LOCUS       NM_018012              13593 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens kinesin family member 26B (KIF26B), mRNA.
ACCESSION   NM_018012 XM_371354 XM_936780
VERSION     NM_018012.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13593)
  AUTHORS   Li,Q., Zhan,X. and Tan,Y.
  TITLE     Identification of KIF26B as a Tumor Marker for Oral Squamous Cell
            Carcinoma
  JOURNAL   Discov Med 36 (185), 1280-1288 (2024)
   PUBMED   38926114
  REMARK    GeneRIF: Identification of KIF26B as a Tumor Marker for Oral
            Squamous Cell Carcinoma.
REFERENCE   2  (bases 1 to 13593)
  AUTHORS   Huang,L.M. and Zhang,M.J.
  TITLE     Kinesin 26B modulates M2 polarization of macrophage by activating
            cancer-associated fibroblasts to aggravate gastric cancer
            occurrence and metastasis
  JOURNAL   World J Gastroenterol 30 (20), 2689-2708 (2024)
   PUBMED   38855156
  REMARK    GeneRIF: Kinesin 26B modulates M2 polarization of macrophage by
            activating cancer-associated fibroblasts to aggravate gastric
            cancer occurrence and metastasis.
REFERENCE   3  (bases 1 to 13593)
  AUTHORS   Cong,S., Fu,Y., Zhao,X., Guo,Q., Liang,T., Wu,D., Wang,J. and
            Zhang,G.
  TITLE     KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the
            Progression of Ovarian Cancer
  JOURNAL   J Immunol Res 2024, 4817924 (2024)
   PUBMED   38380081
  REMARK    GeneRIF: KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit
            the Progression of Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13593)
  AUTHORS   Liu,Z., Zhou,X., Chen,B., Wu,Z., Zhang,C., Gu,C., Li,J. and Yang,X.
  TITLE     Noncoding RNAs-based high KIF26B expression correlates with poor
            prognosis and tumor immune infiltration in colon cancer
  JOURNAL   Cell Cycle 22 (14-16), 1726-1742 (2023)
   PUBMED   37436127
  REMARK    GeneRIF: Noncoding RNAs-based high KIF26B expression correlates
            with poor prognosis and tumor immune infiltration in colon cancer.
REFERENCE   5  (bases 1 to 13593)
  AUTHORS   Bartik,Z.I., Sillen,U., Djos,A., Lindholm,A. and Fransson,S.
  TITLE     Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations
            in familial vesicoureteral reflux
  JOURNAL   PLoS One 17 (11), e0277524 (2022)
   PUBMED   36417404
  REMARK    GeneRIF: Whole exome sequencing identifies KIF26B, LIFR and LAMC1
            mutations in familial vesicoureteral reflux.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 13593)
  AUTHORS   Zhang,H., Ma,R.R., Wang,X.J., Su,Z.X., Chen,X., Shi,D.B., Guo,X.Y.,
            Liu,H.T. and Gao,P.
  TITLE     KIF26B, a novel oncogene, promotes proliferation and metastasis by
            activating the VEGF pathway in gastric cancer
  JOURNAL   Oncogene 36 (40), 5609-5619 (2017)
   PUBMED   28581513
  REMARK    GeneRIF: KIF26B, a novel oncogene regulated by miR-372, promotes
            proliferation and metastasis through the VEGF pathway in gastric
            cancer
            Erratum:[Oncogene. 2022 Apr;41(17):2528. doi:
            10.1038/s41388-022-02268-z.. PMID: 35322198]
REFERENCE   7  (bases 1 to 13593)
  AUTHORS   Pu,Y., Yi,Q., Zhao,F., Wang,H., Cai,W. and Cai,S.
  TITLE     MiR-20a-5p represses multi-drug resistance in osteosarcoma by
            targeting the KIF26B gene
  JOURNAL   Cancer Cell Int 16, 64 (2016)
   PUBMED   27499703
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 13593)
  AUTHORS   Wang,J., Cui,F., Wang,X., Xue,Y., Chen,J., Yu,Y., Lu,H., Zhang,M.,
            Tang,H. and Peng,Z.
  TITLE     Elevated kinesin family member 26B is a prognostic biomarker and a
            potential therapeutic target for colorectal cancer
  JOURNAL   J Exp Clin Cancer Res 34 (1), 13 (2015)
   PUBMED   25652119
  REMARK    GeneRIF: KIF26B plays an important role in colorectal
            carcinogenesis and functions as a novel prognostic indicator and a
            potential therapeutic target for CRC.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 13593)
  AUTHORS   Wang,Q., Zhao,Z.B., Wang,G., Hui,Z., Wang,M.H., Pan,J.F. and
            Zheng,H.
  TITLE     High expression of KIF26B in breast cancer associates with poor
            prognosis
  JOURNAL   PLoS One 8 (4), e61640 (2013)
   PUBMED   23585914
  REMARK    GeneRIF: High expression of KIF26B in breast cancer associates with
            poor prognosis.
