LOCUS       NM_007317               2081 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens kinesin family member 22 (KIF22), transcript variant
            1, mRNA.
ACCESSION   NM_007317
VERSION     NM_007317.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2081)
  AUTHORS   Zhai,M., Miao,J., Zhang,R., Liu,R., Li,F., Shen,Y., Wang,T., Xu,X.,
            Gao,G., Hu,J., He,A. and Bai,J.
  TITLE     KIF22 promotes multiple myeloma progression by regulating the
            CDC25C/CDK1/cyclinB1 pathway
  JOURNAL   J Cancer Res Clin Oncol 150 (5), 239 (2024)
   PUBMED   38713252
  REMARK    GeneRIF: KIF22 promotes multiple myeloma progression by regulating
            the CDC25C/CDK1/cyclinB1 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2081)
  AUTHORS   Zhong,Z. and Zhong,H.
  TITLE     KIF22 promotes the proliferation and glycolysis of melanoma by
            activating EGFR/STAT3 signaling
  JOURNAL   Clinics (Sao Paulo) 78, 100307 (2023)
   PUBMED   37944197
  REMARK    GeneRIF: KIF22 promotes the proliferation and glycolysis of
            melanoma by activating EGFR/STAT3 signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2081)
  AUTHORS   Zhang,R., Ma,L., Wei,Y., Wei,K., Song,T., Du,Z. and Feng,Z.
  TITLE     KIF22 Promotes Development of Pancreatic Cancer by Regulating the
            MEK/ERK/P21 Signaling Axis
  JOURNAL   Biomed Res Int 2022, 6000925 (2022)
   PUBMED   35578724
  REMARK    GeneRIF: KIF22 Promotes Development of Pancreatic Cancer by
            Regulating the MEK/ERK/P21 Signaling Axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2081)
  AUTHORS   Li,B., Zhu,F.C., Yu,S.X., Liu,S.J. and Li,B.Y.
  TITLE     Suppression of KIF22 Inhibits Cell Proliferation and Xenograft
            Tumor Growth in Colon Cancer
  JOURNAL   Cancer Biother Radiopharm 35 (1), 50-57 (2020)
   PUBMED   31657617
  REMARK    GeneRIF: Suppression of KIF22 Inhibits Cell Proliferation and
            Xenograft Tumor Growth in Colon Cancer.
REFERENCE   5  (bases 1 to 2081)
  AUTHORS   Liu,Y., Li,R.H., Ren,G. and Jiang,J.
  TITLE     Suppression of KIF22 Inhibits Cell Proliferation and Xenograft
            Tumor Growth in Tongue Squamous Cell Carcinoma
  JOURNAL   Biomed Res Int 2020, 6387545 (2020)
   PUBMED   32090103
  REMARK    GeneRIF: Suppression of KIF22 Inhibits Cell Proliferation and
            Xenograft Tumor Growth in Tongue Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2081)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   7  (bases 1 to 2081)
  AUTHORS   Song,J., Murakami,H., Yang,Z.Q., Koga,C., Adati,N., Murata,T.,
            Geltinger,C., Saito-Ohara,F., Ikeuchi,T., Matsumura,M., Itakura,K.,
            Kanazawa,I., Sun,K. and Yokoyama,K.K.
  TITLE     Human genes for KNSL4 and MAZ are located close to one another on
            chromosome 16p11.2
  JOURNAL   Genomics 52 (3), 374-377 (1998)
   PUBMED   9790757
REFERENCE   8  (bases 1 to 2081)
  AUTHORS   Song,J., Murakami,H., Tsutsui,H., Tang,X., Matsumura,M.,
            Itakura,K., Kanazawa,I., Sun,K. and Yokoyama,K.K.
  TITLE     Genomic organization and expression of a human gene for
            Myc-associated zinc finger protein (MAZ)
  JOURNAL   J Biol Chem 273 (32), 20603-20614 (1998)
   PUBMED   9685418
REFERENCE   9  (bases 1 to 2081)
  AUTHORS   Tokai,N., Fujimoto-Nishiyama,A., Toyoshima,Y., Yonemura,S.,
            Tsukita,S., Inoue,J. and Yamamota,T.
