LOCUS       NM_194313               6295 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens kinesin family member 24 (KIF24), mRNA.
ACCESSION   NM_194313 NM_018278 XM_294563
VERSION     NM_194313.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6295)
  AUTHORS   Reilly,M.L., Ain,N.U., Muurinen,M., Tata,A., Huber,C., Simon,M.,
            Ishaq,T., Shaw,N., Rusanen,S., Pekkinen,M., Hogler,W.,
            Knapen,M.F.C.M., van den Born,M., Saunier,S., Naz,S.,
            Cormier-Daire,V., Benmerah,A. and Makitie,O.
  TITLE     Biallelic KIF24 Variants Are Responsible for a Spectrum of Skeletal
            Disorders Ranging From Lethal Skeletal Ciliopathy to Severe
            Acromesomelic Dysplasia
  JOURNAL   J Bone Miner Res 37 (9), 1642-1652 (2022)
   PUBMED   35748595
  REMARK    GeneRIF: Biallelic KIF24 Variants Are Responsible for a Spectrum of
            Skeletal Disorders Ranging From Lethal Skeletal Ciliopathy to
            Severe Acromesomelic Dysplasia.
REFERENCE   2  (bases 1 to 6295)
  AUTHORS   O'Neill,A.C., Uzbas,F., Antognolli,G., Merino,F., Draganova,K.,
            Jack,A., Zhang,S., Pedini,G., Schessner,J.P., Cramer,K.,
            Schepers,A., Metzger,F., Esgleas,M., Smialowski,P., Guerrini,R.,
            Falk,S., Feederle,R., Freytag,S., Wang,Z., Bahlo,M., Jungmann,R.,
            Bagni,C., Borner,G.H.H., Robertson,S.P., Hauck,S.M. and Gotz,M.
  TITLE     Spatial centrosome proteome of human neural cells uncovers
            disease-relevant heterogeneity
  JOURNAL   Science 376 (6599), eabf9088 (2022)
   PUBMED   35709258
REFERENCE   3  (bases 1 to 6295)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6295)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6295)
  AUTHORS   Huang,N., Zhang,D., Li,F., Chai,P., Wang,S., Teng,J. and Chen,J.
  TITLE     M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating
            CP110-CEP97 complex localization at the mother centriole
  JOURNAL   Nat Commun 9 (1), 4511 (2018)
   PUBMED   30375385
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6295)
  AUTHORS   Zou,J.X., Duan,Z., Wang,J., Sokolov,A., Xu,J., Chen,C.Z., Li,J.J.
            and Chen,H.W.
  TITLE     Kinesin family deregulation coordinated by bromodomain protein
            ANCCA and histone methyltransferase MLL for breast cancer cell
            growth, survival, and tamoxifen resistance
  JOURNAL   Mol Cancer Res 12 (4), 539-549 (2014)
   PUBMED   24391143
REFERENCE   7  (bases 1 to 6295)
  AUTHORS   Kobayashi,T., Tsang,W.Y., Li,J., Lane,W. and Dynlacht,B.D.
  TITLE     Centriolar kinesin Kif24 interacts with CP110 to remodel
            microtubules and regulate ciliogenesis
  JOURNAL   Cell 145 (6), 914-925 (2011)
   PUBMED   21620453
  REMARK    GeneRIF: Study found that loss of Kif24 leads to the disappearance
            of CP110 from mother centrioles in cycling cells able to form
            cilia; thus, identifying a centriolar kinesin that specifically
            remodels a subset of microtubules, thereby regulating cilia
            assembly.
REFERENCE   8  (bases 1 to 6295)
  AUTHORS   Venturelli,E., Villa,C., Fenoglio,C., Clerici,F., Marcone,A.,
            Benussi,L., Ghidoni,R., Gallone,S., Scalabrini,D., Cortini,F.,
            Fumagalli,G., Cappa,S., Binetti,G., Franceschi,M., Rainero,I.,
            Giordana,M.T., Mariani,C., Bresolin,N., Scarpini,E. and
            Galimberti,D.
  TITLE     Is KIF24 a genetic risk factor for Frontotemporal Lobar
            Degeneration?
  JOURNAL   Neurosci Lett 482 (3), 240-244 (2010)
   PUBMED   20670673
  REMARK    GeneRIF: KIF24 rs17350674 polymorphism likely acts as a risk factor
            for sporadic Lobar Degeneration
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 6295)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   10 (bases 1 to 6295)
  AUTHORS   Miki,H., Setou,M., Kaneshiro,K. and Hirokawa,N.
