LOCUS       NP_001239031            1623 aa            linear   PRI 20-SEP-2024
DEFINITION  kinesin-like protein KIF21B isoform 3 [Homo sapiens].
ACCESSION   NP_001239031
VERSION     NP_001239031.1
DBSOURCE    REFSEQ: accession NM_001252102.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1623)
  AUTHORS   Liu,B., Qiang,L., Guan,B. and Ji,Z.
  TITLE     Targeting kinesin family member 21B by miR-132-3p represses cell
            proliferation, migration and invasion in gastric cancer
  JOURNAL   Bioengineered 13 (4), 9006-9018 (2022)
   PUBMED   35341446
  REMARK    GeneRIF: Targeting kinesin family member 21B by miR-132-3p
            represses cell proliferation, migration and invasion in gastric
            cancer.
REFERENCE   2  (residues 1 to 1623)
  AUTHORS   Hooikaas,P.J., Damstra,H.G., Gros,O.J., van Riel,W.E., Martin,M.,
            Smits,Y.T., van Loosdregt,J., Kapitein,L.C., Berger,F. and
            Akhmanova,A.
  TITLE     Kinesin-4 KIF21B limits microtubule growth to allow rapid
            centrosome polarization in T cells
  JOURNAL   Elife 9, e62876 (2020)
   PUBMED   33346730
  REMARK    GeneRIF: Kinesin-4 KIF21B limits microtubule growth to allow rapid
            centrosome polarization in T cells.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1623)
  AUTHORS   Asselin,L., Rivera Alvarez,J., Heide,S., Bonnet,C.S., Tilly,P.,
            Vitet,H., Weber,C., Bacino,C.A., Baranano,K., Chassevent,A.,
            Dameron,A., Faivre,L., Hanchard,N.A., Mahida,S., McWalter,K.,
            Mignot,C., Nava,C., Rastetter,A., Streff,H., Thauvin-Robinet,C.,
            Weiss,M.M., Zapata,G., Zwijnenburg,P.J.G., Saudou,F., Depienne,C.,
            Golzio,C., Heron,D. and Godin,J.D.
  TITLE     Mutations in the KIF21B kinesin gene cause neurodevelopmental
            disorders through imbalanced canonical motor activity
  JOURNAL   Nat Commun 11 (1), 2441 (2020)
   PUBMED   32415109
  REMARK    GeneRIF: Mutations in the KIF21B kinesin gene cause
            neurodevelopmental disorders through imbalanced canonical motor
            activity.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1623)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 1623)
  AUTHORS   van Riel,W.E., Rai,A., Bianchi,S., Katrukha,E.A., Liu,Q.,
            Heck,A.J., Hoogenraad,C.C., Steinmetz,M.O., Kapitein,L.C. and
            Akhmanova,A.
  TITLE     Kinesin-4 KIF21B is a potent microtubule pausing factor
  JOURNAL   Elife 6, e24746 (2017)
   PUBMED   28290984
  REMARK    GeneRIF: Thus, KIF21B combines microtubule-binding and regulatory
            activities that together constitute an autonomous microtubule
            pausing factor.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1623)
  AUTHORS   Franke,A., McGovern,D.P., Barrett,J.C., Wang,K.,
            Radford-Smith,G.L., Ahmad,T., Lees,C.W., Balschun,T., Lee,J.,
            Roberts,R., Anderson,C.A., Bis,J.C., Bumpstead,S., Ellinghaus,D.,
            Festen,E.M., Georges,M., Green,T., Haritunians,T., Jostins,L.,
            Latiano,A., Mathew,C.G., Montgomery,G.W., Prescott,N.J.,
            Raychaudhuri,S., Rotter,J.I., Schumm,P., Sharma,Y., Simms,L.A.,
            Taylor,K.D., Whiteman,D., Wijmenga,C., Baldassano,R.N., Barclay,M.,
            Bayless,T.M., Brand,S., Buning,C., Cohen,A., Colombel,J.F.,
            Cottone,M., Stronati,L., Denson,T., De Vos,M., D'Inca,R.,
            Dubinsky,M., Edwards,C., Florin,T., Franchimont,D., Gearry,R.,
            Glas,J., Van Gossum,A., Guthery,S.L., Halfvarson,J.,
            Verspaget,H.W., Hugot,J.P., Karban,A., Laukens,D., Lawrance,I.,
            Lemann,M., Levine,A., Libioulle,C., Louis,E., Mowat,C., Newman,W.,
            Panes,J., Phillips,A., Proctor,D.D., Regueiro,M., Russell,R.,
            Rutgeerts,P., Sanderson,J., Sans,M., Seibold,F., Steinhart,A.H.,
            Stokkers,P.C., Torkvist,L., Kullak-Ublick,G., Wilson,D.,
            Walters,T., Targan,S.R., Brant,S.R., Rioux,J.D., D'Amato,M.,
            Weersma,R.K., Kugathasan,S., Griffiths,A.M., Mansfield,J.C.,
            Vermeire,S., Duerr,R.H., Silverberg,M.S., Satsangi,J.,
            Schreiber,S., Cho,J.H., Annese,V., Hakonarson,H., Daly,M.J. and
            Parkes,M.
