LOCUS       NM_001252102            9334 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens kinesin family member 21B (KIF21B), transcript variant
            3, mRNA.
ACCESSION   NM_001252102
VERSION     NM_001252102.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9334)
  AUTHORS   Liu,B., Qiang,L., Guan,B. and Ji,Z.
  TITLE     Targeting kinesin family member 21B by miR-132-3p represses cell
            proliferation, migration and invasion in gastric cancer
  JOURNAL   Bioengineered 13 (4), 9006-9018 (2022)
   PUBMED   35341446
  REMARK    GeneRIF: Targeting kinesin family member 21B by miR-132-3p
            represses cell proliferation, migration and invasion in gastric
            cancer.
REFERENCE   2  (bases 1 to 9334)
  AUTHORS   Hooikaas,P.J., Damstra,H.G., Gros,O.J., van Riel,W.E., Martin,M.,
            Smits,Y.T., van Loosdregt,J., Kapitein,L.C., Berger,F. and
            Akhmanova,A.
  TITLE     Kinesin-4 KIF21B limits microtubule growth to allow rapid
            centrosome polarization in T cells
  JOURNAL   Elife 9, e62876 (2020)
   PUBMED   33346730
  REMARK    GeneRIF: Kinesin-4 KIF21B limits microtubule growth to allow rapid
            centrosome polarization in T cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9334)
  AUTHORS   Asselin,L., Rivera Alvarez,J., Heide,S., Bonnet,C.S., Tilly,P.,
            Vitet,H., Weber,C., Bacino,C.A., Baranano,K., Chassevent,A.,
            Dameron,A., Faivre,L., Hanchard,N.A., Mahida,S., McWalter,K.,
            Mignot,C., Nava,C., Rastetter,A., Streff,H., Thauvin-Robinet,C.,
            Weiss,M.M., Zapata,G., Zwijnenburg,P.J.G., Saudou,F., Depienne,C.,
            Golzio,C., Heron,D. and Godin,J.D.
  TITLE     Mutations in the KIF21B kinesin gene cause neurodevelopmental
            disorders through imbalanced canonical motor activity
  JOURNAL   Nat Commun 11 (1), 2441 (2020)
   PUBMED   32415109
  REMARK    GeneRIF: Mutations in the KIF21B kinesin gene cause
            neurodevelopmental disorders through imbalanced canonical motor
            activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9334)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 9334)
  AUTHORS   van Riel,W.E., Rai,A., Bianchi,S., Katrukha,E.A., Liu,Q.,
            Heck,A.J., Hoogenraad,C.C., Steinmetz,M.O., Kapitein,L.C. and
            Akhmanova,A.
  TITLE     Kinesin-4 KIF21B is a potent microtubule pausing factor
  JOURNAL   Elife 6, e24746 (2017)
   PUBMED   28290984
  REMARK    GeneRIF: Thus, KIF21B combines microtubule-binding and regulatory
            activities that together constitute an autonomous microtubule
            pausing factor.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9334)
  AUTHORS   Franke,A., McGovern,D.P., Barrett,J.C., Wang,K.,
            Radford-Smith,G.L., Ahmad,T., Lees,C.W., Balschun,T., Lee,J.,
            Roberts,R., Anderson,C.A., Bis,J.C., Bumpstead,S., Ellinghaus,D.,
            Festen,E.M., Georges,M., Green,T., Haritunians,T., Jostins,L.,
            Latiano,A., Mathew,C.G., Montgomery,G.W., Prescott,N.J.,
            Raychaudhuri,S., Rotter,J.I., Schumm,P., Sharma,Y., Simms,L.A.,
            Taylor,K.D., Whiteman,D., Wijmenga,C., Baldassano,R.N., Barclay,M.,
            Bayless,T.M., Brand,S., Buning,C., Cohen,A., Colombel,J.F.,
            Cottone,M., Stronati,L., Denson,T., De Vos,M., D'Inca,R.,
            Dubinsky,M., Edwards,C., Florin,T., Franchimont,D., Gearry,R.,
            Glas,J., Van Gossum,A., Guthery,S.L., Halfvarson,J.,
            Verspaget,H.W., Hugot,J.P., Karban,A., Laukens,D., Lawrance,I.,
            Lemann,M., Levine,A., Libioulle,C., Louis,E., Mowat,C., Newman,W.,
            Panes,J., Phillips,A., Proctor,D.D., Regueiro,M., Russell,R.,
            Rutgeerts,P., Sanderson,J., Sans,M., Seibold,F., Steinhart,A.H.,
            Stokkers,P.C., Torkvist,L., Kullak-Ublick,G., Wilson,D.,
            Walters,T., Targan,S.R., Brant,S.R., Rioux,J.D., D'Amato,M.,
            Weersma,R.K., Kugathasan,S., Griffiths,A.M., Mansfield,J.C.,
            Vermeire,S., Duerr,R.H., Silverberg,M.S., Satsangi,J.,
            Schreiber,S., Cho,J.H., Annese,V., Hakonarson,H., Daly,M.J. and
            Parkes,M.
