LOCUS       NM_006845               2862 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens kinesin family member 2C (KIF2C), transcript variant
            1, mRNA.
ACCESSION   NM_006845
VERSION     NM_006845.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2862)
  AUTHORS   Kalkan,B.M., Ozcan,S.C., Cicek,E., Gonen,M. and Acilan,C.
  TITLE     Nek2A prevents centrosome clustering and induces cell death in
            cancer cells via KIF2C interaction
  JOURNAL   Cell Death Dis 15 (3), 222 (2024)
   PUBMED   38493150
  REMARK    GeneRIF: Nek2A prevents centrosome clustering and induces cell
            death in cancer cells via KIF2C interaction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2862)
  AUTHORS   Deng,H., Gong,X., Ji,G., Li,C. and Cheng,S.
  TITLE     KIF2C promotes clear cell renal cell carcinoma progression via
            activating JAK2/STAT3 signaling pathway
  JOURNAL   Mol Cell Probes 72, 101938 (2023)
   PUBMED   37863123
  REMARK    GeneRIF: KIF2C promotes clear cell renal cell carcinoma progression
            via activating JAK2/STAT3 signaling pathway.
REFERENCE   3  (bases 1 to 2862)
  AUTHORS   Li,S., Ma,Y., Wu,C. and Hou,X.
  TITLE     Knockdown of kinesin family member 2C restricts cell proliferation
            and induces cell cycle arrest in gastric cancer
  JOURNAL   Histol Histopathol 38 (8), 907-916 (2023)
   PUBMED   36448588
  REMARK    GeneRIF: Knockdown of kinesin family member 2C restricts cell
            proliferation and induces cell cycle arrest in gastric cancer.
REFERENCE   4  (bases 1 to 2862)
  AUTHORS   Xiong,J., Wu,R., He,A., Hou,P., Wang,J., Zhang,R., Liao,W., Wu,L.
            and Li,E.
  TITLE     Comprehensive analysis of the effects of KIF2C on prognosis,
            biological functions and immune infiltration in PAAD
  JOURNAL   Tissue Cell 78, 101900 (2022)
   PUBMED   36029726
  REMARK    GeneRIF: Comprehensive analysis of the effects of KIF2C on
            prognosis, biological functions and immune infiltration in PAAD.
REFERENCE   5  (bases 1 to 2862)
  AUTHORS   Cheng,L.J., Zhou,Z.M., Li,J.M., Zhu,H., Zhu,H., Zhou,Y.D.,
            Wang,L.R., Lin,M. and Sha,J.H.
  TITLE     Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in
            human testis
  JOURNAL   Life Sci 71 (23), 2741-2757 (2002)
   PUBMED   12383881
  REMARK    GeneRIF: identification as a candidate gene for the testis-specific
            KRPs and its specific expression in the testis was correlated with
            spermatogenesis and may be correlated with male infertility
REFERENCE   6  (bases 1 to 2862)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   7  (bases 1 to 2862)
  AUTHORS   Sugata,N., Li,S., Earnshaw,W.C., Yen,T.J., Yoda,K., Masumoto,H.,
            Munekata,E., Warburton,P.E. and Todokoro,K.
  TITLE     Human CENP-H multimers colocalize with CENP-A and CENP-C at active
            centromere--kinetochore complexes
  JOURNAL   Hum Mol Genet 9 (19), 2919-2926 (2000)
   PUBMED   11092768
REFERENCE   8  (bases 1 to 2862)
  AUTHORS   Wordeman,L., Wagenbach,M. and Maney,T.
  TITLE     Mutations in the ATP-binding domain affect the subcellular
            distribution of mitotic centromere-associated kinesin (MCAK)
  JOURNAL   Cell Biol Int 23 (4), 275-286 (1999)
   PUBMED   10600236
REFERENCE   9  (bases 1 to 2862)
  AUTHORS   Maney,T., Hunter,A.W., Wagenbach,M. and Wordeman,L.
  TITLE     Mitotic centromere-associated kinesin is important for anaphase
            chromosome segregation
  JOURNAL   J Cell Biol 142 (3), 787-801 (1998)
   PUBMED   9700166
REFERENCE   10 (bases 1 to 2862)
  AUTHORS   Kim,I.G., Jun,D.Y., Sohn,U. and Kim,Y.H.
  TITLE     Cloning and expression of human mitotic centromere-associated
            kinesin gene
  JOURNAL   Biochim Biophys Acta 1359 (3), 181-186 (1997)
   PUBMED   9434124
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU130795.1, BC008764.2,
            BC014924.1 and BU615368.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006845.3.