  TITLE     All kinesin superfamily protein, KIF, genes in mouse and human
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7004-7011 (2001)
   PUBMED   11416179
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353662.19, HY066968.1,
            BU660279.1, DA906271.1, DT932659.1, BF895212.1, BP871643.1,
            DV080194.1, DV080193.1, BC110502.1, AK125180.1 and BE856625.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_194313.3.
            
            Summary: This gene encodes a member of the kinesin superfamily of
            microtubule-based motor proteins which are involved in the
            intracellular transport of membranous organelles, protein
            complexes, and mRNAs. They also play critical roles in mitosis,
            morphogenesis, and signal transduction. The encoded protein
            contains an N-terminal sterile alpha motif (SAM) domain and an
            ATP-binding kinesin motor domain. It binds centriolar coiled coil
            protein 110 and centrosomal protein 97 and localizes to the mother
            centriole to regulate ciliogenesis by controlling microtubule
            polymerization. [provided by RefSeq, Mar 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.28037.1,
                                           SRR14038191.3520174.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402558.7/ ENSP00000384433.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL353662.19        161651-161669       c
            20-68               HY066968.1         2-50
            69-330              BU660279.1         5-266
            331-413             DA906271.1         484-566
            414-605             BU660279.1         350-541
            606-606             AL353662.19        143330-143330       c
            607-889             DT932659.1         83-365
            890-1354            BF895212.1         108-572
            1355-1464           BP871643.1         341-450
            1465-1465           AL353662.19        104270-104270       c
            1466-1599           BP871643.1         452-585
            1600-1600           AL353662.19        101689-101689       c
            1601-1614           DV080194.1         362-375             c
            1615-1748           DV080193.1         8-141
            1749-4980           BC110502.1         39-3270
            4981-6148           AK125180.1         1627-2794
            6149-6295           BE856625.1         11-157              c
FEATURES             Location/Qualifiers
     source          1..6295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..6295
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /note="kinesin family member 24"
                     /db_xref="GeneID:347240"
                     /db_xref="HGNC:HGNC:19916"
                     /db_xref="MIM:613747"
     exon            1..163
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            164..811
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..4295
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /codon_start=1
                     /product="kinesin-like protein KIF24"
                     /protein_id="NP_919289.2"
                     /db_xref="CCDS:CCDS6551.2"
                     /db_xref="GeneID:347240"
                     /db_xref="HGNC:HGNC:19916"
                     /db_xref="MIM:613747"
                     /translation="MASWLYECLCEAELAQYYSHFTALGLQKIDELAKITMKDYSKLG
                     VHDMNDRKRLFQLIKIIKIMQEEDKAVSIPERHLQTSSLRIKSQELRSGPRRQLNFDS
                     PADNKDRNASNDGFEMCSLSDFSANEQKSTYLKVLEHMLPDDSQYHTKTGILNATAGD
