LOCUS       NM_005733               3095 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens kinesin family member 20A (KIF20A), mRNA.
ACCESSION   NM_005733
VERSION     NM_005733.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3095)
  AUTHORS   Wu,M., Wu,X. and Han,J.
  TITLE     KIF20A Promotes CRC Progression and the Warburg Effect through the
            C-Myc/HIF-1alpha Axis
  JOURNAL   Protein Pept Lett 31 (2), 107-115 (2024)
   PUBMED   38037834
  REMARK    GeneRIF: KIF20A Promotes CRC Progression and the Warburg Effect
            through the C-Myc/HIF-1alpha Axis.
REFERENCE   2  (bases 1 to 3095)
  AUTHORS   Zhang,L., Song,W., Shi,J. and Chen,Y.
  TITLE     Circ_0084188 Regulates the progression of colorectal cancer through
            the miR-769-5p/KIF20A axis
  JOURNAL   Biochem Genet 61 (5), 1727-1744 (2023)
   PUBMED   36763221
  REMARK    GeneRIF: Circ_0084188 Regulates the progression of colorectal
            cancer through the miR-769-5p/KIF20A axis.
REFERENCE   3  (bases 1 to 3095)
  AUTHORS   Ye,L., Tong,S., Wang,Y., Wang,Y. and Ma,W.
  TITLE     Grade scoring system reveals distinct molecular subtypes and
            identifies KIF20A as a novel biomarker for predicting temozolomide
            treatment efficiency in gliomas
  JOURNAL   J Cancer Res Clin Oncol 149 (12), 9857-9876 (2023)
   PUBMED   37248320
  REMARK    GeneRIF: Grade scoring system reveals distinct molecular subtypes
            and identifies KIF20A as a novel biomarker for predicting
            temozolomide treatment efficiency in gliomas.
REFERENCE   4  (bases 1 to 3095)
  AUTHORS   Liu,B., Su,J., Fan,B., Ni,X. and Jin,T.
  TITLE     High expression of KIF20A in bladder cancer as a potential
            prognostic target for poor survival of renal cell carcinoma
  JOURNAL   Medicine (Baltimore) 102 (2), e32667 (2023)
   PUBMED   36637953
  REMARK    GeneRIF: High expression of KIF20A in bladder cancer as a potential
            prognostic target for poor survival of renal cell carcinoma.
REFERENCE   5  (bases 1 to 3095)
  AUTHORS   Jin,Z., Tao,S., Zhang,C., Xu,D. and Zhu,Z.
  TITLE     KIF20A promotes the development of fibrosarcoma via PI3K-Akt
            signaling pathway
  JOURNAL   Exp Cell Res 420 (1), 113322 (2022)
   PUBMED   36037925
  REMARK    GeneRIF: KIF20A promotes the development of fibrosarcoma via
            PI3K-Akt signaling pathway.
REFERENCE   6  (bases 1 to 3095)
  AUTHORS   Hill,E., Clarke,M. and Barr,F.A.
  TITLE     The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis
  JOURNAL   EMBO J 19 (21), 5711-5719 (2000)
   PUBMED   11060022
  REMARK    GeneRIF: KIF20A (Rab6KIFL/MKlp2) is required for cytokinesis
REFERENCE   7  (bases 1 to 3095)
  AUTHORS   Opdam,F.J., Echard,A., Croes,H.J., van den Hurk,J.A., van de
            Vorstenbosch,R.A., Ginsel,L.A., Goud,B. and Fransen,J.A.
  TITLE     The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type
            specifically expressed and localised to the Golgi apparatus
  JOURNAL   J Cell Sci 113 (Pt 15), 2725-2735 (2000)
   PUBMED   10893188
REFERENCE   8  (bases 1 to 3095)
  AUTHORS   Lai,F., Fernald,A.A., Zhao,N. and Le Beau,M.M.
  TITLE     cDNA cloning, expression pattern, genomic structure and chromosomal
            location of RAB6KIFL, a human kinesin-like gene
  JOURNAL   Gene 248 (1-2), 117-125 (2000)
   PUBMED   10806357
REFERENCE   9  (bases 1 to 3095)
  AUTHORS   Horrevoets,A.J., Fontijn,R.D., van Zonneveld,A.J., de Vries,C.J.,
            ten Cate,J.W. and Pannekoek,H.
  TITLE     Vascular endothelial genes that are responsive to tumor necrosis
            factor-alpha in vitro are expressed in atherosclerotic lesions,
            including inhibitor of apoptosis protein-1, stannin, and two novel
            genes
  JOURNAL   Blood 93 (10), 3418-3431 (1999)
   PUBMED   10233894
REFERENCE   10 (bases 1 to 3095)
  AUTHORS   Echard,A., Jollivet,F., Martinez,O., Lacapere,J.J., Rousselet,A.,
            Janoueix-Lerosey,I. and Goud,B.
