LOCUS       NM_001173464            6371 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens kinesin family member 21A (KIF21A), transcript variant
            1, mRNA.
ACCESSION   NM_001173464
VERSION     NM_001173464.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6371)
  AUTHORS   Bhola,P.T., Mishra,R., Posey,J.E., Hamilton,L.E., Graham,G.E.,
            Punetha,J., Lupski,J.R., Boycott,K.M., D'Amours,D. and
            Kernohan,K.D.
  CONSRTM   Care4Rare Canada Consortium
  TITLE     Phenotypic heterogeneity associated with KIF21A: Two new cases and
            review of the literature
  JOURNAL   Am J Med Genet A 194 (3), e63455 (2024)
   PUBMED   37921537
  REMARK    GeneRIF: Phenotypic heterogeneity associated with KIF21A: Two new
            cases and review of the literature.
            Review article
REFERENCE   2  (bases 1 to 6371)
  AUTHORS   Falb,R.J., Muller,A.J., Klein,W., Grimmel,M., Grasshoff,U.,
            Spranger,S., Stobe,P., Gauck,D., Kuechler,A., Dikow,N.,
            Schwaibold,E.M.C., Schmidt,C., Averdunk,L., Buchert,R.,
            Heinrich,T., Prodan,N., Park,J., Kehrer,M., Sturm,M., Kelemen,O.,
            Hartmann,S., Horn,D., Emmerich,D., Hirt,N., Neumann,A.,
            Kristiansen,G., Gembruch,U., Haen,S., Siebert,R., Hentze,S.,
            Hoopmann,M., Ossowski,S., Waldmuller,S., Beck-Wodl,S., Glaser,D.,
            Tekesin,I., Distelmaier,F., Riess,O., Kagan,K.O., Dufke,A. and
            Haack,T.B.
  TITLE     Bi-allelic loss-of-function variants in KIF21A cause severe fetal
            akinesia with arthrogryposis multiplex
  JOURNAL   J Med Genet 60 (1), 48-56 (2023)
   PUBMED   34740919
  REMARK    GeneRIF: Bi-allelic loss-of-function variants in KIF21A cause
            severe fetal akinesia with arthrogryposis multiplex.
REFERENCE   3  (bases 1 to 6371)
  AUTHORS   Xia,C.R., Shi,L.H., Nan,J., Hao,Y.Z. and Jia,Y.
  TITLE     [Identification of a novel KIF21A gene mutation in a Chinese family
            with congenital fibrosis of the extraocular muscles]
  JOURNAL   Zhonghua Yan Ke Za Zhi 58 (3), 213-214 (2022)
   PUBMED   35280030
  REMARK    GeneRIF: [Identification of a novel KIF21A gene mutation in a
            Chinese family with congenital fibrosis of the extraocular
            muscles].
REFERENCE   4  (bases 1 to 6371)
  AUTHORS   Lucanus,A.J., Thike,A.A., Tan,X.F., Lee,K.W., Guo,S., King,V.P.C.,
            Yap,V.B., Bay,B.H., Tan,P.H. and Yip,G.W.
  TITLE     KIF21A regulates breast cancer aggressiveness and is prognostic of
            patient survival and tumor recurrence
  JOURNAL   Breast Cancer Res Treat 191 (1), 63-75 (2022)
   PUBMED   34698969
  REMARK    GeneRIF: KIF21A regulates breast cancer aggressiveness and is
            prognostic of patient survival and tumor recurrence.
REFERENCE   5  (bases 1 to 6371)
  AUTHORS   Xu,Y., Guo,C., Pan,W., Zhao,C., Ding,Y., Xie,X., Wei,Z., Sun,Y. and
            Yu,C.
  TITLE     Nephrotic-syndrome-associated mutation of KANK2 induces pathologic
            binding competition with physiological interactor KIF21A
  JOURNAL   J Biol Chem 297 (2), 100958 (2021)
   PUBMED   34274317
  REMARK    GeneRIF: Nephrotic-syndrome-associated mutation of KANK2 induces
            pathologic binding competition with physiological interactor
            KIF21A.
REFERENCE   6  (bases 1 to 6371)
  AUTHORS   Magli,A., de Berardinis,T., D'Esposito,F. and Gagliardi,V.
  TITLE     Clinical and surgical data of affected members of a classic CFEOM I
            family
  JOURNAL   BMC Ophthalmol 3, 6 (2003)
   PUBMED   12702216
  REMARK    GeneRIF: Surgery is effective at improving ptosis in the majority
            of patients with classic CFEOM (congenital fibiosis of the
            extraocular muscles).