  TITLE     Genome-wide meta-analysis increases to 71 the number of confirmed
            Crohn's disease susceptibility loci
  JOURNAL   Nat Genet 42 (12), 1118-1125 (2010)
   PUBMED   21102463
REFERENCE   7  (bases 1 to 9334)
  AUTHORS   Goris,A., Boonen,S., D'hooghe,M.B. and Dubois,B.
  TITLE     Replication of KIF21B as a susceptibility locus for multiple
            sclerosis
  JOURNAL   J Med Genet 47 (11), 775-776 (2010)
   PUBMED   20587413
  REMARK    GeneRIF: Data show the association of SNPs in KIF21B with multiple
            sclerosis in a Belgian study population.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 9334)
  CONSRTM   International Multiple Sclerosis Genetics Consortium (IMSGC)
  TITLE     Comprehensive follow-up of the first genome-wide association study
            of multiple sclerosis identifies KIF21B and TMEM39A as
            susceptibility loci
  JOURNAL   Hum Mol Genet 19 (5), 953-962 (2010)
   PUBMED   20007504
  REMARK    GeneRIF: Comprehensive follow-up of the first genome-wide
            association study of multiple sclerosis identifies KIF21B as
            susceptibility loci
REFERENCE   9  (bases 1 to 9334)
  AUTHORS   Harada,M., Ishihara,Y., Itoh,K. and Yamanaka,R.
  TITLE     Kinesin superfamily protein-derived peptides with the ability to
            induce glioma-reactive cytotoxic T lymphocytes in human leukocyte
            antigen-A24+ glioma patients
  JOURNAL   Oncol Rep 17 (3), 629-636 (2007)
   PUBMED   17273744
REFERENCE   10 (bases 1 to 9334)
  AUTHORS   Marszalek,J.R., Weiner,J.A., Farlow,S.J., Chun,J. and
            Goldstein,L.S.
  TITLE     Novel dendritic kinesin sorting identified by different process
            targeting of two related kinesins: KIF21A and KIF21B
  JOURNAL   J Cell Biol 145 (3), 469-479 (1999)
   PUBMED   10225949
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358473.10, AB007918.2,
            BC137281.1, DR002414.1 and BC052964.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001252102.1.
            
            Summary: This gene encodes a member of the kinesin superfamily.
            Kinesins are ATP-dependent microtubule-based motor proteins that
            are involved in the intracellular transport of membranous
            organelles. Single nucleotide polymorphisms in this gene are
            associated with inflammatory bowel disease and multiple sclerosis.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Nov
            2011].
