LOCUS       NM_001284259            6441 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens kinesin family member 20B (KIF20B), transcript variant
            1, mRNA.
ACCESSION   NM_001284259 XM_005270290
VERSION     NM_001284259.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6441)
  AUTHORS   Mbugua,R.W., Takano,A., Tsevegjav,B., Yokose,T., Yamashita,T.,
            Miyagi,Y. and Daigo,Y.
  TITLE     Characterization of KIF20B as a novel prognostic biomarker and
            therapeutic target for breast cancer
  JOURNAL   Int J Oncol 64 (4) (2024)
   PUBMED   38426627
  REMARK    GeneRIF: Characterization of KIF20B as a novel prognostic biomarker
            and therapeutic target for breast cancer.
REFERENCE   2  (bases 1 to 6441)
  AUTHORS   Yang,J., Xu,L. and Han,X.
  TITLE     KIF20B Correlates with LUAD Progression and Is an Independent Risk
            Factor
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (3), 49-59 (2024)
   PUBMED   38305288
  REMARK    GeneRIF: KIF20B Correlates with LUAD Progression and Is an
            Independent Risk Factor.
REFERENCE   3  (bases 1 to 6441)
  AUTHORS   Li,Z.Y., Wang,Z.X. and Li,C.C.
  TITLE     Kinesin family member 20B regulates tongue cancer progression by
            promoting cell proliferation
  JOURNAL   Mol Med Rep 19 (3), 2202-2210 (2019)
   PUBMED   30664160
  REMARK    GeneRIF: the high level of KIF20B in oral squamous cell carcinoma
            was significantly associated with poor clinicopathological features
            and survival. KIF20B might promote cancer development through
            enhancing cell proliferation in vitro, and might be a potential
            biomarker of oral squamous cell carcinoma.
REFERENCE   4  (bases 1 to 6441)
  AUTHORS   Georges,A., Coyaud,E., Marcon,E., Greenblatt,J., Raught,B. and
            Frappier,L.
  TITLE     USP7 Regulates Cytokinesis through FBXO38 and KIF20B
  JOURNAL   Sci Rep 9 (1), 2724 (2019)
   PUBMED   30804394
  REMARK    GeneRIF: USP7 Regulates Cytokinesis through FBXO38 and KIF20B.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6441)
  AUTHORS   Lin,W.F., Lin,X.L., Fu,S.W., Yang,L., Tang,C.T., Gao,Y.J.,
            Chen,H.Y. and Ge,Z.Z.
  TITLE     Pseudopod-associated protein KIF20B promotes Gli1-induced
            epithelial-mesenchymal transition modulated by pseudopodial actin
            dynamic in human colorectal cancer
  JOURNAL   Mol Carcinog 57 (7), 911-925 (2018)
   PUBMED   29573464
  REMARK    GeneRIF: KIF20B may be a potential biomarker and promising
            treatment target for CRC.
REFERENCE   6  (bases 1 to 6441)
  AUTHORS   Abaza,A., Soleilhac,J.M., Westendorf,J., Piel,M., Crevel,I.,
            Roux,A. and Pirollet,F.
  TITLE     M phase phosphoprotein 1 is a human plus-end-directed
            kinesin-related protein required for cytokinesis
  JOURNAL   J Biol Chem 278 (30), 27844-27852 (2003)
   PUBMED   12740395
  REMARK    GeneRIF: MPP1 is a new mitotic molecular motor required for
            completion of cytokinesis
REFERENCE   7  (bases 1 to 6441)
  AUTHORS   Kamimoto,T., Zama,T., Aoki,R., Muro,Y. and Hagiwara,M.
  TITLE     Identification of a novel kinesin-related protein, KRMP1, as a
            target for mitotic peptidyl-prolyl isomerase Pin1
  JOURNAL   J Biol Chem 276 (40), 37520-37528 (2001)
   PUBMED   11470801
REFERENCE   8  (bases 1 to 6441)
  AUTHORS   Fritzler,M.J., Kerfoot,S.M., Feasby,T.E., Zochodne,D.W.,
            Westendorf,J.M., Dalmau,J.O. and Chan,E.K.