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6371)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   8  (bases 1 to 6371)
  AUTHORS   Marszalek,J.R., Weiner,J.A., Farlow,S.J., Chun,J. and
            Goldstein,L.S.
  TITLE     Novel dendritic kinesin sorting identified by different process
            targeting of two related kinesins: KIF21A and KIF21B
  JOURNAL   J Cell Biol 145 (3), 469-479 (1999)
   PUBMED   10225949
REFERENCE   9  (bases 1 to 6371)
  AUTHORS   Engle,E.C., Kunkel,L.M., Specht,L.A. and Beggs,A.H.
  TITLE     Mapping a gene for congenital fibrosis of the extraocular muscles
            to the centromeric region of chromosome 12
  JOURNAL   Nat Genet 7 (1), 69-73 (1994)
   PUBMED   8075644
REFERENCE   10 (bases 1 to 6371)
  AUTHORS   Whitman,M.C., Jurgens,J.A., Hunter,D.G. and Engle,E.C.
  TITLE     Congenital Fibrosis of the Extraocular Muscles Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301522
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB290166.1, AY368076.1,
            AB051495.2 and AW131223.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001173464.1.
            
            Summary: This gene encodes a member of the KIF4 subfamily of
            kinesin-like motor proteins. The encoded protein is characterized
            by an N-terminal motor domain a coiled-coil stalk domain and a
            C-terminal WD-40 repeat domain. This protein may be involved in
            microtubule dependent transport. Mutations in this gene are the
            cause of congenital fibrosis of extraocular muscles-1. Alternate
            splicing results in multiple transcript variants.[provided by
            RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY368076.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361418.10/ ENSP00000354878.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AB290166.1         271-404
            135-5178            AY368076.1         1-5044
            5179-6370           AB051495.2         4979-6170
            6371-6371           AW131223.1         13-13               c
FEATURES             Location/Qualifiers
     source          1..6371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..6371
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /note="kinesin family member 21A"
                     /db_xref="GeneID:55605"
                     /db_xref="HGNC:HGNC:19349"
                     /db_xref="MIM:608283"
     exon            1..194
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..5175
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinesin-like protein KIF2; renal carcinoma antigen
                     NY-REN-62"
                     /codon_start=1
                     /product="kinesin-like protein KIF21A isoform 1"
                     /protein_id="NP_001166935.1"
                     /db_xref="CCDS:CCDS53776.1"
                     /db_xref="GeneID:55605"
                     /db_xref="HGNC:HGNC:19349"
                     /db_xref="MIM:608283"
                     /translation="MLGAPDESSVRVAVRIRPQLAKEKIEGCHICTSVTPGEPQVFLG
                     KDKAFTFDYVFDIDSQQEQIYIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGF
                     DVNIVEEELGIISRAVKHLFKSIEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLF
                     DTTRDIDAKSKKSNIRIHEDSTGGIYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQ
                     MNVQSSRSHAIFTIHVCQTRVCPQIDADNATDNKIISESAQMNEFETLTAKFHFVDLA
                     GSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATHVPYRDSKLTRLLQD
                     SLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQQINALRSE
                     ITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDALR
                     SRITQLVSDQANHVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLT
                     RATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKRLQKLEESN
                     REERSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDI
                     DGGESSDESDSESDEKANYQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKL
                     MMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQAAQK
                     EHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEEQEKARLTESRRNREIAQL
                     KKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVTRKLSSSD
                     APAQDTGSSAAAVETDASRTGAQQKMRIPVARVQALPTPATNGNRKKYQRKGLTGRVF
                     ISKTARMKWQLLERRVTDIIMQKMTISNMEADMNRLLKQREELTKRREKLSKRREKIV
                     KENGEGDKNVANINEEMESLTANIDYINDSISDCQANIMQMEEAKEEGETLDVTAVIN
                     ACTLTEARYLLDHFLSMGINKGLQAAQKEAQIKVLEGRLKQTEITSATQNQLLFHMLK
                     EKAELNPELDALLGHALQDLDSVPLENVEDSTDEDAPLNSPGSEGSTLSSDLMKLCGE
                     VKPKNKARRRTTTQMELLYADSSELASDTSTGDASLPGPLTPVAEGQEIGMNTETSGT
                     SAREKELSPPPGLPSKIGSISRQSSLSEKKIPEPSPVTRRKAYEKAEKSKAKEQKHSD
                     SGTSEASLSPPSSPPSRPRNELNVFNRLTVSQGNTSVQQDKSDESDSSLSEVHRSSRR
                     GIINPFPASKGIRAFPLQCIHIAEGHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQ
                     EIMSLGGHPNNVVSVKYCNYTSLVFTVSTSYIKVWDIRDSAKCIRTLTSSGQVTLGDA
                     CSASTSRTVAIPSGENQINQIALNPTGTFLYAASGNAVRMWDLKRFQSTGKLTGHLGP
                     VMCLTVDQISSGQDLIITGSKDHYIKMFDVTEGALGTVSPTHNFEPPHYDGIEALTIQ
                     GDNLFSGSRDNGIKKWDLTQKDLLQQVPNAHKDWVCALGVVPDHPVLLSGCRGGILKV
                     WNMDTFMPVGEMKGHDSPINAICVNSTHIFTAADDRTVRIWKARNLQDGQISDTGDLG
                     EDIASN"
     exon            195..417
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            418..600
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            601..750
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            751..885
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1053
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1169
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1365
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1555
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1619
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1823
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1862
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1953
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2071
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2260
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2460
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2568
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2637
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2852
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3006
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3201
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3303
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3469
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3490
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..3551
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3606
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3821
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3822..3929
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            3930..4058
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4059..4097
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4098..4109
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4110..4246
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4247..4427
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4428..4592
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4593..4710
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4711..4881
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..5081
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     exon            5082..6371
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6348..6353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /note="hexamer: AATAAA"
     polyA_site      6371
                     /gene="KIF21A"
                     /gene_synonym="CFEOM1; FEOM1; FEOM3A"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcccaa catggctgga gcgcggcgga ggtgagccgg ccgcccgccc gcagacgccc