            Erratum:[PLoS One. 2013;8(6).
            doi:10.1371/annotation/f7a306c2-3de5-4b59-9825-09e4cbc884bf]
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 13593)
  AUTHORS   Fanous,A.H., Zhou,B., Aggen,S.H., Bergen,S.E., Amdur,R.L., Duan,J.,
            Sanders,A.R., Shi,J., Mowry,B.J., Olincy,A., Amin,F.,
            Cloninger,C.R., Silverman,J.M., Buccola,N.G., Byerley,W.F.,
            Black,D.W., Freedman,R., Dudbridge,F., Holmans,P.A., Ripke,S.,
            Gejman,P.V., Kendler,K.S. and Levinson,D.F.
  CONSRTM   Schizophrenia Psychiatric Genome-Wide Association Study (GWAS)
            Consortium
  TITLE     Genome-wide association study of clinical dimensions of
            schizophrenia: polygenic effect on disorganized symptoms
  JOURNAL   Am J Psychiatry 169 (12), 1309-1317 (2012)
   PUBMED   23212062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY923834.1 and AC104462.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 24, 2017 this sequence version replaced NM_018012.3.
            
            Summary: The protein encoded by this gene is an intracellular motor
            protein thought to transport organelles along microtubules. The
            encoded protein is required for kidney development. Elevated levels
            of this protein have been found in some breast and colorectal
            cancers. [provided by RefSeq, Mar 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY923834.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407071.7/ ENSP00000385545.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7287              AY923834.1         2-7288
            7288-13593          AC104462.1         158822-165127
FEATURES             Location/Qualifiers
     source          1..13593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..13593
                     /gene="KIF26B"
                     /note="kinesin family member 26B"
                     /db_xref="GeneID:55083"
                     /db_xref="HGNC:HGNC:25484"
                     /db_xref="MIM:614026"
     exon            1..503
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..6767
                     /gene="KIF26B"
                     /codon_start=1
                     /product="kinesin-like protein KIF26B"
                     /protein_id="NP_060482.2"
                     /db_xref="CCDS:CCDS44342.1"
                     /db_xref="GeneID:55083"
                     /db_xref="HGNC:HGNC:25484"
                     /db_xref="MIM:614026"
                     /translation="MNSVAGNKERLAVSTRGKKYGVNEVCSPTKPAAPFSPESWYRKA
                     YEESRAGSRPTPEGAGSALGSSGTPSPGSGTSSPSSFTGSPGPASPGIGTSSPGSLGG
                     SPGFGTGSPGSGSGGGSSPGSDRGVWCENCNARLVELKRQALRLLLPGPFPGKDPAFS
                     AVIHDKLQVPNTIRKAWNDRDNRCDICATHLNQLKQEAIQMVLTLEQAAGSEHYDASP
                     CSPPPLSNIPTLVGSRHVGGLQQPRDWAFVPAPCATSNYTGFANKHGSKPSSLGVSNG
                     AEKKSGSPTHQAKVSLQMATSPSNGNILNSVAIQAHQYLDGTWSLSRTNGVTLYPYQI
                     SQLMTESSREGLTEAVLNRYNADKPSACSVPASQGSCVASETSTGTSVAASFFARAAQ
                     KLNLSSKKKKHRPSTSSAAEPPLFATSFSGILQTSPPPAPPCLLRAVNKVKDTPGLGK
                     VKVMLRICSTLARDTSESSSFLKVDPRKKQITLYDPLTCGGQNAFQKRGNQVPPKMFA
                     FDAVFPQDASQAEVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGKDDSMQNL
                     GIIPCAISWLFKLINERKEKTGARFSVRVSAVEVWGKEENLRDLLSEVATGSLQDGQS