  TITLE     Autoantibodies from patients with idiopathic ataxia bind to M-phase
            phosphoprotein-1 (MPP1)
  JOURNAL   J Investig Med 48 (1), 28-39 (2000)
   PUBMED   10695267
REFERENCE   9  (bases 1 to 6441)
  AUTHORS   Matsumoto-Taniura,N., Pirollet,F., Monroe,R., Gerace,L. and
            Westendorf,J.M.
  TITLE     Identification of novel M phase phosphoproteins by expression
            cloning
  JOURNAL   Mol Biol Cell 7 (9), 1455-1469 (1996)
   PUBMED   8885239
REFERENCE   10 (bases 1 to 6441)
  AUTHORS   Westendorf,J.M., Rao,P.N. and Gerace,L.
  TITLE     Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2
            monoclonal antibody and determination of the phosphorylated epitope
  JOURNAL   Proc Natl Acad Sci U S A 91 (2), 714-718 (1994)
   PUBMED   8290587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL157400.8 and AL157389.12.
            
            On May 13, 2020 this sequence version replaced NM_001284259.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033337.1, SRR18074967.554468.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371728.8/ ENSP00000360793.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AL157400.8         136064-136154
            92-239              AL157400.8         139768-139915
            240-326             AL157400.8         143641-143727
            327-443             AL157400.8         143819-143935
            444-582             AL157400.8         144401-144539
            583-767             AL157400.8         145435-145619
            768-804             AL157389.12        2125-2161
            805-1032            AL157389.12        3033-3260
            1033-1144           AL157389.12        4514-4625
            1145-1216           AL157389.12        5502-5573
            1217-1363           AL157389.12        5654-5800
            1364-1526           AL157389.12        6788-6950
            1527-1814           AL157389.12        7497-7784
            1815-1954           AL157389.12        12042-12181
            1955-2093           AL157389.12        13098-13236
            2094-2322           AL157389.12        14371-14599
            2323-2363           AL157389.12        15934-15974
            2364-2483           AL157389.12        17206-17325
            2484-2637           AL157389.12        20981-21134
            2638-3868           AL157389.12        25465-26695
            3869-4007           AL157389.12        27036-27174
            4008-4127           AL157389.12        31886-32005
            4128-4188           AL157389.12        33977-34037
            4189-4314           AL157389.12        39424-39549
            4315-4439           AL157389.12        40645-40769
            4440-4595           AL157389.12        42596-42751
            4596-4772           AL157389.12        46784-46960
            4773-4883           AL157389.12        48604-48714
            4884-5081           AL157389.12        50716-50913
            5082-5183           AL157389.12        56368-56469
            5184-5334           AL157389.12        56816-56966
            5335-5477           AL157389.12        60767-60909
            5478-6441           AL157389.12        62049-63012
FEATURES             Location/Qualifiers
     source          1..6441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..6441
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /note="kinesin family member 20B"
                     /db_xref="GeneID:9585"
                     /db_xref="HGNC:HGNC:7212"
                     /db_xref="MIM:605498"
     exon            1..91
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            92..239
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..5555
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitotic kinesin-like protein; cancer/testis antigen 90;
                     mitotic kinesin-related protein; M-phase phosphoprotein 1;
                     kinesin-like protein KIF20B; kinesin-related motor
                     interacting with PIN1"
                     /codon_start=1
                     /product="kinesin-like protein KIF20B isoform 1"
                     /protein_id="NP_001271188.1"
                     /db_xref="CCDS:CCDS60590.1"
                     /db_xref="GeneID:9585"
                     /db_xref="HGNC:HGNC:7212"
