LOCUS       NP_006836                725 aa            linear   PRI 23-MAR-2024
DEFINITION  kinesin-like protein KIF2C isoform 1 [Homo sapiens].
ACCESSION   NP_006836
VERSION     NP_006836.2
DBSOURCE    REFSEQ: accession NM_006845.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 725)
  AUTHORS   Kalkan,B.M., Ozcan,S.C., Cicek,E., Gonen,M. and Acilan,C.
  TITLE     Nek2A prevents centrosome clustering and induces cell death in
            cancer cells via KIF2C interaction
  JOURNAL   Cell Death Dis 15 (3), 222 (2024)
   PUBMED   38493150
  REMARK    GeneRIF: Nek2A prevents centrosome clustering and induces cell
            death in cancer cells via KIF2C interaction.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 725)
  AUTHORS   Deng,H., Gong,X., Ji,G., Li,C. and Cheng,S.
  TITLE     KIF2C promotes clear cell renal cell carcinoma progression via
            activating JAK2/STAT3 signaling pathway
  JOURNAL   Mol Cell Probes 72, 101938 (2023)
   PUBMED   37863123
  REMARK    GeneRIF: KIF2C promotes clear cell renal cell carcinoma progression
            via activating JAK2/STAT3 signaling pathway.
REFERENCE   3  (residues 1 to 725)
  AUTHORS   Li,S., Ma,Y., Wu,C. and Hou,X.
  TITLE     Knockdown of kinesin family member 2C restricts cell proliferation
            and induces cell cycle arrest in gastric cancer
  JOURNAL   Histol Histopathol 38 (8), 907-916 (2023)
   PUBMED   36448588
  REMARK    GeneRIF: Knockdown of kinesin family member 2C restricts cell
            proliferation and induces cell cycle arrest in gastric cancer.
REFERENCE   4  (residues 1 to 725)
  AUTHORS   Xiong,J., Wu,R., He,A., Hou,P., Wang,J., Zhang,R., Liao,W., Wu,L.
            and Li,E.
  TITLE     Comprehensive analysis of the effects of KIF2C on prognosis,
            biological functions and immune infiltration in PAAD
  JOURNAL   Tissue Cell 78, 101900 (2022)
   PUBMED   36029726
  REMARK    GeneRIF: Comprehensive analysis of the effects of KIF2C on
            prognosis, biological functions and immune infiltration in PAAD.
REFERENCE   5  (residues 1 to 725)
  AUTHORS   Cheng,L.J., Zhou,Z.M., Li,J.M., Zhu,H., Zhu,H., Zhou,Y.D.,
            Wang,L.R., Lin,M. and Sha,J.H.
  TITLE     Expression of a novel HsMCAK mRNA splice variant, tsMCAK gene, in
            human testis
  JOURNAL   Life Sci 71 (23), 2741-2757 (2002)
   PUBMED   12383881
  REMARK    GeneRIF: identification as a candidate gene for the testis-specific
            KRPs and its specific expression in the testis was correlated with
            spermatogenesis and may be correlated with male infertility
REFERENCE   6  (residues 1 to 725)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
REFERENCE   7  (residues 1 to 725)
  AUTHORS   Sugata,N., Li,S., Earnshaw,W.C., Yen,T.J., Yoda,K., Masumoto,H.,
            Munekata,E., Warburton,P.E. and Todokoro,K.
  TITLE     Human CENP-H multimers colocalize with CENP-A and CENP-C at active
            centromere--kinetochore complexes
  JOURNAL   Hum Mol Genet 9 (19), 2919-2926 (2000)
   PUBMED   11092768
REFERENCE   8  (residues 1 to 725)
  AUTHORS   Wordeman,L., Wagenbach,M. and Maney,T.
  TITLE     Mutations in the ATP-binding domain affect the subcellular
            distribution of mitotic centromere-associated kinesin (MCAK)
  JOURNAL   Cell Biol Int 23 (4), 275-286 (1999)
   PUBMED   10600236
REFERENCE   9  (residues 1 to 725)
  AUTHORS   Maney,T., Hunter,A.W., Wagenbach,M. and Wordeman,L.
