LOCUS       NM_001098511            7958 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens kinesin family member 2A (KIF2A), transcript variant
            2, mRNA.
ACCESSION   NM_001098511
VERSION     NM_001098511.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7958)
  AUTHORS   Sun,M., Wang,Y., Xin,G., Yang,B., Jiang,Q. and Zhang,C.
  TITLE     NuSAP regulates microtubule flux and Kif2A localization to ensure
            accurate chromosome congression
  JOURNAL   J Cell Biol 223 (2) (2024)
   PUBMED   38117947
  REMARK    GeneRIF: NuSAP regulates microtubule flux and Kif2A localization to
            ensure accurate chromosome congression.
REFERENCE   2  (bases 1 to 7958)
  AUTHORS   Henkin,G., Brito,C., Thomas,C. and Surrey,T.
  TITLE     The minus-end depolymerase KIF2A drives flux-like treadmilling of
            gammaTuRC-uncapped microtubules
  JOURNAL   J Cell Biol 222 (10) (2023)
   PUBMED   37615667
  REMARK    GeneRIF: The minus-end depolymerase KIF2A drives flux-like
            treadmilling of gammaTuRC-uncapped microtubules.
REFERENCE   3  (bases 1 to 7958)
  AUTHORS   Bai,F., He,Z., Zhou,H. and Gan,W.
  TITLE     Kinesin family member 2A links with advanced tumor stage, reduced
            chemosensitivity and worse prognosis in gastric cancer
  JOURNAL   J Clin Lab Anal 36 (5), e24313 (2022)
   PUBMED   35313389
  REMARK    GeneRIF: Kinesin family member 2A links with advanced tumor stage,
            reduced chemosensitivity and worse prognosis in gastric cancer.
REFERENCE   4  (bases 1 to 7958)
  AUTHORS   Lei,G., Xin,X. and Hu,X.
  TITLE     Clinical significance of kinesin family member 2A as a facilitating
            biomarker of disease surveillance and prognostication in cervical
            cancer patients
  JOURNAL   Ir J Med Sci 191 (2), 665-670 (2022)
   PUBMED   33797694
  REMARK    GeneRIF: Clinical significance of kinesin family member 2A as a
            facilitating biomarker of disease surveillance and prognostication
            in cervical cancer patients.
REFERENCE   5  (bases 1 to 7958)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 7958)
  AUTHORS   Ganem,N.J., Upton,K. and Compton,D.A.
  TITLE     Efficient mitosis in human cells lacking poleward microtubule flux
  JOURNAL   Curr Biol 15 (20), 1827-1832 (2005)
   PUBMED   16243029
  REMARK    GeneRIF: Spindles in human mitotic cells depleted of the kinesin-13
            proteins Kif2a and MCAK lack detectable flux and that such cells
            frequently fail to segregate all chromosomes appropriately at
            anaphase.
REFERENCE   7  (bases 1 to 7958)
  AUTHORS   Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E.,
            Fan,J.B., Abraham,R.T. and Jiang,W.
  TITLE     Functional analysis of human microtubule-based motor proteins, the
            kinesins and dyneins, in mitosis/cytokinesis using RNA interference
  JOURNAL   Mol Biol Cell 16 (7), 3187-3199 (2005)
   PUBMED   15843429
REFERENCE   8  (bases 1 to 7958)
  AUTHORS   Ganem,N.J. and Compton,D.A.
  TITLE     The KinI kinesin Kif2a is required for bipolar spindle assembly
            through a functional relationship with MCAK
  JOURNAL   J Cell Biol 166 (4), 473-478 (2004)
   PUBMED   15302853
  REMARK    GeneRIF: Kif2a has a role in bipolar spindle assembly along with
            MCAK
REFERENCE   9  (bases 1 to 7958)
  AUTHORS   Johnson,J.M., Castle,J., Garrett-Engele,P., Kan,Z., Loerch,P.M.,
            Armour,C.D., Santos,R., Schadt,E.E., Stoughton,R. and
            Shoemaker,D.D.