                     /db_xref="MIM:605498"
                     /translation="MESNFNQEGVPRPSYVFSADPIARPSEINFDGIKLDLSHEFSLV
                     APNTEANSFESKDYLQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLS
                     EKSSGQMAQKFSFSKVFGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTY
                     TFQGTEENIGILPRTLNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSA
                     LLRQIKEVTVHNDSDDTLYGSLTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFF
                     EIYNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGI
                     KHQSVAFTKLNNASSRSHSIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQN
                     EGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKI
                     CMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNS
                     NSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKA
                     FISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETL
                     LQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEETHNYVGFEDIIDSL
                     QDNVADIKKQAEIAHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTKEELKK
                     RENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCND
                     KADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSA
                     ITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVH
                     FQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETAT
                     RSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLG
                     NDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKL
                     QAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGK
                     RALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEF
                     QEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKE
                     ELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKI
                     NELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMR
                     MTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTD
                     VLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERF
                     FKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKR
                     IISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVST
                     ENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKC
                     ENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKK
                     EGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSE
                     ISSPIDISGQVILMDQKMKESDHQIIKRRLRTKTAK"
     exon            240..326
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..443
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..582
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..767
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..804
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1032
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1144
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1216
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1363
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1526
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1814
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1954
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2093
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2322
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2363
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2483
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2637
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..3868
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..4007
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4008..4127
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4128..4188
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4189..4314
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4315..4439
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4440..4595
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4596..4772
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4773..4883
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4884..5081
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5082..5183