                     SYVQTEISTSLFSPNYLSAILGDCDIPIIQRISHVSGYNYGIPHSCIRQNTSEKQNPW
                     TEMEKIRVCVRKRPLGMREVRRGEINIITVEDKETLLVHEKKEAVDLTQYILQHVFYF
                     DEVFGEACTNQDVYMKTTHPLIQHIFNGGNATCFAYGQTGAGKTYTMIGTHENPGLYA
                     LAAKDIFRQLEVSQPRKHLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHMVQIVGL
                     QELQVDSVELLLEVILKGSKERSTGATGVNADSSRSHAVIQIQIKDSAKRTFGRISFI
                     DLAGSERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLK
                     DSFIGNAKTCMIANISPSHVATEHTLNTLRYADRVKELKKGIKCCTSVTSRNRTSGNS
                     SPKRIQSSPGALSEDKCSPKKVKLGFQQSLTVAAPGSTRGKVHPLTSHPPNIPFTSAP
                     KVSGKRGGSRGSPSQEWVIHASPVKGTVRSGHVAKKKPEESAPLCSEKNRMGNKTVLG
                     WESRASGPGEGLVRGKLSTKCKKVQTVQPVQKQLVSRVELSFGNAHHRAEYSQDSQRG
                     TPARPASEAWTNIPPHQKEREEHLRFYHQQFQQPPLLQQKLKYQPLKRSLRQYRPPEG
                     QLTNETPPLFHSYSENHDGAQVEELDDSDFSEDSFSHISSQRATKQRNTLENSEDSFF
                     LHQTWGQGPEKQVAERQQSLFSSPRTGDKKDLTKSWVDSRDPINHRRAALDHSCSPSK
                     GPVDWSRENSTSSGPSPRDSLAEKPYCSQVDFIYRQERGGGSSFDLRKDASQSEVSGE
                     NEGNLPSPEEDGFTISLSHVAVPGSPDQRDTVTTPLREVSADGPIQVTSTVKNGHAVP
                     GEDPRGQLGTHAEYASGLMSPLTMSLLENPDNEGSPPSEQLVQDGATHSLVAESTGGP
                     VVSHTVPSGDQEAALPVSSATRHLWLSSSPPDNKPGGDLPALSPSPIRQHPADKLPSR
                     EADLGEACQSRETVLFSHEHMGSEQYDADAEETGLDGSWGFPGKPFTTIHMGVPHSGP
                     TLTPRTGSSDVADQLWAQERKHPTRLGWQEFGLSTDPIKLPCNSENVTWLKPRPISRC
                     LARPSSPLVPSCSPKTAGTLRQPTLEQAQQVVIRAHQEQLDEMAELGFKEETLMSQLA
                     SNDFEDFVTQLDEIMVLKSKCIQSLRSQLQLYLTCHGPTAAPEGTVPS"
     exon            812..1001
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1099
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1315
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1403
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1525
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1631
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1703
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1813
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..4060
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4154
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            4155..6295
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6126..6131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /note="hexamer: AATAAA"
     polyA_site      6149
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
     regulatory      6270..6275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /note="hexamer: AATACA"
     polyA_site      6295
                     /gene="KIF24"
                     /gene_synonym="bA571F15.4; C9orf48"
                     /note="major polyA site"
ORIGIN      
        1 gttcgaactg gcgcttggcg gcgttgccat ggagatgcgg cctggccgcc gccggtggct
       61 cccgggttga cgggactgtt aggttgcggg ctttggggct cactcccgac ggcattgtct
      121 tctcctcttc tcagacaggg cagaccgagg agtttggacc gagagtttat agaaacctat
      181 tcaccaaaat ggcatcctgg ttatatgaat gtctttgtga agctgaactt gcacagtatt
      241 attctcattt cactgccctt ggccttcaga aaatagatga attagccaag attacaatga
      301 aggactactc caaattagga gtccatgaca tgaacgaccg caaacgtctc ttccaactta
      361 tcaaaattat taagattatg caagaagaag ataaagcagt cagtatccca gagcgtcatc
      421 ttcagacaag cagcctgcgc atcaaatctc aggaattaag atctggccct cgcagacagc
      481 tgaattttga ttctcctgct gacaataaag acagaaatgc cagcaatgat gggtttgaaa
      541 tgtgcagttt atcagatttc tctgcaaatg aacagaagtc cacttaccta aaagtgctag