  TITLE     Genome-wide meta-analysis increases to 71 the number of confirmed
            Crohn's disease susceptibility loci
  JOURNAL   Nat Genet 42 (12), 1118-1125 (2010)
   PUBMED   21102463
REFERENCE   7  (residues 1 to 1623)
  AUTHORS   Goris,A., Boonen,S., D'hooghe,M.B. and Dubois,B.
  TITLE     Replication of KIF21B as a susceptibility locus for multiple
            sclerosis
  JOURNAL   J Med Genet 47 (11), 775-776 (2010)
   PUBMED   20587413
  REMARK    GeneRIF: Data show the association of SNPs in KIF21B with multiple
            sclerosis in a Belgian study population.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (residues 1 to 1623)
  CONSRTM   International Multiple Sclerosis Genetics Consortium (IMSGC)
  TITLE     Comprehensive follow-up of the first genome-wide association study
            of multiple sclerosis identifies KIF21B and TMEM39A as
            susceptibility loci
  JOURNAL   Hum Mol Genet 19 (5), 953-962 (2010)
   PUBMED   20007504
  REMARK    GeneRIF: Comprehensive follow-up of the first genome-wide
            association study of multiple sclerosis identifies KIF21B as
            susceptibility loci
REFERENCE   9  (residues 1 to 1623)
  AUTHORS   Harada,M., Ishihara,Y., Itoh,K. and Yamanaka,R.
  TITLE     Kinesin superfamily protein-derived peptides with the ability to
            induce glioma-reactive cytotoxic T lymphocytes in human leukocyte
            antigen-A24+ glioma patients
  JOURNAL   Oncol Rep 17 (3), 629-636 (2007)
   PUBMED   17273744
REFERENCE   10 (residues 1 to 1623)
  AUTHORS   Marszalek,J.R., Weiner,J.A., Farlow,S.J., Chun,J. and
            Goldstein,L.S.
  TITLE     Novel dendritic kinesin sorting identified by different process
            targeting of two related kinesins: KIF21A and KIF21B
  JOURNAL   J Cell Biol 145 (3), 469-479 (1999)
   PUBMED   10225949
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358473.10, AB007918.2,
            BC137281.1, DR002414.1 and BC052964.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the kinesin superfamily.
            Kinesins are ATP-dependent microtubule-based motor proteins that
            are involved in the intracellular transport of membranous
            organelles. Single nucleotide polymorphisms in this gene are
            associated with inflammatory bowel disease and multiple sclerosis.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Nov
            2011].
            
            Transcript Variant: This variant (3) differs in the 3' UTR and uses
            an alternate splice site in the 3' coding region, which results in
            a frameshift, compared to variant 1. The encoded isoform (3) is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137281.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000461742.7/ ENSP00000433808.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1623
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     Protein         1..1623
                     /product="kinesin-like protein KIF21B isoform 3"
                     /note="kinesin-like protein KIF21B"
                     /calculated_mol_wt=181015
     Region          7..371
                     /region_name="KISc_KIF4"
                     /note="Kinesin motor domain, KIF4-like subfamily; cd01372"
                     /db_xref="CDD:276823"
     Site            order(16,87,90,92..95,273)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276823"
     Site            order(323,326,329)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276823"
     Region          379..>539
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          400..1099
                     /region_name="Interaction with TRIM3.