       61 cagcctactg cgcccgagtc ccgcggcccc agtggcgcct cagctctgcg gtgccgaggc
      121 ccaacggctc gatcgctgcc cgccgccagc atgttgggcg ccccggacga gagctccgtg
      181 cgggtggctg tcagaataag accacagctt gccaaagaga agattgaagg atgccatatt
      241 tgtacatctg tcacaccagg agagcctcag gtcttcctag ggaaagataa ggcttttact
      301 tttgactatg tatttgacat tgactcccag caagagcaga tctacattca atgtatagaa
      361 aaactaattg aaggttgctt tgaaggatac aatgctacag tttttgctta tggacaaact
      421 ggagctggta aaacatacac aatgggaaca ggatttgatg ttaacattgt tgaggaagaa
      481 ctgggtatta tttctcgagc tgttaaacac ctttttaaga gtattgaaga aaaaaaacac
      541 atagcaatta aaaatgggct tcctgctcca gattttaaag tgaatgccca attcttagag
      601 ctctataatg aagaggtcct tgacttattt gataccactc gtgatattga tgcaaaaagt
      661 aaaaaatcaa atataagaat tcatgaagat tcaactggag gaatttatac tgtgggcgtt
      721 acaacacgta ctgtgaatac agaatcagag atgatgcagt gtttgaagtt gggtgcttta
      781 tcccggacaa ctgccagtac ccagatgaat gttcagagct ctcgttcaca tgccattttt
      841 accattcatg tgtgtcaaac cagagtgtgt ccccaaatag atgctgacaa tgcaactgat
      901 aataaaatta tttctgaatc agcacagatg aatgaatttg aaaccctgac tgcaaagttc
      961 cattttgttg atctcgcagg atctgaaaga ctgaagcgta ctggagctac aggcgagagg
     1021 gcaaaagaag gcatttctat caactgtgga cttttggcac ttggcaatgt aataagtgcc
     1081 ttgggagaca agagcaagag ggccacacat gtcccctata gagattccaa gctaacaaga
     1141 ctactacagg attccctcgg gggtaatagc caaacaatca tgatagcatg tgtcagccct
     1201 tcagacagag actttatgga aacgttaaac accctgaaat acgccaatcg agctagaaat
     1261 atcaagaata aggtgatggt caatcaggac agagctagtc agcaaatcaa tgcacttcgt
     1321 agtgaaatca cacgacttca gatggagctc atggagtaca aaacaggtaa aagaataatt
     1381 gacgaagagg gtgtggaaag catcaatgac atgtttcatg agaatgctat gctacagact
     1441 gaaaataata acctgcgtgt aagaattaaa gccatgcaag agacggttga tgcattgagg
     1501 tccagaatta cacagcttgt tagtgatcag gccaaccatg ttcttgccag agcaggtgaa
     1561 ggaaatgagg agattagtaa tatgattcat agttatataa aagaaatcga agatctcagg
     1621 gcaaaattat tagaaagtga agcagtgaat gagaaccttc gaaaaaactt gacaagagcc
     1681 acagcaagag cgccatattt cagcggatca tcaacttttt ctcctaccat actatcctca
     1741 gacaaagaaa ccattgaaat tatagaccta gcaaaaaaag atttagagaa gttgaaaaga
     1801 aaagaaaaga ggaagaaaaa aaggctacag aaacttgagg aaagcaatcg agaagaaaga
     1861 agtgtggctg gtaaagagga taatacagac actgaccaag agaagaaaga agaaaagggt
     1921 gtttcggaaa gagaaaacaa tgaattagaa gtggaagaaa gtcaagaagt gagtgatcat
     1981 gaggatgaag aagaggagga ggaggaggag gaagatgaca ttgatggggg tgaaagttct
     2041 gatgaatcag attctgaatc agatgaaaaa gccaattatc aagcagactt ggcaaacatt
     2101 acttgtgaaa ttgcaattaa gcaaaagctg attgatgaac tagaaaacag ccagaaaaga
     2161 ctgcagactc tgaaaaagca gtatgaagag aagctaatga tgctgcaaca taaaattcgg
     2221 gatactcagc ttgaaagaga ccaggtgctt caaaacttag gctcggtaga atcttactca
     2281 gaagaaaaag caaaaaaagt taggtctgaa tatgaaaaga aactccaagc catgaacaaa
     2341 gaactgcaga gacttcaagc agctcaaaaa gaacatgcaa ggttgcttaa aaatcagtct
     2401 cagtatgaaa agcaattgaa gaaattgcag caggatgtga tggaaatgaa aaaaacaaag
     2461 gttcgcctaa tgaaacaaat gaaagaagaa caagagaaag ccagactgac tgagtctaga
     2521 agaaacagag agattgctca gttgaaaaag gatcaacgta aaagagatca tcaacttaga
     2581 cttctggaag cccaaaaaag aaaccaagaa gtggttctac gtcgcaaaac tgaagaggtt
     2641 acggctcttc gtcggcaagt aagacccatg tcagataaag tggctgggaa agttactcgg
     2701 aagctgagtt catctgatgc acctgctcag gacacaggtt ccagtgcagc tgctgtcgaa
     2761 acagatgcat caaggacagg agcccagcag aaaatgagaa ttcctgtggc gagagtccag
     2821 gccttaccaa cgccggcaac aaatggaaac aggaaaaaat atcagaggaa aggattgact
     2881 ggccgagtgt ttatttccaa gacagctcgc atgaagtggc agctccttga gcgcagggtc
     2941 acagacatca tcatgcagaa gatgaccatt tccaacatgg aggcagatat gaatagactc
     3001 ctcaagcaac gggaggaact cacaaaaaga cgagagaaac tttcaaaaag aagggagaag
     3061 atagtcaagg agaatggaga gggagataaa aatgtggcta atatcaatga agagatggag
     3121 tcactgactg ctaatatcga ttacatcaat gacagtattt ctgattgtca ggccaacata