      601 aacacatgct accagatgat tcccagtacc atacaaaaac aggaattctg aatgccacag
      661 ctggtgattc ctatgtgcaa acagaaatca gcacttcact cttttcacca aattaccttt
      721 ctgcaatact gggggattgt gatattccca ttattcaaag aatctctcat gtttcagggt
      781 ataactatgg aatccctcat tcttgtatca gacagaacac ttcagagaaa cagaatcctt
      841 ggactgagat ggagaaaatc agagtttgtg ttcgaaaacg ccccctgggc atgagggagg
      901 tacgtcgtgg agaaattaat attattactg tagaagacaa agaaactcta cttgtgcatg
      961 agaagaaaga agcagttgac ctcactcaat atattctgca gcatgttttt tattttgatg
     1021 aagtctttgg tgaggcgtgc accaatcagg atgtatacat gaagactact cacccactta
     1081 ttcagcatat tttcaatgga ggcaatgcca cttgctttgc ttatggacag acaggtgctg
     1141 gaaagaccta caccatgata ggaactcatg agaacccagg attgtatgct ctagctgcca
     1201 aagatatctt caggcaacta gaagtgtccc agccaagaaa gcacctcttt gtgtggatca
     1261 gcttctatga aatttactgt ggacagcttt atgacctcct aaatagaaga aaaaggctct
     1321 ttgcaagaga agatagcaag cacatggtgc agatagtggg actgcaagag cttcaggtgg
     1381 acagtgtgga gctcctctta gaggtgatct taaagggcag caaggagcgc agcactgggg
     1441 ccactggagt taatgcagac tcctcccgct cccatgccgt catccaaatt cagatcaaag
     1501 attcagccaa gaggacattt ggcaggatct cttttattga cttggctggc agtgaaagag
     1561 cagcagatgc aagggactca gatagacaga caaagatgga aggtgcagaa ataaatcaga
     1621 gtctactggc tctgaaggaa tgtatccgag cactggatca ggaacacacc catactccct
     1681 tcaggcaaag caaactaact caggtcctga aggactcttt catcggcaat gccaaaacct
     1741 gcatgatcgc caacatctca ccaagccacg tggccactga acacactctc aacaccttgc
     1801 gctatgctga ccgggtcaaa gaactaaaga aaggcattaa gtgttgcact tcagttacca
     1861 gtcgaaatcg gacatctgga aactcctctc caaaacgaat tcagagctcc cctggggctt
     1921 tgtcagagga caaatgttct cccaaaaaag tcaagctggg atttcagcag tcactcacag
     1981 tggcagcccc tggttccacg agagggaagg tccatcctct gaccagccac ccacccaaca
     2041 ttccttttac ttctgcacct aaggtctctg gtaaaagggg tggctccaga gggagtcctt
     2101 cacaagagtg ggtcattcat gctagccctg tgaaaggaac tgtgcgctct ggacatgtgg
     2161 ccaaaaaaaa gccagaagag tcagcaccat tgtgctctga gaaaaatcga atgggcaaca
     2221 aaactgtcct tgggtgggaa agcagggcct caggcccagg agaaggccta gtgcgtggta
     2281 agctgtccac caagtgcaag aaagtgcaga cagtgcagcc agtacagaag cagcttgtgt
     2341 ctcgagttga gctctccttt ggcaacgccc accacagggc tgagtacagt caagacagcc
     2401 agaggggcac gcctgctagg cctgcctctg aagcttggac aaacatcccg ccacatcaga
     2461 aggagaggga ggaacatctg cgtttctatc accagcagtt ccaacagcca cctctcctcc
     2521 aacagaagtt aaaataccaa ccactgaaaa ggtctttacg ccagtacagg cccccagagg
     2581 gtcagctcac gaatgagact ccgcctctgt tccactctta ctctgaaaac catgatggag
     2641 cccaagtaga ggaacttgat gacagtgatt tcagtgaaga ttctttttca cacatctcta
     2701 gtcagagggc cacaaagcaa aggaacaccc tggagaatag cgaagactca ttcttcctgc
     2761 accagacgtg gggacagggt cctgagaagc aggtggcaga aagacagcag agtctgtttt
     2821 ctagccccag gacaggtgac aagaaagatc taactaaaag ctgggtggac tccagggacc
     2881 ccataaacca cagaagagca gcactcgatc acagctgcag cccaagtaag gggcccgtgg
     2941 actggagcag agagaactct acttcctcag ggccttctcc cagagacagc ctggcagaga
     3001 agccatactg ttcacaggta gatttcatat atagacagga aagaggtgga ggctcttcct
     3061 ttgatctcag aaaggatgcc tcccaaagtg aggtttctgg ggagaatgag ggcaacttgc
     3121 catccccaga ggaagatggt ttcactatct cattgtccca cgttgcagtt cctggatccc
     3181 cagaccaaag agacacagtc accacacctc tgagagaagt cagtgcagac ggcccaatcc
     3241 aggtgaccag cactgtgaaa aacggtcatg ctgtcccagg agaggatcct agggggcagt
     3301 taggcacgca tgctgaatat gcttctggac tcatgtctcc cctcaccatg tccctcctgg
     3361 agaacccaga caacgaaggg tctcctccct cggagcagct ggtccaggat ggggctacgc
     3421 acagtctagt ggcagagagc acagggggcc cagttgtgag ccacacagtg ccatctggtg