  TITLE     Interaction of a Golgi-associated kinesin-like protein with Rab6
  JOURNAL   Science 279 (5350), 580-585 (1998)
   PUBMED   9438855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC402781.1, BC012999.2, AK025790.1 and AC106752.3.
            
            On Nov 23, 2018 this sequence version replaced NM_005733.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025790.1, BC012999.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394894.8/ ENSP00000378356.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                DC402781.1         394-471
            79-3037             BC012999.2         1-2959
            3038-3087           AK025790.1         2981-3030
            3088-3095           AC106752.3         9045-9052
FEATURES             Location/Qualifiers
     source          1..3095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..3095
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /note="kinesin family member 20A"
                     /db_xref="GeneID:10112"
                     /db_xref="HGNC:HGNC:9787"
                     /db_xref="MIM:605664"
     exon            1..91
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            92..277
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2785
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /note="RAB6 interacting, kinesin-like (rabkinesin6);
                     mitotic kinesin-like protein 2; GG10_2; rabkinesin-6;
                     rab6-interacting kinesin-like protein"
                     /codon_start=1
                     /product="kinesin-like protein KIF20A"
                     /protein_id="NP_005724.1"
                     /db_xref="CCDS:CCDS4199.1"
                     /db_xref="GeneID:10112"
                     /db_xref="HGNC:HGNC:9787"
                     /db_xref="MIM:605664"
                     /translation="MSQGILSPPAGLLSDDDVVVSPMFESTAADLGSVVRKNLLSDCS
                     VVSTSLEDKQQVPSEDSMEKVKVYLRVRPLLPSELERQEDQGCVRIENVETLVLQAPK
                     DSFALKSNERGIGQATHRFTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYTYG
                     VTNSGKTHTIQGTIKDGGILPRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIR
                     QEEMKKLSLLNGGLQEEELSTSLKRSVYIESRIGTSTSFDSGIAGLSSISQCTSSSQL
                     DETSHRWAQPDTAPLPVPANIRFSIWISFFEIYNELLYDLLEPPSQQRKRQTLRLCED
                     QNGNPYVKDLNWIHVQDAEEAWKLLKVGRKNQSFASTHLNQNSSRSHSIFSIRILHLQ
                     GEGDIVPKISELSLCDLAGSERCKDQKSGERLKEAGNINTSLHTLGRCIAALRQNQQN
                     RSKQNLVPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHVAKFSAIASQLV
                     HAPPMQLGFPSLHSFIKEHSLQVSPSLEKGAKADTGLDDDIENEADISMYGKEELLQV
                     VEAMKTLLLKERQEKLQLEMHLRDEICNEMVEQMQQREQWCSEHLDTQKELLEEMYEE
                     KLNILKESLTSFYQEEIQERDEKIEELEALLQEARQQSVAHQQSGSELALRRSQRLAA
                     SASTQQLQEVKAKLQQCKAELNSTTEELHKYQKMLEPPPSAKPFTIDVDKKLEEGQKN
                     IRLLRTELQKLGESLQSAERACCHSTGAGKLRQALTTCDDILIKQDQTLAELQNNMVL
                     VKLDLRKKAACIAEQYHTVLKLQGQVSAKKRLGTNQENQQPNQQPPGKKPFLRNLLPR
                     TPTCQSSTDCSPYARILRSRRSPLLKSGPFGKKY"
     exon            278..367
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            368..487
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            488..626
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            627..814
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            815..944
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1139
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1251
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1320
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1464
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1630
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1795
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1935
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2038
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2237
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2329
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2467
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..3095
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2932..2937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /note="hexamer: ATTATA"
     polyA_site      2955
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /note="major polyA site"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /note="hexamer: ATTAAA"