                     PGVYLCEDPICGTQLQNQSELRAPTAEKAAFFLDAAIASRRSHQQDCDEDDHRNSHVF
                     FTLHIYQYRMEKSGKGGMSGGRSRLHLIDLGSCVKALSKNREGGSGLCLSLSALGNVI
                     LALVNGSKHIPYKESKLAMLLRESLGNMNCRTTMIAHISAAVGSYAETLSTIQIASRV
                     LRMKKKKTKYTSSSSGGESSCEEGRMRRPTQLRPFHTRATVDPDFPIAHLSSDPDYSS
                     SSEQSCDTVIYIGPNGTALSDKELTDNEGPPDFVPIVPALQKTRGDSRPAEAGEAAAG
                     KSERDCLKCNTFAELQERLDCIDGSEEPSSFPFEELPAQFGPEQASRGPRLSQAAGAS
                     PLSESDKEDNGSEGQLTNREGPELPASKMQRSHSPVPAAAPAHSPSPASPRSVPGSSS
                     QHSASPLVQSPSLQSSRESLNSCGFVEGKPRPMGSPRLGIASLSKTSEYKPPSSPSQR
                     CKVYTQKGVLPSPAPLPPSSKDSGVASRESLLQPEVRTPPVGMSPQVLKKSMSAGSEG
                     FPETPVDDEQQAATPSESKKEILSTTMVTVQQPLELNGEDELVFTLVEELTISGVLDS
                     GRPTSIISFNSDCSARALASGSRPVSIISSISEDLECYSSTAPVSEVSITQFLPLPKM
                     SLDEKAQDAGSRRSSISSWLSEMSAGSEGEQSCHSFIAQTCFGHGEAMAEPVASEFVS
                     SLQNTAVVCREKPKASPDNLLILSEMGDDSFNKAAPIKGCKISTVSKAMVTISNTANL
                     SSCEGYIPMKTNITVYPCIAMSPRNIQEPEAPTATPKAGPTLAQSRESKENSAKKEMK
                     FEDPWLKREEEVKKETAHPNEEGMMRCETATGPSNAETRAEQEQDGKPSPGDRLSSSS
                     GEVSASPVTDNFRRVVDGCEMALPGLATQSPVHPNKSVKSSSLPRAFQKASRQEEPDS
                     LSYYCAAETNGVGAASGTPPSKATLEGKVASPKHCVLARPKGTPPLPPVRKSSLDQKN
                     RASPQHSASGSGTSSPLNQPAAFPAGLPDEPSGKTKDASSSSKLFSAKLEQLASRSNS
                     LGRATVSHYECLSLERAESLSSVSSRLHAGKDGTMPRAGRSLGRSAGTSPPSSGASPK
                     AGQSKISAVSRLLLASPRARGPSASTTKTLSFSTKSLPQAVGQGSSSPPGGKHTPWST
                     QSLSRNRSSGLASKLPLRAVSGRISELLQGGAGARGLQLRAGPEAEARGGALAEDEPA
                     AAHLLPSPYSKITPPRRPHRCSSGHGSDNSSVLSGELPPAMGKTALFYHSGGSSGYES
                     VMRDSEATGSASSAQDSTSENSSSVGGRCRSLKTPKKRSNPGSQRRRLIPALSLDTSS
                     PVRKPPNSTGVRWVDGPLRSSPRGLGEPFEIKVYEIDDVERLQRRRGGASKEAMCFNA
                     KLKILEHRQQRIAEVRAKYEWLMKELEATKQYLMLDPNKWLSEFDLEQVWELDSLEYL
                     EALECVTERLESRVNFCKAHLMMITCFDITSRRR"
     exon            504..905
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1439
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1606
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1790
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1997
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2091
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2354
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2538
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2698
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2861
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..6264
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            6265..6467
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            6468..6618
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     exon            6619..13593
                     /gene="KIF26B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13571..13576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF26B"
                     /note="hexamer: ATTAAA"
     polyA_site      13593
                     /gene="KIF26B"
                     /note="major polyA site"
ORIGIN      
        1 agttaccaag ctcggtgaag gagacaagtt cccacagctg actcggctcg gctctcccac
       61 cttcccggca gcggccgcga gccctgattg tatccctcgc tttcctcgtg ggggagcacg