  TITLE     Genome-wide survey of human alternative pre-mRNA splicing with exon
            junction microarrays
  JOURNAL   Science 302 (5653), 2141-2144 (2003)
   PUBMED   14684825
REFERENCE   10 (bases 1 to 7958)
  AUTHORS   Debernardi,S., Fontanella,E., De Gregorio,L., Pierotti,M.A. and
            Delia,D.
  TITLE     Identification of a novel human kinesin-related gene (HK2) by the
            cDNA differential display technique
  JOURNAL   Genomics 42 (1), 67-73 (1997)
   PUBMED   9177777
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC034242.6 and AC016637.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 4, 2019 this sequence version replaced NM_001098511.2.
            
            Summary: The protein encoded by this gene is a plus end-directed
            motor required for normal mitotic progression. The encoded protein
            is required for normal spindle activity during mitosis and is
            necessary for normal brain development. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.2397310.1,
                                           SRR14372080.2474877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407818.8/ ENSP00000385000.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               AC034242.6         32302-32632         c
            332-426             AC016637.7         19142-19236
            427-546             AC016637.7         20060-20179
            547-601             AC016637.7         22078-22132
            602-724             AC016637.7         24600-24722
            725-825             AC016637.7         25287-25387
            826-921             AC016637.7         27171-27266
            922-976             AC016637.7         29703-29757
            977-1139            AC016637.7         30149-30311
            1140-1230           AC016637.7         33254-33344
            1231-1294           AC016637.7         33478-33541
            1295-1386           AC016637.7         34462-34553
            1387-1529           AC016637.7         35190-35332
            1530-1734           AC016637.7         35707-35911
            1735-1845           AC016637.7         37255-37365
            1846-1913           AC016637.7         38426-38493
            1914-2027           AC016637.7         44450-44563
            2028-2178           AC016637.7         45699-45849
            2179-2280           AC016637.7         49673-49774
            2281-2416           AC016637.7         53130-53265
            2417-7958           AC016637.7         57496-63037
FEATURES             Location/Qualifiers
     source          1..7958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.1"
     gene            1..7958
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /note="kinesin family member 2A"
                     /db_xref="GeneID:3796"
                     /db_xref="HGNC:HGNC:6318"
                     /db_xref="MIM:602591"
     exon            1..331
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2502
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Kinesin, heavy chain, 2; kinesin-like protein KIF2A;
                     kinesin-2; kinesin heavy chain member 2A"
                     /codon_start=1
                     /product="kinesin-like protein KIF2A isoform 2"