            
            Transcript Variant: This variant (3) differs in the 3' UTR and uses
            an alternate splice site in the 3' coding region, which results in
            a frameshift, compared to variant 1. The encoded isoform (3) is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137281.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000461742.7/ ENSP00000433808.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL358473.10        40520-40533         c
            15-306              AB007918.2         1-292
            307-5734            BC137281.1         1-5428
            5735-6135           DR002414.1         219-619
            6136-9334           BC052964.1         151-3349
FEATURES             Location/Qualifiers
     source          1..9334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..9334
                     /gene="KIF21B"
                     /note="kinesin family member 21B"
                     /db_xref="GeneID:23046"
                     /db_xref="HGNC:HGNC:29442"
                     /db_xref="MIM:608322"
     exon            1..372
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..5203
                     /gene="KIF21B"
                     /note="isoform 3 is encoded by transcript variant 3;
                     kinesin-like protein KIF21B"
                     /codon_start=1
                     /product="kinesin-like protein KIF21B isoform 3"
                     /protein_id="NP_001239031.1"
                     /db_xref="CCDS:CCDS58055.1"
                     /db_xref="GeneID:23046"
                     /db_xref="HGNC:HGNC:29442"
                     /db_xref="MIM:608322"
                     /translation="MAGQGDCCVKVAVRIRPQLSKEKIEGCHICTSVTPGEPQVLLGK
                     DKAFTYDFVFDLDTWQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFD
                     MATSEEEQGIIPRAIAHLFGGIAERKRRAQEQGVAGPEFKVSAQFLELYNEEILDLFD
                     STRDPDTRHRRSNIKIHEDANGGIYTTGVTSRLIHSQEELIQCLKQGALSRTTASTQM
                     NVQSSRSHAIFTIHLCQMRMCTQPDLVNEAVTGLPDGTPPSSEYETLTAKFHFVDLAG
                     SERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVPYRDSKLTRLLQDS
                     LGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQISALRAEI
                     ARLQMELMEYKAGKRVIGEDGAEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINN
                     RVTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSR
                     ASARSPYSLGASPAAPAFGGSPASSMEDASEVIRRAKQDLERLKKKEVRQRRKSPEKE
                     AFKKRAKLQQENSEETDENEAEEEEEERDESGCEEEEGREDEDEDSGSEESLVDSDSD
                     PEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQ
                     LERDRVLQNLSTMECYTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSR
                     YERELKKLQAEVAEMKKAKVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQI
                     RALESQKRQQEMVLRRKTQEVSALRRLAKPMSERVAGRAGLKPPMLDSGAEVSASTTS
                     SEAESGARSVSSIVRQWNRKINHFLGDHPAPTVNGTRPARKKFQKKGASQSFSKAARL
                     KWQSLERRIIDIVMQRMTIVNLEADMERLIKKREELFLLQEALRRKRERLQAESPEEE
                     KGLQELAEEIEVLAANIDYINDGITDCQATIVQLEETKEELDSTDTSVVISSCSLAEA
                     RLLLDNFLKASIDKGLQVAQKEAQIRLLEGRLRQTDMAGSSQNHLLLDALREKAEAHP
                     ELQALIYNVQQENGYASTDEEISEFSEGSFSQSFTMKGSTSHDDFKFKSEPKLSAQMK
                     AVSAECLGPPLDISTKNITKSLASLVEIKEDGVGFSVRDPYYRDRVSRTVSLPTRGST
                     FPRQSRATETSPLTRRKSYDRGQPIRSTDVGFTPPSSPPTRPRNDRNVFSRLTSNQSQ
                     GSALDKSDDSDSSLSEVLRGIISPVGGAKGARTAPLQCVSMAEGHTKPILCLDATDEL
                     LFTGSKDRSCKMWNLVTGQEIAALKGHPNNVVSIKYCSHSGLVFSVSTSYIKVWDIRD