      121 gactgacttg gctgaagaaa atgccagttc tgtggatgtg gccgtgacaa gaggacgtgc
      181 ggctggaaga ggcagaaggg gacgaggaaa agcatgcttt gaagagaaga ataaaccagc
      241 gaccccaacc ctttctgcaa attggtgcta ttacttgtgg gatccatttg ctttcattcc
      301 ctcccacccc accgctgaag aaaccttgcc ctgagggctg agagccagcc ccctgcagcc
      361 gggggacgct tctgggttgg aggaccttct ggatgtagcg tcggtggaac ctttagatac
      421 tctcctctgg aaaagccacc atgaattcgg tagctgggaa taaagagagg cttgcggtct
      481 ccaccagggg caagaaatac ggggtgaatg aagtctgctc gcccaccaag cccgcagcgc
      541 ccttctcccc ggaaagctgg taccggaaag catacgagga gtcgcgcgcc ggcagccggc
      601 ccactcctga gggcgcgggc tcagcgctcg gctcctcggg gaccccgtct cccggctcgg
      661 gcacctcgtc cccgagctcg ttcaccggct ccccgggacc cgcctccccc ggcatcggca
      721 ctagttcgcc gggctccttg ggcggctctc cgggcttcgg cacaggctcc ccgggctccg
      781 gcagcggcgg cggctcctcc cccggctcgg accgcggcgt ctggtgcgag aactgcaacg
      841 cccgcctggt ggagctcaag aggcaggccc tgaggttgct cctcccgggg cccttcccgg
      901 gcaaggaccc tgctttctcg gctgtgattc acgacaaact ccaggtcccc aacaccatcc
      961 ggaaggcatg gaacgaccgg gacaaccgct gtgacatttg cgccactcac ctgaaccagt
     1021 tgaagcagga ggccatccag atggtgctga cgttggagca ggcagccggc agtgagcact
     1081 acgacgcctc gccctgctcc ccgccaccgc tctccaacat ccccaccctg gtggggtccc
     1141 ggcacgtggg tgggctccag cagcccagag actgggcctt tgtgcccgcc ccctgtgcca
     1201 cctccaacta cacaggcttc gccaacaagc acggcagcaa acccagcagc cttggggtca
     1261 gcaatggggc ggaaaagaag agcgggtccc caacccacca ggccaaggtc agcctccaga
     1321 tggccaccag tccaagcaat gggaacatcc tcaattcggt ggccatccag gctcaccagt
     1381 acctggatgg cacctggtcc ctgtcgagaa ccaacggggt caccctgtac ccataccaga
     1441 tctcccagct gatgacagag agtagccggg agggactaac agaagcagtg ctgaaccgct
     1501 acaatgcaga caagccttcc gcctgcagtg tcccagcctc gcagggctcc tgcgtggcca
     1561 gcgagacttc cacaggcaca tcggtggccg cctccttctt tgcacgagct gcccagaagt
     1621 taaatctgtc ttctaaaaag aagaaacatc ggccttccac ttcttccgct gccgaaccac
     1681 cgctctttgc aaccagcttc agtgggattc tgcagacctc ccctccccca gccccaccct
     1741 gcctgctgag ggctgtcaac aaggtgaagg acaccccggg gctgggcaag gtgaaagtca
     1801 tgcttcgcat ctgttccacc ttggctcgag atacttcaga atccagctct ttcttaaagg
     1861 tggacccacg gaagaagcag atcaccttgt acgatcccct gacttgtgga ggtcaaaatg
     1921 ccttccaaaa gagaggcaac caggttcctc caaagatgtt tgccttcgat gcagtttttc
     1981 cacaagacgc ttctcaggct gaagtgtgtg caggcaccgt ggcagaggtg atccagtctg
     2041 tggtcaacgg ggcagatggc tgcgtgttct gtttcggcca cgccaaactg ggaaaatcct
     2101 acaccatgat cggaaaggat gattccatgc agaacctggg catcattccc tgtgccatct
     2161 cttggctctt caagctcata aacgaacgca aggaaaagac cggcgcccgt ttctcagtcc
     2221 gggtttccgc cgtggaagtg tgggggaagg aggagaacct gcgggacctg ctgtcggagg
     2281 tggccacggg cagcctgcag gacggccagt ccccgggcgt gtacctctgt gaggacccca
     2341 tctgcggcac gcagctgcag aaccagagcg agctgcgggc ccccaccgca gagaaggctg
     2401 cctttttcct ggatgccgcc attgcctccc gcaggagcca ccaacaggac tgtgatgagg
     2461 acgaccaccg caactcacac gtgttcttca cactgcacat ctaccagtac cggatggaga
     2521 agagcgggaa agggggaatg tctggaggtc gcagccgcct gcatctcatt gatctcggca
     2581 gctgtgtgaa agctcttagc aaaaatcgag aaggaggctc agggctgtgt ctctcgctgt
     2641 ctgctctggg caatgtcatc ctggctctcg tcaatggcag caaacacatt ccatacaaag
     2701 agagcaagct cgccatgttg ctgcgggagt ctctggggaa catgaactgc cgtaccacca
     2761 tgatcgcgca catctcggcc gcggtcggga gctacgcgga gaccctgtcc accatccaga
