LOCUS       NM_032559               2267 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens kinesin family member 2B (KIF2B), mRNA.
ACCESSION   NM_032559
VERSION     NM_032559.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2267)
  AUTHORS   Laucius,C.D., Orr,B. and Compton,D.A.
  TITLE     Chromosomal instability suppresses the growth of K-Ras-induced lung
            adenomas
  JOURNAL   Cell Cycle 18 (15), 1702-1713 (2019)
   PUBMED   31179849
  REMARK    GeneRIF: Chromosomal instability suppresses the growth of
            K-Ras-induced lung adenomas.
REFERENCE   2  (bases 1 to 2267)
  AUTHORS   Qin,B., Cao,D., Wu,H., Mo,F., Shao,H., Chu,J., Powell,M.,
            Aikhionbare,F., Wang,D., Fu,C., He,P., Pan,W., Wang,W., Liu,X. and
            Yao,X.
  TITLE     Phosphorylation of SKAP by GSK3beta ensures chromosome segregation
            by a temporal inhibition of Kif2b activity
  JOURNAL   Sci Rep 6, 38791 (2016)
   PUBMED   27982129
  REMARK    GeneRIF: GSK3beta-SKAP-Kif2b signaling axis constitutes a dynamic
            link between spindle microtubule plus-ends and mitotic chromosomes
            to achieve faithful cell division.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2267)
  AUTHORS   Watanabe,T., Kakeno,M., Matsui,T., Sugiyama,I., Arimura,N.,
            Matsuzawa,K., Shirahige,A., Ishidate,F., Nishioka,T., Taya,S.,
            Hoshino,M. and Kaibuchi,K.
  TITLE     TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells
            through KIF2A phosphorylation
  JOURNAL   J Cell Biol 210 (5), 737-751 (2015)
   PUBMED   26323690
REFERENCE   4  (bases 1 to 2267)
  AUTHORS   Shrestha,R.L. and Draviam,V.M.
  TITLE     Lateral to end-on conversion of chromosome-microtubule attachment
            requires kinesins CENP-E and MCAK
  JOURNAL   Curr Biol 23 (16), 1514-1526 (2013)
   PUBMED   23891108
  REMARK    Erratum:[Curr Biol. 2013 Dec 2;23(23):2440-1]
REFERENCE   5  (bases 1 to 2267)
  AUTHORS   Welburn,J.P. and Cheeseman,I.M.
  TITLE     The microtubule-binding protein Cep170 promotes the targeting of
            the kinesin-13 depolymerase Kif2b to the mitotic spindle
  JOURNAL   Mol Biol Cell 23 (24), 4786-4795 (2012)
   PUBMED   23087211
  REMARK    GeneRIF: Data indicate that Cep170 association with the C-terminus
            of Kif2b enhances localization of Kif2b to the spindle.
REFERENCE   6  (bases 1 to 2267)
  AUTHORS   Bakhoum,S.F., Thompson,S.L., Manning,A.L. and Compton,D.A.
  TITLE     Genome stability is ensured by temporal control of
            kinetochore-microtubule dynamics
  JOURNAL   Nat Cell Biol 11 (1), 27-35 (2009)
   PUBMED   19060894
  REMARK    GeneRIF: Here we show that two microtubule-depolymerizing kinesins,
            Kif2b and MCAK, stimulate kinetochore-microtubule dynamics during
            distinct phases of mitosis to correct mal-orientations.
REFERENCE   7  (bases 1 to 2267)
  AUTHORS   Manning,A.L., Ganem,N.J., Bakhoum,S.F., Wagenbach,M., Wordeman,L.
            and Compton,D.A.
  TITLE     The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct
            roles during mitosis in human cells
  JOURNAL   Mol Biol Cell 18 (8), 2970-2979 (2007)
   PUBMED   17538014
  REMARK    GeneRIF: These data demonstrate that Kif2b function is required for
            spindle assembly and chromosome movement and that the microtubule
            depolymerase activities of Kif2a, Kif2b, and MCAK fulfill distinct
            functions during mitosis in human cells.
REFERENCE   8  (bases 1 to 2267)
  AUTHORS   Matsuda,S., Matsuda,Y. and D'Adamio,L.