                     SAKCIRTLTSSGQVISGDACAATSTRAITSAQGEHQINQIALSPSGTMLYAASGNAVR
                     IWELSRFQPVGKLTGHIGPVMCLTVTQTASQHDLVVTGSKDHYVKMFELGECVTGTIG
                     PTHNFEPPHYDGIECLAIQGDILFSGSRDNGIKKWDLDQQELIQQIPNAHKDWVCALA
                     FIPGRPMLLSACRAGVIKVWNVDNFTPIGEIKGHDSPINAICTNAKHIFTASSDLTVK
                     FWSVRRLPHSGPP"
     exon            373..595
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            596..778
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            779..928
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1063
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1231
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1347
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1543
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1733
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1797
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..2016
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2098
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2216
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2408
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2608
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2716
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2785
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..3018
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3166
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3361
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3463
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..3629
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3681
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            3682..3739
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3945
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4020
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4134
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            4135..4173
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            4174..4310
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            4311..4491
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            4492..4656
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            4657..4774
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            4775..4945
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            4946..5145
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     exon            5146..9334
                     /gene="KIF21B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9315..9320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF21B"
                     /note="hexamer: AATAAA"
     polyA_site      9334
                     /gene="KIF21B"
                     /note="major polyA site"
ORIGIN      
        1 gttcgcgctg cggcgggagg tggctgccgg gtgggaggtg tgtgcgcgtg tgccgcgccg
       61 tagggagcgg cgggtcgcgc cgccggctgt cagctagctc cgcgccgccg cccgatggcg
      121 cgaggaggcg cgcgggccca gccccggggg gccggccgcg ggtgagcccc tcggcctgcc
      181 gcccgcgagc atgtcacctc cagccgccgc cgccgcagcc tccgccagcc gcgcccgcgc
      241 ccccgcctcc cgcagccgca gccgctgcct cgggcattgg cccccagacc cccgcctctg
      301 atccacgccc agaccctagc tccagagggc catggccggc cagggggact gctgcgtcaa
      361 ggtggccgtc aggatccggc cccagctgtc gaaggagaag attgagggct gtcacatctg
      421 tacctctgtt accccgggag agccccaggt cctgctgggg aaggacaagg ccttcaccta
      481 tgactttgtc ttcgacctgg acacctggca agaacagatc tattccacct gtgtgagcaa
      541 gctcatcgag ggctgcttcg agggctataa tgccacggtg ctggcctatg ggcagacggg
      601 ggccgggaag acgtacacca tgggcactgg ctttgacatg gcaacgtcgg aggaggagca