     2821 ttgcatcgag agtcttgagg atgaagaaaa agaagacgaa gtacacatcc agctcgtccg
     2881 gcggggagag ctcctgcgaa gaaggccgca tgcgcaggcc cacccagctg agacccttcc
     2941 acaccagggc cacggtggac cctgacttcc ccatcgctca cctgtccagc gaccccgact
     3001 actcctccag cagcgagcag tcctgcgaca ccgtcatcta catcgggccc aacggcacgg
     3061 ccctctctga caaggagctc accgacaacg agggcccccc agactttgtc cctatcgtgc
     3121 cagccctgca gaagacccgg ggcgacagcc ggcccgcaga ggcaggagag gctgcagccg
     3181 gcaagtcaga aagggactgc ctgaagtgca acacgtttgc cgagctgcag gagaggctgg
     3241 actgcatcga cggcagcgag gagcccagca gctttccttt cgaagaactg cctgctcagt
     3301 ttgggccaga gcaggcaagc agaggccccc ggttaagcca agcagcgggg gcaagcccac
     3361 tctctgagtc tgataaggaa gataatgggt ccgaaggtca gctgaccaac agagaaggcc
     3421 ctgaactccc agcctccaag atgcagagga gtcactcacc tgtgcccgcc gcggcacccg
     3481 cccacagccc cagcccggcc tcacccagga gcgtcccggg cagcagtagc cagcacagcg
     3541 cctccccact cgtgcagagc cccagcctcc agagcagccg ggagagcctc aactcctgcg
     3601 gcttcgtgga aggcaagccc aggcccatgg gctccccccg gctgggcatc gccagcctgt
     3661 ccaagacctc ggagtacaag ccacccagct ctccttccca gagatgcaaa gtctacaccc
     3721 agaagggggt cctgccgtct cccgccccac tgcctccctc gagcaaggat tccggcgtgg
     3781 cgtctaggga gtccttgctg cagcccgagg tgcgtacgcc cccggttgga atgagccccc
     3841 aggttttgaa aaaatccatg tctgctggga gcgaagggtt cccggaaact cctgtcgatg
     3901 atgagcagca ggcagctact ccttcagagt ccaagaagga gatcctgagc accacgatgg
     3961 tgacggtgca gcagccactg gagctgaacg gtgaggacga gctggtgttc acgctggtgg
     4021 aggagctgac catcagcggg gtcctggaca gcggccgccc caccagcatc atcagcttca
     4081 acagcgactg ctctgcacgg gccctggcct cgggctcgcg gcccgtcagc atcatcagca
     4141 gcatcagcga ggacctggag tgctactcca gcacggcccc cgtctccgag gtcagcatca
     4201 cacagttctt gcccctcccg aagatgagcc tggatgagaa ggcccaggac gcagggagca
     4261 gacgctcttc catcagctcc tggctgagcg agatgagcgc gggcagtgag ggtgagcagt
     4321 cgtgccacag tttcatagcc cagacgtgtt ttgggcacgg ggaggcaatg gcagaacctg
     4381 tggcctcgga gtttgtcagc agcctccaga acaccgctgt ggtgtgcaga gagaagccca
     4441 aggccagccc cgacaacttg ctcatcctgt ctgagatggg agatgactct ttcaacaaag
     4501 cagcccccat caaaggctgc aaaatatcca cagtgagcaa ggccatggtc accatctcca
     4561 acacggccaa tctgagcagc tgcgaggggt acatccccat gaagaccaat atcacagttt
     4621 acccctgcat tgccatgagc ccccggaaca tccaagagcc ggaggccccc accgccaccc
     4681 ccaaagcagg ccccacatta gcccagtccc gggagagtaa ggaaaacagt gcaaagaaag
     4741 agatgaaatt tgaggacccg tggctgaaac gagaagagga agtgaaaaaa gagacggctc
     4801 atcccaatga agaagggatg atgaggtgtg agactgccac gggcccctcg aatgctgaga
     4861 ccagagcaga gcaggagcag gacggaaagc ccagtccggg agacaggctc agcagcagca
     4921 gcggagaggt gtcggcctcc ccggtcactg acaacttcag gagggtcgtg gatgggtgtg
     4981 agatggccct gcccggtttg gccacccaga gccccgtgca tcccaacaaa agcgtcaagt
     5041 ccagcagcct tcccagggcc tttcagaagg ccagccggca ggaggagccg gacagcctct
     5101 cctattactg cgctgctgag accaacgggg tgggtgcagc ctcgggcacc ccgccctcca
     5161 aggctaccct ggaggggaag gtggcttccc ccaagcactg tgttctggct cggcccaaag
     5221 ggactccccc tctgccccct gtccgaaagt ccagcctgga ccagaagaac cgggccagcc
     5281 ctcagcacag tgccagcggc agcggcacca gcagccccct gaaccaacca gccgccttcc
     5341 cggcgggcct cccagacgag cctagcggca agacgaagga cgccagcagc agcagcaagc
     5401 tcttcagtgc caagctggag cagctggcca gcagaagcaa ctcgctgggc agggcgacag
     5461 tcagccacta cgaatgcctc tccctggagc gggccgagag cctgtcctcc gtgagctccc