  TITLE     Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like
            protein 2, is bridged to the kinesin light chain by the scaffold
            protein JNK-interacting protein 1
  JOURNAL   J Biol Chem 278 (40), 38601-38606 (2003)
   PUBMED   12893827
  REMARK    GeneRIF: kinesin-I-dependent neuronal AbetaPP transport, which
            controls AbetaPP processing, may be regulated by JIP1
REFERENCE   9  (bases 1 to 2267)
  AUTHORS   Sindelar,C.V., Budny,M.J., Rice,S., Naber,N., Fletterick,R. and
            Cooke,R.
  TITLE     Two conformations in the human kinesin power stroke defined by
            X-ray crystallography and EPR spectroscopy
  JOURNAL   Nat Struct Biol 9 (11), 844-848 (2002)
   PUBMED   12368902
  REMARK    GeneRIF: when microtubules are absent, the neck linker exists in
            equilibrium between two structural states; microtubule binding may
            activate the nucleotide-sensing mechanism of kinesin
REFERENCE   10 (bases 1 to 2267)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019315.9 and AF333335.2.
            
            On May 17, 2019 this sequence version replaced NM_032559.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC033802.1, SRR5189667.121511.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268919.6/ ENSP00000268919.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1619              AC019315.9         100978-102596       c
            1620-2267           AF333335.2         1647-2294
FEATURES             Location/Qualifiers
     source          1..2267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..2267
                     /gene="KIF2B"
                     /note="kinesin family member 2B"
                     /db_xref="GeneID:84643"
                     /db_xref="HGNC:HGNC:29443"
                     /db_xref="MIM:615142"
     exon            1..2267
                     /gene="KIF2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..2129
                     /gene="KIF2B"
                     /note="kinesin protein; testis tissue sperm-binding
                     protein Li 82P"
                     /codon_start=1
                     /product="kinesin-like protein KIF2B"
                     /protein_id="NP_115948.4"
                     /db_xref="CCDS:CCDS32685.1"
                     /db_xref="GeneID:84643"
                     /db_xref="HGNC:HGNC:29443"
                     /db_xref="MIM:615142"
                     /translation="MASQFCLPESPCLSPLKPLKPHFGDIQEGIYVAIQRSDKRIHLA
                     VVTEINRENYWVTVEWVEKAVKKGKKIDLETILLLNPALDSAEHPMPPPPLSPLALAP
                     SSAIRDQRTATKWVAMIPQKNQTASGDSLDVRVPSKPCLMKQKKSPCLWEIQKLQEQR
                     EKRRRLQQEIRARRALDVNTRNPNYEIMHMIEEYRRHLDSSKISVLEPPQEHRICVCV
                     RKRPLNQRETTLKDLDIITVPSDNVVMVHESKQKVDLTRYLQNQTFCFDHAFDDKASN
                     ELVYQFTAQPLVESIFRKGMATCFAYGQTGSGKTYTMGGDFSGTAQDCSKGIYALVAQ
                     DVFLLLRNSTYEKLDLKVYGTFFEIYGGKVYDLLNWKKKLQVLEDGNQQIQVVGLQEK
                     EVCCVEEVLNLVEIGNSCRTSRQTPVNAHSSRSHAVFQIILKSGRIMHGKFSLVDLAG
                     NERGADTTKASRKRQLEGAEINKSLLALKECILALGQNKPHTPFRASKLTLVLRDSFI
                     GQNSSTCMIATISPGMTSCENTLNTLRYANRVKKLNVDVRPYHRGHYPIGHEAPRMLK
                     SHIGNSEMSLQRDEFIKIPYVQSEEQKEIEEVETLPTLLGKDTTISGKGSSQWLENIQ