     3181 atgcagatgg aagaagcaaa ggaagaaggt gagacattgg atgttactgc agtcattaat
     3241 gcctgcaccc ttacagaagc ccgatacctg ctagatcact tcctgtcaat gggcatcaat
     3301 aagggtcttc aggctgccca gaaagaggct caaattaaag tactggaagg tcgactcaaa
     3361 caaacagaaa taaccagtgc tacccaaaac cagctcttat tccatatgtt gaaagagaag
     3421 gcagaattaa atcctgagct agatgcttta ctaggccatg ctttacaaga tctagatagc
     3481 gtaccattag aaaatgtaga ggatagtact gatgaggatg ctcctttaaa cagcccagga
     3541 tcagaaggaa gcacgctgtc ttcagatctc atgaagcttt gtggtgaagt gaaacctaag
     3601 aacaaggccc gaaggagaac caccactcag atggaattgc tgtatgcaga tagcagtgaa
     3661 ctagcttcag acactagtac aggagatgcc tccttgcctg gccctctcac acctgttgca
     3721 gaagggcaag agattggaat gaatacagag acaagtggta cttctgctag ggaaaaagag
     3781 ctctctcccc cacctggctt accttctaag ataggcagca tttccaggca gtcatctcta
     3841 tcagaaaaaa aaattccaga gccttctcct gtaacaagga gaaaggcata tgagaaagca
     3901 gaaaaatcaa aggccaagga acaaaagcac tcagattctg gaacttcaga ggctagtctt
     3961 tcacctcctt cttccccacc aagccggccc cgtaatgaac tgaatgtttt taatcgtctt
     4021 actgtttctc agggaaacac atcagttcag caggataagt ctgatgaaag tgactcctct
     4081 ctctcggagg tacacagatc ctccagaagg ggcataatca acccatttcc tgcttcaaaa
     4141 ggaatcagag cttttccact tcagtgtatt cacatagctg aagggcatac aaaagctgtg
     4201 ctctgtgtgg attctactga tgatctcctc ttcactggat caaaagatcg tacttgtaaa
     4261 gtatggaatc tggtgactgg gcaggaaata atgtcactgg ggggtcatcc caacaatgtc
     4321 gtgtctgtaa aatactgtaa ttataccagt ttggtcttca ctgtatcaac atcttatatt
     4381 aaggtgtggg atatcagaga ttcagcaaag tgcattcgaa cactaacgtc ttcaggtcaa
     4441 gttactcttg gagatgcttg ttctgcaagt accagtcgaa cagtagctat tccttctgga
     4501 gagaaccaga tcaatcaaat tgccctaaac ccaactggca ccttcctcta tgctgcttct
     4561 ggaaatgctg tcaggatgtg ggatcttaaa aggtttcagt ctacaggaaa gttaacagga
     4621 cacctaggcc ctgttatgtg ccttactgtg gatcagattt ccagtggaca agatctaatc
     4681 atcactggct ccaaggatca ttacatcaaa atgtttgatg ttacagaagg agctcttggg
     4741 actgtgagtc ccacccacaa ttttgaaccc cctcattatg atggcataga agcactaacc
     4801 attcaagggg ataacctatt tagtgggtct agagataatg gaatcaagaa atgggactta
     4861 actcaaaaag accttcttca gcaagttcca aatgcacata aggattgggt ctgtgccctg
     4921 ggagtggtgc cagaccaccc agttttgctc agtggctgca gagggggcat tttgaaagtc
     4981 tggaacatgg atacttttat gccagtggga gagatgaagg gtcatgatag tcctatcaat
     5041 gccatatgtg ttaattccac ccacattttt actgcagctg atgatcgaac tgtgagaatt
     5101 tggaaggctc gcaatttgca agatggtcag atctctgaca caggagatct gggggaagat
     5161 attgccagta attaaacatg aatgaagata ggttgtaaac tgaatgctgt gataatactc
     5221 tgtattcttt atggaaaatg ttgtcctgta cttactaggc aaaacgtatg aatcggatta
     5281 actggaaaat atatctgaat tcaactgctg actataaatg gtattctaat aaaattgtgt
     5341 actatcctgt gtgcttagtt ttaagatcaa ccaatagata tatatcctac aattgatata
     5401 ttgctttatt cacactttta ttgtggctga atttttgtgc ctatctataa aacacacttt
     5461 caaattattt gaattaccaa gacgtctgct tttgtgacag tcagaaaaca cacctggaat
     5521 acgatgcagc ccaccattaa ctcattcatg tagtttattc aagtgattta tgtatttaaa
     5581 ctaaatattg aaaatgttag tcaaattgtg gtttgcttgt caggtattta tatcagtctg
     5641 tagtggattc ccaaatttca aagctctttt aatgtaatgg acaaaaataa gatatgagaa
     5701 tattattgat gaattttcat aaggtggaat tgatcttaat ctactaacag agaagggtag
     5761 acagtttgtg ttaaatgttg gcatttactt gtattgacca aagttttgca gctctactat
     5821 attctgtgct caggactaaa atgctgttaa tttttttttt tttttccagt gctgtgcata
     5881 tattctgtga tgggaaacat tgttgatgtc ctaacagaaa tatattttga tctattttcc
     5941 tatggagttg tttctattat gaccatttaa ttttgttttt atttaatagt agtatttcct
     6001 tcccttttat ctaatttttt atatgctgct aaatatattt taaatatact atgtttgcga
     6061 accttggtag ctatgatgag agctattatc atctgtggtg ggaaaagcta tgtaaatagg
     6121 tagattgtat agagagacta tcttgtgttg tgcctgtatg aatttttaaa agttgttgac
     6181 tggattttgc aaaaggatgt ataatatttc tgtctgctca gaatattaat ttgtaaattc
     6241 tgcaagttta atttttatgt agatggtata acatttgaaa atattgtctt atgtgatttt
     6301 ttcccctgaa aatatttgct tgtaaatgaa aacttagcta gggcttaaat aaacatgttg
     6361 ctatgaaatt a
//