      661 gggcatcatc ccgagggcca tcgcacacct ctttgggggc attgccgagc gcaagcgccg
      721 ggcacaggag cagggcgtgg ctggacctga gttcaaagtc agcgcccagt ttctggagct
      781 ctacaacgag gagatccttg acctgtttga cagcacccgt gaccctgaca cccgccaccg
      841 caggtccaac atcaagatcc acgaggacgc aaacggtggc atctacacca ctggcgtcac
      901 ttctcgcctc atccactccc aggaggagct gatccagtgc ctgaagcagg gggccctgtc
      961 ccgcaccaca gccagcaccc agatgaacgt gcagagctca cgctcccacg ccatcttcac
     1021 catccacctg tgccagatgc gcatgtgcac ccagcccgac ctggtgaatg aggcggtgac
     1081 tgggcttcct gatggtacac ctccctcgag tgagtatgag acactcactg ctaagtttca
     1141 ctttgtggac ctggccggct cagagcggct gaagcggaca ggggctactg gcgagcgggc
     1201 caaggagggc atctccatca actgtggcct gctggccttg ggcaatgtga tcagcgcctt
     1261 aggggaccag agcaagaagg tggtgcacgt tccctacagg gactccaagc tcactcggct
     1321 cctccaggat tcgctggggg gcaacagcca gaccatcatg atcgcctgtg tgagcccctc
     1381 agaccgagat ttcatggaga ccctcaacac actcaaatat gccaatcggg cccgcaacat
     1441 caagaacaag gtggtagtga accaggacaa gaccagccag caaatcagtg cactgcgggc
     1501 tgagattgct cggctgcaga tggagctgat ggagtataag gcgggcaagc gagtgatagg
     1561 agaggatggc gctgagggct atagtgatct gttccgagag aatgccatgc tacagaagga
     1621 gaatggggcc ctgcggctgc gggtgaaagc catgcaggag gccatcgatg ccatcaacaa
     1681 ccgcgtcacc cagctcatga gccaggaggc caacctgctg ctagccaagg ccggcgatgg
     1741 caatgaggcc attggtgcgc tgatccagaa ctacatccgg gagatcgagg agctacggac
     1801 taagcttcta gagagtgaag ccatgaacga gtccctgcgc cgcagcctct cacgggcctc
     1861 ggctaggagc ccctactccc tgggtgcttc tccagccgcc ccggccttcg ggggcagccc
     1921 tgccagctcc atggaggatg cctcggaggt gatccgcagg gccaagcagg acctggagcg
     1981 gctaaagaag aaggaggtca ggcagcggag gaagagcccc gagaaggaag ccttcaaaaa
     2041 gagggcaaaa ctccaacagg agaacagcga ggagacggat gagaacgagg cggaggagga
     2101 ggaggaagag cgagacgaga gtggctgtga ggaggaggaa gggcgcgagg atgaagatga
     2161 ggactcgggc agtgaagaga gcctggtgga ctcagactca gaccccgagg agaaggaggt
     2221 gaacttccag gcggacctgg ccgacctgac ttgtgagatc gaaatcaagc agaagctgat
     2281 cgacgagctg gagaacagcc agcggcggtt gcagacgctc aagcaccagt atgaggaaaa
     2341 gctgattctg ctgcagaaca agatccgaga cacacagctg gagcgcgacc gtgtgctgca
     2401 gaacctcagc accatggagt gctatactga ggagaaggcc aacaagatca aggcagacta
     2461 tgagaagagg ctgcgggaga tgaaccggga cctgcagaag ctgcaggccg cccagaaaga
     2521 gcacgcccgg ctgcttaaga accagtcgcg ctacgagagg gagctgaaga agctacaggc
     2581 cgaggtggct gagatgaaga aggccaaggt ggccctgatg aagcagatgc gtgaggagca
     2641 acagcggcgg cggctagtgg agaccaagag gaaccgggag atcgcacagc tcaagaagga
     2701 gcagcggcga caggagtttc agatccgagc tctggagtcc cagaagcggc agcaggagat
     2761 ggtcctgagg aggaagaccc aggaggtttc tgcactgagg cgcctggcca agcccatgtc
     2821 tgagcgggtg gcagggcgtg caggactaaa gccacccatg ctggactctg gggctgaggt
     2881 gtcggccagc actacctcat ctgaggctga atcaggggcc cgctctgtct ccagcatcgt
     2941 gcgccagtgg aaccgcaaaa tcaaccactt cttgggggac catcctgcgc ccactgtcaa
     3001 tggcacccgt cctgcccgaa agaagttcca gaagaagggg gccagccaga gcttcagtaa
     3061 ggcggcaagg ctcaagtggc agtccctgga gcgacggatc attgacatcg tcatgcagag
     3121 aatgaccatt gtcaacctgg aggctgacat ggagcggctc atcaagaaaa gggaggagct
     3181 gttcctcctg caggaggcac tgcggaggaa gcgggagcgg ctgcaggctg agagccccga
     3241 ggaagagaag gggctgcagg agctggctga ggagatcgag gtgctggcag ccaacattga
     3301 ctacatcaat gacggcatca ccgactgcca ggccaccatc gtgcagctgg aggagaccaa
     3361 ggaggagctg gactccacag acacatccgt ggtcatcagc tcctgctccc tggctgaagc
     3421 ccgcctcctg ctagacaact tcctcaaggc atccattgac aaggggctgc aagtggcaca
     3481 aaaggaagcc cagatccggc tgttggaggg ccgactgagg cagacggata tggcaggctc