  TITLE     Kid, a novel kinesin-like DNA binding protein, is localized to
            chromosomes and the mitotic spindle
  JOURNAL   EMBO J 15 (3), 457-467 (1996)
   PUBMED   8599929
REFERENCE   10 (bases 1 to 2081)
  AUTHORS   Zhang,S. and Nonoyama,M.
  TITLE     The cellular proteins that bind specifically to the Epstein-Barr
            virus origin of plasmid DNA replication belong to a gene family
  JOURNAL   Proc Natl Acad Sci U S A 91 (7), 2843-2847 (1994)
   PUBMED   8146198
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009133.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2019 this sequence version replaced NM_007317.2.
            
            Summary: The protein encoded by this gene is a member of the
            kinesin-like protein family. The family members are
            microtubule-dependent molecular motors that transport organelles
            within cells and move chromosomes during cell division. The
            C-terminal half of this protein has been shown to bind DNA. Studies
            with the Xenopus homolog suggests its essential role in metaphase
            chromosome alignment and maintenance. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223431.1, BC004352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000160827.9/ ENSP00000160827.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC009133.7         74560-74638         c
            80-275              AC009133.7         68301-68496         c
            276-403             AC009133.7         66888-67015         c
            404-558             AC009133.7         66642-66796         c
            559-768             AC009133.7         66205-66414         c
            769-999             AC009133.7         65895-66125         c
            1000-1153           AC009133.7         65608-65761         c
            1154-1289           AC009133.7         65341-65476         c
            1290-1458           AC009133.7         62452-62620         c
            1459-1618           AC009133.7         61781-61940         c
            1619-1686           AC009133.7         61324-61391         c
            1687-1899           AC009133.7         60363-60575         c
            1900-1959           AC009133.7         60215-60274         c
            1960-2081           AC009133.7         60005-60126         c
FEATURES             Location/Qualifiers
     source          1..2081
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2081
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /note="kinesin family member 22"
                     /db_xref="GeneID:3835"
                     /db_xref="HGNC:HGNC:6391"
                     /db_xref="MIM:603213"
     exon            1..79
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2007
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /note="isoform 1 is encoded by transcript variant 1; oriP
                     binding protein; origin of plasmid DNA replication-binding
                     protein; kinesin-like DNA-binding protein pseudogene;
                     kinesin-like protein 4"
                     /codon_start=1
                     /product="kinesin-like protein KIF22 isoform 1"
                     /protein_id="NP_015556.1"
                     /db_xref="CCDS:CCDS10653.1"
                     /db_xref="GeneID:3835"
                     /db_xref="HGNC:HGNC:6391"
                     /db_xref="MIM:603213"
                     /translation="MAAGGSTQQRRREMAAASAAAISGAGRCRLSKIGATRRPPPARV
                     RVAVRLRPFVDGTAGASDPPCVRGMDSCSLEIANWRNHQETLKYQFDAFYGERSTQQD
                     IYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLTRE
                     EGAEGRPWALSVTMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLSQKPISSF
                     ADFERHFLPASRNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPFRQREGKLYLIDLA
                     GSEDNRRTGNKGLRLKESGAINTSLFVLGKVVDALNQGLPRVPYRDSKLTRLLQDSLG
                     GSAHSILIANIAPERRFYLDTVSALNFAARSKEVINRPFTNESLQPHALGPVKLSQKE
                     LLGPPEAKRARGPEEEEIGSPEPMAAPASASQKLSPLQKLSSMDPAMLERLLSLDRLL