     polyA_site      3045
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /note="major polyA site"
     regulatory      3065..3070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /note="hexamer: ATTAAA"
     regulatory      3077..3082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
                     /note="hexamer: TATAAA"
     polyA_site      3087
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
     polyA_site      3095
                     /gene="KIF20A"
                     /gene_synonym="MKLP2; RAB6KIFL; RCM6"
ORIGIN      
        1 ggagttgtgc tctgcggctg cgaaagtcca gcttcggcga ctaggtgtga gtaagccagt
       61 atcccaggag gagcaagtgg cacgtcttcg gacctaggct gcccctgccg tcatgtcgca
      121 agggatcctt tctccgccag cgggcttgct gtccgatgac gatgtcgtag tttctcccat
      181 gtttgagtcc acagctgcag atttggggtc tgtggtacgc aagaacctgc tatcagactg
      241 ctctgtcgtc tctacctccc tagaggacaa gcagcaggtt ccatctgagg acagtatgga
      301 gaaggtgaaa gtatacttga gggttaggcc cttgttacct tcagagttgg aacgacagga
      361 agatcagggt tgtgtccgta ttgagaatgt ggagaccctt gttctacaag cacccaagga
      421 ctcttttgcc ctgaagagca atgaacgggg aattggccaa gccacacaca ggttcacctt
      481 ttcccagatc tttgggccag aagtgggaca ggcatccttc ttcaacctaa ctgtgaagga
      541 gatggtaaag gatgtactca aagggcagaa ctggctcatc tatacatatg gagtcactaa
      601 ctcagggaaa acccacacga ttcaaggtac catcaaggat ggagggattc tcccccggtc
      661 cctggcgctg atcttcaata gcctccaagg ccaacttcat ccaacacctg atctgaagcc
      721 cttgctctcc aatgaggtaa tctggctaga cagcaagcag atccgacagg aggaaatgaa
      781 gaagctgtcc ctgctaaatg gaggcctcca agaggaggag ctgtccactt ccttgaagag
      841 gagtgtctac atcgaaagtc ggataggtac cagcaccagc ttcgacagtg gcattgctgg
      901 gctctcttct atcagtcagt gtaccagcag tagccagctg gatgaaacaa gtcatcgatg
      961 ggcacagcca gacactgccc cactacctgt cccggcaaac attcgcttct ccatctggat
     1021 ctcattcttt gagatctaca acgaactgct ttatgaccta ttagaaccgc ctagccaaca
     1081 gcgcaagagg cagactttgc ggctatgcga ggatcaaaat ggcaatccct atgtgaaaga
     1141 tctcaactgg attcatgtgc aagatgctga ggaggcctgg aagctcctaa aagtgggtcg
     1201 taagaaccag agctttgcca gcacccacct caaccagaac tccagccgca gtcacagcat
     1261 cttctcaatc aggatcctac accttcaggg ggaaggagat atagtcccca agatcagcga
     1321 gctgtcactc tgtgatctgg ctggctcaga gcgctgcaaa gatcagaaga gtggtgaacg
     1381 gttgaaggaa gcaggaaaca ttaacacctc tctacacacc ctgggccgct gtattgctgc
     1441 ccttcgtcaa aaccagcaga accggtcaaa gcagaacctg gttcccttcc gtgacagcaa
     1501 gttgactcga gtgttccaag gtttcttcac aggccgaggc cgttcctgca tgattgtcaa
     1561 tgtgaatccc tgtgcatcta cctatgatga aactcttcat gtggccaagt tctcagccat
     1621 tgctagccag cttgtgcatg ccccacctat gcaactggga ttcccatccc tgcactcgtt
     1681 catcaaggaa catagtcttc aggtatcccc cagcttagag aaaggggcta aggcagacac
     1741 aggccttgat gatgatattg aaaatgaagc tgacatctcc atgtatggca aagaggagct
     1801 cctacaagtt gtggaagcca tgaagacact gcttttgaag gaacgacagg aaaagctaca
     1861 gctggagatg catctccgag atgaaatttg caatgagatg gtagaacaga tgcaacagcg
     1921 ggaacagtgg tgcagtgaac atttggacac ccaaaaggaa ctattggagg aaatgtatga
     1981 agaaaaacta aatatcctca aggagtcact gacaagtttt taccaagaag agattcagga
     2041 gcgggatgaa aagattgaag agctagaagc tctcttgcag gaagccagac aacagtcagt
     2101 ggcccatcag caatcagggt ctgaattggc cctacggcgg tcacaaaggt tggcagcttc
     2161 tgcctccacc cagcagcttc aggaggttaa agctaaatta cagcagtgca aagcagagct
     2221 aaactctacc actgaagagt tgcataagta tcagaaaatg ttagaaccac caccctcagc
     2281 caagcccttc accattgatg tggacaagaa gttagaagag ggccagaaga atataaggct
     2341 gttgcggaca gagcttcaga aacttggtga gtctctccaa tcagcagaga gagcttgttg
     2401 ccacagcact ggggcaggaa aacttcgtca agccttgacc acttgtgatg acatcttaat
     2461 caaacaggac cagactctgg ctgaactgca gaacaacatg gtgctagtga aactggacct
     2521 tcggaagaag gcagcatgta ttgctgagca gtatcatact gtgttgaaac tccaaggcca
     2581 ggtttctgcc aaaaagcgcc ttggtaccaa ccaggaaaat cagcaaccaa accaacaacc
     2641 accagggaag aaaccattcc ttcgaaattt acttccccga acaccaacct gccaaagctc
     2701 aacagactgc agcccttatg cccggatcct acgctcacgg cgttcccctt tactcaaatc
     2761 tgggcctttt ggcaaaaagt actaaggctg tggggaaaga gaagagcagt catggccctg
     2821 aggtgggtca gctactctcc tgaagaaata ggtctctttt atgctttacc atatatcagg
     2881 aattatatcc aggatgcaat actcagacac tagctttttt ctcacttttg tattataacc
     2941 acctatgtaa tctcatgttg ttgttttttt ttatttactt atatgatttc tatgcacaca
     3001 aaaacagtta tattaaagat attattgttc acatttttta ttgaattcca aatgtagcaa
     3061 aatcattaaa acaaattata aaagggacag aaaaa
//
