctcca gtcatagcaa ttctgtagtt tcctcacatt
     5341 tactgtgtct ttgtccacaa atgaaatatg ttgtaaggtc agtgttaatt tcgtgagacg
     5401 atatagatga acacacttgc tcattttttg aaataaatat gcagatttaa aatgagtggc
     5461 acatatatat aaataggtta ttgaatgggt attctctttt ccctttaatt taaaaagtga
     5521 tatttattta ttaaaaggag cattggtaga attattggtt tatagtatct tctttaataa
     5581 tccttacaat tacatatact aataggatgt taaaattatc atcgtgtttc ctatttgtgt
     5641 ttagattctt ataaagcatg agatgagtaa tcaagggaag ggtcgcatct ccatgtttgc
     5701 cccatgaata gaatccattt gacaagccat ttcatttcct ttctggagaa agggagttgt
     5761 tttttttttc tttttacagc aaaaatttaa ggttttattg ggggaggggg tggtgctact
     5821 tcctctgtaa catgttttta aaactatgat tatggttttt ggttgttttt tgttttgttt
     5881 gtttcctttt agtctgtttt taatatcctt ccccttaact cttaaggaaa gtcttctttc
     5941 ctacagggct gtgaattaag gaatgggtag cgtttacatt taagtacacc aatgtctgcc
     6001 caatttccta atgtatacat ttgttttatt ttaaattatt ttttgttctt aaaaatacta
     6061 gaagaaaaca tagatgtttc tagtgccttt gaacttatac tgtagtctga ctaatttaat
     6121 gaataacttc agtagcatta ctataatact gtatgctggc caaaattaca aattacagtt
     6181 tgttgcatca gtttcaaaag ccatgctttc attgtatttt atgtataaat tgtatttgtt
     6241 caagttgtat atattggtat tgtatgtata catgcagcat ggttaaataa gaataaaaat
     6301 cttttaccta a
//