                     /protein_id="NP_001091981.1"
                     /db_xref="CCDS:CCDS47216.1"
                     /db_xref="GeneID:3796"
                     /db_xref="HGNC:HGNC:6318"
                     /db_xref="MIM:602591"
                     /translation="MATANFGKIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWI
                     ENGDTKGKEIDLESIFSLNPDLVPDEEIEPSPETPPPPASSAKVNKIVKNRRTVASIK
                     NDPPSRDNRVVGSARARPSQFPEQSSSAQQNGSVSDISPVQAAKKEFGPPSRRKSNCV
                     KEVEKLQEKREKRRLQQQELREKRAQDVDATNPNYEIMCMIRDFRGSLDYRPLTTADP
                     IDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRF
                     DYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDC
                     SKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQ
                     QVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLH
                     GKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASK
                     LTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKEFGISPSDIPFSQGS
                     GSRPDLSPSYEYDDFSPSVTRVKELTVDPTAAGDVRPIMHHPPNQIDDLETQWGVGSS
                     PQRDDLKLLCEQNEEEVSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWLEDEKA
                     LLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDKVKSFRAALQEEEQASKQINPKR
                     PRAL"
     exon            332..426
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..546
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..601
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..724
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..825
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..921
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..976
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1139
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1230
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1294
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1386
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1529
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1734
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1845
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1913
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2027
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2178
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2280
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2416
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..7958
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5656..5661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /note="hexamer: AATAAA"
     polyA_site      5674
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /note="major polyA site"
     regulatory      7939..7944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /note="hexamer: AATGAA"
     polyA_site      7958
                     /gene="KIF2A"
                     /gene_synonym="CDCBM3; HK2; KIF2"
                     /note="major polyA site"
ORIGIN      
        1 actctacccc gcgccgtctc acggccccgg ccctagcttc accccgacta cccggcgtgc
       61 gcgtcctcct gccggcctgc aggcccgggg cctccgcctg cttccccaca gctgctcctt
      121 gcggccccgc ttgcgttcac gctgtcgccc gggccggcgc ggccgcgggc aaccgctccc