     5521 ggctgcacgc gggcaaggac ggcaccatgc cccgcgcggg gaggagcctg ggccgcagcg
     5581 ccgggacctc gccccccagc tccggggcct cgcccaaggc cggccagtcc aagatctccg
     5641 ccgtgagcag actcctcctg gccagcccca gagcgcgcgg cccgtccgcc tccaccacca
     5701 aaaccctcag cttctccacc aagtccctgc cgcaggcggt gggccagggc tccagctcgc
     5761 cccccggtgg gaagcacacg ccctggtcca cgcagtccct cagcaggaac aggagctcgg
     5821 gcctggcctc caagcttccc ctgcgggccg tcagcgggcg catctcggag ctgctgcagg
     5881 gtggcgcggg cgcccggggc ttgcagctgc gggccgggcc cgaggcggag gcgcgcgggg
     5941 gggccctggc cgaggacgag cccgcggccg cgcacctgct cccgtcgccc tacagcaaga
     6001 tcacgccccc gcggaggccc caccgctgca gcagcggcca cggcagcgac aacagcagcg
     6061 tgctgagcgg ggagctcccg ccggccatgg ggaagacggc cctgttctac cacagcggcg
     6121 gcagcagcgg ctacgagagc gtgatgcggg acagcgaggc caccggcagc gcgtcctcgg
     6181 cgcaggactc cacgagcgag aacagcagct ccgtgggcgg caggtgccgg agcctcaaga
     6241 ccccgaagaa acgctccaat ccaggttctc agagacggag gcttatccca gcactatccc
     6301 tggacacctc ttcccctgtg agaaaacccc ccaacagcac aggcgtccgc tgggtggatg
     6361 gccccttgcg gagcagcccg aggggccttg gggaaccctt tgagattaaa gtctatgaaa
     6421 tcgatgacgt ggagcgcctg cagcggcgac gagggggtgc cagcaaggag gccatgtgct
     6481 tcaatgcaaa gctgaagatt ctggaacacc gccagcagag gatcgccgag gtccgcgcga
     6541 agtacgagtg gctgatgaag gagctggagg cgaccaaaca gtatctgatg ctggatccca
     6601 acaagtggct cagtgaattt gacttggagc aggtttggga gctggattcc ctggagtacc
     6661 tggaggcact ggagtgtgtg acggagcgcc tggagagccg tgtcaacttc tgcaaggccc
     6721 atctcatgat gatcacctgc ttcgacatca cctccaggcg ccggtagatg agccagaccc
     6781 ttgtcctagt ggtcccccgc tccccaggac ttcagagatg ttgcacgccc ctaggccctc
     6841 tgtgctgggg catcaaagac aatgaatgag gatgaaggtt ggtggcaagt ctggagcggg
     6901 cgttgagcgg aaggcgagtt ttcttttgtt ttctgtagga aaggtgcaaa cgtcaaacac
     6961 cgtggaagga gaaaaggatg ggaagcccga ggggtgtcca agccctgtga gactgaaaaa
     7021 gcactttgag gaaccttaaa gaccttgttt gtacataaga actgctagca aaagagacct
     7081 cactcttctc ttgctttcgt gagaaaggag gggcgtggat gtaggattgc tgtggaaagc
     7141 gaacacaaaa caacccagaa tgactgatta agtgccttgc aaatctttat tattatccaa
     7201 acatttatgt tcatactttc ttgtgtacag atggtgctag tcaagatgaa aacaacaaaa
     7261 caaacaagaa aaacattttg gaaatgtatt cacagctctt tttctcttgg tgttttatcc
     7321 tatttctgac ttgctgtttc taagtaagtt gtgtttgtag agctatttct taatcagtat
     7381 tgcttatgaa taaatattac ctgtctttta tggttattct ggtgaggcca ctcaaacaga
     7441 gagacttccc tcggcacgag ccagtgtgtg tgtttccaaa gtaggtttgg agcagcaggt
     7501 gacctcgatg ccacatccca acaagcagcg tggtcaggta gacccagaag gttgattgtg
     7561 gggcaggtgc tttagagaac aggtgaggag acggcacctg cagcacaggg gaggaggagt
     7621 cctttgcgac ctgggccctc cctgctcctg ggaggtgggc cgtatgttct gtagaccgtt
     7681 tgcccccctc aagtcctcca cacatgtggt tccttgaccc acaaatccac agtttgcgtg
     7741 gccctcaaaa ttcatattca tttttattcc aaaaagtctt gaacgaaagc tggaaccaat
     7801 tcaccagagc catatttctt tctttagtat tttctagtgt tgtgttgtag attgattaaa
     7861 gtgggttttt ccccagctga gagaccttct caggcttgtt cagagacttc aactgtattg
     7921 gattagaaga aggattcttg agactgtaca tcttgtctgt tgtccagagt acaaggattt
     7981 cagctctcct gtgtcccaaa gcctctatgc caagaaggga caggcttgtc ctctcagtct
     8041 ttgctcctgc ccaaaggcag agagagcttc ccctccataa ctcacacgac cctggatagg
     8101 cagaacatag ctgaagacta tggatgtcca ggtcttggct cccaacaact caggacctca
     8161 aattcagatg ttcctcccta taacaattcc cttaggaatt atgataccca ttttagtgat