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5184..5334
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5335..5477
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5478..6441
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6424..6429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /note="hexamer: AATAAA"
     polyA_site      6441
                     /gene="KIF20B"
                     /gene_synonym="CT90; KRMP1; MPHOSPH1; MPP-1; MPP1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggtgc cctggccgcc attgtttgaa tttgaaaacg gtaacatcgc agtgctgctc
       61 gcgggtctgg ctagtcaggc gaagtttgca gaatggaatc taattttaat caagagggag
      121 tacctcgacc atcttatgtt tttagtgctg acccaattgc aaggccttca gaaataaatt
      181 tcgatggcat taagcttgat ctgtctcatg aattttcctt agttgctcca aatactgagg
      241 caaacagttt cgaatctaaa gattatctcc aggtttgtct tcgaataaga ccatttacac
      301 agtcagaaaa agaacttgag tctgagggct gtgtgcatat tctggattca cagactgttg
      361 tgctgaaaga gcctcaatgc atccttggtc ggttaagtga aaaaagctca gggcagatgg
      421 cacagaaatt cagtttttcc aaggtttttg gcccagcaac tacacagaag gaattctttc
      481 agggttgcat tatgcaacca gtaaaagacc tcttgaaagg acagagtcgt ctgattttta
      541 cttacgggct aaccaattca ggaaaaacat atacatttca agggacagaa gaaaatattg
      601 gcattctgcc tcgaactttg aatgtattat ttgatagtct tcaagaaaga ctgtatacaa
      661 agatgaacct taaaccacat agatccagag aatacttaag gttatcatca gaacaagaga
      721 aagaagaaat tgctagcaaa agtgcattgc ttcggcaaat taaagaggtt actgtgcata
      781 atgatagtga tgatactctt tatggaagtt taactaactc tttgaatatc tcagagtttg
      841 aagaatccat aaaagattat gaacaagcca acttgaatat ggctaatagt ataaaatttt
      901 ctgtgtgggt ttctttcttt gaaatttaca atgaatatat ttatgactta tttgttcctg
      961 tatcatctaa attccaaaag agaaagatgc tgcgcctttc ccaagacgta aagggctatt
     1021 cttttataaa agatctacaa tggattcaag tatctgattc caaagaagcc tatagacttt
     1081 taaaactagg aataaagcac cagagtgttg ccttcacaaa attgaataat gcttccagta
     1141 gaagtcacag catattcact gttaaaatat tacagattga agattctgaa atgtctcgtg
     1201 taattcgagt cagtgaatta tctttatgtg atcttgctgg ttcagaacga actatgaaga
     1261 cacagaatga aggtgaaagg ttaagagaga ctgggaatat caacacttct ttattgactc
     1321 tgggaaagtg tattaacgtc ttgaagaata gtgaaaagtc aaagtttcaa cagcatgtgc
     1381 ctttccggga aagtaaactg actcactatt ttcaaagttt ttttaatggt aaagggaaaa
     1441 tttgtatgat tgtcaatatc agccaatgtt atttagccta tgatgaaaca ctcaatgtat
     1501 tgaagttctc cgccattgca caaaaagttt gtgtcccaga cactttaaat tcctctcaag
     1561 agaaattatt tggacctgtc aaatcttctc aagatgtatc actagacagt aattcaaaca
     1621 gtaaaatatt aaatgtaaaa agagccacca tttcatggga aaatagtcta gaagatttga
     1681 tggaagacga ggatttggtt gaggagctag aaaacgctga agaaactcaa aatgtggaaa
     1741 ctaaacttct tgatgaagat ctagataaaa cattagagga aaataaggct ttcattagcc
     1801 acgaggagaa aagaaaactg ttggacttaa tagaagactt gaaaaaaaaa ctgataaatg
     1861 aaaaaaagga aaaattaacc ttggaattta aaattcgaga agaagttaca caggagttta
     1921 ctcagtattg ggctcaacgg gaagctgact ttaaggagac tctgcttcaa gaacgagaga
     1981 tattagaaga aaatgctgaa cgtcgtttgg ctatcttcaa ggatttggtt ggtaaatgtg
     2041 acactcgaga agaagcagcg aaagacattt gtgccacaaa agttgaaact gaagaaacac
     2101 ataattatgt aggatttgaa gatattattg attctcttca agataatgtt gctgatatta
     2161 agaaacaggc tgaaattgct cacttatata ttgcatctct tcctgacccc caggaagcta
     2221 ctgcttgttt agaactaaag tttaatcaaa ttaaagctga attagctaaa accaaaggag
     2281 aattaatcaa aaccaaagaa gagttaaaaa agagagaaaa tgaatcagat tcattgattc
     2341 aagagcttga gacatctaat aagaaaataa ttacacagaa tcaaagaatt aaagaattga
     2401 taaatataat tgatcaaaaa gaagatacta tcaacgaatt tcagaaccta aagtctcata
     2461 tggaaaacac atttaaatgc aatgacaagg ctgatacatc ttctttaata ataaacaata
     2521 aattgatttg taatgaaaca gttgaagtac ctaaggacag caaatctaaa atctgttcag
     2581 aaagaaaaag agtaaatgaa aatgaacttc agcaagatga accaccagca aagaaagggt
     2641 ctatccatgt tagttcagct atcactgaag accaaaagaa aagtgaagaa gtgcgaccga
     2701 acattgcaga aattgaagac atcagagttt tacaagaaaa taatgaagga ctgagagcat
     2761 ttttactcac tattgagaat gaacttaaaa atgaaaagga agaaaaagca gaattaaata
     2821 aacagattgt tcattttcag caggaacttt ctctttctga aaaaaagaat ttaactttaa
     2881 gtaaagaggt ccaacaaatt cagtcaaatt atgatattgc aattgctgaa ttacatgtgc
     2941 agaaaagtaa aaatcaagaa caggaggaaa agatcatgaa attgtcaaat gagatagaaa