      181 cctcccacac ctaccccgcc ccctccccgc cttttccgcc ctccggtccc cctccctcgg
      241 cccgctgctg ctgctccaga tgaggtgatg gcaacggcca acttcggcaa gatccagatc
      301 gggatttacg tggagatcaa gcgcagcgat ggccgaatac atcaagcaat ggtaacatct
      361 ttaaatgaag ataatgaaag tgtaactgtt gaatggatag aaaatggaga tacaaaaggc
      421 aaagagattg acctggagag catcttttca cttaaccctg accttgttcc tgatgaagaa
      481 attgaaccca gtccagaaac acctccacct ccagcatcct cagccaaagt aaacaaaatt
      541 gtaaagaatc gacggactgt agcttctatt aagaatgacc ctccttcaag agataataga
      601 gtggttggtt cagcacgtgc acggcccagt caatttcctg aacagtcttc ctctgcacaa
      661 cagaatggta gtgtttcaga tatatctcca gttcaagctg caaaaaagga atttggaccc
      721 ccttcacgta gaaaatctaa ttgtgtgaaa gaagtagaaa aactgcaaga aaaacgagag
      781 aaaaggagat tgcaacagca agaacttaga gaaaaaagag cccaggacgt tgatgctaca
      841 aacccaaatt atgaaattat gtgtatgatc agagacttta gaggaagttt ggattataga
      901 ccattaacaa cagcagatcc tattgatgaa cataggatat gtgtgtgtgt aagaaaacga
      961 ccactcaata aaaaagaaac tcaaatgaaa gatcttgatg taatcacaat tcctagtaaa
     1021 gatgttgtga tggtacatga accaaaacaa aaagtagatt taacaaggta cctagaaaac
     1081 caaacatttc gttttgatta tgcctttgat gactcagctc ctaatgaaat ggtttacagg
     1141 tttactgcta gaccactagt ggaaactata tttgaaaggg gaatggctac atgctttgct
     1201 tatgggcaga ctggaagtgg aaaaactcat actatgggtg gtgacttttc aggaaagaac
     1261 caagattgtt ctaaaggaat ttatgcatta gcagctcgag atgtcttttt aatgctaaag
     1321 aagccaaact ataagaagct agaacttcaa gtatatgcaa ccttctttga aatttatagt
     1381 ggaaaggtgt ttgacttgct aaacaggaaa acaaaattaa gagttctaga agatggaaaa
     1441 cagcaggttc aagtggtggg attacaggaa cgggaggtca aatgtgttga agatgtactg
     1501 aaactcattg acataggcaa cagttgcaga acatccggtc aaacatctgc aaatgcacat
     1561 tcatctcgga gccatgcagt gtttcagatt attcttagaa ggaaaggaaa actacatggc
     1621 aaattttctc tcattgattt ggctggaaat gaaagaggag ctgatacttc cagtgcggac
     1681 aggcaaacta ggcttgaagg tgctgaaatt aataaaagcc ttttagcact caaggagtgc
     1741 atcagagcct taggtagaaa taaacctcat actcctttcc gtgcaagtaa actcactcag
     1801 gtgttaagag attctttcat aggtgaaaac tctcgtacct gcatgattgc cacaatctct
     1861 ccaggaatgg catcctgtga aaatactctt aatacattaa gatatgcaaa tagagtaaag
     1921 gagtttggaa ttagtccatc agacattccc ttctcacagg gtagtggcag tcgccctgat
     1981 ctctctcctt cttatgaata tgacgacttt tctccttcag ttaccagggt caaagaattg
     2041 actgtagatc caactgctgc tggtgatgtt cgtccaataa tgcaccatcc accaaaccag
     2101 attgatgact tagagacaca gtggggtgtg gggagttccc ctcagagaga tgatctaaaa
     2161 cttctttgtg aacaaaatga agaagaagtc tctccacagt tgtttacttt ccacgaagct
     2221 gtttcacaaa tggtagaaat ggaagaacaa gttgtagaag atcacagggc agtgttccag
     2281 gaatctattc ggtggttaga agatgaaaag gccctcttag agatgactga agaagtagat
     2341 tatgatgtcg attcatatgc tacacaactt gaagctattc ttgagcaaaa aatagacatt
     2401 ttaactgaac tgcgggataa agtgaaatct ttccgtgcag ctctacaaga ggaggaacaa
     2461 gccagcaagc aaatcaaccc gaagagaccc cgtgcccttt aaaccggcat ttgctgctaa
     2521 aggataccca gaaccctcac tactgtaaca tacaacggtt cagctgtaag ggccatttga
     2581 aagtttggaa ttttaagtgt ctgtggaaaa tgttttgtcc ttcacctgaa ttacatttca
     2641 attttgtgaa acactctttt gtctacaaaa tgcttctagt ccaggaggca caaccaagaa
     2701 ctgggattaa tgaagcattt tgtttcattt acacaaatag tgatttactt ttggagatcc