  TITLE     Mitotic centromere-associated kinesin is important for anaphase
            chromosome segregation
  JOURNAL   J Cell Biol 142 (3), 787-801 (1998)
   PUBMED   9700166
REFERENCE   10 (residues 1 to 725)
  AUTHORS   Kim,I.G., Jun,D.Y., Sohn,U. and Kim,Y.H.
  TITLE     Cloning and expression of human mitotic centromere-associated
            kinesin gene
  JOURNAL   Biochim Biophys Acta 1359 (3), 181-186 (1997)
   PUBMED   9434124
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU130795.1, BC008764.2,
            BC014924.1 and BU615368.1.
            
            On Feb 2, 2008 this sequence version replaced NP_006836.1.
            
            Summary: This gene encodes a kinesin-like protein that functions as
            a microtubule-dependent molecular motor. The encoded protein can
            depolymerize microtubules at the plus end, thereby promoting
            mitotic chromosome segregation. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005691.1, AB264115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372224.9/ ENSP00000361298.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..725
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     Protein         1..725
                     /product="kinesin-like protein KIF2C isoform 1"
                     /note="mitotic centromere-associated kinesin; kinesin-like
                     protein KIF2C; kinesin-like protein 6; testis tissue
                     sperm-binding protein Li 68n"
                     /calculated_mol_wt=81182
     Region          2..254
                     /region_name="Globular. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99661.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Site            22
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Region          89..116
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99661.2)"
     Site            95
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by AURKB.
                     /evidence=ECO:0000269|PubMed:14960279; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Region          98..101
                     /region_name="Microtubule tip localization signal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99661.2)"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Site            109
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70096; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Site            111
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70096; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Site            115
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Site            166
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Site            175
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Site            187
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Site            192
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70096; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Region          207..238
                     /region_name="Negative regulator of microtubule-binding.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99661.2)"
     Region          258..586
                     /region_name="KISc_KIF2_like"
                     /note="Kinesin motor domain, KIF2-like group; cd01367"
                     /db_xref="CDD:276818"
     Site            order(266,348,351,353..356,492)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276818"
     Region          415..418
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99661.2)"
     Site            519
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Site            order(540,543,546)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276818"
     Site            621
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     Site            633
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q99661.2)"
     CDS             1..725
                     /gene="KIF2C"
                     /gene_synonym="CT139; KNSL6; MCAK"
                     /coded_by="NM_006845.4:97..2274"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS512.1"
                     /db_xref="GeneID:11004"
                     /db_xref="HGNC:HGNC:6393"
                     /db_xref="MIM:604538"
ORIGIN      
        1 mamdsslqar lfpglaikiq rsnglihsan vrtvnleksc vsvewaegga tkgkeidfdd
       61 vaainpellq llplhpkdnl plqenvtiqk qkrrsvnski papkeslrsr strmstvsel
      121 ritaqendme velpaaansr kqfsvppapt rpscpavaei plrmvseeme eqvhsirgss
      181 sanpvnsvrr ksclvkevek mknkreekka qnsemrmkra qeydssfpnw efarmikefr
      241 atlechpltm tdpieehric vcvrkrplnk qelakkeidv isipskclll vhepklkvdl
      301 tkylenqafc fdfafdetas nevvyrftar plvqtifegg katcfaygqt gsgkthtmgg
      361 dlsgkaqnas kgiyamasrd vfllknqpcy rklglevyvt ffeiyngklf dllnkkaklr
      421 vledgkqqvq vvglqehlvn saddvikmid mgsacrtsgq tfansnssrs hacfqiilra
      481 kgrmhgkfsl vdlagnerga dtssadrqtr megaeinksl lalkeciral gqnkahtpfr
      541 eskltqvlrd sfigensrtc miatispgis sceytlntlr yadrvkelsp hsgpsgeqli
      601 qmeteemeac sngalipgnl skeeeelssq mssfneamtq ireleekame elkeiiqqgp
      661 dwlelsemte qpdydletfv nkaesalaqq akhfsalrdv ikalrlamql eeqasrqiss
      721 kkrpq
//