     3541 ctcccagaac catctgctcc tggacgccct gcgtgagaag gctgaagctc accccgagct
     3601 gcaggccctc atctacaatg tgcagcagga gaatggctac gccagcacag atgaggagat
     3661 ctcagagttc tctgagggca gcttctccca gtcattcacc atgaaaggct ccaccagcca
     3721 tgacgatttc aagttcaaga gcgagcccaa actgtctgcc caaatgaaag ctgtgtcggc
     3781 tgagtgcctg ggccccccac tggatatctc caccaagaac atcaccaagt ccctggcctc
     3841 cctcgttgag atcaaagagg acggagtggg cttctctgtc cgagacccct attaccggga
     3901 cagggtctcg cgcaccgtca gtctgcctac ccggggcagc actttcccta ggcaatctcg
     3961 agccacagag acgtccccgc tgacgagaag gaagtcctac gaccgagggc agcccattag
     4021 gtccacagat gtgggattca cacccccatc atcccctccc actcggcccc gcaatgaccg
     4081 caatgtcttc tctcgtctca ccagtaatca gagccagggg tcagcgctgg acaagtctga
     4141 tgacagcgac tcctctttgt cggaggtcct gaggggcatc atctccccgg ttggaggagc
     4201 caagggtgca cggacggccc cactgcagtg tgtctccatg gccgaaggcc acaccaagcc
     4261 catcctctgc ctggatgcca cagatgagtt gctattcaca gggtccaaag accgaagctg
     4321 caagatgtgg aacttggtta cgggacagga gatcgcagct ctaaagggcc accccaacaa
     4381 cgtggtctcc atcaagtact gcagccactc ggggcttgtg ttctccgtgt ccacctccta
     4441 catcaaggtg tgggacatcc gggactcagc caagtgcatt cggactctca cgtcctcggg
     4501 ccaggtgatc tcaggggatg cctgtgccgc cacatccacc cgtgccatca ccagtgctca
     4561 gggcgagcat cagatcaacc agatcgccct cagcccttcg ggcaccatgc tgtacgccgc
     4621 ctcgggcaat gccgtccgca tctgggagct tagcaggttc cagcctgtcg gcaagctgac
     4681 tggccacatc ggccctgtga tgtgcctgac ggtcacccag acggccagcc agcatgacct
     4741 cgtggtgact ggctccaagg accactacgt taagatgttc gagctgggcg agtgtgtgac
     4801 gggcaccatc ggccccactc acaacttcga gcccccgcac tacgatggca tcgagtgtct
     4861 cgccatccag ggagacatcc tgttcagtgg ctcccgagat aacggcatca agaagtggga
     4921 cctagaccag caggagctca tccagcaaat ccccaatgcg cacaaggact gggtgtgcgc
     4981 cctggccttc atcccgggcc gccccatgct gctcagcgcc tgccgtgcgg gtgtcatcaa
     5041 ggtctggaac gtggacaact tcacacccat cggtgagatc aagggccacg acagtcccat
     5101 caatgccatc tgcaccaatg ccaagcatat cttcacagcc tccagtgacc tgacggtgaa
     5161 gttctggagt gtccggcggt taccccacag cggcccaccc taggagtgag gtcagaggga
     5221 tgcccccgga ccctcgaccc cagcagcctg gacaccatgg aagggaagct gtgacccggc
     5281 cgatggggcc agctgctctg gggacagagg gcgtggcccc ctctcctgcc ctcctccctc
     5341 tcccttggcc ttcccacagg acactgttcc ctcatccctc ccctgcctct caggagcctc
     5401 tgggtgagag agaggctggg gaggaaatta agctgtgaag ccaaagggca ttatcccttc
     5461 ttgttcccct cctggcagtc gtggccacat tgtctcctgc tgaaccggct ctgccccttt
     5521 ctcaggcctt tggcccagtg gtggagccct gtggggaggt gcagcagcct ggccccatcc
     5581 cacccttccg aggagctggc ctccccgctt ctcccagccc agcctctaga gccactgcac
     5641 ctgcctctga gcccaaaaag ataagtcctc aggtagctaa ggaaaccagg tgtgggcggc
     5701 tgggccttgc agctaaccct taaccctctg gcaacccgca gatagcccca actggcccca
     5761 acagttccct ggggtccctt ttggatgggg ccaaggtgga gctgctagaa agattccttt
     5821 ggggagatgg tcagaaatac ttcagttatt tattattttg ttatttttat tttttgctgt
     5881 tgcctcctgg aaacggactt gaagtttctt cccctatatt ctttccctca gctcttgggg
     5941 gccagaaatc ccaaagggag tccgctgccc cggccctcca gggccgcctc ctctgtttgc
     6001 tttgcagagg agggaactgc tccttcgact ctgcagctca ggcctgtccc cgacacagcc
     6061 cccagggagt cttctagcta cccctggcct ctaggccgcc tgacgctcag tgccttcctc
     6121 cgttccgggg cctggcaccc gtgccgggca gccttacacc agccatgccc gcggcaccac
     6181 atgtgtcttc tcactcgcga ggtcttgtgc ccagcgcccc cgggaaggcg ggggcgctca
     6241 ccccacagcc caggccccgg ggttctgccc cacagtcctg cgtgggccac gtaggaagca
     6301 gcatgggggc tgtgtctgct gggaggtggc ttggatgggg aggacagccc ggcaccctga
     6361 cccccgcccc tccccagccc tgcagtcccc cactgggccg gggagtctct ccagcttctc