     2761 ttgtcagttt tattttctat ttgatgaagt aagactgtgg actcaatcca gagccagata
     2821 gtagggggaa gccacagcat ttccttttaa ctcagttcaa tttttgtagt gagactgagc
     2881 agttttaaat cctttgcgtg catgcatacc tcatcagtga ttgtacatac cttgcccact
     2941 cctagagaca gctgtgctca ccttttcctg ctttgtgcct tgattaaggc tactgaccct
     3001 aaatttctga agcacagcca agaaaaatta cattccttgt cattgtaaat tacctttgtg
     3061 tgtacatttt tactgtattt gagacatttt ttgtgtgtga ctagttaatt ttgcaggatg
     3121 tgccatatca ttgaacggaa ctaaagtctg tgacagtgga tatagctgct ggaccattcc
     3181 atcttatatg taaagaaatc tggaattatt attttaaaac catataacat gtgattataa
     3241 tttttcttag cattttcttt gtaaagaact acaatataaa ctagttggtg tataataaaa
     3301 agtaatgaaa ttctgagaag agttttatct taggaaaata catatatatg cagtgtgtgt
     3361 gccagtgtgg tattaacaag actaatagtg cagtttgatc cttaccaata tcattactta
     3421 atttgaagtg ttcattagca ccccaaaata taccttttct atgtactgtt aaaagaaatt
     3481 ggcttctgat gcatgaacat ttacatgtac attgaaagta gtccataata gaagttagtt
     3541 taagccaagt gtagacagta cattactccc ttgaaaaaga attaagttga aagagttgac
     3601 tttgccttaa aaggcagatc taacccaagc tccatccagt accaaatgtg aaacttcatt
     3661 gttgtttggt gagaatcgcc aaattctcac taatacattg gtatggtgta gggcatgcta
     3721 ctttttaaac agcagcactt atttttacag attgctactc caaggaagaa aactggccac
     3781 ttttcatgta aatattttgt tcaaagattt gtatatctct ctaggagttt tccctcagtt
     3841 cccaggatgg ggtccaggag tagattaaca gctaaaaatc tcccaaggat atcttgtttt
     3901 gatttattta ctccagggaa ctatcagctc cttcacagga gccaaagggg agctatgaat
     3961 agagggtcac atgagccaga ttctttactg ttcataaaac ccagagagta gttgtgaaag
     4021 atcctaatac aattgtgaaa agctctgtaa acatgaaatc taaaacaaat gtagattttc
     4081 acaatatgct tattaataaa tgaagtctat ggaataagtt ttagagataa tttacttcag
     4141 tcacctttgt tttggaaagg actcaggttt tcttgcagct gtaagatata ttctatttgt
     4201 gtttatttca aagggaagag gaaggatgga gaactgttac aattgacctt gcaaaggata
     4261 tttaaaaaaa aggtagtttt tgagattaac caactttcaa agggcaataa agacatgtga
     4321 atttgctcat tttaaagcac aacagatgat tagcttcaaa tttattattt gcattggatg
     4381 ggtactgtct ttggaaagtc tccttataga caaatatgct gccttacact atgatggctt
     4441 cattctgatc aggtatttta aaaattagta ccagaaaaga tactggaggt aatataatac
     4501 agtccttcag ctttacagat agtgaaaact gaaggccaga aaaggaacta aaactcagca
     4561 gttcataggg gtagagggaa ataacctgag aaagccgagt taaatcttaa aatttttact
     4621 ataaggatag agatgataca agtgaactct gcaaaatagt tttgtgaaat taaacaaaaa
     4681 aatctactct taatgtatat tatttcatat ttgtttaaca aaagcagctt gatgcctttg
     4741 ttctggatta tacattaaga acaagcatta ttttaattat gtagtaacat ttactatgac
     4801 tttgaagcca gatttcaaaa tctggctttg ttaaattaat tggaaacact cttctattaa
     4861 gttaggtatt aaaaaaagcc aaatatcaat aaagatattt ttattaattt tttatagaaa
     4921 caaaatagct actataactc tattatagta tattaacagc acttagtatt atattgactt
     4981 aaacatagta gctaataaaa ctagtttatg acatctattg aaattctcag tctgacagtt
     5041 ttaaaatagc ttaaaactaa gcaccaggta tatgaaaaag gaactggaaa ttttaattgt
     5101 ccagaaatca taggaatact gggaacctgt agttatggga aatggctgtt tttctgaagt
     5161 tgaaaccagt ttcaattaca aaaccctctg aaattttgct aagcctatag ttatctccct
     5221 aagaaccata aaaaaagata attttattgt taatttcatt ccagtttagc ttcctcattt
     5281 tacatgttgg gagtcatgcc ctttaatatg cctggcactg cacggtggca gtagcagact
     5341 tgggcttacc cagaacccta agtctctgac gctataggat agcgaaagag gtaggcaatc