            
            Summary: This gene encodes a kinesin-like protein that functions as
            a microtubule-dependent molecular motor. The encoded protein can
            depolymerize microtubules at the plus end, thereby promoting
            mitotic chromosome segregation. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005691.1, AB264115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372224.9/ ENSP00000361298.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AU130795.1         20-61
            43-2181             BC008764.2         1-2139
            2182-2839           BC014924.1         2138-2795
            2840-2862           BU615368.1         16-38               c
FEATURES             Location/Qualifiers
     source          1..2862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..2862
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /note="kinesin family member 2C"
                     /db_xref="GeneID:11004"
                     /db_xref="HGNC:HGNC:6393"
                     /db_xref="MIM:604538"
     exon            1..166
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2274
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitotic centromere-associated kinesin; kinesin-like
                     protein KIF2C; kinesin-like protein 6; testis tissue
                     sperm-binding protein Li 68n"
                     /codon_start=1
                     /product="kinesin-like protein KIF2C isoform 1"
                     /protein_id="NP_006836.2"
                     /db_xref="CCDS:CCDS512.1"
                     /db_xref="GeneID:11004"
                     /db_xref="HGNC:HGNC:6393"
                     /db_xref="MIM:604538"
                     /translation="MAMDSSLQARLFPGLAIKIQRSNGLIHSANVRTVNLEKSCVSVE
                     WAEGGATKGKEIDFDDVAAINPELLQLLPLHPKDNLPLQENVTIQKQKRRSVNSKIPA
                     PKESLRSRSTRMSTVSELRITAQENDMEVELPAAANSRKQFSVPPAPTRPSCPAVAEI
                     PLRMVSEEMEEQVHSIRGSSSANPVNSVRRKSCLVKEVEKMKNKREEKKAQNSEMRMK
                     RAQEYDSSFPNWEFARMIKEFRATLECHPLTMTDPIEEHRICVCVRKRPLNKQELAKK
                     EIDVISIPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQ
                     TIFEGGKATCFAYGQTGSGKTHTMGGDLSGKAQNASKGIYAMASRDVFLLKNQPCYRK
                     LGLEVYVTFFEIYNGKLFDLLNKKAKLRVLEDGKQQVQVVGLQEHLVNSADDVIKMID
                     MGSACRTSGQTFANSNSSRSHACFQIILRAKGRMHGKFSLVDLAGNERGADTSSADRQ
                     TRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIATIS
                     PGISSCEYTLNTLRYADRVKELSPHSGPSGEQLIQMETEEMEACSNGALIPGNLSKEE
                     EELSSQMSSFNEAMTQIRELEEKAMEELKEIIQQGPDWLELSEMTEQPDYDLETFVNK
                     AESALAQQAKHFSALRDVIKALRLAMQLEEQASRQISSKKRPQ"
     exon            167..261
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            262..363
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            364..412
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            413..535
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            536..658
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            659..759
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            760..855
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            856..910
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1073
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1164
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1228
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1320
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1463
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1668
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1779
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1847
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1953
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2067
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2191
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2862