                     ERAGGVHHDIDFCIARSLSILEQKIDALTEIQKKLKLLLADLHVKSKVE"
     regulatory      2247..2252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF2B"
                     /note="hexamer: AATACA"
     polyA_site      2254
                     /gene="KIF2B"
     polyA_site      2267
                     /gene="KIF2B"
                     /note="major polyA site"
ORIGIN      
        1 acagactgca accctgctca gtgctccggg cgcttcaggc tggcttgggt cctgctgctc
       61 caaccccaag ggccctggag cgctccctga tacctccatc actcaccatg gccagccagt
      121 tctgcctccc tgaatcccca tgtctctcgc ccctgaaacc cttgaagcca catttcggag
      181 acatccaaga gggcatctac gtggcgatcc agcgcagtga caagcggatc cacctcgctg
      241 tggtcacgga gatcaacaga gaaaactatt gggtcacggt agagtgggtg gagaaagcag
      301 tcaaaaaagg caagaagatt gacctggaga ccatactcct gctgaatcca gctctggact
      361 ctgctgaaca ccccatgccg cccccgccct tatccccctt ggctctggcg ccctcttcgg
      421 ccatcaggga ccagcgtacc gccacgaaat gggttgcgat gatcccccag aaaaaccaaa
      481 cagcctcagg ggacagcctg gatgtgaggg tccccagcaa accttgtctg atgaagcaga
      541 aaaagtctcc ctgcctctgg gaaatccaga aactgcagga gcagcgggaa aagcgcaggc
      601 ggctgcagca ggagatccga gctagacgcg ccctcgatgt caataccaga aaccccaact
      661 acgaaatcat gcacatgatc gaagagtatc gcaggcacct ggacagcagc aagatctcag
      721 tcctggagcc cccgcaagaa catcgcatct gcgtctgcgt gaggaagcgg cctctcaacc
      781 agcgagagac aaccttaaag gacctggata tcatcaccgt cccctcggac aatgtggtta
      841 tggtgcatga gtccaagcaa aaggtggacc tcactcgcta cctgcagaac cagaccttct
      901 gcttcgacca tgccttcgat gacaaagcct ccaacgagtt ggtgtaccag ttcaccgccc
      961 agccactggt ggagtccatc ttccgcaagg gcatggccac ctgctttgcc tatgggcaga
     1021 cgggaagtgg gaagacgtac accatgggtg gagacttttc aggaacggcc caagattgtt
     1081 ctaagggcat ttatgctctg gtggcacagg atgtctttct cctgctcaga aactccacat
     1141 atgagaagct ggacctcaaa gtctatggga cattttttga gatttatggg ggcaaggtgt
     1201 atgatttgtt gaactggaag aagaagctgc aagtccttga ggatggcaat cagcaaatcc
     1261 aagtggtcgg gctgcaggag aaagaggtgt gttgtgtgga ggaagtgctg aacctggtgg
     1321 aaatagggaa tagctgtcgg acttccaggc aaacacctgt caacgctcac tcatccagga
     1381 gccatgcagt gttccagatc atcctgaagt caggacggat aatgcatggc aagttttccc
     1441 tcgttgattt agctgggaat gaaagaggag cagatacaac caaggccagc cggaaaaggc
     1501 agctggaagg ggcagagatt aacaagagtc ttctagccct caaagaatgt attctggctt
     1561 tgggtcagaa caagcctcac accccattca gagccagcaa actcacactg gtgctccggg
     1621 actcctttat aggccagaac tcctccactt gcatgattgc taccatctct ccggggatga
     1681 cctcttgtga aaacactctc aacactttaa gatatgcaaa cagagtaaaa aaattaaatg
     1741 tagatgtaag gccctaccat cgtggccact atccgattgg acatgaggca ccaaggatgt
     1801 taaaaagtca catcggaaat tcagaaatgt cccttcagag ggatgaattt attaaaatac
     1861 cttatgtaca gagtgaggag cagaaagaga ttgaagaggt tgaaacatta cccactctgt
     1921 tagggaagga taccacaatt tcagggaagg gatctagcca atggctggaa aacatccagg
     1981 agagagctgg tggagtacac catgatattg atttttgcat tgcccggtct ttgtccattt
     2041 tggagcagaa aattgatgct ctgaccgaga tccaaaagaa actgaaatta ttactagctg
     2101 acctccacgt gaagagcaag gtagagtgaa gccaatggcg agagatcagg tccgaaatgc
     2161 tgcattgctg cagtttccac cactcttata caggaaaact gtccaaatta tctaaagatc
     2221 ctcctgagaa gcttaaaaca tcttaaaata cactgatggg aaacatg
//