     5401 gtaacagaca ctgtatagga taaataggga agagaatgag agaaccaaaa taaaaataat
     5461 ttaagaaaca attgttttac tgtacatgtg aataacaaga aatggtacgg ggaatgtgaa
     5521 taacacgaaa tggtatgggg aatgtgtgac tagtgaagca tattttaact tttttattac
     5581 tggaggaaca gagctaaagg cctaaagaag gccttacagt atataacagt aaatagaaga
     5641 gtaacatctt tatacaataa actgttagaa atgataagtg taaagttgtg cgtctctgcg
     5701 gctcctgaac ttgaagatta ttatgaatag attggaccag cattatatat taaaaacttt
     5761 gatacttaga actttccaac tttaaaattc agaatcataa atggtgacaa cagtagtagt
     5821 attgaaccaa aaatagtcaa gtaaataatg tctcagtaaa gcaaaagcat tatcttctca
     5881 aatacaaaaa atacaaaatt catttctttt cttgaccttg aaaatttctg ttttccaaat
     5941 acctaggaaa aatgaatacc ttctgcgttg aatccatgta gcaatctgaa aaaagaaatc
     6001 aaaatggaat ggtactgaaa agctaatttg tagcacataa cggtatatag ttctatacca
     6061 ttaatactaa aacatgaata cagcatgctt acagagccca cccactccta atactagtta
     6121 ttaaagaaac gttactggct gggcgcagtg gcttatgcct gtaatcccag cactttggga
     6181 ggctgaggcg ggtggattac ctgaggtcag tagttcgaga acagtctggc caacatggtg
     6241 aaaccccgtc tctactaaaa atacaaaaat tagcctggca tggtggcaca tgcctgtaat
     6301 cccagctact cgggtggttg aggcaggaga tttgcctgaa cccaggaggc ggaggttgca
     6361 gtgagctgag attgtgccac tggagtccag cctgggtgac agagcaagac tctgtctcaa
     6421 aaaaaaaaaa aaaagaaatg ttattgtctg actaaattta taagatatgt attggttaaa
     6481 accatgccat gttggtgcct ctttcattag agcctttatg tcgtaatgaa tttgactaaa
     6541 attatcttag actttcatta tcccaggcct aagaactcac tggcatttgt ttcaaggtaa
     6601 ctgaacaaga agctgtttgg aattggcaga agtcagatga aaaaccaatc ttacatgccc
     6661 cttcttcctc tcttgagctg ttgtttatat tcaaattaaa tacacattgt ttctctctgt
     6721 agatacctat gtacttaata gattctagtt agtaaactgc acatgcccaa taactttgag
     6781 gaaatttagt gaaaatgaag aaaaagagaa aatatttctc tttagacctg aggttatgtt
     6841 taggctggcc catagaaaca ggtccagata aatttctaaa aaagcaaagt agatatttat
     6901 gaatagtatt caatgcctag gattaacatc taaaatgact cagtagtact gctagccagc
     6961 caataaaata taaactccat ttgtcttagt tatatagaac tgtgtttcca gcttagaaaa
     7021 agtcaaacca atgactttta gaacaatcta ctctcatttt ttattcagcc tctagaacat
     7081 ggaagcttta aaagtgaatt ggctaaatag gcaagacctt ctgaaagtta acatcttaat
     7141 gattaaaaac agtaagtaca ggttagtaat tacctgggta attaattgaa gccttattct
     7201 gttttcataa gacttacttg cttaattcaa gcaaaacaaa ttttggtcta aattacctag
     7261 ataattatga cagcttttta cttgagaagt gtagaacttg cttcaggcta caaaactgta
     7321 ttattcctaa atggataacc aggtaggatt ctaactggca ttattgtatg cttaagattg
     7381 atttaacaac agctattccc agtaaggaaa ttttaaaaat cagatccagt tacatgtatt
     7441 atgatttttc taccttatgg actattttgg agggataagc tattaagact aagactatga
     7501 atgagagttg gggaaggagc aggaagggag gaacctgcac accacattgg aacctgcaca
     7561 ccacattaac acaaaggcaa tcttctggct cggactgttc tttactactg ttcttaaaga
     7621 aaatgttcat tctgctgcag ctaactagcc tccatcttct acaccaaata ctattccatg
     7681 ccatggaagt gctatgcaat aactctccca ggtagcacct tataccgctt aaaagccttt
     7741 aaaatctcca atctgaaggt gtcacagtaa agaaatgtaa acacttagga aaacaaaaat
     7801 gtaattacct gatgaagtca tctatgtcca tggaacgggc ccgtttgtca ctaaaacctg
     7861 tgctggttag gatttgctgt attttatctg ctatgctgaa atcttctggt attatctatc
     7921 aatataagat tcagaataaa tgaacgacat atctttaa
//