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2821..2826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /note="hexamer: AATAAA"
     regulatory      2834..2839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /note="hexamer: AATAAA"
     polyA_site      2839
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /note="major polyA site"
     polyA_site      2862
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
ORIGIN      
        1 aaactgcggc ggtttacgcg gcgttaagac ttcgtagggt tagcgaaatt gaggtttctt
       61 ggtattgcgc gtttctcttc cttgctgact ctccgaatgg ccatggactc gtcgcttcag
      121 gcccgcctgt ttcccggtct cgctatcaag atccaacgca gtaatggttt aattcacagt
      181 gccaatgtaa ggactgtgaa cttggagaaa tcctgtgttt cagtggaatg ggcagaagga
      241 ggtgccacaa agggcaaaga gattgatttt gatgatgtgg ctgcaataaa cccagaactc
      301 ttacagcttc ttcccttaca tccgaaggac aatctgccct tgcaggaaaa tgtaacaatc
      361 cagaaacaaa aacggagatc cgtcaactcc aaaattcctg ctccaaaaga aagtcttcga
      421 agccgctcca ctcgcatgtc cactgtctca gagcttcgca tcacggctca ggagaatgac
      481 atggaggtgg agctgcctgc agctgcaaac tcccgcaagc agttttcagt tcctcctgcc
      541 cccactaggc cttcctgccc tgcagtggct gaaataccat tgaggatggt cagcgaggag
      601 atggaagagc aagtccattc catccgaggc agctcttctg caaaccctgt gaactcagtt
      661 cggaggaaat catgtcttgt gaaggaagtg gaaaaaatga agaacaagcg agaagagaag
      721 aaggcccaga actctgaaat gagaatgaag agagctcagg agtatgacag tagttttcca
      781 aactgggaat ttgcccgaat gattaaagaa tttcgggcta ctttggaatg tcatccactt
      841 actatgactg atcctatcga agagcacaga atatgtgtct gtgttaggaa acgcccactg
      901 aataagcaag aattggccaa gaaagaaatt gatgtgattt ccattcctag caagtgtctc
      961 ctcttggtac atgaacccaa gttgaaagtg gacttaacaa agtatctgga gaaccaagca
     1021 ttctgctttg actttgcatt tgatgaaaca gcttcgaatg aagttgtcta caggttcaca
     1081 gcaaggccac tggtacagac aatctttgaa ggtggaaaag caacttgttt tgcatatggc
     1141 cagacaggaa gtggcaagac acatactatg ggcggagacc tctctgggaa agcccagaat
     1201 gcatccaaag ggatctatgc catggcctcc cgggacgtct tcctcctgaa gaatcaaccc
     1261 tgctaccgga agttgggcct ggaagtctat gtgacattct tcgagatcta caatgggaag
     1321 ctgtttgacc tgctcaacaa gaaggccaag ctgcgcgtgc tggaggacgg caagcaacag
     1381 gtgcaagtgg tggggctgca ggagcatctg gttaactctg ctgatgatgt catcaagatg
     1441 atcgacatgg gcagcgcctg cagaacctct gggcagacat ttgccaactc caattcctcc
     1501 cgctcccacg cgtgcttcca aattattctt cgagctaaag ggagaatgca tggcaagttc
     1561 tctttggtag atctggcagg gaatgagcga ggcgcggaca cttccagtgc tgaccggcag
     1621 acccgcatgg agggcgcaga aatcaacaag agtctcttag ccctgaagga gtgcatcagg
     1681 gccctgggac agaacaaggc tcacaccccg ttccgtgaga gcaagctgac acaggtgctg
     1741 agggactcct tcattgggga gaactctagg acttgcatga ttgccacgat ctcaccaggc
     1801 ataagctcct gtgaatatac tttaaacacc ctgagatatg cagacagggt caaggagctg
     1861 agcccccaca gtgggcccag tggagagcag ttgattcaaa tggaaacaga agagatggaa
     1921 gcctgctcta acggggcgct gattccaggc aatttatcca aggaagagga ggaactgtct
     1981 tcccagatgt ccagctttaa cgaagccatg actcagatca gggagctgga ggagaaggct
     2041 atggaagagc tcaaggagat catacagcaa ggaccagact ggcttgagct ctctgagatg
     2101 accgagcagc cagactatga cctggagacc tttgtgaaca aagcggaatc tgctctggcc
     2161 cagcaagcca agcatttctc agccctgcga gatgtcatca aggccttgcg cctggccatg
     2221 cagctggaag agcaggctag cagacaaata agcagcaaga aacggcccca gtgacgactg
     2281 caaataaaaa tctgtttggt ttgacaccca gcctcttccc tggccctccc cagagaactt
     2341 tgggtacctg gtgggtctag gcagggtctg agctgggaca ggttctggta aatgccaagt
     2401 atgggggcat ctgggcccag ggcagctggg gagggggtca gagtgacatg ggacactcct
     2461 tttctgttcc tcagttgtcg ccctcacgag aggaaggagc tcttagttac ccttttgtgt
     2521 tgcccttctt tccatcaagg ggaatgttct cagcatagag ctttctccgc agcatcctgc
     2581 ctgcgtggac tggctgctaa tggagagctc cctggggttg tcctggctct ggggagagag
     2641 acggagcctt tagtacagct atctgctggc tctaaacctt ctacgccttt gggccgagca
     2701 ctgaatgtct tgtactttaa aaaaatgttt ctgagacctc tttctacttt actgtctccc
     2761 tagagatcct agaggatccc tactgttttc tgttttatgt gtttatacat tgtatgtaac
     2821 aataaagaga aaaaataaat cagctgttta agtgtgtgga aa
//