     3481 atcaagaggc agccttgcca gtgtcttcag caactaggca cctgtggctg tcctcatctc
     3541 cccctgataa taagcctggt ggtgatcttc cagctctgtc cccatcaccc atccgtcagc
     3601 acccagctga caagctgccc agcagggagg cagacctagg agaggcctgc cagagcagag
     3661 agactgtact tttctcccac gaacacatgg gtagtgagca gtatgatgct gatgcagagg
     3721 agacggggct ggatggctcc tggggtttcc caggaaagcc cttcaccacc atacatatgg
     3781 gggtacccca ttctggacct acactcaccc cacgaacagg aagtagtgat gtggctgacc
     3841 agctctgggc ccaggagaga aaacatccta caaggcttgg ttggcaggag tttggtttgt
     3901 ccacagaccc catcaagttg ccctgcaaca gtgaaaatgt cacatggctc aaacccaggc
     3961 cgatctcaag gtgcttagca aggccaagtt ctcccttggt tcccagctgc tctcccaaga
     4021 ctgcagggac actccgtcag cccaccctgg agcaagcgca gcaggtggtc atccgagcac
     4081 accaggaaca gctggatgaa atggctgagc tcggcttcaa ggaggagacg ctgatgagcc
     4141 agctggcttc taatgatttt gaagattttg tgacccagct ggatgaaatc atggttctga
     4201 aatccaagtg tatccagagt ctgaggagcc agctgcagct ctatctcacc tgccacgggc
     4261 ccaccgcagc ccctgaggga acagtgccgt cttagagcca gaccctgtgc cgagatggtg
     4321 ggggccctgc aggagtctgt gctgggctct caggctggag gagcctctgc caggtcctcc
     4381 ctgcacacac cagaacccac acgctggtcc tgcctatgct agcgtcaccc cagccccacg
     4441 tggcttcaga taggtcccag cttctccctc agggacaggc ccctgtccct cagttccatg
     4501 cacaggagtg cctccaaggg tgggccaggc cgaagaacct aatgcctttc ccttgtgcct
     4561 agagaatatg attaactaac cccttgcctg tgggaatata tttgggtcta ataaccctga
     4621 agtttctaag tttggggatc agaggatggg gtggtcagtg gtagcctaga ggtcagaggt
     4681 cacaagacag agaagacaac atgctgagac cagaggcttc accagctgaa ttctgtgcct
     4741 aacttagaag actaaacact ggcccaaact taaccattgg tgctaggggg acaggggtgg
     4801 ggtgagctct gccccatcag cccttggaga ttgatttggg gatttagagg cgtttttgaa
     4861 aatgtaaata gcataaacct tgacttgatg tgtcactgac agcagcagat gtgagacagg
     4921 ccttatattt acagctccct tcccttcctg caatccagtg ttgaggcaga agagggtgcc
     4981 tgtgtcacac atcaattttt ctcctgactt ttgctcgggt gaaaggcctc tgtacaatgc
     5041 ccgatactct catgcttcca tggcagctcc tggctcctat ctgggacacc tcactaccca
     5101 gccccctcat ggaatagtcc atctcctagc ctggccttca tccagttcac cctgcccagc
     5161 caccctgcct ctcaggggtc tgtgttggga accttggcag ttgaacagag tgctctgttc
     5221 aacagtctga ggcctctgaa acagaattca cacacaaacc ttcagccaag ttctgcctgc
     5281 tgtgtatctt tttagcagga agcagctcag gacagggaag acaaagtagc ctccaggtgc
     5341 caattacttt aaagccactc tgggtcaaat ggagattcat gagtcacggc cttggcccga
     5401 acgcccatta ctatgtgagc ctttatttcc ttcagataaa ggataacttt ttacggtttt
     5461 aaaaggaggg cttaattaaa aggccaagaa gagggttaaa tggctctctt gagacactag
     5521 cagcctggtc cagtcaccct ttgtcagcct gacagtgcct catctgaccg ccagggggca
     5581 tccttattgg tgcttcccgg ctgcagggca ctgcggcccc tccctcacat gatcactaaa
     5641 aaccttcaaa gacccagtct agccaaaagc tcaagtggga caatggcaca gtattaaggt
     5701 caaggacaaa aacttactta ctttaggaat gaaccctatt ctatcatcat atacaacagc
     5761 accactgaga gctggtgaaa cagtttaaat cccatcctct gcttgtggca aatgatgcat
     5821 aaatgcctgc tgctcacagt aaaagggctt cttcctcttt tactgggtga tccccctgaa
     5881 ggcccagcct atcccaactc cacagtcagg aaggcctacg tccttggtcc acagacggag
     5941 ctgggccagg tttaaaagac tcagtctagg cttgcctttg caaaccaaaa acgaggacag
     6001 gtctgaagtg ggaagaaagc tccgaaatag aaaacggtta ggtcctattc tatccccagc
     6061 aaatctaagc aagaaatctc tttatacacc acatggcccc cccactccca taaaacagcc
     6121 ttggtaataa agaagttatc acaccaagac atacctttta gatttttatt agtagttctc
     6181 tctgaagaat caaaatagtt agttagcaaa ttattttaga ttcaagactg tatatccttt
     6241 gtatttagat ctttaatgat gtacaacata atacaaaaca aaccagagag actga
//