     8221 tgatagaaac ctggggtaca gagtggtcaa gggatttccc tgataaaagc tgtggtgctg
     8281 atgatagtgc agcccagaat ctaagagtcc ctgcagcctt cgcatcgagg atggtactta
     8341 ggcgtgtgca gagcacgctt cccttttgcc ctcaaatgca gcatatcttc atgagcctat
     8401 ttatttccaa gctaggctgt ctttattaac caacaactca gccccagcca ctccccaagc
     8461 ggggaaaaaa acactacgtt tcttggtcag tgtacctctg gacactgcag cccacacagc
     8521 tggctgaact cggtaaatgg gaaccgaagt cttgtgagct tcacatgacc tgatcctttg
     8581 ttatcagaac agggttcagg tggccctgtt ggctcatgtg ctttggaagc cagctccctg
     8641 ggtcacgagt ctggctttgc actttccata agagtctgct tctatgcaaa ggtgcaaaca
     8701 ggagacatgc ccaaatctgc tggctgaaca ggctaaacta cagtgagagg ctgctctggc
     8761 atggctcgtt cttccttctg tgtatctccc aagtctgaca agtgtgttgc cctgggaagc
     8821 aggacctccc tgagctcctt aaccttgacc ccattctgca ggacagtcgc atgctctggg
     8881 ctcgcctctg gcctcaaagc acttgtgtaa gtgggcttgc ttaacagtaa tatccttgga
     8941 ggcttctgga cccaaaggga agccaatcct tcgagtttgc cattgggctg ctggttgctg
     9001 gtttcaaaca tatagttcat gaaaagtctt taattggaga ttttcaaagg tgaatattct
     9061 gtttttgttg gaaagaaact catctgatga gtcatcgatg agtttggctt tcgcccctgc
     9121 cacatcctcc cctgaggttc cttccatgct gcactgcctt cctttagcca gtgacagagc
     9181 ctggtgccct tcctggactg aaaccgatgg aatccttccg aggggagtgg cattcggctt
     9241 gcctcctgcc taaatctgct tttatccatt tgtagcaact ttatgctgta acaaaaggcg
     9301 gaaggaaacc aagagttctc ttagcaagtc agactccttc ccaagatggc aatcacagaa
     9361 cacctcgcag gatctcgcag gccacggtga aggagaatgc tttatgttga tgttgtccat
     9421 tctctctctc ttctctttgc ttttttttga cctaaataag ctgcaaacat gttaatttac
     9481 caatattgat aaaccacatg aagaaatcag gcattttacg ttatgatgtg cttgttcctg
     9541 tctctgccta taaattgact gtattgatga tgaaggaagg agttccggct gaccattctg
     9601 aagcagtccc agtcacggga ggatgcctta cccagtggcc agacatgata gttccaggtc
     9661 tccccttggt tttggtgata gagaacccaa ggaggcaagg gggaatatca acgaacccat
     9721 ttctatttca ttacccacaa gcgaaaggac tagaaaaaaa tatttgaaat taacatttag
     9781 atgcataggt ctaactcctt gtgtgaacct gtcctcctca ccccctgctc caaatatgtg
     9841 aggtggaagc attagcagcg gagcaaaact aagatctaag aacgggcggt ggtgctattg
     9901 tgtccctggg agtcactcca cgtcgcattg cacggtggtg ctgaggagcg agagtttgct
     9961 ttatcatggg ctttcagttc ccacctgcga gctgcaaact ttgatcttgt tgtccttgaa
    10021 ttcccctcta catcacgagg aagctgtctc tttcatctct tccggatttg gaatcagaac
    10081 actctgcccg ttgtttattc gccagttgcc attcttaaca tgggggagca ttaagatgca
    10141 aatgcagaga tgtgtcctgt cttgacaaag gtgggaaccc ctgagctgga gaaggggctc
    10201 ctctcatgag aagctggggt aaacagccag gcatcgcagc gtggggaatt agacaggcag
    10261 gaatctggcc tggtttgtca taaattagcc ttcaacttga agtctattat gttcttataa
    10321 ggcggtagtg acttcagtcc agccgcatct accatccagg gtggaggttc aaaaagtctt
    10381 atacgcacct acaagtctca cgcttgctgc tcagactttc tgataaaatc tcagagttct
    10441 gtttgtattg accaaaaatg cagttgtgcc cacttgggtg tgtatctcat gtccttgtaa
    10501 accagccacc ttctttggat agaaggcaag gctgacaaat ctgcagattt gttcaatgca
    10561 aacacagccg tctatatcat tggccactgc tgattatatt gagtgttttt aggtttttta
    10621 ggtttcttat tccaaaaagg attttagact gtaaaatgac taaagatgag ttaatttcca
    10681 aactaaaaaa ggaaggagtc ctgcctgtac tcattgttct ttcctgctgg actagtaacc
    10741 cattcttgga gcacacacag agtccctcgc ttctaaagac aatacgtctt aaaccctgaa
    10801 aacttgccag tgagaaagag gttgaaagtc ctgtttgcta ttagttgagg ctaagccgtc
    10861 tgctgccact gtccctgggg cctccatgct gccgccgggg tatgtggccc agctgtcccc