     3001 ctgctacaag aagcattaca aataatgttt cacaaataaa attaatgcac acgaaaatag
     3061 acgaactacg tactcttgat tcagtttctc agatttcaaa catagatttg ctcaatctca
     3121 gggatctgtc aaatggttct gaggaggata atttgccaaa tacacagtta gaccttttag
     3181 gtaatgatta tttggtaagt aagcaagtta aagaatatcg aattcaagaa cccaataggg
     3241 aaaattcttt ccactctagt attgaagcta tttgggaaga atgtaaagag attgtgaagg
     3301 cctcttccaa aaaaagtcat cagattgagg aactggaaca acaaattgaa aaattgcagg
     3361 cagaagtaaa aggctataag gatgaaaaca atagactaaa ggagaaggag cataaaaacc
     3421 aagatgacct actaaaagaa aaagaaactc ttatacagca gctgaaagaa gaattgcaag
     3481 aaaaaaatgt tactcttgat gttcaaatac agcatgtagt tgaaggaaag agagcgcttt
     3541 cagaacttac acaaggtgtt acttgctata aggcaaaaat aaaggaactt gaaacaattt
     3601 tagagactca gaaagttgaa tgtagtcatt cagccaagtt agaacaagac attttggaaa
     3661 aggaatctat catcttaaag ctagaaagaa atttgaagga atttcaagaa catcttcagg
     3721 attctgtcaa aaacaccaaa gatttaaatg taaaggaact caagctgaaa gaagaaatca
     3781 cacagttaac aaataatttg caagatatga aacatttact tcaattaaaa gaagaagaag
     3841 aagaaaccaa caggcaagaa acagaaaaat tgaaagagga actctctgca agctctgctc
     3901 gtacccagaa tctgaaagca gatcttcaga ggaaggaaga agattatgct gacctgaaag
     3961 agaaactgac tgatgccaaa aagcagatta agcaagtaca gaaagaggta tctgtaatgc
     4021 gtgatgagga taaattactg aggattaaaa ttaatgaact ggagaaaaag aaaaaccagt
     4081 gttctcagga attagatatg aaacagcgaa ccattcagca actcaaggag cagttaaata
     4141 atcagaaagt ggaagaagct atacaacagt atgagagagc atgcaaagat ctaaatgtta
     4201 aagagaaaat aattgaagac atgcgaatga cactagaaga acaggaacaa actcaggtag
     4261 aacaggatca agtgcttgag gctaaattag aggaagttga aaggctggcc acagaattgg
     4321 aaaaatggaa ggaaaaatgc aatgatttgg aaaccaaaaa caatcaaagg tcaaataaag
     4381 aacatgagaa caacacagat gtgcttggaa agctcactaa tcttcaagat gagttacagg
     4441 agtctgaaca gaaatataat gctgatagaa agaaatggtt agaagaaaaa atgatgctta
     4501 tcactcaagc gaaagaagca gagaatatac gaaataaaga gatgaaaaaa tatgctgagg
     4561 acagggagcg tttttttaag caacagaatg aaatggaaat actgacagcc cagctgacag
     4621 agaaagatag tgaccttcaa aagtggcgag aagaacgaga tcaactggtt gcagctttag
     4681 aaatacagct aaaagcactg atatccagta atgtacagaa agataatgaa attgaacaac
     4741 taaaaaggat catatcagag acttctaaaa tagaaacaca aatcatggat atcaagccca
     4801 aacgtattag ttcagcagat cctgacaaac ttcaaactga acctctatcg acaagttttg
     4861 aaatttccag aaataaaata gaggatggat ctgtagtcct tgactcttgt gaagtgtcaa
     4921 cagaaaatga tcaaagcact cgatttccaa aacctgagtt agagattcaa tttacacctt
     4981 tacagccaaa caaaatggca gtgaaacacc ctggttgtac cacaccagtg acagttaaga
     5041 ttcccaaggc tcggaagagg aagagtaatg aaatggagga ggacttggtg aaatgtgaaa
     5101 ataagaagaa tgctacaccc agaactaatt tgaaatttcc tatttcagat gatagaaatt
     5161 cttctgtcaa aaaggaacaa aaggttgcca tacgtccatc atctaagaaa acatattctt
     5221 tacggagtca ggcatccata attggtgtaa acctggccac taagaaaaaa gaaggaacac
     5281 tacagaaatt tggagacttc ttacaacatt ctccctcaat tcttcaatca aaagcaaaga
     5341 agataattga aacaatgagc tcttcaaagc tctcaaatgt agaagcaagt aaagaaaatg
     5401 tgtctcaacc aaaacgagcc aaacggaaat tatacacaag tgaaatttca tctcctattg
     5461 atatatcagg ccaagtgatt ttaatggacc agaaaatgaa ggagagtgat caccagatta
     5521 tcaaacgacg acttcgaaca aaaacagcca aataaatcac ttatggaaat gtttaatata
     5581 aattttatag tcatagtcat tggaacttgc atcctgtatt gtaaatataa atgtatatat
     5641 tatgcattaa atcactctgc atatagattg ctgttttata catagtataa ttttaattca
     5701 ataaatgagt caaaatttgt atatttttat aaggcttttt tataatagct tctttcaaac
     5761 tgtatttccc tattatctca gacattggat cagtgaagat cctaggaaag aggctgttat
     5821 tctcatttat tttgctatac aggatgtaat aggtcaggta tttggtttac ttatatttaa
     5881 caatgtctta tgaatttttt ttactttatc tgttatacaa ctgattttac atatctgttt
     5941 ggattatagc taggatttgg agaataagtg tgtacagatc acaaaacatg tatatacatt
     6001 atttagaaaa gatctcaagt ctttaattag aatgtctcac ttattttgta aacattttgt
     6061 gggtacatag tacatgtata tatttacggg gtatgtgaga tgttttgaca caggcatgca
     6121 atgtgaaata cgtgtatcat ggagaatgag gtatccatcc cctcaagcat ttttcctttg
     6181 aattacagat aatccaatta cattctttag atcatttaaa aatatacaag taagttatta
     6241 ttgattatag tcactctatt gtgctatcag atagtagatc attcttttta tcttatttgt
     6301 ttttgtaccc attaaccatc cccacctccc cctgcaaccg tcagtaccct taccagccac
     6361 tggtaaccat tcttctactc tgtatgccca tgaggtcaat tgattttatt tttagatccc
     6421 ataaataaat gagaacatgc a
//