                     ASQGSQGAPLLSTPKRERMVLMKTVEEKDLEIERLKTKQKELEAKMLAQKAEEKENHC
                     PTMLRPLSHRTVTGAKPLKKAVVMPLQLIQEQAASPNAEIHILKNKGRKRKLESLDAL
                     EPEEKAEDCWELQISPELLAHGRQKILDLLNEGSARDLRSLQRIGPKKAQLIVGWREL
                     HGPFSQVEDLERVEGITGKQMESFLKANILGLAAGQRCGAS"
     exon            80..275
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..403
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..558
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..768
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            769..999
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1153
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1289
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1458
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1618
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1686
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1899
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1959
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2081
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2062..2067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /note="hexamer: AATACA"
     polyA_site      2081
                     /gene="KIF22"
                     /gene_synonym="A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2;
                     SEMDJL2"
                     /note="major polyA site"
ORIGIN      
        1 gggagtggaa tggccgcggg cggctcgacg cagcagaggc gacgcgagat ggcggcagct
       61 tcagcggcgg cgatctcagg agctggtcgc tgtcggctaa gcaagattgg agctactcgt
      121 cgtccacctc cagctcgcgt aagggtggct gtgcgactgc ggccatttgt ggatggaaca
      181 gcgggagcaa gtgatccccc ctgtgtgcgg ggcatggaca gctgctctct agagattgct
      241 aactggagga accaccagga gactctcaaa taccagtttg atgccttcta tggggagagg
      301 agtactcagc aggacatcta tgcaggttca gtgcagccca tcctaaggca cttgctggaa
      361 gggcagaatg ccagtgtgct tgcctatgga cccacaggag ctgggaagac gcacacaatg
      421 ctgggcagcc cagagcaacc tggggtgatc ccgcgggctc tcatggacct cctgcagctc
      481 acaagggagg agggtgccga gggccggcca tgggcccttt ctgtcaccat gtcttaccta
      541 gagatctacc aggagaaggt attagacctc ctggaccctg cttcgggaga cctggtaatc
      601 cgagaagact gccgggggaa tatcctgatt ccgggtctct cccagaagcc catcagtagc
      661 tttgctgatt ttgagcggca cttcctgcca gccagtcgaa atcggactgt aggagccacc
      721 cggctcaacc agcgctcctc ccgcagtcat gctgtgctcc tggtcaaggt ggaccagcgg
      781 gaacgtttgg ccccatttcg ccagcgagag ggaaaactct acctgattga cttggctggg
      841 tcagaggaca accggcgcac aggcaacaag ggccttcggc taaaagagag tggagccatc
      901 aacacctccc tgtttgtcct gggcaaagtg gtagatgcgc tgaatcaggg cctccctcgt
      961 gtaccttatc gggacagcaa gctcactcgc ctattgcagg actctctggg tggctcagcc
     1021 cacagtatcc ttattgccaa cattgcccct gagagacgct tctacctaga cacagtctcc
     1081 gcactcaact ttgctgccag gtccaaggag gtgatcaatc ggccttttac caatgagagc
     1141 ctgcagcctc atgccttggg acctgttaag ctgtctcaga aagaattgct tggtccacca
     1201 gaggcaaaga gagcccgagg ccctgaggaa gaggagatcg ggagccctga gcccatggca
     1261 gctccagcct ctgcctccca gaaactcagc cccctacaga agctaagcag catggacccg
     1321 gccatgctgg agcgcctcct cagcttggac cgtctgcttg cctcccaggg gagccagggg
     1381 gcccctctgt tgagtacccc aaagcgagag cggatggtgc taatgaagac agtggaagag
     1441 aaggacctag agattgagag gcttaagacg aagcaaaaag aactggaggc caagatgttg
     1501 gcccagaagg ctgaggaaaa ggagaaccat tgtcccacaa tgctccggcc cctttcacat
     1561 cgcacagtca caggggcaaa gcccctgaaa aaggctgtgg tgatgcccct acagctaatt
     1621 caggagcagg cagcatcccc aaatgccgag atccacatcc tgaagaataa aggccggaag
     1681 agaaagctgg agtccctgga tgccctagag cctgaggaga aggctgagga ctgctgggag
     1741 ctacagatca gcccggagct actggctcat gggcgccaaa aaatactgga tctgctgaac
     1801 gaaggctcag cccgagatct ccgcagtctt cagcgcattg gcccgaagaa ggcccagcta
     1861 atcgtgggct ggcgggagct ccacggcccc ttcagccagg tggaggacct ggaacgcgtg
     1921 gagggcataa cggggaaaca gatggagtcc ttcctgaagg caaacatcct gggtctcgcc
     1981 gccggccagc gctgtggcgc ctcctgaccg tcgtctcctc actccgcctt ttcaaatttt
     2041 tgtataaccc cgtgttgtgt aaatacagtt tttgctccgg t
//