    10921 ccatgaagga cactcttcaa tgccaccaca cgggagtctg ggcagggagg aaaggcacac
    10981 agcccacttt tctctgcacc aaatgaaaca aagctgggtg ttcagtgtca ctgatgcaag
    11041 taaatgggtc tcaaattttg gtgggggcag tgtttctttg gattctgata cctctttttc
    11101 cacctccaga aagtatctgt caacattggt gggtaacagc ttataaagtg catcacttag
    11161 taatcttcct gacaaaatga cacattttaa aattacaacc tgttcattat ttccatcata
    11221 atgcaagcgt aattctaatc cgggagaaga tactgtcatt taagctcatc ttctcaaaaa
    11281 aattttttct gaaaattcct ggaaactaat ttatccctcc ctaaacaaac acattctgct
    11341 tttgggtggc cctacccaga acctgcagca atgtcataac actggacaca gtgcggcttg
    11401 gggcagtatc aagccttcat tgcatacaaa ccttaatctc taagcatagt tgttcccaag
    11461 gtccacacgt gtggaggcga gtactgaaat accacactca cacatctatt ccatgcgtac
    11521 ctagaaatta ccttcaacac taaaaaaggt tccttctttc attccctatc ctgctaacag
    11581 cccacattgt aatatttgat ttatgaagaa gttctaattt atttgtgaac tcaggatgtt
    11641 gctttacagc attgctcgtg ttctctcatt tacttattat gcatcacggt tggaaatgct
    11701 atccacgtgc cgtgcatcga ggtggagatt tgctggatct gtctgtggct atttttttcc
    11761 atgtttttct cactcaagca aagtctgtta gtggaaacat gggctggggg atggggagag
    11821 gacagataaa gcaagagaat agggattagg gtccaatcct caatgcacag ggcttagttc
    11881 aaaatctaag ctgtttctgt agtaagcagc caaatgggaa agatcccttc gttttgaatt
    11941 tgatgagaat gggcttggaa atccacgccc accggcttgc acggaagagg actcagcctc
    12001 ttcctaatgg ttcaacattc aattcctgag gaaagtgctg atagtattag ttccctacat
    12061 ttccctaaga ctcccatcca acccctagtg ctactgaaga gggtttggga aagcaattgg
    12121 agttccttag cttggatata tatagtacct gtttttttcc tctggaaaaa ccaaagtact
    12181 ttagtgagtc ttacaatctt aaggcatttt gtcccctcac tgggtcccga gaggcaggga
    12241 ggggctaggc cttgagctag gagcaaggac atgggccgcc aggcctggtt gttactagct
    12301 gtgcaacctt gggcgagcct cttcgctttg ctgggcctca ggttcccgag tggaagactg
    12361 ggggtcagaa cagctgccct tctgggagag catcaagaga aagtggtata agtgatggga
    12421 agtgctttga agaaattaaa ggtctgtcta ggagctgggg gtaatcattt acagatgaag
    12481 aaactgaagt ctagtcattg actggcccga gttcacagag tggttttata gcaaaacagg
    12541 gacttgagtc cagcttattg gattcttccc atcagatcat attgcaccag gtatgtgtag
    12601 acatgaacac ataccattcc tctaaggtgt gtgtacatac acggatgtgt gtgtacagga
    12661 ggtacctgac atggtgaaag gccataggac agaaaacctg agttctaatt ccagctttgc
    12721 cagtcgtccc gtccgtgata tattccatag gacagaaaac ctgagttcta attccagctt
    12781 tgccagtcat cctgtccgtg atatattcca taggacagaa aacctgagtt ctaattccag
    12841 ctttgccagt cgtcccgtcc gtgatatatt acctaactcc tccagaactc agttttctaa
    12901 cctataaaat gaagacattg tgctagatga tctttgtggt tccttcaagc tctggatctc
    12961 taattccatg attagtaatg tatgtatgtg tatataaata tgcttatctg tagaaatggg
    13021 cccatttgaa aagtggagac aaggtctgcc caggtgcatt tattgtgcca gaaacagtga
    13081 attcctaaat aagttcataa aatcttgttt tacaattcaa tggtagtgct taatgttact
    13141 gtctgaaatc cactgtttaa ccagatggaa gactggggcc attcaaaaca ttattagttc
    13201 acaagtgttt gctgttaaaa tgcttcaata aaactcattt gttaaagtca gaaattcaac
    13261 tcttctgtac ttgggcaggt cccagcagcc ccttggcagg ctagttttgt gcatgggcct
    13321 ttgcaagcta tataaacgtt aggtgttggc ttgattatga taaatatgag caggctccct
    13381 ggagaacagt ccagaaaaaa agagttatag ttctcacaaa ctggtgacat gaatccatta
    13441 agctgtgtgg cattttccag tgtaaagaca ttgtttgctg gctacgatct ctgacttttt
    13501 gtggcatatg aggtgtaaaa tgttgtcaaa aaagaatctg gtgtttaaaa aaaaatcaaa
    13561 ctatggtggc attaaatgtt cacttttatt cta
//