                     /evidence=ECO:0000250|UniProtKB:Q9QXL1"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Region          <472..>1064
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          509..538
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Region          552..628
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Site            579
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9QXL1; propagated from
                     UniProtKB/Swiss-Prot (O75037.2)"
     Site            582
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9QXL1; propagated from
                     UniProtKB/Swiss-Prot (O75037.2)"
     Region          633..>842
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          830..865
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Region          880..906
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Region          929..1010
                     /region_name="Rcc_KIF21B"
                     /note="regulatory coiled-coil domain found in kinesin-like
                     protein KIF21B; cd22262"
                     /db_xref="CDD:410203"
     Site            order(932..933,936..937,939..940,943..944,946..947,
                     950..951,953..954,957..958,960..961,964..965,968,971..972,
                     978..979,981..982,985..986,988..989,992..993,995..996,
                     999..1000,1002..1003,1006..1007)
                     /site_type="other"
                     /note="putative homodimer interface [polypeptide binding]"
                     /db_xref="CDD:410203"
     Site            1149
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O75037.2)"
     Site            1167
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O75037.2)"
     Region          1194..1251
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Site            1215
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O75037.2)"
     Site            1237
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692;
                     propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Site            1241
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (O75037.2)"
     Region          1305..1613
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Region          1306..1343
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Site            order(1307,1323,1327,1333..1334,1346..1347,1365,
                     1374..1375,1388..1389,1428,1438..1439,1452,1472,1477,
                     1483..1484,1501,1503,1519,1523,1529..1530,1543..1544,1561,
                     1566,1572..1573,1585..1586,1602,1606,1612..1613)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          1312..1346
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1346..1384
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Region          1351..1387
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1407..1450
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1410..1448
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Region          1451..1493
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Region          1456..1500
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1502..1539
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Region          1509..1541
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1543..1582
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (O75037.2)"
     Region          1548..1572
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1590..1612
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1623
                     /gene="KIF21B"
                     /coded_by="NM_001252102.2:332..5203"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS58055.1"
                     /db_xref="GeneID:23046"
                     /db_xref="HGNC:HGNC:29442"
                     /db_xref="MIM:608322"
ORIGIN      
        1 magqgdccvk vavrirpqls kekiegchic tsvtpgepqv llgkdkafty dfvfdldtwq
       61 eqiystcvsk liegcfegyn atvlaygqtg agktytmgtg fdmatseeeq giipraiahl
      121 fggiaerkrr aqeqgvagpe fkvsaqflel yneeildlfd strdpdtrhr rsnikiheda
      181 nggiyttgvt srlihsqeel iqclkqgals rttastqmnv qssrshaift ihlcqmrmct
      241 qpdlvneavt glpdgtppss eyetltakfh fvdlagserl krtgatgera kegisincgl
      301 lalgnvisal gdqskkvvhv pyrdskltrl lqdslggnsq timiacvsps drdfmetlnt
      361 lkyanrarni knkvvvnqdk tsqqisalra eiarlqmelm eykagkrvig edgaegysdl
      421 frenamlqke ngalrlrvka mqeaidainn rvtqlmsqea nlllakagdg neaigaliqn
      481 yireieelrt klleseamne slrrslsras arspyslgas paapafggsp assmedasev
      541 irrakqdler lkkkevrqrr kspekeafkk raklqqense etdeneaeee eeerdesgce
      601 eeegredede dsgseeslvd sdsdpeekev nfqadladlt ceieikqkli delensqrrl
      661 qtlkhqyeek lillqnkird tqlerdrvlq nlstmecyte ekankikady ekrlremnrd
      721 lqklqaaqke harllknqsr yerelkklqa evaemkkakv almkqmreeq qrrrlvetkr
      781 nreiaqlkke qrrqefqira lesqkrqqem vlrrktqevs alrrlakpms ervagraglk
      841 ppmldsgaev sasttsseae sgarsvssiv rqwnrkinhf lgdhpaptvn gtrparkkfq
      901 kkgasqsfsk aarlkwqsle rriidivmqr mtivnleadm erlikkreel fllqealrrk
      961 rerlqaespe eekglqelae eievlaanid yindgitdcq ativqleetk eeldstdtsv
     1021 visscslaea rllldnflka sidkglqvaq keaqirlleg rlrqtdmags sqnhllldal
     1081 rekaeahpel qaliynvqqe ngyastdeei sefsegsfsq sftmkgstsh ddfkfksepk
     1141 lsaqmkavsa eclgppldis tknitkslas lveikedgvg fsvrdpyyrd rvsrtvslpt
     1201 rgstfprqsr atetspltrr ksydrgqpir stdvgftpps spptrprndr nvfsrltsnq
     1261 sqgsaldksd dsdsslsevl rgiispvgga kgartaplqc vsmaeghtkp ilcldatdel
     1321 lftgskdrsc kmwnlvtgqe iaalkghpnn vvsikycshs glvfsvstsy ikvwdirdsa
     1381 kcirtltssg qvisgdacaa tstraitsaq gehqinqial spsgtmlyaa sgnavriwel
     1441 srfqpvgklt ghigpvmclt vtqtasqhdl vvtgskdhyv kmfelgecvt gtigpthnfe
     1501 pphydgiecl aiqgdilfsg srdngikkwd ldqqeliqqi pnahkdwvca lafipgrpml
     1561 lsacragvik vwnvdnftpi geikghdspi naictnakhi ftassdltvk fwsvrrlphs
     1621 gpp
//