     6421 tctctctggt tattcaggag acacattttc ggccttaaaa ctggcatgga gcgcaggccc
     6481 tcccttgcag aaaattatca aggaagaggg agttggcaga gtttctctgc cccggggctg
     6541 gggacgcgga gctccgggga aattgttaaa tcagtgttct ggcgccccct gttgggggaa
     6601 ctctggaatt acaggagtgg gccttggggg ggactgagct ccatccctct cccccgcccc
     6661 acccccaccc aaagttgccc accctgtttt tccgttgcat cgctggtctt gtgcttcccg
     6721 cttcagtctg ggagccaaga gccagcccca cctcccttca gaggacgcag tgacttttgg
     6781 actttccaga ggtggttctg tgtttctgcc cttggctcct ctccgtcttg ggctggggca
     6841 cttggagccc tctccatgtg gcgcccagtg ttggggggag gcaggctcca gtggaggctg
     6901 agtgaggcct ggtcccttcc ccgtgccctc ctcggagctg ccacagaggc taagacggct
     6961 gtcctgctgg tgctggccct gctggatgtg gtattgaagt ctggggcagc tgatagcagg
     7021 aaggagaccc ccttggatgc tggtctcctg ggacctgaac agtctgtcag caatggctgg
     7081 aaatccttct tcctctggcc accccggggg tgccgggcaa cccccttagc tctaagatgt
     7141 ggccacaaat ctcttcccac tcctccccgc caacctgaac agaaagtttt gaccttgcaa
     7201 cctgtaagaa agaatccgtc cgcatgactg tttacaagcg atagaaacac gtaagactct
     7261 gtccccttga gctcccaccc ccgggccggg gatgccccac ctggggtgac tgcactgtag
     7321 ctgcaaggcg tgttcttgca cgaagtgtga tcttatggcc ctgcgagagg tgctcatcat
     7381 catgcccatt ttctgctgtt tctgatgggt cagctacctc acggcggggc cagctctgct
     7441 gtcctggcaa gtgtcattga ctctctaaac ttgaagtcct tcaggagccc tgagcccaac
     7501 atccatgaga caccccgagt tgtgcttcat gagagttgga ttctctgccc actctttcag
     7561 ggatgtccaa ggtccatgtt agggggcagg cccccagctc cactcactgc acaagcaccc
     7621 taaatgttgg aagcacaaaa tggttgtgat ttgagcacaa tggcagggtc ccgcaggcag
     7681 acttgacagg cccaggcccg ggaggatccc cccacgttgg ctctgtccaa agtgagattg
     7741 ggggtgcctg tgtctgggac agggggctgc ccttgctcag accaggcctt ggctcatggc
     7801 ttgtcctaat tctgggactc gtcatcttac ttcttgccct tctgtgccca tcttaagact
     7861 ggaggctgag ccttgtcagg cccagccaca tctttacgcc atgggaccag gagtaaagcg
     7921 ctctctaaac cccgcacccc aaatctctaa acgcctgagt tcaggctgag tcctagccct
     7981 agtgagcctg aagagcttgg actgattccc agtctcctgg gtcaagcccc actttgtgct
     8041 ttcgaagctt atgagcgggt tccctggata gaaggagtct tccatcccca ctgcccttgg
     8101 gcctcttcag catagtcctg tgccagggcc ctgtcctcac tatcagtcag ttcagtattt
     8161 gctttcacgt gagtggcgga ctcttctgaa gcagccagaa ctctcaaagg cagcgcatgg
     8221 agttgccttg cgagatttcc aaggaaggag gaaagattaa caggcggagc ctggcacacc
     8281 caagcctttg aggtggtcag agtgccacct tcagcccctt gggaagggac agcggtgggt
     8341 ctgggagtgg cctcaccctg gattcagcct aggaatctct tcaccctcag ctgtccagcc
     8401 ctgctgcctg tctggggatg tgtggcctgg gcagagggca gtttaaagca caaaaccaca
     8461 tggggaaaac acaaggttgc ggggactttc tcatgtgcct gatgtggtgg agggagacac
     8521 cagcaggtgg ctgcagtgac gttagggaac ataacacttc tttgccctgc tagctctcag
     8581 ctctgggggg catcccccga tgtggtctgg gctgggagca ggcatatccc ctggttgttg
     8641 cctgtgcctg gtctgttcac catcgtgttt gtgtgggcag agcctgccct gcaggagcag
     8701 tgactttctt cccactgtgt gtcccggacc tgtggtatgt gtccctttgc catcccaaac
     8761 aggcaactgc ttgctgctct ccttgcttgg catagcctcc tggtcagtgg ccaatgcccc
     8821 acaggccttc ctgggcctgg ccctcctctc ctgactccca gatccttccc tgccctcttg
     8881 tgtgcaagga cagattttgc agggaaagtt ctgtttcttc tttgatacct ttgttctgtc
     8941 ccctgcccca tccccagcac tcatgatctt gaagccccta tcacactcta gttcagtcct
     9001 gtgaaccatg tcctgagggc cttgcaggga agtaggaaat agaaactcct ccacaaagag
     9061 ccgaggatca gagaagaccc ctgagatgaa tcagggccct gccctgccca ccaactcttt
     9121 tctagcaatc atgtcctgcc caggctgcag gcttcattag gctcctgctg tcctccatga
     9181 tgtgactagc acaaggtgta tatatgtttt gtacctctgc cgatggctgt acatagtgta
     9241 tgaaagttat ttaagcccca tgttgtacat ttctgttcct agattggatg tgtgtgttct
     9301 aagaagttgt cataaataaa acctgaatga ccaa
//
